Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR10C1 Gene

Aliases for OR10C1 Gene

  • Olfactory Receptor Family 10 Subfamily C Member 1 2 3 5
  • Hs6M1-17 2 3 4
  • Olfactory Receptor, Family 10, Subfamily C, Member 2 2 3
  • Olfactory Receptor 10C1 3 4
  • Olfactory Receptor 10C2 3 4
  • OR10C1P 2 3
  • OR10C2 3 4
  • Olfactory Receptor, Family 10, Subfamily C, Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor Family 10 Subfamily C Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 10, Subfamily C, Member 1 2
  • Seven Transmembrane Helix Receptor 3
  • Olfactory Receptor OR6-31 3
  • OR6-31 3
  • OR10C1 5

External Ids for OR10C1 Gene

Previous HGNC Symbols for OR10C1 Gene

  • OR10C2

Previous GeneCards Identifiers for OR10C1 Gene

  • GC06P029465
  • GC06U900299
  • GC06P029493
  • GC06P029517
  • GC06P029407
  • GC06Po29337

Summaries for OR10C1 Gene

Entrez Gene Summary for OR10C1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jul 2015]

GeneCards Summary for OR10C1 Gene

OR10C1 (Olfactory Receptor Family 10 Subfamily C Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10A4.

UniProtKB/Swiss-Prot Summary for OR10C1 Gene

Gene Wiki entry for OR10C1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR10C1 Gene

Genomics for OR10C1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR10C1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J029510 Enhancer 0.6 Ensembl 10.7 +71.0 70995 0.2 ZIC2 BHLHE40 ZBTB48 CTCF GLIS1 ZNF398 ZNF561 ZNF366 RAD21 HIC1 OR11A1 OR2H1 OR5V1 OR10C1 OR2H2 HLA-W MAS1LP1 piR-37170-058 NONHSAG046542.2 LINC02829
GH06J029414 Enhancer 0.4 Ensembl 12.2 -24.4 -24405 0.2 CTCF SCRT1 RAD21 SCRT2 OR12D1 OR10C1 OR5V1 OR11A1 OR2H1 OR12D2 LOC105379641
GH06J029509 Enhancer 0.4 FANTOM5 10.7 +70.0 70003 0.1 IKZF1 RUNX3 OR11A1 OR2H1 OR5V1 OR10C1 OR2H2 NONHSAG046542.2 LINC02829 piR-37170-058 MAS1L UBD
GH06J029467 Enhancer 0.2 FANTOM5 19.4 +28.4 28393 0.3 OR10C1 ZFP57 MAS1L OR11A1 OR14J1 OR2W1 OR2J3 OR2B3 OR12D2 OR5V1
GH06J029394 Enhancer 0.2 Ensembl 11.4 -44.4 -44405 0.2 OR12D2 OR10C1 OR5V1 OR11A1 OR2H1 GABBR1 SUMO2P1 OR2H2 MICD ZFP57
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10C1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR10C1

Top Transcription factor binding sites by QIAGEN in the OR10C1 gene promoter:
  • AREB6
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • SEF-1 (1)
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for OR10C1 Gene

Latest Assembly
chr6:29,439,306-29,440,977
(GRCh38/hg38)
Size:
1,672 bases
Orientation:
Plus strand

Previous Assembly
chr6:29,407,716-29,408,754
(GRCh37/hg19 by Entrez Gene)
Size:
1,039 bases
Orientation:
Plus strand

chr6:29,407,083-29,408,731
(GRCh37/hg19 by Ensembl)
Size:
1,649 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr6(ALT_REF_LOCI_1):704,970-706,641 (+)
  • chr6(ALT_REF_LOCI_2):925,755-927,426 (+)
  • chr6(ALT_REF_LOCI_3):704,828-706,499 (+)
  • chr6(ALT_REF_LOCI_4):704,441-706,112 (+)
  • chr6(ALT_REF_LOCI_5):704,675-706,346 (+)
  • chr6(ALT_REF_LOCI_6):704,775-706,446 (+)
  • chr6(ALT_REF_LOCI_7):748,317-749,988 (+)

Genomic View for OR10C1 Gene

Genes around OR10C1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10C1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for OR10C1 Gene

  • Protein details for OR10C1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96KK4-O10C1_HUMAN
    Recommended name:
    Olfactory receptor 10C1
    Protein Accession:
    Q96KK4
    Secondary Accessions:
    • Q5SUN7
    • Q96R18

    Protein attributes for OR10C1 Gene

    Size:
    312 amino acids
    Molecular mass:
    34384 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB44507.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for OR10C1 Gene

