Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR10AC1 Gene

Aliases for OR10AC1 Gene

  • Olfactory Receptor Family 10 Subfamily AC Member 1 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor, Family 10, Subfamily AC, Member 1 Pseudogene 2 3
  • Olfactory Receptor 10AC1 3 4
  • Olfactory Receptor OR7-5 3 4
  • OR10AC1P 3 4
  • Olfactory Receptor, Family 10, Subfamily AC, Member 1 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 10, Subfamily W, Member 1 Pseudogene 3
  • Seven Transmembrane Helix Receptor 3
  • Putative Olfactory Receptor 10AC1 3
  • OR10AC1 5

External Ids for OR10AC1 Gene

Previous HGNC Symbols for OR10AC1 Gene

  • OR10AC1P

Summaries for OR10AC1 Gene

Entrez Gene Summary for OR10AC1 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jan 2017]

GeneCards Summary for OR10AC1 Gene

OR10AC1 (Olfactory Receptor Family 10 Subfamily AC Member 1 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity.

UniProtKB/Swiss-Prot Summary for OR10AC1 Gene

Additional gene information for OR10AC1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR10AC1 Gene

Genomics for OR10AC1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR10AC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J143519 Enhancer 0.6 Ensembl ENCODE 250.7 +1.0 968 4.6 ZIC2 FEZF1 GLIS1 POLR2A EP300 ZFHX2 OR10AC1 TAS2R41 FAM131B TAS2R60 EPHA1 ARHGEF35 EPHA1-AS1 CTAGE6 EPHB6 OR2A7
GH07J143505 Enhancer 0.9 Ensembl 0.4 +13.2 13206 3.9 IKZF1 MYC NCOR1 ZNF592 NFIC NONO HES1 BHLHE40 MBD2 MNT LOC154761 TCAF2 EPHA1 EPHA1-AS1 CASP2 RN7SL535P TAS2R41 OR2A1 ENSG00000232533 ZYX
GH07J143484 Enhancer 1 Ensembl ENCODE 0.3 +30.1 30068 11.2 NCOR1 IKZF1 JUND ZNF10 YY1 REST CEBPB BHLHE40 CTCF EP300 OR2R1P TAS2R60 EPHA1-AS1 CTAGE6 EPHA1 ARHGEF35 LOC154761 lnc-EPHA1-3 TAS2R41 OR10AC1
GH07J143498 Enhancer 0.7 Ensembl ENCODE 0.4 +20.6 20568 7.4 JUND NRF1 CEBPB POLR2A EP300 NR2F2 CBFA2T3 TAS2R41 FAM131B EPHA1-AS1 CTAGE6 TAS2R60 EPHA1 OR2A13P HSALNG0061966 LOC105375547 piR-61945-474
GH07J143512 Enhancer 0.3 ENCODE 0.4 +6.8 6758 1.3 JUND FOS TAS2R60 EPHA1 ARHGEF35 OR10AC1 piR-61945-474 TAS2R41 EPHA1-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10AC1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR10AC1

Genomic Locations for OR10AC1 Gene

Latest Assembly
chr7:143,509,256-143,519,469
(GRCh38/hg38)
Size:
10,214 bases
Orientation:
Minus strand

Previous Assembly
chr7:143,207,960-143,209,104
(GRCh37/hg19 by Entrez Gene)
Size:
1,145 bases
Orientation:
Minus strand

chr7:143,208,026-143,209,004
(GRCh37/hg19 by Ensembl)
Size:
979 bases
Orientation:
Minus strand

Alternative Locations (GRCh38/hg38)

  • chr7(PATCHES):130,231-131,375 (-)

Genomic View for OR10AC1 Gene

Genes around OR10AC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10AC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10AC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10AC1 Gene

Proteins for OR10AC1 Gene

  • Protein details for OR10AC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH08-O10AC_HUMAN
    Recommended name:
    Olfactory receptor 10AC1
    Protein Accession:
    Q8NH08

    Protein attributes for OR10AC1 Gene

    Size:
    325 amino acids
    Molecular mass:
    35157 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05833.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for OR10AC1 Gene

Post-translational modifications for OR10AC1 Gene

  • Glycosylation at Asn6

Other Protein References for OR10AC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OR10AC1 Gene

Domains & Families for OR10AC1 Gene

Gene Families for OR10AC1 Gene

Protein Domains for OR10AC1 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR10AC1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR7-5 (O10AC_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NH08

UniProtKB/Swiss-Prot:

O10AC_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10AC1: view

Function for OR10AC1 Gene

Molecular function for OR10AC1 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR10AC1 Gene

Gene Ontology (GO) - Molecular Function for OR10AC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR10AC1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10AC1 Gene

Localization for OR10AC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10AC1 Gene

Cell membrane. Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for OR10AC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR10AC1: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for OR10AC1 Gene

Pathways & Interactions for OR10AC1 Gene

genes like me logo Genes that share pathways with OR10AC1: view

Pathways by source for OR10AC1 Gene

1 KEGG pathway for OR10AC1 Gene

Interacting Proteins for OR10AC1 Gene

Gene Ontology (GO) - Biological Process for OR10AC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10AC1: view

No data available for SIGNOR curated interactions for OR10AC1 Gene

Drugs & Compounds for OR10AC1 Gene

No Compound Related Data Available

Transcripts for OR10AC1 Gene

mRNA/cDNA for OR10AC1 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for OR10AC1 Gene

No ASD Table

Relevant External Links for OR10AC1 Gene

GeneLoc Exon Structure for
OR10AC1

Expression for OR10AC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR10AC1 Gene

genes like me logo Genes that share expression patterns with OR10AC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10AC1 Gene

Orthologs for OR10AC1 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for OR10AC1 Gene

Organism Taxonomy Gene Similarity Type Details
Mouse
(Mus musculus)
Mammalia Or10ac1 45 Olfr455
  • chr6:42,538,070-42,539,020
Species where no ortholog for OR10AC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR10AC1 Gene

ENSEMBL:
Gene Tree for OR10AC1 (if available)
TreeFam:
Gene Tree for OR10AC1 (if available)
Alliance of Genome Resources:
Additional Orthologs for OR10AC1

Paralogs for OR10AC1 Gene

No data available for Paralogs for OR10AC1 Gene

Variants for OR10AC1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for OR10AC1 Gene

O10AC_HUMAN-Q8NH08
A stop codon due to a single nucleotide insertion in the gene coding for this protein at position Ile-90 is responsible for functional diversity thus producing a pseudogene.

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR10AC1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Additional Variant Information for OR10AC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10AC1
Leiden Open Variation Database (LOVD)
OR10AC1

No data available for Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for OR10AC1 Gene

Disorders for OR10AC1 Gene

Additional Disease Information for OR10AC1

No disorders were found for OR10AC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10AC1 Gene

Publications for OR10AC1 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR10AC1 Gene

Sources for OR10AC1 Gene