Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR10G6 Gene

Aliases for OR10G6 Gene

  • Olfactory Receptor Family 10 Subfamily G Member 6 2 3 5
  • Olfactory Receptor OR11-280 3 4
  • Olfactory Receptor 10G6 3 4
  • OR10G6P 3 4
  • OR10G6Q 2 3
  • Olfactory Receptor, Family 10, Subfamily G, Member 6 Pseudogene 2
  • Olfactory Receptor, Family 10, Subfamily G, Member 6 2
  • Seven Transmembrane Helix Receptor 3
  • OR10G6 5

External Ids for OR10G6 Gene

Previous HGNC Symbols for OR10G6 Gene

  • OR10G6P

Previous GeneCards Identifiers for OR10G6 Gene

  • GC11M123404
  • GC11M123370
  • GC11M123864

Summaries for OR10G6 Gene

Entrez Gene Summary for OR10G6 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10G6 Gene

OR10G6 (Olfactory Receptor Family 10 Subfamily G Member 6) is a Protein Coding gene. Diseases associated with OR10G6 include Monkeypox. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10G3.

UniProtKB/Swiss-Prot Summary for OR10G6 Gene

Gene Wiki entry for OR10G6 Gene

Additional gene information for OR10G6 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR10G6 Gene

Genomics for OR10G6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR10G6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J123977 Enhancer 0.6 ENCODE 0.4 +17.0 17032 2 SOX6 EP300 CTBP1 NFE2 CEBPB TRIM24 ATF4 NFE2L2 CEBPG ATF3 OR10S1 ZNF202 OR10G6
GH11J123998 Enhancer 0.2 Ensembl 0.7 -3.7 -3740 0.2 OR10S1 OR10G6 piR-61614-031 OR10G4
GH11J124008 Enhancer 0.2 FANTOM5 0.4 -13.5 -13513 0.4 OR10G5P OR8D1 OR4D5 OR10G9 OR8D4 OR6T1 OR10G4 OR6M1 OR8G1 OR10S1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10G6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR10G6

Genomic Locations for OR10G6 Gene

Genomic Locations for OR10G6 Gene
chr11:123,994,163-123,995,161
(GRCh38/hg38)
Size:
999 bases
Orientation:
Minus strand
chr11:123,864,870-123,865,868
(GRCh37/hg19)
Size:
999 bases
Orientation:
Minus strand

Genomic View for OR10G6 Gene

Genes around OR10G6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10G6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10G6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10G6 Gene

Proteins for OR10G6 Gene

  • Protein details for OR10G6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH81-O10G6_HUMAN
    Recommended name:
    Olfactory receptor 10G6
    Protein Accession:
    Q8NH81

    Protein attributes for OR10G6 Gene

    Size:
    332 amino acids
    Molecular mass:
    36823 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10G6 Gene

Post-translational modifications for OR10G6 Gene

  • Glycosylation at Asn26

Other Protein References for OR10G6 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10G6 Gene

Domains & Families for OR10G6 Gene

Gene Families for OR10G6 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10G6 Gene

InterPro:
Blocks:
  • Olfactory receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for OR10G6 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-280 (O10G6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NH81

UniProtKB/Swiss-Prot:

O10G6_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10G6: view

Function for OR10G6 Gene

Molecular function for OR10G6 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR10G6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR10G6: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10G6 Gene

Localization for OR10G6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10G6 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10G6 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for OR10G6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR10G6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10G6 Gene

Pathways & Interactions for OR10G6 Gene

genes like me logo Genes that share pathways with OR10G6: view

Pathways by source for OR10G6 Gene

Interacting Proteins for OR10G6 Gene

Gene Ontology (GO) - Biological Process for OR10G6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10G6: view

No data available for SIGNOR curated interactions for OR10G6 Gene

Drugs & Compounds for OR10G6 Gene

No Compound Related Data Available

Transcripts for OR10G6 Gene

mRNA/cDNA for OR10G6 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR10G6 Gene

No ASD Table

Relevant External Links for OR10G6 Gene

GeneLoc Exon Structure for
OR10G6

Expression for OR10G6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR10G6 Gene

Protein differential expression in normal tissues from HIPED for OR10G6 Gene

This gene is overexpressed in Breast (42.5) and Bone (26.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR10G6 Gene



Protein tissue co-expression partners for OR10G6 Gene

genes like me logo Genes that share expression patterns with OR10G6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10G6 Gene

Orthologs for OR10G6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10G6 Gene

Organism Taxonomy Gene Similarity Type Details
Mouse
(Mus musculus)
Mammalia Or10g6 46 Olfr981 31
  • 91 (a)
OneToOne
Or9e1 46 Olfr311
  • chr11:58,841,116-58,842,039
Dog
(Canis familiaris)
Mammalia OR10G6 31
  • 90 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia OR10G6 31
  • 87 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia OR10G6 31
  • 83 (a)
OneToOne
Species where no ortholog for OR10G6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR10G6 Gene

ENSEMBL:
Gene Tree for OR10G6 (if available)
TreeFam:
Gene Tree for OR10G6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR10G6: view image

Paralogs for OR10G6 Gene

(449) SIMAP similar genes for OR10G6 Gene using alignment to 1 proteins:

  • O10G6_HUMAN

Pseudogenes.org Pseudogenes for OR10G6 Gene

genes like me logo Genes that share paralogs with OR10G6: view

Variants for OR10G6 Gene

Additional dbSNP identifiers (rs#s) for OR10G6 Gene

Variation tolerance for OR10G6 Gene

Gene Damage Index Score: 3.52; 55.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10G6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10G6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for OR10G6 Gene

Disorders for OR10G6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OR10G6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
monkeypox
  • monkeypox virus infection
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for OR10G6

genes like me logo Genes that share disorders with OR10G6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR10G6 Gene

Publications for OR10G6 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR10G6 Gene

Sources for OR10G6 Gene