Post-translational modifications for OR10C1 Gene

  • Glycosylation at Asn4
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10C1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10C1 Gene

Domains & Families for OR10C1 Gene

Gene Families for OR10C1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10C1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR10C1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor 10C2 (O10C1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96KK4

UniProtKB/Swiss-Prot:

O10C1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10C1: view

Function for OR10C1 Gene

Molecular function for OR10C1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.
GENATLAS Biochemistry:
olfactory receptor,family 10,subfamily C,member 1,G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for OR10C1 Gene

Gene Ontology (GO) - Molecular Function for OR10C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA,IBA 21873635
genes like me logo Genes that share ontologies with OR10C1: view
genes like me logo Genes that share phenotypes with OR10C1: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR10C1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10C1 Gene

Localization for OR10C1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10C1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10C1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR10C1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10C1 Gene

Pathways & Interactions for OR10C1 Gene

genes like me logo Genes that share pathways with OR10C1: view

Pathways by source for OR10C1 Gene

Interacting Proteins for OR10C1 Gene

Gene Ontology (GO) - Biological Process for OR10C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10C1: view

No data available for SIGNOR curated interactions for OR10C1 Gene

Drugs & Compounds for OR10C1 Gene

No Compound Related Data Available

Transcripts for OR10C1 Gene

mRNA/cDNA for OR10C1 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR10C1

Alternative Splicing Database (ASD) splice patterns (SP) for OR10C1 Gene

No ASD Table

Relevant External Links for OR10C1 Gene

GeneLoc Exon Structure for
OR10C1

Expression for OR10C1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR10C1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR10C1

SOURCE GeneReport for Unigene cluster for OR10C1 Gene:

Hs.631997
genes like me logo Genes that share expression patterns with OR10C1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10C1 Gene

Orthologs for OR10C1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR10C1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC471942 29
  • 98.82 (n)
OR10C1 30
  • 97 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia OR10C1 29 30
  • 85.58 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC100856344 29
  • 84.24 (n)
OR10C1 30
  • 84 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Or10c1 45 Olfr95 29 16 30
  • 82.05 (n)
OneToOne
Or10al5 45 Olfr121
  • chr17:37,751,856-37,752,818
Or10am5 45 Olfr1349
  • chr7:6,514,477-6,515,637
Rat
(Rattus norvegicus)
Mammalia Olr1744 29
  • 80.88 (n)
Oppossum
(Monodelphis domestica)
Mammalia OR10C1 30
  • 78 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 52 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 30
  • 42 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia OR10C1 30
  • 48 (a)
OneToOne
Species where no ortholog for OR10C1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR10C1 Gene

ENSEMBL:
Gene Tree for OR10C1 (if available)
TreeFam:
Gene Tree for OR10C1 (if available)
Alliance of Genome Resources:
Additional Orthologs for OR10C1

Paralogs for OR10C1 Gene

(447) SIMAP similar genes for OR10C1 Gene using alignment to 2 proteins:

  • O10C1_HUMAN
  • Q6IFQ5_HUMAN
genes like me logo Genes that share paralogs with OR10C1: view

Variants for OR10C1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR10C1 Gene

O10C1_HUMAN-Q96KK4
A stop codon at position Gln-55 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in African-Americans than in non-Africans.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR10C1 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs11968123 Benign: not provided 29,440,944(+) T/Gp.Met310Arg
NM_013941.3(OR10C1):c.929T>G (p.Met310Arg)
MISSENSE
rs11755182 -- p.Arg89Ser
rs17177632 -- p.Met100Val
rs17177639 -- p.Arg121Cys
rs17177646 -- p.Arg138Trp

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR10C1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR10C1 Gene

Variant ID Type Subtype PubMed ID
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1145096 CNV deletion 24896259
nsv830624 CNV loss 17160897

Variation tolerance for OR10C1 Gene

Residual Variation Intolerance Score: 98.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.21; 92.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10C1 Gene

Human Gene Mutation Database (HGMD)
OR10C1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10C1
Leiden Open Variation Database (LOVD)
OR10C1

SNP Genotyping and Copy Number Assays for research

Disorders for OR10C1 Gene

Additional Disease Information for OR10C1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for OR10C1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10C1 Gene

Publications for OR10C1 Gene

  1. Sequence variations at the human leukocyte antigen-linked olfactory receptor cluster do not influence female preferences for male odors. (PMID: 19833159) Thompson EE … Ober C (Human immunology 2010) 3 40
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4
  3. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  4. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T … Lancet D (BMC genomics 2012) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR10C1 Gene

Sources for OR10C1 Gene