Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR10G7 Gene

Aliases for OR10G7 Gene

  • Olfactory Receptor Family 10 Subfamily G Member 7 2 3 5
  • Olfactory Receptor OR11-283 3 4
  • Olfactory Receptor 10G7 3 4
  • Olfactory Receptor, Family 10, Subfamily G, Member 7 2
  • OR11-283 3
  • OR10G7 5

External Ids for OR10G7 Gene

Previous GeneCards Identifiers for OR10G7 Gene

  • GC11U990343
  • GC11M123447
  • GC11M123413
  • GC11M123908

Summaries for OR10G7 Gene

Entrez Gene Summary for OR10G7 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10G7 Gene

OR10G7 (Olfactory Receptor Family 10 Subfamily G Member 7) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10G9.

UniProtKB/Swiss-Prot Summary for OR10G7 Gene

Gene Wiki entry for OR10G7 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR10G7 Gene

Genomics for OR10G7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR10G7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J123740 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 9.8 +299.5 299529 4.4 BCLAF1 ZNF207 ZNF600 MYC NCOR1 POLR2A NFIC YY1 MXD4 REST ZNF202 lnc-ZNF202-1 lnc-GRAMD1B-6 VWA5A CLMP OR6X1 OR10G7 OR6M1 OR10G4 OR8G2P
GH11J124521 Enhancer 0.2 FANTOM5 18.4 -480.2 -480171 0.3 OR8A1 OR8B8 OR10G7 OR8G2P OR8G1 OR8B12 OR8D1 OR8D2 OR8B10P OR8A3P
GH11J123695 Enhancer 0.2 FANTOM5 13.2 +346.0 345991 0.4 HSALNG0087845 OR6X1 OR8D4 OR10G4 OR4D5 OR10G7 SCN3B ZNF202 OR6M1 OR6T1
GH11J123583 Enhancer 0.2 FANTOM5 12.8 +457.5 457457 0.4 OR10G7 OR6X1 OR10G4 OR6T1 OR4D5 OR6M1 OR8D4 OR10S1 MN309418 SF3A3P2
GH11J124191 Enhancer 0.3 FANTOM5 3.1 -150.8 -150764 0.3 MAFG VWA5A OR8A1 OR6X1 OR10G7 OR8G2P OR8B12 OR4D5 OR10G4 OR8G1 OR6M1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10G7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR10G7

Top Transcription factor binding sites by QIAGEN in the OR10G7 gene promoter:
  • CP2
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • IRF-1
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for OR10G7 Gene

Latest Assembly
chr11:124,036,013-124,041,325
(GRCh38/hg38)
Size:
5,313 bases
Orientation:
Minus strand

Previous Assembly
chr11:123,906,720-123,912,032
(GRCh37/hg19 by Entrez Gene)
Size:
5,313 bases
Orientation:
Minus strand

chr11:123,908,773-123,909,717
(GRCh37/hg19 by Ensembl)
Size:
945 bases
Orientation:
Minus strand

Genomic View for OR10G7 Gene

Genes around OR10G7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10G7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10G7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10G7 Gene

Proteins for OR10G7 Gene

  • Protein details for OR10G7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGN6-O10G7_HUMAN
    Recommended name:
    Olfactory receptor 10G7
    Protein Accession:
    Q8NGN6
    Secondary Accessions:
    • Q6IFE8

    Protein attributes for OR10G7 Gene

    Size:
    311 amino acids
    Molecular mass:
    34517 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10G7 Gene

Post-translational modifications for OR10G7 Gene

  • Glycosylation at Asn3
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10G7 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10G7 Gene

Domains & Families for OR10G7 Gene

Gene Families for OR10G7 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10G7 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR10G7 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-283 (O10G7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGN6

UniProtKB/Swiss-Prot:

O10G7_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10G7: view

Function for OR10G7 Gene

Molecular function for OR10G7 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR10G7 Gene

Gene Ontology (GO) - Molecular Function for OR10G7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR10G7: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR10G7

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10G7 Gene

Localization for OR10G7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10G7 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10G7 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10G7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR10G7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10G7 Gene

