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Aliases for OR10A7 Gene

Aliases for OR10A7 Gene

  • Olfactory Receptor Family 10 Subfamily A Member 7 2 3 5
  • Olfactory Receptor OR12-6 3 4
  • Olfactory Receptor 10A7 3 4
  • Olfactory Receptor, Family 10, Subfamily A, Member 7 2
  • OR12-6 3

External Ids for OR10A7 Gene

Previous GeneCards Identifiers for OR10A7 Gene

  • GC12U990195
  • GC12P053902
  • GC12P053903
  • GC12P055614

Summaries for OR10A7 Gene

Entrez Gene Summary for OR10A7 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10A7 Gene

OR10A7 (Olfactory Receptor Family 10 Subfamily A Member 7) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10A4.

UniProtKB/Swiss-Prot for OR10A7 Gene

Gene Wiki entry for OR10A7 Gene

Additional gene information for OR10A7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10A7 Gene

Genomics for OR10A7 Gene

GeneHancer (GH) Regulatory Elements for OR10A7 Gene

Promoters and enhancers for OR10A7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J055173 Enhancer 0.5 Ensembl 11.3 -43.4 -43424 8.8 ZNF316 NFE2 MAFG JUNB EMSY OR10A7 ITGA5 DNAJC14 OR10U1P OR9R1P
GH12J055195 Enhancer 0.3 Ensembl 11.2 -24.8 -24824 1.2 ZBTB40 OR10U1P OR10A7 OR10P1 METTL7B GC12P055220
GH12J055467 Enhancer 0.6 FANTOM5 Ensembl 3.6 +247.1 247076 3.8 CREB1 CEBPG ETV6 GC12M055463 OR6C68 APOF OR10A7 MMP19 OR6C2 ENSG00000258763 OR6C70
GH12J055198 Enhancer 0.2 Ensembl 11.2 -21.2 -21224 2 OR10A7 OR10P1 DNAJC14 OR10U1P GC12P055220
GH12J055182 Enhancer 0.2 Ensembl 11 -36.7 -36724 3.4 OR10A7 OR10U1P OR9R1P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10A7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR10A7 gene promoter:
  • FOXI1
  • HFH-3
  • RORalpha2

Genomic Locations for OR10A7 Gene

Genomic Locations for OR10A7 Gene
chr12:55,221,025-55,221,975
(GRCh38/hg38)
Size:
951 bases
Orientation:
Plus strand
chr12:55,614,809-55,615,759
(GRCh37/hg19)
Size:
951 bases
Orientation:
Plus strand

Genomic View for OR10A7 Gene

Genes around OR10A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10A7 Gene

Proteins for OR10A7 Gene

  • Protein details for OR10A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NGE5-O10A7_HUMAN
    Recommended name:
    Olfactory receptor 10A7
    Protein Accession:
    Q8NGE5
    Secondary Accessions:
    • Q6IFD5
    • Q96R19

    Protein attributes for OR10A7 Gene

    Size:
    316 amino acids
    Molecular mass:
    35695 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10A7 Gene

Post-translational modifications for OR10A7 Gene

  • Glycosylation at isoforms=5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10A7 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10A7 Gene

Domains & Families for OR10A7 Gene

Gene Families for OR10A7 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10A7 Gene

Suggested Antigen Peptide Sequences for OR10A7 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR12-6 (O10A7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NGE5

UniProtKB/Swiss-Prot:

O10A7_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10A7: view

Function for OR10A7 Gene

Molecular function for OR10A7 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR10A7 Gene

Gene Ontology (GO) - Molecular Function for OR10A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA 21873635
genes like me logo Genes that share ontologies with OR10A7: view
genes like me logo Genes that share phenotypes with OR10A7: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for OR10A7 - Now 50% OFF >
  • * OR10A7 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * OR10A7 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10A7 Gene

Localization for OR10A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10A7 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10A7 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR10A7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10A7 Gene

