Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR10AG1 Gene

Aliases for OR10AG1 Gene

  • Olfactory Receptor Family 10 Subfamily AG Member 1 2 3 5
  • Olfactory Receptor OR11-160 3 4
  • Olfactory Receptor 10AG1 3 4
  • Olfactory Receptor, Family 10, Subfamily AG, Member 1 2
  • OR11-160 3

External Ids for OR10AG1 Gene

Previous GeneCards Identifiers for OR10AG1 Gene

  • GC00U903069
  • GC11U900153
  • GC11M055493
  • GC11M055737
  • GC11M055968
  • GC11M056189
  • GC11M056203
  • GC11M056265
  • GC11M056179
  • GC11M056183

Summaries for OR10AG1 Gene

Entrez Gene Summary for OR10AG1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10AG1 Gene

OR10AG1 (Olfactory Receptor Family 10 Subfamily AG Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10A5.

UniProtKB/Swiss-Prot Summary for OR10AG1 Gene

Gene Wiki entry for OR10AG1 Gene

Additional gene information for OR10AG1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR10AG1 Gene

Genomics for OR10AG1 Gene

GeneHancer (GH) Regulatory Elements for OR10AG1 Gene

Promoters and enhancers for OR10AG1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J055978 Enhancer 0.3 Ensembl 0.4 -9.3 -9256 1.2 POU5F1 NANOG OR10AG1 OR7E5P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10AG1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR10AG1

Top Transcription factor binding sites by QIAGEN in the OR10AG1 gene promoter:
  • AML1a
  • FOXO4
  • Ik-3
  • LCR-F1
  • MyoD
  • POU6F1 (c2)
  • PPAR-gamma1
  • PPAR-gamma2
  • TBP
  • TFIID

Genomic Locations for OR10AG1 Gene

Genomic Locations for OR10AG1 Gene
chr11:55,965,755-55,969,945
(GRCh38/hg38)
Size:
4,191 bases
Orientation:
Minus strand
chr11:55,734,975-55,735,990
(GRCh37/hg19)
Size:
1,016 bases
Orientation:
Minus strand

Genomic View for OR10AG1 Gene

Genes around OR10AG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10AG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10AG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10AG1 Gene

Proteins for OR10AG1 Gene

  • Protein details for OR10AG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH19-O10AG_HUMAN
    Recommended name:
    Olfactory receptor 10AG1
    Protein Accession:
    Q8NH19
    Secondary Accessions:
    • B2RNH4
    • Q6IEU3

    Protein attributes for OR10AG1 Gene

    Size:
    301 amino acids
    Molecular mass:
    34105 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10AG1 Gene

Post-translational modifications for OR10AG1 Gene

  • Glycosylation at Asn82
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10AG1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10AG1 Gene

Domains & Families for OR10AG1 Gene

Gene Families for OR10AG1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10AG1 Gene

Blocks:
  • Olfactory receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OR10AG1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-160 (O10AG_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NH19

UniProtKB/Swiss-Prot:

O10AG_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10AG1: view

Function for OR10AG1 Gene

Molecular function for OR10AG1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR10AG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR10AG1: view
genes like me logo Genes that share phenotypes with OR10AG1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10AG1 Gene

Localization for OR10AG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10AG1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10AG1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10AG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR10AG1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10AG1 Gene

Pathways & Interactions for OR10AG1 Gene

genes like me logo Genes that share pathways with OR10AG1: view

Pathways by source for OR10AG1 Gene

1 KEGG pathway for OR10AG1 Gene

Interacting Proteins for OR10AG1 Gene

;

Gene Ontology (GO) - Biological Process for OR10AG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10AG1: view

No data available for SIGNOR curated interactions for OR10AG1 Gene

Drugs & Compounds for OR10AG1 Gene

No Compound Related Data Available

Transcripts for OR10AG1 Gene

mRNA/cDNA for OR10AG1 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR10AG1 Gene

No ASD Table

Relevant External Links for OR10AG1 Gene

GeneLoc Exon Structure for
OR10AG1

Expression for OR10AG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR10AG1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR10AG1

SOURCE GeneReport for Unigene cluster for OR10AG1 Gene:

Hs.554525
genes like me logo Genes that share expression patterns with OR10AG1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10AG1 Gene

