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Aliases for OR10AD1 Gene

Aliases for OR10AD1 Gene

  • Olfactory Receptor Family 10 Subfamily AD Member 1 2 3 5
  • Olfactory Receptor, Family 10, Subfamily AD, Member 1 Pseudogene 2 3
  • Olfactory Receptor OR12-1 3 4
  • OR10AD1P 3 4
  • Olfactory Receptor, Family 10, Subfamily AD, Member 1 2
  • Olfactory Receptor 10AD1 3
  • OR12-1 3

External Ids for OR10AD1 Gene

Previous HGNC Symbols for OR10AD1 Gene

  • OR10AD1P

Previous GeneCards Identifiers for OR10AD1 Gene

  • GC12U900019
  • GC12M046883
  • GC12M046884
  • GC12M048596

Summaries for OR10AD1 Gene

Entrez Gene Summary for OR10AD1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10AD1 Gene

OR10AD1 (Olfactory Receptor Family 10 Subfamily AD Member 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity.

UniProtKB/Swiss-Prot for OR10AD1 Gene

  • Odorant receptor.

Gene Wiki entry for OR10AD1 Gene

Additional gene information for OR10AD1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10AD1 Gene

Genomics for OR10AD1 Gene

GeneHancer (GH) Regulatory Elements for OR10AD1 Gene

Promoters and enhancers for OR10AD1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J047804 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 3.3 +387.9 387934 25.6 ZFP64 FEZF1 DMAP1 IRF4 ZNF213 ZNF143 SP3 MEF2D GLIS1 NBN HDAC7 ENSG00000274737 CCNT1 LOC390314 KANSL2 SENP1 RAPGEF3 ASB8 VDR SLC48A1
GH12J048186 Enhancer 0.7 FANTOM5 7 +19.3 19304 0.4 CTCF MXI1 PKNOX1 ZSCAN4 EBF1 MEF2B ZSCAN21 FOSL1 POLR2A IKZF1 ZNF641 LOC102725258 OR10AD1 RPL32P27 OR8S1 ENSG00000279875 CCDC184
GH12J048022 Enhancer 0.5 FANTOM5 8.5 +184.1 184060 0 ZNF335 ZNF362 ZNF384 ZBTB8A TCF7L2 TRIM28 VDR ENSG00000205537 OR10AD1 ENSG00000257955 COL2A1 LOC105369750
GH12J047831 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 2.7 +371.4 371355 5 HDGF ATF1 TCF12 GATA2 ATF7 RUNX3 MCM3 ATF4 GMEB1 SMARCA4 HDAC7 LOC390314 SENP1 LOC102725258 CCNT1 CCDC184 H1FNT KANSL2 RPAP3 CACNB3
GH12J047899 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 1.2 +304.8 304836 3.1 ARID4B ZNF48 RAD21 RFX5 ZNF614 HSF1 SCRT2 ZNF143 FOS THAP11 VDR CCNT1 SENP1 KANSL2 RPAP3 TMEM106C ZNF641 OR10AD1 GC12P047906 ENSG00000205537
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10AD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR10AD1 gene promoter:
  • Meis-1a
  • Meis-1
  • HOXA9B
  • HOXA9
  • C/EBPbeta
  • NF-1
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3

Genomic Locations for OR10AD1 Gene

Genomic Locations for OR10AD1 Gene
3,911 bases
Minus strand
1,090 bases
Minus strand

Genomic View for OR10AD1 Gene

Genes around OR10AD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10AD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10AD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10AD1 Gene

Proteins for OR10AD1 Gene

  • Protein details for OR10AD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 10AD1
    Protein Accession:
    Secondary Accessions:
    • B9EGT9
    • Q6IFA8

    Protein attributes for OR10AD1 Gene

    317 amino acids
    Molecular mass:
    35698 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10AD1 Gene

Post-translational modifications for OR10AD1 Gene

Other Protein References for OR10AD1 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10AD1 Gene

