Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR10H1 Gene

Aliases for OR10H1 Gene

  • Olfactory Receptor Family 10 Subfamily H Member 1 2 3 5
  • Olfactory Receptor OR19-27 3 4
  • Olfactory Receptor 10H1 3 4
  • Olfactory Receptor, Family 10, Subfamily H, Member 1 2

External Ids for OR10H1 Gene

Previous GeneCards Identifiers for OR10H1 Gene

  • GC19M016403
  • GC19M015763
  • GC19M015779
  • GC19M015780
  • GC19M015917

Summaries for OR10H1 Gene

Entrez Gene Summary for OR10H1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10H1 Gene

OR10H1 (Olfactory Receptor Family 10 Subfamily H Member 1) is a Protein Coding gene. Diseases associated with OR10H1 include Morgagni Cataract. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10H5.

UniProtKB/Swiss-Prot Summary for OR10H1 Gene

Gene Wiki entry for OR10H1 Gene

Additional gene information for OR10H1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR10H1 Gene

Genomics for OR10H1 Gene

GeneHancer (GH) Regulatory Elements for OR10H1 Gene

Promoters and enhancers for OR10H1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J015815 Enhancer 0.4 ENCODE 500.7 +0.1 118 0.1 CTCF MNT FOS FOSL2 OR10H1 piR-48209-333 lnc-OR7C2-1
GH19J015679 Enhancer 0.8 ENCODE 11.3 +135.0 134974 3.2 EP300 NCOR1 KDM6A TGIF2 SKI TEAD1 TBX3 FOXA2 CREB1 CEBPB CYP4F24P CYP4F12 OR10H1 CYP4F11 RNU6-782P piR-51367-001 lnc-OR7C2-1
GH19J015911 Promoter 0.6 Ensembl 10.7 -96.1 -96136 0.4 ZNF335 CTCF EZH2 SUZ12 ENSG00000267056 LOC729654 CYP4F11 OR10H4 OR10H5 CYP4F12 OR10H1 ENSG00000279717 lnc-OR10H4-2 lnc-OR7C2-1
GH19J015913 Enhancer 0.3 Ensembl 10.7 -97.8 -97837 0.6 RBM25 ZMYM3 ENSG00000267056 LOC729654 CYP4F11 OR10H4 OR10H5 CYP4F12 OR10H1 lnc-OR7C2-1
GH19J015883 Enhancer 0.3 Ensembl 11.8 -67.9 -67937 0.4 SPI1 CYP4F11 OR10H1 OR10H5 lnc-CYP4F11-1 CYP4F2 CYP4F36P lnc-OR7C2-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10H1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR10H1

Top Transcription factor binding sites by QIAGEN in the OR10H1 gene promoter:
  • AhR
  • CREB
  • E47
  • FOXD1
  • ITF-2
  • NRF-2
  • RP58
  • Tal-1beta
  • ZID

Genomic Locations for OR10H1 Gene

Genomic Locations for OR10H1 Gene
chr19:15,804,549-15,815,664
(GRCh38/hg38)
Size:
11,116 bases
Orientation:
Minus strand
chr19:15,917,817-15,918,936
(GRCh37/hg19)
Size:
1,120 bases
Orientation:
Minus strand

Genomic View for OR10H1 Gene

Genes around OR10H1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10H1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10H1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10H1 Gene

Proteins for OR10H1 Gene

  • Protein details for OR10H1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4A9-O10H1_HUMAN
    Recommended name:
    Olfactory receptor 10H1
    Protein Accession:
    Q9Y4A9
    Secondary Accessions:
    • Q6IFQ2
    • Q96R59

    Protein attributes for OR10H1 Gene

    Size:
    318 amino acids
    Molecular mass:
    35254 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10H1 Gene

Post-translational modifications for OR10H1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10H1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10H1 Gene

Domains & Families for OR10H1 Gene

Gene Families for OR10H1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10H1 Gene

Blocks:
  • Olfactory receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OR10H1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR19-27 (O10H1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y4A9

UniProtKB/Swiss-Prot:

O10H1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10H1: view

Function for OR10H1 Gene

Molecular function for OR10H1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 10,subfamily H,member 1,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR10H1 Gene

Gene Ontology (GO) - Molecular Function for OR10H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0004984 olfactory receptor activity IEA --
GO:0004993 G protein-coupled serotonin receptor activity IBA 21873635
GO:0030594 neurotransmitter receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR10H1: view
genes like me logo Genes that share phenotypes with OR10H1: view

