Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR10H1 Gene

Aliases for OR10H1 Gene

  • Olfactory Receptor Family 10 Subfamily H Member 1 2 3 5
  • Olfactory Receptor OR19-27 3 4
  • Olfactory Receptor 10H1 3 4
  • Olfactory Receptor, Family 10, Subfamily H, Member 1 2
  • OR10H1 5

External Ids for OR10H1 Gene

Previous GeneCards Identifiers for OR10H1 Gene

  • GC19M016403
  • GC19M015763
  • GC19M015779
  • GC19M015780
  • GC19M015917

Summaries for OR10H1 Gene

Entrez Gene Summary for OR10H1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10H1 Gene

OR10H1 (Olfactory Receptor Family 10 Subfamily H Member 1) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10H5.

UniProtKB/Swiss-Prot Summary for OR10H1 Gene

Gene Wiki entry for OR10H1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR10H1 Gene

Genomics for OR10H1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR10H1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J015815 Enhancer 0.4 ENCODE 250.7 +0.1 118 0.1 CTCF MNT FOS HSALNG0124396-001 HSALNG0124396-002 OR10H1 OR10H5 lnc-OR7C2-1
GH19J015679 Enhancer 0.8 ENCODE 11.3 +135.0 134974 3.2 CEBPA ATF3 CHD4 YY1 HOMEZ THAP11 FOXA2 KDM6A SMAD4 RXRA CYP4F24P CYP4F12 OR10H1 CYP4F11 RNU6-782P piR-51367-001 OR10H2 lnc-OR7C2-1
GH19J015812 Enhancer 0.8 Ensembl ENCODE 7 +2.9 2946 1.4 IKZF1 REST DEK CTCF RAD21 CUX1 SMC3 ZNF143 ZNF512B MCM2 CYP4F24P MED26 CYP4F12 OR10H1 CLEC4OP HSALNG0124396-001 HSALNG0124396-002 piR-48209-333 OR10H5 lnc-OR7C2-1
GH19J015911 Promoter 0.5 Ensembl 10.7 -96.1 -96137 0.4 CTCF ZNF335 ENSG00000267056 LOC729654 CYP4F11 OR10H4 OR10H5 CYP4F12 OR10H1 HSALNG0124404 CYP4F2 lnc-OR7C2-1
GH19J015883 Enhancer 0.3 Ensembl 11.8 -67.9 -67937 0.4 SPI1 CYP4F11 OR10H1 OR10H5 HSALNG0124401 lnc-CYP4F11-1 HSALNG0124400 CYP4F2 lnc-OR7C2-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10H1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR10H1

Top Transcription factor binding sites by QIAGEN in the OR10H1 gene promoter:
  • AhR
  • CREB
  • E47
  • FOXD1
  • ITF-2
  • NRF-2
  • RP58
  • Tal-1beta
  • ZID

Genomic Locations for OR10H1 Gene

Latest Assembly
chr19:15,804,549-15,815,664
(GRCh38/hg38)
Size:
11,116 bases
Orientation:
Minus strand

Previous Assembly
chr19:15,915,359-15,926,474
(GRCh37/hg19 by Entrez Gene)
Size:
11,116 bases
Orientation:
Minus strand

chr19:15,917,817-15,918,936
(GRCh37/hg19 by Ensembl)
Size:
1,120 bases
Orientation:
Minus strand

Genomic View for OR10H1 Gene

Genes around OR10H1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10H1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10H1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10H1 Gene

Proteins for OR10H1 Gene

  • Protein details for OR10H1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4A9-O10H1_HUMAN
    Recommended name:
    Olfactory receptor 10H1
    Protein Accession:
    Q9Y4A9
    Secondary Accessions:
    • Q6IFQ2
    • Q96R59

    Protein attributes for OR10H1 Gene

    Size:
    318 amino acids
    Molecular mass:
    35254 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10H1 Gene

Post-translational modifications for OR10H1 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10H1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10H1 Gene

Domains & Families for OR10H1 Gene

Gene Families for OR10H1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10H1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR10H1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR19-27 (O10H1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y4A9

UniProtKB/Swiss-Prot:

O10H1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10H1: view

Function for OR10H1 Gene

Molecular function for OR10H1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 10,subfamily H,member 1,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR10H1 Gene

Gene Ontology (GO) - Molecular Function for OR10H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
GO:0004993 G protein-coupled serotonin receptor activity IBA 21873635
GO:0030594 neurotransmitter receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR10H1: view
genes like me logo Genes that share phenotypes with OR10H1: view

miRNA for OR10H1 Gene

miRTarBase miRNAs that target OR10H1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR10H1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR10H1 Gene