Domains & Families for OR10AD1 Gene

Gene Families for OR10AD1 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10AD1 Gene

Suggested Antigen Peptide Sequences for OR10AD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10AD1: view

Function for OR10AD1 Gene

Molecular function for OR10AD1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR10AD1 Gene

Gene Ontology (GO) - Molecular Function for OR10AD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR10AD1: view
genes like me logo Genes that share phenotypes with OR10AD1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10AD1 Gene

Localization for OR10AD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10AD1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10AD1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10AD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR10AD1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10AD1 Gene

Pathways & Interactions for OR10AD1 Gene

genes like me logo Genes that share pathways with OR10AD1: view

Pathways by source for OR10AD1 Gene

1 KEGG pathway for OR10AD1 Gene

Interacting Proteins for OR10AD1 Gene

Gene Ontology (GO) - Biological Process for OR10AD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10AD1: view

No data available for SIGNOR curated interactions for OR10AD1 Gene

Drugs & Compounds for OR10AD1 Gene

No Compound Related Data Available

Transcripts for OR10AD1 Gene

mRNA/cDNA for OR10AD1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR10AD1 Gene

Olfactory receptor, family 10, subfamily AD, member 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR10AD1 Gene

No ASD Table

Relevant External Links for OR10AD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR10AD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR10AD1 Gene

mRNA differential expression in normal tissues according to GTEx for OR10AD1 Gene

This gene is overexpressed in Pituitary (x4.5) and Testis (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of OR10AD1 Gene:


SOURCE GeneReport for Unigene cluster for OR10AD1 Gene:


Evidence on tissue expression from TISSUES for OR10AD1 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with OR10AD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10AD1 Gene

Orthologs for OR10AD1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10AD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia LOC486584 33
  • 88.06 (n)
OR10AD1 34
  • 82 (a)
(Bos Taurus)
Mammalia OR10AD1 33
  • 87.2 (n)
-- 34
  • 83 (a)
-- 34
  • 78 (a)
(Mus musculus)
Mammalia Olfr287 34 33
  • 84.5 (n)
Or10ad1c 51 Olfr288 16 34
  • 79 (a)
Olfr286 34
  • 79 (a)
Or10ad1b-ps 51 Olfr286-ps1
  • chr15:98,226,677-98,227,628
Or10ad1-ps 51 Olfr287-ps1
  • chr15:98,207,446-98,208,382
Species where no ortholog for OR10AD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10AD1 Gene

Gene Tree for OR10AD1 (if available)
Gene Tree for OR10AD1 (if available)
Evolutionary constrained regions (ECRs) for OR10AD1: view image

Paralogs for OR10AD1 Gene

(436) SIMAP similar genes for OR10AD1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR10AD1: view

No data available for Paralogs for OR10AD1 Gene

Variants for OR10AD1 Gene

Sequence variations from dbSNP and Humsavar for OR10AD1 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000855240 -- 48,202,384(-) C/T coding_sequence_variant, synonymous_variant
rs1001804158 -- 48,203,939(-) G/C upstream_transcript_variant
rs1002276237 -- 48,203,487(-) G/C upstream_transcript_variant
rs1002860392 -- 48,204,904(-) C/T upstream_transcript_variant
rs1004119663 -- 48,203,969(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR10AD1 Gene

Variant ID Type Subtype PubMed ID
esv2759898 CNV gain+loss 17122850
esv33956 CNV loss 17666407
esv34439 CNV gain 17911159
esv3629429 CNV gain 21293372
nsv8971 CNV gain+loss 18304495

Variation tolerance for OR10AD1 Gene

Residual Variation Intolerance Score: 91.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.27; 95.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10AD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10AD1 Gene

Disorders for OR10AD1 Gene

Additional Disease Information for OR10AD1

No disorders were found for OR10AD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10AD1 Gene

Publications for OR10AD1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  4. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 58
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR10AD1 Gene

Sources for OR10AD1 Gene

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