Free for academic non-profit institutions. Other users need a Commercial license
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR10G7 (Olfactory Receptor Family 10 Subfamily G Member 7) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10G9.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J123740 | Promoter/Enhancer | 2.2 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas | 9.8 | +299.5 | 299529 | 4.4 | PRDM10 TFE3 ZNF512 LEF1 POLR2A ZNF7 BACH1 JUND GABPA MTA2 | ZNF202 lnc-GRAMD1B-6 lnc-ZNF202-1 VWA5A CLMP OR6X1 OR10G7 OR6M1 OR10G4 OR8G2P | |
GH11J124521 | Enhancer | 0.2 | FANTOM5 | 18.4 | -480.2 | -480171 | 0.3 | OR8A1 OR8B8 OR10G7 OR8G2P OR8G1 OR8B12 OR8D1 OR8D2 OR8B10P OR8A3P | ||
GH11J123695 | Enhancer | 0.2 | FANTOM5 | 13.2 | +346.0 | 345991 | 0.4 | OR6X1 OR8D4 OR10G4 OR4D5 OR10G7 SCN3B ZNF202 OR6M1 OR6T1 OR10G9 | ||
GH11J123583 | Enhancer | 0.2 | FANTOM5 | 12.8 | +457.5 | 457457 | 0.4 | OR10G7 OR6X1 OR10G4 OR6T1 OR4D5 OR6M1 OR8D4 OR10S1 MN309418 SF3A3P2 | ||
GH11J124191 | Enhancer | 0.4 | FANTOM5 | 3.1 | -150.8 | -150764 | 0.3 | FOSL1 MAFG | VWA5A OR8A1 OR6X1 OR10G7 OR8G2P OR8B12 OR4D5 OR10G4 OR8G1 OR6M1 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IEA | -- |
GO:0007608 | sensory perception of smell | IEA | -- |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | LOC737779 30 |
|
||
OR10G7 31 |
|
OneToOne | |||
Dog (Canis familiaris) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Mouse (Mus musculus) |
Mammalia | Olfr979 31 |
|
ManyToMany | |
Or10g7 46 Olfr978 30 17 31 |
|
ManyToMany |
|
||
Olfr980 31 |
|
ManyToMany | |||
Cow (Bos Taurus) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100485341 30 |
|
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs11219420 | - | p.Ile28Val | |||
rs11827843 | - | p.Thr13Met | |||
rs3894197 | - | p.Thr5Ser | |||
rs3894198 | - | p.Ala18Val | |||
rs3894199 | - | p.Gly20Ala |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv82n21 | CNV | gain | 19592680 |
esv2665842 | CNV | deletion | 23128226 |
esv2760192 | CNV | loss | 21179565 |
esv3627969 | CNV | loss | 21293372 |
nsv975236 | CNV | duplication | 23825009 |
No disorders were found for OR10G7 Gene.