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Aliases for OR10H3 Gene

Aliases for OR10H3 Gene

  • Olfactory Receptor Family 10 Subfamily H Member 3 2 3 5
  • Olfactory Receptor OR19-24 3 4
  • Olfactory Receptor 10H3 3 4
  • Olfactory Receptor, Family 10, Subfamily H, Member 3 2

External Ids for OR10H3 Gene

Previous GeneCards Identifiers for OR10H3 Gene

  • GC19M016317
  • GC19P016245
  • GC19P015697
  • GC19P015713
  • GC19P015852

Summaries for OR10H3 Gene

Entrez Gene Summary for OR10H3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10H3 Gene

OR10H3 (Olfactory Receptor Family 10 Subfamily H Member 3) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10H4.

UniProtKB/Swiss-Prot for OR10H3 Gene

Gene Wiki entry for OR10H3 Gene

Additional gene information for OR10H3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10H3 Gene

Genomics for OR10H3 Gene

GeneHancer (GH) Regulatory Elements for OR10H3 Gene

Promoters and enhancers for OR10H3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J015826 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 9.4 +94.8 94780 12.9 SP1 ZFX ELF3 CC2D1A ZKSCAN8 CBFA2T2 ZNF148 MLLT1 POLR2A GTF2F1 ENSG00000273782 ENSG00000269578 AKAP8 MED26 SIN3B CHERP C19orf44 BRD4 CYP4F24P UCA1
GH19J016168 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 10.1 +431.0 430976 1.6 CBFA2T2 SMARCC2 RAD51 NFYA USF1 NFYB ZNF580 ZNF189 USF2 BCOR OR10H3 OR10H2 AP1M1 OR10H4 CIB3 GC19M016168 ENSG00000269243
GH19J016063 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2.3 +334.9 334928 18.7 ZNF473 SP1 CC2D1A ELF3 ZFX CTCF ZKSCAN8 CBFA2T2 ZNF148 NKRF TPM4 AKAP8 CHERP ENSG00000269578 BRD4 C19orf44 ENSG00000267904 ENSG00000268087 MED26 ENSG00000268743
GH19J015820 Enhancer 0.2 FANTOM5 7.8 +83.0 82979 0.1 OR10H4 OR10H5 CYP4F11 OR10H3 OR10H2 AKAP8 RASAL3 ZNF861P OR10H1
GH19J015865 Enhancer 0.2 FANTOM5 1.9 +126.5 126470 0.1 LOC105369202 LINC01835 GC19M015863 OR10H3 OR10H2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10H3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR10H3 gene promoter:
  • AhR
  • c-Myc
  • CREB
  • E47
  • ITF-2
  • Max1
  • RFX1
  • RP58
  • Tal-1beta

Genomic Locations for OR10H3 Gene

Genomic Locations for OR10H3 Gene
4,359 bases
Plus strand
951 bases
Plus strand

Genomic View for OR10H3 Gene

Genes around OR10H3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10H3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10H3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10H3 Gene

Proteins for OR10H3 Gene

  • Protein details for OR10H3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 10H3
    Protein Accession:
    Secondary Accessions:
    • Q2HIZ3
    • Q6IFQ0

    Protein attributes for OR10H3 Gene

    316 amino acids
    Molecular mass:
    35721 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10H3 Gene

Post-translational modifications for OR10H3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR10H3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10H3 Gene

Domains & Families for OR10H3 Gene

Gene Families for OR10H3 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10H3 Gene

Suggested Antigen Peptide Sequences for OR10H3 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR19-24 (O10H3_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10H3: view

Function for OR10H3 Gene

Molecular function for OR10H3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 10,subfamily H,member 3,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR10H3 Gene

Gene Ontology (GO) - Molecular Function for OR10H3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0004984 olfactory receptor activity IEA --
GO:0004993 G protein-coupled serotonin receptor activity IBA 21873635
GO:0030594 neurotransmitter receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR10H3: view
genes like me logo Genes that share phenotypes with OR10H3: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for OR10H3 - Now 50% OFF >
  • * OR10H3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * OR10H3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10H3 Gene