Pathways & Interactions for OR10A7 Gene

genes like me logo Genes that share pathways with OR10A7: view

Pathways by source for OR10A7 Gene

Interacting Proteins for OR10A7 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)
https://version11.string-db.org/api/image/network?species=9606&limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000326718%0d9606.ENSP00000233596%0d9606.ENSP00000248572%0d9606.ENSP00000259030%0d9606.ENSP00000296142%0d9606.ENSP00000303482%0d
Selected Interacting proteins: ENSP00000326718 Q8NGE5-O10A7_HUMAN for OR10A7 Gene via STRING IID

Gene Ontology (GO) - Biological Process for OR10A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell IEA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10A7: view

No data available for SIGNOR curated interactions for OR10A7 Gene

Drugs & Compounds for OR10A7 Gene

No Compound Related Data Available

Transcripts for OR10A7 Gene

mRNA/cDNA for OR10A7 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for OR10A7 Gene

Olfactory receptor, family 10, subfamily A, member 7:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for OR10A7 - Now 50% OFF >
  • * OR10A7 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * OR10A7 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for OR10A7 Gene

No ASD Table

Relevant External Links for OR10A7 Gene

GeneLoc Exon Structure for
OR10A7
ECgene alternative splicing isoforms for
OR10A7

Expression for OR10A7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR10A7 Gene

Protein differential expression in normal tissues from HIPED for OR10A7 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR10A7 Gene



Protein tissue co-expression partners for OR10A7 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR10A7 Gene:

OR10A7

SOURCE GeneReport for Unigene cluster for OR10A7 Gene:

Hs.554557
genes like me logo Genes that share expression patterns with OR10A7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10A7 Gene

Orthologs for OR10A7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR10A7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC467020 34
  • 98.73 (n)
dog
(Canis familiaris)
Mammalia OR26G07 35
  • 92 (a)
OneToOne
OR10A7 34
  • 89.31 (n)
cow
(Bos Taurus)
Mammalia OR10A7 35 34
  • 88.78 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 59 (a)
ManyToMany
-- 35
  • 59 (a)
ManyToMany
-- 35
  • 59 (a)
ManyToMany
-- 35
  • 58 (a)
ManyToMany
-- 35
  • 58 (a)
ManyToMany
-- 35
  • 58 (a)
ManyToMany
-- 35
  • 56 (a)
ManyToMany
-- 35
  • 55 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Olfr1349 35
  • 49 (a)
ManyToMany
Or10i1-ps 51 Olfr1542-ps1
  • chr10:130,093,286-130,093,836
chicken
(Gallus gallus)
Aves OR10A4 34
  • 58.16 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 49 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485112 34
  • 56.39 (n)
Species where no ortholog for OR10A7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10A7 Gene

ENSEMBL:
Gene Tree for OR10A7 (if available)
TreeFam:
Gene Tree for OR10A7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR10A7: view image

Paralogs for OR10A7 Gene

(448) SIMAP similar genes for OR10A7 Gene using alignment to 1 proteins:

  • O10A7_HUMAN

Pseudogenes.org Pseudogenes for OR10A7 Gene

genes like me logo Genes that share paralogs with OR10A7: view

Variants for OR10A7 Gene

Sequence variations from dbSNP and Humsavar for OR10A7 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000275885 -- 55,219,819(+) A/G upstream_transcript_variant
rs1000792555 -- 55,219,460(+) G/A upstream_transcript_variant
rs1001508281 -- 55,219,033(+) C/T upstream_transcript_variant
rs1002049099 -- 55,221,450(+) G/A coding_sequence_variant, synonymous_variant
rs1004466526 -- 55,220,290(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR10A7 Gene

Variant ID Type Subtype PubMed ID
nsv559001 CNV loss 21841781

Variation tolerance for OR10A7 Gene

Residual Variation Intolerance Score: 93.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.58; 56.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10A7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10A7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10A7 Gene

Disorders for OR10A7 Gene

Additional Disease Information for OR10A7

No disorders were found for OR10A7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10A7 Gene

Publications for OR10A7 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  3. Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia. (PMID: 24152035) Goodbourn PT … Mollon JD (Genes, brain, and behavior 2014) 3 58
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 58

Products for OR10A7 Gene

Sources for OR10A7 Gene

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