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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR10G6 (Olfactory Receptor Family 10 Subfamily G Member 6) is a Protein Coding gene. Diseases associated with OR10G6 include Monkeypox. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10G3.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J123977 | Enhancer | 0.6 | ENCODE | 0.4 | +17.0 | 17032 | 2 | SOX6 EP300 CTBP1 NFE2 CEBPB TRIM24 ATF4 NFE2L2 CEBPG ATF3 | OR10S1 ZNF202 OR10G6 | |
GH11J123998 | Enhancer | 0.2 | Ensembl | 0.7 | -3.7 | -3740 | 0.2 | OR10S1 OR10G6 piR-61614-031 OR10G4 | ||
GH11J124008 | Enhancer | 0.2 | FANTOM5 | 0.4 | -13.5 | -13513 | 0.4 | OR10G5P OR8D1 OR4D5 OR10G9 OR8D4 OR6T1 OR10G4 OR6M1 OR8G1 OR10S1 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IEA | -- |
GO:0007608 | sensory perception of smell | IEA | -- |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of mammals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Mouse (Mus musculus) |
Mammalia | Or10g6 46 Olfr981 31 |
|
OneToOne |
|
Or9e1 46 Olfr311 |
|
|
|||
Dog (Canis familiaris) |
Mammalia | OR10G6 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | OR10G6 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | OR10G6 31 |
|
OneToOne |
Disorder | Aliases | PubMed IDs |
---|---|---|
monkeypox |
|
|