Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR10G9 Gene

Aliases for OR10G9 Gene

  • Olfactory Receptor Family 10 Subfamily G Member 9 2 3 5
  • Olfactory Receptor 10G10 3 4
  • Olfactory Receptor 10G9 3 4
  • OR10G10P 3 4
  • Olfactory Receptor, Family 10, Subfamily G, Member 9 2
  • Olfactory Receptor OR11-272 3
  • OR10G9 5

External Ids for OR10G9 Gene

Previous HGNC Symbols for OR10G9 Gene

  • OR10G10P

Previous GeneCards Identifiers for OR10G9 Gene

  • GC11U990584
  • GC11P123398
  • GC11P123893

Summaries for OR10G9 Gene

Entrez Gene Summary for OR10G9 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10G9 Gene

OR10G9 (Olfactory Receptor Family 10 Subfamily G Member 9) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10G4.

UniProtKB/Swiss-Prot Summary for OR10G9 Gene

Gene Wiki entry for OR10G9 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR10G9 Gene

Genomics for OR10G9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR10G9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J124008 Enhancer 0.2 FANTOM5 17.6 -14.3 -14339 0.4 OR10G5P OR8D1 OR4D5 OR10G9 OR8D4 OR6T1 OR10G4 OR6M1 OR8G1 OR10S1
GH11J123695 Enhancer 0.2 FANTOM5 1.7 -327.7 -327679 0.4 HSALNG0087845 OR6X1 OR8D4 OR10G4 OR4D5 OR10G7 SCN3B ZNF202 OR6M1 OR6T1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10G9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR10G9

Top Transcription factor binding sites by QIAGEN in the OR10G9 gene promoter:
  • AhR
  • AML1a
  • AREB6
  • CP2
  • GATA-1
  • LCR-F1
  • PPAR-alpha

Genomic Locations for OR10G9 Gene

Latest Assembly
chr11:124,023,013-124,023,948
(GRCh38/hg38)
Size:
936 bases
Orientation:
Plus strand

Previous Assembly
chr11:123,893,720-123,894,655
(GRCh37/hg19 by Entrez Gene)
Size:
936 bases
Orientation:
Plus strand

chr11:123,893,720-123,894,655
(GRCh37/hg19 by Ensembl)
Size:
936 bases
Orientation:
Plus strand

Genomic View for OR10G9 Gene

Genes around OR10G9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10G9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10G9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10G9 Gene

Proteins for OR10G9 Gene

  • Protein details for OR10G9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGN4-O10G9_HUMAN
    Recommended name:
    Olfactory receptor 10G9
    Protein Accession:
    Q8NGN4

    Protein attributes for OR10G9 Gene

    Size:
    311 amino acids
    Molecular mass:
    34574 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10G9 Gene

Post-translational modifications for OR10G9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR10G9 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10G9 Gene

Domains & Families for OR10G9 Gene

Gene Families for OR10G9 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10G9 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR10G9 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 10G10 (O10G9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGN4

UniProtKB/Swiss-Prot:

O10G9_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10G9: view

Function for OR10G9 Gene

Molecular function for OR10G9 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR10G9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR10G9: view

Phenotypes for OR10G9 Gene

genes like me logo Genes that share phenotypes with OR10G9: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR10G9

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10G9 Gene

Localization for OR10G9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10G9 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10G9 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10G9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR10G9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10G9 Gene

Pathways & Interactions for OR10G9 Gene

genes like me logo Genes that share pathways with OR10G9: view

Pathways by source for OR10G9 Gene

Interacting Proteins for OR10G9 Gene

Gene Ontology (GO) - Biological Process for OR10G9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10G9: view

No data available for SIGNOR curated interactions for OR10G9 Gene

Drugs & Compounds for OR10G9 Gene

No Compound Related Data Available

Transcripts for OR10G9 Gene

mRNA/cDNA for OR10G9 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR10G9

Alternative Splicing Database (ASD) splice patterns (SP) for OR10G9 Gene

No ASD Table

Relevant External Links for OR10G9 Gene

GeneLoc Exon Structure for
OR10G9

Expression for OR10G9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR10G9 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR10G9

SOURCE GeneReport for Unigene cluster for OR10G9 Gene:

Hs.553636
genes like me logo Genes that share expression patterns with OR10G9: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10G9 Gene

Orthologs for OR10G9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10G9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466867 29
  • 98.5 (n)
OR10G9 30
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC489340 29
  • 87.25 (n)
-- 30
  • 87 (a)
ManyToMany
-- 30
  • 86 (a)
ManyToMany
-- 30
  • 84 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Or10g9b 45 Olfr980 30
  • 86 (a)
ManyToMany
Or10g9 45 Olfr979 29 16 30
  • 85.1 (n)
ManyToMany
Olfr978 30
  • 85 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia LOC526286 29
  • 85.53 (n)
-- 30
  • 82 (a)
ManyToMany
-- 30
  • 81 (a)
ManyToMany
-- 30
  • 81 (a)
ManyToMany
-- 30
  • 81 (a)
ManyToMany
-- 30
  • 80 (a)
ManyToMany
-- 30
  • 79 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Olr1334 29
  • 84.99 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 78 (a)
ManyToMany
-- 30
  • 72 (a)
ManyToMany
-- 30
  • 72 (a)
ManyToMany
-- 30
  • 71 (a)
ManyToMany
-- 30
  • 71 (a)
ManyToMany
-- 30
  • 71 (a)
ManyToMany
-- 30
  • 67 (a)
ManyToMany
Species where no ortholog for OR10G9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR10G9 Gene

ENSEMBL:
Gene Tree for OR10G9 (if available)
TreeFam:
Gene Tree for OR10G9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR10G9: view image
Alliance of Genome Resources:
Additional Orthologs for OR10G9

Paralogs for OR10G9 Gene

(450) SIMAP similar genes for OR10G9 Gene using alignment to 1 proteins:

  • O10G9_HUMAN
genes like me logo Genes that share paralogs with OR10G9: view

Variants for OR10G9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR10G9 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs11535718 Benign: not provided 124,023,281(+) C/T
NM_001001953.1(OR10G9):c.269C>T (p.Ala90Val)
MISSENSE
rs12366219 Benign: not provided 124,023,412(+) A/Gp.Met134Val
NM_001001953.1(OR10G9):c.400A>G (p.Met134Val)
MISSENSE
rs28499345 Benign: not provided 124,023,429(+) A/G
NM_001001953.1(OR10G9):c.417A>G (p.Arg139=)
SYNONYMOUS
rs11219413 -- p.Gln172Arg
rs12221656 -- p.His228Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR10G9 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR10G9 Gene

Variant ID Type Subtype PubMed ID
dgv82n21 CNV gain 19592680
esv2582148 CNV deletion 19546169
nsv972082 CNV duplication 23825009

Variation tolerance for OR10G9 Gene

Residual Variation Intolerance Score: 98.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.07; 84.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10G9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10G9
Leiden Open Variation Database (LOVD)
OR10G9

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10G9 Gene

Disorders for OR10G9 Gene

Additional Disease Information for OR10G9

No disorders were found for OR10G9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10G9 Gene

Publications for OR10G9 Gene

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3

Products for OR10G9 Gene

Sources for OR10G9 Gene