Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR10G3 Gene

Aliases for OR10G3 Gene

  • Olfactory Receptor Family 10 Subfamily G Member 3 2 3 5
  • Olfactory Receptor OR14-40 3 4
  • Olfactory Receptor 10G3 3 4
  • Olfactory Receptor, Family 10, Subfamily G, Member 3 2
  • OR14-40 3
  • OR10G3 5

External Ids for OR10G3 Gene

Previous GeneCards Identifiers for OR10G3 Gene

  • GC14U990087
  • GC14M021108
  • GC14M022037

Summaries for OR10G3 Gene

Entrez Gene Summary for OR10G3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10G3 Gene

OR10G3 (Olfactory Receptor Family 10 Subfamily G Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10G2.

UniProtKB/Swiss-Prot Summary for OR10G3 Gene

Gene Wiki entry for OR10G3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR10G3 Gene

Genomics for OR10G3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR10G3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J021997 Promoter/Enhancer 0.9 FANTOM5 Ensembl ENCODE 13.9 -418.4 -418433 2.2 CTCF SPI1 RAD21 TRIM22 TRAV17 OR10G3 OR4E2 OR10G2 TRAV18 lnc-ABHD4-12 TRA
GH14J021703 Enhancer 0.8 VISTA Ensembl 10.7 -124.0 -123987 2 FEZF1 FOXA2 ZNF217 PKNOX1 MYNN MTA2 WT1 OR10G3 ENSG00000256350 HSALNG0099908 TRAV2 OR4E1 TRA
GH14J021992 Enhancer 0.3 FANTOM5 3.6 -412.8 -412821 0.1 CREB1 OR10G3 OR4E2 TRAV16 TRAV17 lnc-ABHD4-12 TRA
GH14J021216 Enhancer 0.4 FANTOM5 1.7 +363.3 363286 0.3 RBM22 TRAV8-5 OR10G2 OR5AU1 RNASE8 OR4E2 OR10G3 LINC00641 HSALNG0021083 HNRNPC
GH14J021555 Enhancer 1.3 ENCODE CraniofacialAtlas dbSUPER 0.4 +22.8 22825 3.5 ZNF654 SSRP1 ZMYM3 CEBPA ZNF10 POLR2A YY1 CTCF REST TRIM22 RF00017-1364 piR-56480-017 SALL2 ENSG00000257096 SNORD8 ENSG00000241035 SNORD9 RPGRIP1 RBBP4P5 OR10G3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10G3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR10G3

Top Transcription factor binding sites by QIAGEN in the OR10G3 gene promoter:
  • AREB6
  • COUP
  • COUP-TF
  • COUP-TF1
  • FOXO4
  • GATA-2
  • HNF-4alpha1
  • HNF-4alpha2
  • HOXA9
  • Nkx2-5

Genomic Locations for OR10G3 Gene

Latest Assembly
chr14:21,568,520-21,580,076
(GRCh38/hg38)
Size:
11,557 bases
Orientation:
Minus strand

Previous Assembly
chr14:22,036,651-22,048,210
(GRCh37/hg19 by Entrez Gene)
Size:
11,560 bases
Orientation:
Minus strand

chr14:22,037,934-22,038,875
(GRCh37/hg19 by Ensembl)
Size:
942 bases
Orientation:
Minus strand

Genomic View for OR10G3 Gene

Genes around OR10G3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10G3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10G3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10G3 Gene

Proteins for OR10G3 Gene

  • Protein details for OR10G3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGC4-O10G3_HUMAN
    Recommended name:
    Olfactory receptor 10G3
    Protein Accession:
    Q8NGC4
    Secondary Accessions:
    • Q6IET7
    • Q96R77

    Protein attributes for OR10G3 Gene

    Size:
    313 amino acids
    Molecular mass:
    35055 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10G3 Gene

Post-translational modifications for OR10G3 Gene

  • Glycosylation at Asn5 and Asn85
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10G3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10G3 Gene

Domains & Families for OR10G3 Gene

Gene Families for OR10G3 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10G3 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR10G3 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR14-40 (O10G3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGC4

UniProtKB/Swiss-Prot:

O10G3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10G3: view

Function for OR10G3 Gene

Molecular function for OR10G3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR10G3 Gene

Gene Ontology (GO) - Molecular Function for OR10G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR10G3: view
genes like me logo Genes that share phenotypes with OR10G3: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR10G3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OR10G3 Gene

Localization for OR10G3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10G3 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10G3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR10G3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10G3 Gene

Pathways & Interactions for OR10G3 Gene

genes like me logo Genes that share pathways with OR10G3: view

Pathways by source for OR10G3 Gene

Interacting Proteins for OR10G3 Gene

Gene Ontology (GO) - Biological Process for OR10G3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10G3: view

No data available for SIGNOR curated interactions for OR10G3 Gene

Drugs & Compounds for OR10G3 Gene

No Compound Related Data Available

Transcripts for OR10G3 Gene

mRNA/cDNA for OR10G3 Gene

1 REFSEQ mRNAs :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR10G3

Alternative Splicing Database (ASD) splice patterns (SP) for OR10G3 Gene

No ASD Table

Relevant External Links for OR10G3 Gene

GeneLoc Exon Structure for
OR10G3

Expression for OR10G3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR10G3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OR10G3 Gene

This gene is overexpressed in Pituitary (x49.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR10G3 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR10G3

SOURCE GeneReport for Unigene cluster for OR10G3 Gene:

Hs.554581
genes like me logo Genes that share expression patterns with OR10G3: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10G3 Gene

Orthologs for OR10G3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10G3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC467384 29
  • 99.25 (n)
OR10G3 30
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia OR10G3 30
  • 89 (a)
OneToOne
LOC101904323 29
  • 88.82 (n)
Mouse
(Mus musculus)
Mammalia Or10g3b 45 Olfr1513 30
  • 84 (a)
OneToMany
Or10g3 45 Olfr1512 29 16 30
  • 83.07 (n)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Olr1640 29
  • 83.49 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 82 (a)
OneToMany
-- 30
  • 81 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 66 (a)
OneToMany
Species where no ortholog for OR10G3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR10G3 Gene

ENSEMBL:
Gene Tree for OR10G3 (if available)
TreeFam:
Gene Tree for OR10G3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR10G3: view image
Alliance of Genome Resources:
Additional Orthologs for OR10G3

Paralogs for OR10G3 Gene

(451) SIMAP similar genes for OR10G3 Gene using alignment to 1 proteins:

  • O10G3_HUMAN
genes like me logo Genes that share paralogs with OR10G3: view

Variants for OR10G3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR10G3 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs17792778 -- p.Ser73Gly

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR10G3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR10G3 Gene

Variant ID Type Subtype PubMed ID
esv2422459 CNV duplication 17116639

Variation tolerance for OR10G3 Gene

Residual Variation Intolerance Score: 93.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.37; 70.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10G3 Gene

Human Gene Mutation Database (HGMD)
OR10G3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10G3
Leiden Open Variation Database (LOVD)
OR10G3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10G3 Gene

Disorders for OR10G3 Gene

Additional Disease Information for OR10G3

No disorders were found for OR10G3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10G3 Gene

Publications for OR10G3 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  3. The human T-cell receptor TCRAC/TCRDC (C alpha/C delta) region: organization, sequence, and evolution of 97.6 kb of DNA. (PMID: 8188290) Koop BF … Hood L (Genomics 1994) 2 3
  4. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y … Ge F (Molecular & cellular proteomics : MCP 2013) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR10G3 Gene

Sources for OR10G3 Gene