Pathways & Interactions for OR10G7 Gene

genes like me logo Genes that share pathways with OR10G7: view

Pathways by source for OR10G7 Gene

Interacting Proteins for OR10G7 Gene

Gene Ontology (GO) - Biological Process for OR10G7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10G7: view

No data available for SIGNOR curated interactions for OR10G7 Gene

Drugs & Compounds for OR10G7 Gene

No Compound Related Data Available

Transcripts for OR10G7 Gene

mRNA/cDNA for OR10G7 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR10G7

Alternative Splicing Database (ASD) splice patterns (SP) for OR10G7 Gene

No ASD Table

Relevant External Links for OR10G7 Gene

GeneLoc Exon Structure for
OR10G7

Expression for OR10G7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR10G7 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR10G7

SOURCE GeneReport for Unigene cluster for OR10G7 Gene:

Hs.553761
genes like me logo Genes that share expression patterns with OR10G7: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10G7 Gene

Orthologs for OR10G7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR10G7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC737779 29
  • 97.96 (n)
OR10G7 30
  • 96 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 30
  • 85 (a)
ManyToMany
-- 30
  • 85 (a)
ManyToMany
-- 30
  • 85 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Olfr979 30
  • 85 (a)
ManyToMany
Or10g7 45 Olfr978 29 16 30
  • 84.89 (n)
ManyToMany
Olfr980 30
  • 84 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 30
  • 79 (a)
ManyToMany
-- 30
  • 79 (a)
ManyToMany
-- 30
  • 79 (a)
ManyToMany
-- 30
  • 79 (a)
ManyToMany
-- 30
  • 78 (a)
ManyToMany
-- 30
  • 78 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 77 (a)
ManyToMany
-- 30
  • 71 (a)
ManyToMany
-- 30
  • 70 (a)
ManyToMany
-- 30
  • 70 (a)
ManyToMany
-- 30
  • 70 (a)
ManyToMany
-- 30
  • 70 (a)
ManyToMany
-- 30
  • 68 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100485341 29
  • 58.03 (n)
Species where no ortholog for OR10G7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR10G7 Gene

ENSEMBL:
Gene Tree for OR10G7 (if available)
TreeFam:
Gene Tree for OR10G7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR10G7: view image
Alliance of Genome Resources:
Additional Orthologs for OR10G7

Paralogs for OR10G7 Gene

(450) SIMAP similar genes for OR10G7 Gene using alignment to 1 proteins:

  • O10G7_HUMAN

Pseudogenes.org Pseudogenes for OR10G7 Gene

genes like me logo Genes that share paralogs with OR10G7: view

Variants for OR10G7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR10G7 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs11219420 -- p.Ile28Val
rs11827843 -- p.Thr13Met
rs3894197 -- p.Thr5Ser
rs3894198 -- p.Ala18Val
rs3894199 -- p.Gly20Ala

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR10G7 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR10G7 Gene

Variant ID Type Subtype PubMed ID
dgv82n21 CNV gain 19592680
esv2665842 CNV deletion 23128226
esv2760192 CNV loss 21179565
esv3627969 CNV loss 21293372
nsv975236 CNV duplication 23825009

Variation tolerance for OR10G7 Gene

Residual Variation Intolerance Score: 98.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.45; 64.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10G7 Gene

Human Gene Mutation Database (HGMD)
OR10G7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10G7
Leiden Open Variation Database (LOVD)
OR10G7

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10G7 Gene

Disorders for OR10G7 Gene

Additional Disease Information for OR10G7

No disorders were found for OR10G7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10G7 Gene

Publications for OR10G7 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Expression and function of the ectopic olfactory receptor OR10G7 in patients with atopic dermatitis. (PMID: 30445058) Tham EH … Goleva E (The Journal of allergy and clinical immunology 2019) 3
  3. Genome-wide association study identifies candidate genes for male fertility traits in humans. (PMID: 22633400) Kosova G … Ober C (American journal of human genetics 2012) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR10G7 Gene

Sources for OR10G7 Gene