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Aliases for OR10G4 Gene

Aliases for OR10G4 Gene

  • Olfactory Receptor Family 10 Subfamily G Member 4 2 3 5
  • Olfactory Receptor OR11-278 3 4
  • Olfactory Receptor, Family 10, Subfamily G, Member 4 2
  • Olfactory Receptor 10G4 3
  • OR11-278 3

External Ids for OR10G4 Gene

Previous GeneCards Identifiers for OR10G4 Gene

  • GC11U990358
  • GC11P123424
  • GC11P123391
  • GC11P123886

Summaries for OR10G4 Gene

Entrez Gene Summary for OR10G4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10G4 Gene

OR10G4 (Olfactory Receptor Family 10 Subfamily G Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10G9.

UniProtKB/Swiss-Prot for OR10G4 Gene

  • Odorant receptor.

Gene Wiki entry for OR10G4 Gene

Additional gene information for OR10G4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10G4 Gene

Genomics for OR10G4 Gene

GeneHancer (GH) Regulatory Elements for OR10G4 Gene

Promoters and enhancers for OR10G4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J123740 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 8.2 -270.9 -270924 3.8 HNRNPUL1 PKNOX1 ARNT MLX ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF202 VWA5A CLMP OR6X1 OR10G7 OR6M1 OR10G4 OR8G2P OR4D5 TMEM225
GH11J123695 Enhancer 0.2 FANTOM5 13.7 -317.7 -317663 0.4 OR6X1 OR8D4 OR10G4 OR4D5 OR10G7 SCN3B ZNF202 OR6M1 OR6T1 OR10G9
GH11J124008 Enhancer 0.2 FANTOM5 13.5 -4.3 -4323 0.4 OR10G5P OR8D1 OR4D5 OR10G9 OR8D4 OR10G4 OR6M1 OR8G1 OR10S1 OR8D2
GH11J123583 Enhancer 0.2 FANTOM5 8.7 -429.1 -429129 0.4 OR10G7 OR6X1 OR10G4 OR6T1 OR4D5 OR6M1 OR8D4 OR10S1 GC11M123576 GC11M123593
GH11J124191 Enhancer 0.4 FANTOM5 2.3 +179.1 179092 0.3 FOSL1 MAFG VWA5A OR8A1 OR6X1 OR10G7 OR8G2P OR8B12 OR4D5 OR10G4 OR8G1 OR6M1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10G4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR10G4 gene promoter:
  • PPAR-alpha
  • GATA-1
  • AhR
  • LCR-F1
  • AREB6
  • FOXO1a
  • AML1a

Genomic Locations for OR10G4 Gene

Genomic Locations for OR10G4 Gene
5,736 bases
Plus strand
936 bases
Plus strand

Genomic View for OR10G4 Gene

Genes around OR10G4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10G4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10G4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10G4 Gene

Proteins for OR10G4 Gene

  • Protein details for OR10G4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 10G4
    Protein Accession:
    Secondary Accessions:
    • Q6IEW0

    Protein attributes for OR10G4 Gene

    311 amino acids
    Molecular mass:
    34569 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10G4 Gene

Post-translational modifications for OR10G4 Gene

  • Glycosylation at Asn3
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10G4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10G4 Gene

Domains & Families for OR10G4 Gene

Gene Families for OR10G4 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10G4 Gene

Suggested Antigen Peptide Sequences for OR10G4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10G4: view

Function for OR10G4 Gene

Molecular function for OR10G4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR10G4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR10G4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10G4 Gene

Localization for OR10G4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10G4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10G4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10G4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR10G4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10G4 Gene

Pathways & Interactions for OR10G4 Gene

genes like me logo Genes that share pathways with OR10G4: view

Pathways by source for OR10G4 Gene

Interacting Proteins for OR10G4 Gene

Gene Ontology (GO) - Biological Process for OR10G4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10G4: view

No data available for SIGNOR curated interactions for OR10G4 Gene

Drugs & Compounds for OR10G4 Gene

No Compound Related Data Available

Transcripts for OR10G4 Gene

mRNA/cDNA for OR10G4 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR10G4 Gene

Olfactory receptor, family 10, subfamily G, member 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR10G4 Gene

No ASD Table

Relevant External Links for OR10G4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR10G4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR10G4 Gene

mRNA differential expression in normal tissues according to GTEx for OR10G4 Gene

This gene is overexpressed in Pancreas (x38.6), Testis (x7.5), and Colon - Transverse (x6.9).

Protein differential expression in normal tissues from HIPED for OR10G4 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR10G4 Gene

Protein tissue co-expression partners for OR10G4 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR10G4 Gene:


SOURCE GeneReport for Unigene cluster for OR10G4 Gene:

genes like me logo Genes that share expression patterns with OR10G4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10G4 Gene

Orthologs for OR10G4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10G4 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Olfr979 34
  • 86 (a)
Olfr978 34
  • 85 (a)
Olfr980 16 34 33
  • 84.95 (n)
(Canis familiaris)
Mammalia -- 34
  • 86 (a)
-- 34
  • 85 (a)
-- 34
  • 82 (a)
(Rattus norvegicus)
Mammalia Olr1335 33
  • 83.76 (n)
(Bos Taurus)
Mammalia -- 34
  • 82 (a)
-- 34
  • 82 (a)
-- 34
  • 80 (a)
-- 34
  • 80 (a)
-- 34
  • 79 (a)
-- 34
  • 79 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 78 (a)
-- 34
  • 72 (a)
-- 34
  • 72 (a)
-- 34
  • 71 (a)
-- 34
  • 70 (a)
-- 34
  • 70 (a)
-- 34
  • 68 (a)
Species where no ortholog for OR10G4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10G4 Gene

Gene Tree for OR10G4 (if available)
Gene Tree for OR10G4 (if available)
Evolutionary constrained regions (ECRs) for OR10G4: view image

Paralogs for OR10G4 Gene

Paralogs for OR10G4 Gene

(449) SIMAP similar genes for OR10G4 Gene using alignment to 1 proteins:

  • O10G4_HUMAN
genes like me logo Genes that share paralogs with OR10G4: view

Variants for OR10G4 Gene

Sequence variations from dbSNP and Humsavar for OR10G4 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000393936 -- 124,016,430(+) G/A coding_sequence_variant, missense_variant
rs1000580941 -- 124,016,149(+) C/A/G coding_sequence_variant, stop_gained
rs1002400411 -- 124,014,567(+) A/T upstream_transcript_variant
rs1004308781 -- 124,014,828(+) A/G upstream_transcript_variant
rs1005384482 -- 124,015,295(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR10G4 Gene

Variant ID Type Subtype PubMed ID
dgv82n21 CNV gain 19592680
esv2582148 CNV deletion 19546169
nsv983070 CNV duplication 23825009

Variation tolerance for OR10G4 Gene

Residual Variation Intolerance Score: 92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 22.27; 99.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10G4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10G4 Gene

Disorders for OR10G4 Gene

Additional Disease Information for OR10G4

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for OR10G4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10G4 Gene

Publications for OR10G4 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  3. The missense of smell: functional variability in the human odorant receptor repertoire. (PMID: 24316890) Mainland JD … Matsunami H (Nature neuroscience 2014) 3 58
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR10G4 Gene

Sources for OR10G4 Gene

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