Localization for OR10H3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10H3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10H3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10H3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030425 dendrite IBA 21873635
genes like me logo Genes that share ontologies with OR10H3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10H3 Gene

Pathways & Interactions for OR10H3 Gene

genes like me logo Genes that share pathways with OR10H3: view

Pathways by source for OR10H3 Gene

1 BioSystems pathway for OR10H3 Gene
1 KEGG pathway for OR10H3 Gene

Gene Ontology (GO) - Biological Process for OR10H3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA 21873635
GO:0007268 chemical synaptic transmission IBA 21873635
GO:0007608 sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10H3: view

No data available for SIGNOR curated interactions for OR10H3 Gene

Drugs & Compounds for OR10H3 Gene

No Compound Related Data Available

Transcripts for OR10H3 Gene

mRNA/cDNA for OR10H3 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for OR10H3 Gene

Olfactory receptor, family 10, subfamily H, member 3:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for OR10H3 - Now 50% OFF >
  • * OR10H3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * OR10H3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for OR10H3 Gene

No ASD Table

Relevant External Links for OR10H3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR10H3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR10H3 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR10H3 Gene:


SOURCE GeneReport for Unigene cluster for OR10H3 Gene:

genes like me logo Genes that share expression patterns with OR10H3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10H3 Gene

Orthologs for OR10H3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10H3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC468756 34
  • 98.42 (n)
OR10H3 35
  • 96 (a)
(Canis familiaris)
Mammalia cOR10H10 34
  • 84.5 (n)
-- 35
  • 41 (a)
(Bos Taurus)
Mammalia -- 35
  • 81 (a)
-- 35
  • 80 (a)
-- 35
  • 79 (a)
-- 35
  • 79 (a)
-- 35
  • 78 (a)
-- 35
  • 71 (a)
-- 35
  • 68 (a)
(Rattus norvegicus)
Mammalia LOC100909683 34
  • 80.85 (n)
(Mus musculus)
Mammalia Or10h28 51 Olfr63 17 35 34
  • 79.89 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 66 (a)
-- 35
  • 66 (a)
-- 35
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 61 (a)
Species where no ortholog for OR10H3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10H3 Gene

Gene Tree for OR10H3 (if available)
Gene Tree for OR10H3 (if available)
Evolutionary constrained regions (ECRs) for OR10H3: view image

Paralogs for OR10H3 Gene

(439) SIMAP similar genes for OR10H3 Gene using alignment to 1 proteins:

  • O10H3_HUMAN
genes like me logo Genes that share paralogs with OR10H3: view

Variants for OR10H3 Gene

Sequence variations from dbSNP and Humsavar for OR10H3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000236121 -- 15,741,976(+) C/G coding_sequence_variant, stop_gained
rs1001514495 -- 15,742,575(+) G/A downstream_transcript_variant
rs1002622740 -- 15,739,686(+) G/A upstream_transcript_variant
rs1002965783 -- 15,740,864(+) G/C upstream_transcript_variant
rs1004489279 -- 15,741,198(+) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR10H3 Gene

Variant ID Type Subtype PubMed ID
dgv3454n100 CNV gain 25217958
esv3260 OTHER inversion 18987735
esv3334671 CNV duplication 20981092
nsv1059468 CNV gain 25217958
nsv1064684 CNV gain 25217958
nsv1079032 OTHER inversion 25765185
nsv1133007 OTHER inversion 24896259
nsv1141884 OTHER inversion 24896259
nsv1153107 OTHER inversion 26484159
nsv526168 CNV gain 19592680

Variation tolerance for OR10H3 Gene

Residual Variation Intolerance Score: 71.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.06; 96.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10H3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10H3 Gene

Disorders for OR10H3 Gene

Additional Disease Information for OR10H3

No disorders were found for OR10H3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10H3 Gene

Publications for OR10H3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for OR10H3 Gene

Sources for OR10H3 Gene

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