Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR10D3 Gene

Aliases for OR10D3 Gene

  • Olfactory Receptor Family 10 Subfamily D Member 3 (Putative) 2 3 5
  • Olfactory Receptor, Family 10, Subfamily D, Member 3 (Non-Functional) 2 3
  • Olfactory Receptor, Family 10, Subfamily D, Member 3 Pseudogene 2 3
  • Putative Olfactory Receptor 10D3 3 4
  • Olfactory Receptor OR11-293 3 4
  • HTPCRX09 3 4
  • OR10D3P 3 4
  • Seven Transmembrane Helix Receptor 3

External Ids for OR10D3 Gene

Previous HGNC Symbols for OR10D3 Gene

  • OR10D3P

Previous GeneCards Identifiers for OR10D3 Gene

  • GC11P124055

Summaries for OR10D3 Gene

Entrez Gene Summary for OR10D3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10D3 Gene

OR10D3 (Olfactory Receptor Family 10 Subfamily D Member 3 (Putative)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10G7.

UniProtKB/Swiss-Prot Summary for OR10D3 Gene

Additional gene information for OR10D3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR10D3 Gene

Genomics for OR10D3 Gene

GeneHancer (GH) Regulatory Elements for OR10D3 Gene

Promoters and enhancers for OR10D3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J124087 Enhancer 0.4 Ensembl 11.2 -97.0 -97044 0.2 EP300 MXI1 FOSL1 RAD21 LOC105369545 OR10D3 VWA5A lnc-VWA5A-2
GH11J124173 Enhancer 0.8 Ensembl ENCODE 0.4 -9.2 -9222 1.4 EP300 GTF2E2 RFX1 ZNF316 SMC3 FOS NFE2 JUND MAFK MAFG VWA5A OR8D1 piR-39099-057 OR10D3
GH11J124177 Enhancer 0.5 FANTOM5 Ensembl 0.4 -5.7 -5744 1.2 SPI1 VWA5A TBRG1 OR8B12 OR10D3 piR-39099-057
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10D3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR10D3

Genomic Locations for OR10D3 Gene

Genomic Locations for OR10D3 Gene
chr11:124,183,345-124,188,780
(GRCh38/hg38)
Size:
5,436 bases
Orientation:
Plus strand
chr11:124,055,923-124,056,952
(GRCh37/hg19)
Size:
1,030 bases
Orientation:
Plus strand

Genomic View for OR10D3 Gene

Genes around OR10D3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10D3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10D3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10D3 Gene

Proteins for OR10D3 Gene

  • Protein details for OR10D3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH80-O10D3_HUMAN
    Recommended name:
    Putative olfactory receptor 10D3
    Protein Accession:
    Q8NH80

    Protein attributes for OR10D3 Gene

    Size:
    312 amino acids
    Molecular mass:
    34812 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10D3 Gene

Post-translational modifications for OR10D3 Gene

No Post-translational modifications

Other Protein References for OR10D3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10D3 Gene

Domains & Families for OR10D3 Gene

Gene Families for OR10D3 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10D3 Gene

Blocks:
  • Olfactory receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OR10D3 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-293 (O10D3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NH80

UniProtKB/Swiss-Prot:

O10D3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10D3: view

Function for OR10D3 Gene

Molecular function for OR10D3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR10D3 Gene

Gene Ontology (GO) - Molecular Function for OR10D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR10D3: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10D3 Gene

Localization for OR10D3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10D3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10D3 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for OR10D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR10D3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10D3 Gene

Pathways & Interactions for OR10D3 Gene

genes like me logo Genes that share pathways with OR10D3: view

Pathways by source for OR10D3 Gene

Interacting Proteins for OR10D3 Gene

;

Gene Ontology (GO) - Biological Process for OR10D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10D3: view

No data available for SIGNOR curated interactions for OR10D3 Gene

Drugs & Compounds for OR10D3 Gene

No Compound Related Data Available

Transcripts for OR10D3 Gene

mRNA/cDNA for OR10D3 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR10D3 Gene

No ASD Table

Relevant External Links for OR10D3 Gene

GeneLoc Exon Structure for
OR10D3

Expression for OR10D3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR10D3 Gene

mRNA differential expression in normal tissues according to GTEx for OR10D3 Gene

This gene is overexpressed in Testis (x53.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR10D3

SOURCE GeneReport for Unigene cluster for OR10D3 Gene:

Hs.538726
genes like me logo Genes that share expression patterns with OR10D3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10D3 Gene

Orthologs for OR10D3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10D3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OR10D3 31
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OR10D3 31
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Or10d3 47 Olfr958 31
  • 89 (a)
OneToOne
Or10o1-ps 47 Olfr929-ps1
  • chr9:38,907,182-38,907,847
cow
(Bos Taurus)
Mammalia OR10D3 31
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OR10D3 31
  • 70 (a)
OneToOne
Species where no ortholog for OR10D3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10D3 Gene

ENSEMBL:
Gene Tree for OR10D3 (if available)
TreeFam:
Gene Tree for OR10D3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR10D3: view image

Paralogs for OR10D3 Gene

(449) SIMAP similar genes for OR10D3 Gene using alignment to 1 proteins:

  • O10D3_HUMAN

Pseudogenes.org Pseudogenes for OR10D3 Gene

genes like me logo Genes that share paralogs with OR10D3: view

Variants for OR10D3 Gene

Additional dbSNP identifiers (rs#s) for OR10D3 Gene

Variation tolerance for OR10D3 Gene

Gene Damage Index Score: 22.09; 99.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10D3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10D3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for OR10D3 Gene

Disorders for OR10D3 Gene

Additional Disease Information for OR10D3

No disorders were found for OR10D3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10D3 Gene

Publications for OR10D3 Gene

  1. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PMID: 1370859) Parmentier M … Perret J (Nature 1992) 2 3 4 54
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 54
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54

Products for OR10D3 Gene

Sources for OR10D3 Gene