Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR10AD1 Gene

Aliases for OR10AD1 Gene

  • Olfactory Receptor Family 10 Subfamily AD Member 1 2 3 5
  • Olfactory Receptor, Family 10, Subfamily AD, Member 1 Pseudogene 2 3
  • Olfactory Receptor OR12-1 3 4
  • Olfactory Receptor 10AD1 3 4
  • OR10AD1P 3 4
  • Olfactory Receptor, Family 10, Subfamily AD, Member 1 2
  • OR12-1 3

External Ids for OR10AD1 Gene

Previous HGNC Symbols for OR10AD1 Gene

  • OR10AD1P

Previous GeneCards Identifiers for OR10AD1 Gene

  • GC12U900019
  • GC12M046883
  • GC12M046884
  • GC12M048596

Summaries for OR10AD1 Gene

Entrez Gene Summary for OR10AD1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10AD1 Gene

OR10AD1 (Olfactory Receptor Family 10 Subfamily AD Member 1) is a Protein Coding gene. Diseases associated with OR10AD1 include Bladder Exstrophy-Epispadias-Cloacal Exstrophy Complex and Exstrophy Of Bladder. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10A4.

UniProtKB/Swiss-Prot Summary for OR10AD1 Gene

Gene Wiki entry for OR10AD1 Gene

Additional gene information for OR10AD1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR10AD1 Gene

Genomics for OR10AD1 Gene

GeneHancer (GH) Regulatory Elements for OR10AD1 Gene

Promoters and enhancers for OR10AD1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10AD1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR10AD1

Top Transcription factor binding sites by QIAGEN in the OR10AD1 gene promoter:
  • C/EBPbeta
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1a
  • NF-1
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3

Genomic Locations for OR10AD1 Gene

Genomic Locations for OR10AD1 Gene
chr12:48,201,772-48,205,682
(GRCh38/hg38)
Size:
3,911 bases
Orientation:
Minus strand
chr12:48,596,081-48,597,170
(GRCh37/hg19)
Size:
1,090 bases
Orientation:
Minus strand

Genomic View for OR10AD1 Gene

Genes around OR10AD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10AD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10AD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10AD1 Gene

Proteins for OR10AD1 Gene

  • Protein details for OR10AD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGE0-O10AD_HUMAN
    Recommended name:
    Olfactory receptor 10AD1
    Protein Accession:
    Q8NGE0
    Secondary Accessions:
    • B9EGT9
    • Q6IFA8

    Protein attributes for OR10AD1 Gene

    Size:
    317 amino acids
    Molecular mass:
    35698 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10AD1 Gene

Post-translational modifications for OR10AD1 Gene

  • Glycosylation at Asn4

Other Protein References for OR10AD1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10AD1 Gene

Domains & Families for OR10AD1 Gene

Gene Families for OR10AD1 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10AD1 Gene

Blocks:
  • Olfactory receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OR10AD1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR12-1 (O10AD_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGE0

UniProtKB/Swiss-Prot:

O10AD_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10AD1: view

Function for OR10AD1 Gene

Molecular function for OR10AD1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR10AD1 Gene

Gene Ontology (GO) - Molecular Function for OR10AD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IEA --
genes like me logo Genes that share ontologies with OR10AD1: view
genes like me logo Genes that share phenotypes with OR10AD1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10AD1 Gene

Localization for OR10AD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10AD1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10AD1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10AD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR10AD1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10AD1 Gene

Pathways & Interactions for OR10AD1 Gene

genes like me logo Genes that share pathways with OR10AD1: view

Pathways by source for OR10AD1 Gene

1 KEGG pathway for OR10AD1 Gene

Interacting Proteins for OR10AD1 Gene

;

Gene Ontology (GO) - Biological Process for OR10AD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10AD1: view

No data available for SIGNOR curated interactions for OR10AD1 Gene

Drugs & Compounds for OR10AD1 Gene

No Compound Related Data Available

Transcripts for OR10AD1 Gene

mRNA/cDNA for OR10AD1 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR10AD1 Gene

No ASD Table

Relevant External Links for OR10AD1 Gene

GeneLoc Exon Structure for
OR10AD1

Expression for OR10AD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR10AD1 Gene

mRNA differential expression in normal tissues according to GTEx for OR10AD1 Gene

This gene is overexpressed in Pituitary (x4.5) and Testis (x4.1).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR10AD1

SOURCE GeneReport for Unigene cluster for OR10AD1 Gene:

Hs.446790

Evidence on tissue expression from TISSUES for OR10AD1 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with OR10AD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10AD1 Gene

Orthologs for OR10AD1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10AD1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC486584 30
  • 88.06 (n)
OR10AD1 31
  • 82 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OR10AD1 30
  • 87.2 (n)
-- 31
  • 83 (a)
OneToMany
-- 31
  • 78 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Olfr287 31 30
  • 84.5 (n)
OneToMany
Or10ad1c 47 Olfr288 17 31
  • 79 (a)
Olfr286 31
  • 79 (a)
OneToMany
Or10ad1b-ps 47 Olfr286-ps1
  • chr15:98,226,677-98,227,628
Or10ad1-ps 47 Olfr287-ps1
  • chr15:98,207,446-98,208,382
Species where no ortholog for OR10AD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10AD1 Gene

ENSEMBL:
Gene Tree for OR10AD1 (if available)
TreeFam:
Gene Tree for OR10AD1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR10AD1: view image

Paralogs for OR10AD1 Gene

(436) SIMAP similar genes for OR10AD1 Gene using alignment to 1 proteins:

  • O10AD_HUMAN
genes like me logo Genes that share paralogs with OR10AD1: view

Variants for OR10AD1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR10AD1 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs11168459 - p.Tyr279His
rs11830378 - p.Phe275Val
rs17122812 - p.Val8Ala
rs17224674 - p.Arg166Gln

Additional dbSNP identifiers (rs#s) for OR10AD1 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR10AD1 Gene

Variant ID Type Subtype PubMed ID
esv2759898 CNV gain+loss 17122850
esv33956 CNV loss 17666407
esv34439 CNV gain 17911159
esv3629429 CNV gain 21293372
nsv8971 CNV gain+loss 18304495

Variation tolerance for OR10AD1 Gene

Residual Variation Intolerance Score: 91.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.27; 95.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10AD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10AD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10AD1 Gene

Disorders for OR10AD1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for OR10AD1 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for OR10AD1

genes like me logo Genes that share disorders with OR10AD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OR10AD1 Gene

Publications for OR10AD1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 54
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 54
  5. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 54

Products for OR10AD1 Gene

Sources for OR10AD1 Gene