Orthologs for OR10AG1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10AG1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC100686203 30
  • 84.44 (n)
OR10AG1 31
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Or10ag2 47 Olfr1123 17 31 30
  • 79.01 (n)
Or10ag56 47 Olfr1118 31
  • 72 (a)
OneToMany
Or10ag57 47 Olfr1122 31
  • 66 (a)
OneToMany
Or10ag52 47 Olfr1113
  • chr2:87,212,894-87,213,871
Or10ag53 47 Olfr1115
  • chr2:87,251,939-87,252,916
Or10ag54 47 Olfr1116
  • chr2:87,268,846-87,269,766
Or10ag55 47 Olfr1117
  • chr2:87,284,409-87,285,272
Or10ag58 47 Olfr1124
  • chr2:87,434,489-87,435,442
Or10ag59 47 Olfr1129
  • chr2:87,575,086-87,576,027
Or10ag60 47 Olfr1130
  • chr2:87,607,390-87,608,331
Or10ag61 47 Olfr1521
  • chr2:87,268,846-87,269,766
Or12e1 47 Olfr1112
  • chr2:87,191,689-87,192,642
Or12e10 47 Olfr1145
  • chr2:87,809,699-87,810,796
Or12e11-ps 47 Olfr1146-ps1
  • chr2:87,816,533-87,817,455
Or12e12-ps 47 Olfr1147-ps1
  • chr2:87,822,664-87,823,548
Or12e13 47 Olfr1148
  • chr2:87,833,041-87,833,982
Or12e14 47 Olfr1150
  • chr2:87,846,273-87,847,220
Or12e7 47 Olfr1126
  • chr2:87,457,167-87,458,108
Or12e8 47 Olfr1120
  • chr2:87,357,446-87,358,387
Or12e9 47 Olfr1121
  • chr2:87,371,444-87,372,475
rat
(Rattus norvegicus)
Mammalia Olr561 30
  • 77.97 (n)
cow
(Bos Taurus)
Mammalia LOC787428 30
  • 73.99 (n)
-- 31
  • 71 (a)
OneToMany
-- 31
  • 63 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 59 (a)
OneToMany
-- 31
  • 59 (a)
OneToMany
-- 31
  • 59 (a)
OneToMany
-- 31
  • 59 (a)
OneToMany
-- 31
  • 59 (a)
OneToMany
-- 31
  • 59 (a)
OneToMany
-- 31
  • 58 (a)
OneToMany
-- 31
  • 58 (a)
OneToMany
-- 31
  • 58 (a)
OneToMany
-- 31
  • 58 (a)
OneToMany
-- 31
  • 58 (a)
OneToMany
-- 31
  • 58 (a)
OneToMany
-- 31
  • 58 (a)
OneToMany
-- 31
  • 58 (a)
OneToMany
-- 31
  • 58 (a)
OneToMany
-- 31
  • 57 (a)
OneToMany
-- 31
  • 57 (a)
OneToMany
-- 31
  • 56 (a)
OneToMany
-- 31
  • 56 (a)
OneToMany
-- 31
  • 56 (a)
OneToMany
-- 31
  • 56 (a)
OneToMany
-- 31
  • 54 (a)
OneToMany
-- 31
  • 54 (a)
OneToMany
-- 31
  • 53 (a)
OneToMany
-- 31
  • 52 (a)
OneToMany
-- 31
  • 52 (a)
OneToMany
-- 31
  • 52 (a)
OneToMany
-- 31
  • 51 (a)
OneToMany
Species where no ortholog for OR10AG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10AG1 Gene

ENSEMBL:
Gene Tree for OR10AG1 (if available)
TreeFam:
Gene Tree for OR10AG1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR10AG1: view image

Paralogs for OR10AG1 Gene

(456) SIMAP similar genes for OR10AG1 Gene using alignment to 1 proteins:

  • O10AG_HUMAN

Pseudogenes.org Pseudogenes for OR10AG1 Gene

genes like me logo Genes that share paralogs with OR10AG1: view

Variants for OR10AG1 Gene

Additional dbSNP identifiers (rs#s) for OR10AG1 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR10AG1 Gene

Variant ID Type Subtype PubMed ID
dgv1205n100 CNV gain 25217958
dgv1206n100 CNV loss 25217958
dgv1905n54 CNV gain 21841781
dgv52e55 CNV loss 17911159
esv2751030 CNV gain 17911159
esv2759829 CNV loss 17122850
esv3579771 CNV gain 25503493
esv3579782 CNV gain 25503493
esv3626462 CNV loss 21293372
esv3626463 CNV gain 21293372
esv3626464 CNV loss 21293372
esv3626465 CNV gain 21293372
esv3892014 CNV loss 25118596
nsv1044174 CNV loss 25217958
nsv437718 CNV loss 16327808
nsv468568 CNV loss 19166990
nsv469959 CNV loss 18288195
nsv517590 CNV loss 19592680
nsv555080 CNV loss 21841781
nsv555093 CNV loss 21841781
nsv821668 CNV loss 15273396

Variation tolerance for OR10AG1 Gene

Residual Variation Intolerance Score: 83.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.49; 55.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10AG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10AG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR10AG1 Gene

Disorders for OR10AG1 Gene

Additional Disease Information for OR10AG1

No disorders were found for OR10AG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10AG1 Gene

Publications for OR10AG1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 54
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 54

Products for OR10AG1 Gene

Sources for OR10AG1 Gene