Animal Model Products

CRISPR Products

miRNA for OR10H1 Gene

miRTarBase miRNAs that target OR10H1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR10H1 Gene

Localization for OR10H1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10H1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10H1 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for OR10H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030425 dendrite IBA 21873635
genes like me logo Genes that share ontologies with OR10H1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10H1 Gene

Pathways & Interactions for OR10H1 Gene

genes like me logo Genes that share pathways with OR10H1: view

Pathways by source for OR10H1 Gene

1 BioSystems pathway for OR10H1 Gene
1 KEGG pathway for OR10H1 Gene

Interacting Proteins for OR10H1 Gene

;

Gene Ontology (GO) - Biological Process for OR10H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA 21873635
GO:0007268 chemical synaptic transmission IBA 21873635
GO:0007608 sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10H1: view

No data available for SIGNOR curated interactions for OR10H1 Gene

Drugs & Compounds for OR10H1 Gene

No Compound Related Data Available

Transcripts for OR10H1 Gene

mRNA/cDNA for OR10H1 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR10H1 Gene

No ASD Table

Relevant External Links for OR10H1 Gene

GeneLoc Exon Structure for
OR10H1

Expression for OR10H1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR10H1 Gene

mRNA differential expression in normal tissues according to GTEx for OR10H1 Gene

This gene is overexpressed in Bladder (x30.9), Testis (x10.5), and Prostate (x4.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR10H1

SOURCE GeneReport for Unigene cluster for OR10H1 Gene:

Hs.533925
genes like me logo Genes that share expression patterns with OR10H1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10H1 Gene

Orthologs for OR10H1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10H1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OR10H1 31 30
  • 88.43 (n)
ManyToMany
-- 31
  • 85 (a)
ManyToMany
-- 31
  • 85 (a)
ManyToMany
-- 31
  • 85 (a)
ManyToMany
-- 31
  • 83 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia cOR10H13 30
  • 87.79 (n)
-- 31
  • 87 (a)
ManyToMany
-- 31
  • 85 (a)
ManyToMany
-- 31
  • 82 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Or10h1b 47 Olfr55 17 31
  • 85 (a)
Or10h1 47 Olfr239 31 30
  • 83.97 (n)
ManyToMany
Gm4461 31
  • 83 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr1095 30
  • 84.09 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 77 (a)
ManyToMany
-- 31
  • 76 (a)
ManyToMany
-- 31
  • 70 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 71 (a)
OneToMany
Species where no ortholog for OR10H1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10H1 Gene

ENSEMBL:
Gene Tree for OR10H1 (if available)
TreeFam:
Gene Tree for OR10H1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR10H1: view image

Paralogs for OR10H1 Gene

(446) SIMAP similar genes for OR10H1 Gene using alignment to 1 proteins:

  • O10H1_HUMAN
genes like me logo Genes that share paralogs with OR10H1: view

Variants for OR10H1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR10H1 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
716473 Benign: not provided 15,807,367(-) G/T MISSENSE_VARIANT
716474 Benign: not provided 15,807,539(-) C/T MISSENSE_VARIANT
716475 Benign: not provided 15,807,837(-) G/A SYNONYMOUS_VARIANT
718320 Benign: not provided 15,807,690(-) G/C SYNONYMOUS_VARIANT
769960 Benign: not provided 15,807,465(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for OR10H1 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR10H1 Gene

Variant ID Type Subtype PubMed ID
esv2660137 CNV deletion 23128226
esv2671181 CNV deletion 23128226
esv2718244 CNV deletion 23290073
esv3334671 CNV duplication 20981092
nsv1060711 CNV gain 25217958
nsv1064684 CNV gain 25217958
nsv1133007 OTHER inversion 24896259
nsv833766 CNV loss 17160897

Variation tolerance for OR10H1 Gene

Residual Variation Intolerance Score: 91.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.79; 89.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10H1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10H1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10H1 Gene

Disorders for OR10H1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR10H1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
morgagni cataract
  • hypermature cataract
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for OR10H1

genes like me logo Genes that share disorders with OR10H1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR10H1 Gene

Publications for OR10H1 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 54
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 54
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 54
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54

Products for OR10H1 Gene

Sources for OR10H1 Gene