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Aliases for OR10G8 Gene

Aliases for OR10G8 Gene

  • Olfactory Receptor Family 10 Subfamily G Member 8 2 3 5
  • Olfactory Receptor OR11-282 3 4
  • Olfactory Receptor, Family 10, Subfamily G, Member 8 2
  • Olfactory Receptor OR11-274 Pseudogene 3
  • Olfactory Receptor 10G8 3
  • OR11-274 3
  • OR11-282 3

External Ids for OR10G8 Gene

Previous GeneCards Identifiers for OR10G8 Gene

  • GC11U990340
  • GC11P123438
  • GC11P123392
  • GC11P123405
  • GC11P123887
  • GC11P123900

Summaries for OR10G8 Gene

Entrez Gene Summary for OR10G8 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10G8 Gene

OR10G8 (Olfactory Receptor Family 10 Subfamily G Member 8) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10G9.

UniProtKB/Swiss-Prot for OR10G8 Gene

  • Odorant receptor.

Gene Wiki entry for OR10G8 Gene

Additional gene information for OR10G8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10G8 Gene

Genomics for OR10G8 Gene

GeneHancer (GH) Regulatory Elements for OR10G8 Gene

Top Transcription factor binding sites by QIAGEN in the OR10G8 gene promoter:
  • E2F
  • PPAR-alpha
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • CP2
  • GATA-1
  • AhR

Genomic Locations for OR10G8 Gene

Genomic Locations for OR10G8 Gene
3,837 bases
Plus strand
1,045 bases
Plus strand

Genomic View for OR10G8 Gene

Genes around OR10G8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10G8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10G8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10G8 Gene

Proteins for OR10G8 Gene

  • Protein details for OR10G8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 10G8
    Protein Accession:
    Secondary Accessions:
    • B2RNJ3
    • Q6IEV2

    Protein attributes for OR10G8 Gene

    311 amino acids
    Molecular mass:
    34519 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10G8 Gene

Post-translational modifications for OR10G8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OR10G8 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10G8 Gene

Domains & Families for OR10G8 Gene

Gene Families for OR10G8 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10G8 Gene

Suggested Antigen Peptide Sequences for OR10G8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10G8: view

Function for OR10G8 Gene

Molecular function for OR10G8 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR10G8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR10G8: view
genes like me logo Genes that share phenotypes with OR10G8: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10G8 Gene

Localization for OR10G8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10G8 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10G8 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10G8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR10G8: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10G8 Gene

Pathways & Interactions for OR10G8 Gene

genes like me logo Genes that share pathways with OR10G8: view

Pathways by source for OR10G8 Gene

Interacting Proteins for OR10G8 Gene

Gene Ontology (GO) - Biological Process for OR10G8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10G8: view

No data available for SIGNOR curated interactions for OR10G8 Gene

Drugs & Compounds for OR10G8 Gene

No Compound Related Data Available

Transcripts for OR10G8 Gene

mRNA/cDNA for OR10G8 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR10G8 Gene

Olfactory receptor, family 10, subfamily G, member 8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR10G8 Gene

No ASD Table

Relevant External Links for OR10G8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR10G8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR10G8 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR10G8 Gene:


SOURCE GeneReport for Unigene cluster for OR10G8 Gene:

genes like me logo Genes that share expression patterns with OR10G8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10G8 Gene

Orthologs for OR10G8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10G8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC466866 33
  • 97 (n)
OR10G8 34
  • 95 (a)
(Canis familiaris)
Mammalia -- 34
  • 84 (a)
-- 34
  • 84 (a)
-- 34
  • 82 (a)
(Mus musculus)
Mammalia Olfr979 34
  • 83 (a)
Olfr980 34
  • 82 (a)
Olfr978 34
  • 82 (a)
(Bos Taurus)
Mammalia -- 34
  • 78 (a)
-- 34
  • 78 (a)
-- 34
  • 77 (a)
-- 34
  • 77 (a)
-- 34
  • 76 (a)
-- 34
  • 76 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 74 (a)
-- 34
  • 68 (a)
-- 34
  • 68 (a)
-- 34
  • 68 (a)
-- 34
  • 67 (a)
-- 34
  • 67 (a)
-- 34
  • 65 (a)
Species where no ortholog for OR10G8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10G8 Gene

Gene Tree for OR10G8 (if available)
Gene Tree for OR10G8 (if available)
Evolutionary constrained regions (ECRs) for OR10G8: view image

Paralogs for OR10G8 Gene

Paralogs for OR10G8 Gene

(452) SIMAP similar genes for OR10G8 Gene using alignment to 1 proteins:

  • O10G8_HUMAN
genes like me logo Genes that share paralogs with OR10G8: view

Variants for OR10G8 Gene

Sequence variations from dbSNP and Humsavar for OR10G8 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000617513 -- 124,030,745(+) T/C downstream_transcript_variant
rs1003037726 -- 124,028,868(+) G/T upstream_transcript_variant
rs1003073798 -- 124,028,623(+) A/C upstream_transcript_variant
rs1005105280 -- 124,028,875(+) A/G upstream_transcript_variant
rs1005485450 -- 124,029,169(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR10G8 Gene

Variant ID Type Subtype PubMed ID
dgv82n21 CNV gain 19592680
esv2760192 CNV loss 21179565
nsv983071 CNV duplication 23825009

Variation tolerance for OR10G8 Gene

Residual Variation Intolerance Score: 89.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.76; 78.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10G8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10G8 Gene

Disorders for OR10G8 Gene

Additional Disease Information for OR10G8

No disorders were found for OR10G8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10G8 Gene

Publications for OR10G8 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR10G8 Gene

Sources for OR10G8 Gene

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