Localization for OR10H1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10H1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10H1 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for OR10H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030425 dendrite IBA 21873635
genes like me logo Genes that share ontologies with OR10H1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10H1 Gene

Pathways & Interactions for OR10H1 Gene

genes like me logo Genes that share pathways with OR10H1: view

Pathways by source for OR10H1 Gene

1 BioSystems pathway for OR10H1 Gene
1 KEGG pathway for OR10H1 Gene

Interacting Proteins for OR10H1 Gene

Gene Ontology (GO) - Biological Process for OR10H1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA 21873635
GO:0007268 chemical synaptic transmission IBA 21873635
GO:0007608 sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10H1: view

No data available for SIGNOR curated interactions for OR10H1 Gene

Drugs & Compounds for OR10H1 Gene

No Compound Related Data Available

Transcripts for OR10H1 Gene

mRNA/cDNA for OR10H1 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR10H1

Alternative Splicing Database (ASD) splice patterns (SP) for OR10H1 Gene

No ASD Table

Relevant External Links for OR10H1 Gene

GeneLoc Exon Structure for
OR10H1

Expression for OR10H1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR10H1 Gene

mRNA differential expression in normal tissues according to GTEx for OR10H1 Gene

This gene is overexpressed in Bladder (x30.9), Testis (x10.5), and Prostate (x4.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR10H1

SOURCE GeneReport for Unigene cluster for OR10H1 Gene:

Hs.533925
genes like me logo Genes that share expression patterns with OR10H1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10H1 Gene

Orthologs for OR10H1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10H1 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia OR10H1 29 30
  • 88.43 (n)
ManyToMany
-- 30
  • 85 (a)
ManyToMany
-- 30
  • 85 (a)
ManyToMany
-- 30
  • 85 (a)
ManyToMany
-- 30
  • 83 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia cOR10H13 29
  • 87.79 (n)
-- 30
  • 87 (a)
ManyToMany
-- 30
  • 85 (a)
ManyToMany
-- 30
  • 82 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Or10h1b 45 Olfr55 16 30
  • 85 (a)
ManyToMany
Or10h1 45 Olfr239 29 16 30
  • 83.97 (n)
ManyToMany
Gm4461 30
  • 83 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Olr1095 29
  • 84.09 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 77 (a)
ManyToMany
-- 30
  • 76 (a)
ManyToMany
-- 30
  • 70 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 71 (a)
OneToMany
Species where no ortholog for OR10H1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR10H1 Gene

ENSEMBL:
Gene Tree for OR10H1 (if available)
TreeFam:
Gene Tree for OR10H1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR10H1: view image
Alliance of Genome Resources:
Additional Orthologs for OR10H1

Paralogs for OR10H1 Gene

(446) SIMAP similar genes for OR10H1 Gene using alignment to 1 proteins:

  • O10H1_HUMAN
genes like me logo Genes that share paralogs with OR10H1: view

Variants for OR10H1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR10H1 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs138917285 Benign: not provided 15,807,996(-) G/A
NM_013940.3(OR10H1):c.42C>T (p.Leu14=)
SYNONYMOUS
rs148327766 Benign: not provided. Benign: not provided 15,807,690(-) G/AG/C
NM_013940.3(OR10H1):c.348C>T (p.Thr116=)
SYNONYMOUS
rs1859299 Benign: not provided 15,807,624(-) C/A
NM_013940.3(OR10H1):c.414G>T (p.Pro138=)
SYNONYMOUS
rs4081570 Benign: not provided 15,807,837(-) G/A
NM_013940.3(OR10H1):c.201C>T (p.Ser67=)
SYNONYMOUS
rs4808382 Benign: not provided 15,807,844(-) G/Ap.Ala65Val
NM_013940.3(OR10H1):c.194C>T (p.Ala65Val)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR10H1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR10H1 Gene

Variant ID Type Subtype PubMed ID
esv2660137 CNV deletion 23128226
esv2671181 CNV deletion 23128226
esv2718244 CNV deletion 23290073
esv3334671 CNV duplication 20981092
nsv1060711 CNV gain 25217958
nsv1064684 CNV gain 25217958
nsv1133007 OTHER inversion 24896259
nsv833766 CNV loss 17160897

Variation tolerance for OR10H1 Gene

Residual Variation Intolerance Score: 91.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.79; 89.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10H1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10H1
Leiden Open Variation Database (LOVD)
OR10H1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10H1 Gene

Disorders for OR10H1 Gene

Additional Disease Information for OR10H1

No disorders were found for OR10H1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10H1 Gene

Publications for OR10H1 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  4. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR10H1 Gene

Sources for OR10H1 Gene