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Aliases for OR10A6 Gene

Aliases for OR10A6 Gene

  • Olfactory Receptor Family 10 Subfamily A Member 6 (Gene/Pseudogene) 2 3 5
  • Olfactory Receptor OR11-96 3 4
  • Olfactory Receptor, Family 10, Subfamily A, Member 6 (Gene/Pseudogene) 2
  • Olfactory Receptor, Family 10, Subfamily A, Member 6 3
  • Olfactory Receptor 10A6 3
  • OR11-96 3

External Ids for OR10A6 Gene

Previous GeneCards Identifiers for OR10A6 Gene

  • GC11U990581
  • GC11M007914
  • GC11M007905
  • GC11M007949

Summaries for OR10A6 Gene

Entrez Gene Summary for OR10A6 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]

GeneCards Summary for OR10A6 Gene

OR10A6 (Olfactory Receptor Family 10 Subfamily A Member 6 (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10A3.

UniProtKB/Swiss-Prot for OR10A6 Gene

  • Odorant receptor.

Gene Wiki entry for OR10A6 Gene

Additional gene information for OR10A6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10A6 Gene

Genomics for OR10A6 Gene

GeneHancer (GH) Regulatory Elements for OR10A6 Gene

Promoters and enhancers for OR10A6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J007904 Enhancer 0.8 Ensembl ENCODE 11.8 +24.7 24683 4.4 CTCF NANOG CEBPB KLF4 POLR2A SCRT2 GLIS1 ZBTB33 TCF7L2 ENSG00000254951 LOC283299 PIR62490 NLRP10 OR10A6 OR10A3 OVCH2 CASC23 TUB EIF3F
GH11J007900 Enhancer 0.6 ENCODE 11.4 +29.7 29687 2.4 SMARCE1 RXRA CEBPB DPF2 SP1 CTBP1 GATA3 FOS HNF4A PIR32361 NLRP10 OR10A6 OR10A3 CASC23 TUB OVCH2 ENSG00000254951 LOC283299 PIR62490
GH11J007890 Enhancer 1.2 FANTOM5 Ensembl ENCODE 4.6 +38.2 38172 5.8 ELF3 CTCF PKNOX1 EBF1 BATF IRF4 RAD21 RFX5 YY1 POLR2A PIR41542 OR10A3 NLRP14 OR10A6 PIR32361 ENSG00000254951 LOC283299
GH11J007909 Enhancer 0.5 ENCODE 0.3 +21.3 21335 1.7 STAT1 NANOG POU5F1 CEBPB ETS1 OVCH2 NLRP10 EIF3F ENSG00000254951 LOC283299 OR10A6
GH11J007936 Enhancer 0.3 ENCODE 0.4 -5.4 -5399 0.6 CBFA2T3 NLRP10 OVCH2 GC11M007939 OR10A6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10A6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR10A6 gene promoter:
  • AML1a
  • Max1
  • c-Myc
  • MIF-1
  • FOXJ2
  • FOXJ2 (long isoform)
  • STAT1
  • En-1
  • Pbx1a
  • NRSF form 1

Genomic Locations for OR10A6 Gene

Genomic Locations for OR10A6 Gene
chr11:7,924,592-7,931,268
(GRCh38/hg38)
Size:
6,677 bases
Orientation:
Minus strand
chr11:7,949,180-7,950,209
(GRCh37/hg19)
Size:
1,030 bases
Orientation:
Minus strand

Genomic View for OR10A6 Gene

Genes around OR10A6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10A6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10A6 Gene

Proteins for OR10A6 Gene

  • Protein details for OR10A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NH74-O10A6_HUMAN
    Recommended name:
    Olfactory receptor 10A6
    Protein Accession:
    Q8NH74
    Secondary Accessions:
    • Q6IF59

    Protein attributes for OR10A6 Gene

    Size:
    314 amino acids
    Molecular mass:
    35318 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10A6 Gene

Post-translational modifications for OR10A6 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10A6 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10A6 Gene

Domains & Families for OR10A6 Gene

Gene Families for OR10A6 Gene

Protein Domains for OR10A6 Gene

Suggested Antigen Peptide Sequences for OR10A6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NH74

UniProtKB/Swiss-Prot:

O10A6_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10A6: view

Function for OR10A6 Gene

Molecular function for OR10A6 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR10A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR10A6: view

Phenotypes for OR10A6 Gene

genes like me logo Genes that share phenotypes with OR10A6: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10A6 Gene

Localization for OR10A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10A6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10A6 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR10A6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10A6 Gene

Pathways & Interactions for OR10A6 Gene

genes like me logo Genes that share pathways with OR10A6: view

Pathways by source for OR10A6 Gene

Interacting Proteins for OR10A6 Gene

Gene Ontology (GO) - Biological Process for OR10A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10A6: view

No data available for SIGNOR curated interactions for OR10A6 Gene

Drugs & Compounds for OR10A6 Gene

No Compound Related Data Available

Transcripts for OR10A6 Gene

mRNA/cDNA for OR10A6 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(2) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR10A6 Gene

Olfactory receptor, family 10, subfamily A, member 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR10A6 Gene

No ASD Table

Relevant External Links for OR10A6 Gene

GeneLoc Exon Structure for
OR10A6
ECgene alternative splicing isoforms for
OR10A6

Expression for OR10A6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR10A6 Gene

mRNA differential expression in normal tissues according to GTEx for OR10A6 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x19.0) and Skin - Not Sun Exposed (Suprapubic) (x13.6).

NURSA nuclear receptor signaling pathways regulating expression of OR10A6 Gene:

OR10A6

SOURCE GeneReport for Unigene cluster for OR10A6 Gene:

Hs.528593
genes like me logo Genes that share expression patterns with OR10A6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10A6 Gene

Orthologs for OR10A6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR10A6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466433 33
  • 99.04 (n)
dog
(Canis familiaris)
Mammalia OR10A6 33
  • 87.54 (n)
cow
(Bos Taurus)
Mammalia OR10A3 33
  • 84.98 (n)
rat
(Rattus norvegicus)
Mammalia Olr281 33
  • 80.19 (n)
mouse
(Mus musculus)
Mammalia Olfr519 16 33
  • 78.7 (n)
Or10a49 51 Olfr517
  • chr7:108,868,211-108,869,230
Species where no ortholog for OR10A6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10A6 Gene

ENSEMBL:
Gene Tree for OR10A6 (if available)
TreeFam:
Gene Tree for OR10A6 (if available)

Paralogs for OR10A6 Gene

Paralogs for OR10A6 Gene

(450) SIMAP similar genes for OR10A6 Gene using alignment to 1 proteins:

  • O10A6_HUMAN
genes like me logo Genes that share paralogs with OR10A6: view

Variants for OR10A6 Gene

Sequence variations from dbSNP and Humsavar for OR10A6 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000379557 -- 7,928,893(-) C/A upstream_transcript_variant
rs1000496708 -- 7,930,034(-) TTTGTTTG/TTTG upstream_transcript_variant
rs1002351964 -- 7,929,407(-) A/T upstream_transcript_variant
rs1002487751 -- 7,929,219(-) C/T upstream_transcript_variant
rs1003355271 -- 7,928,280(-) T/A coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for OR10A6 Gene

Variant ID Type Subtype PubMed ID
esv3625306 CNV gain 21293372
nsv499766 OTHER inversion 21111241
nsv522758 CNV loss 19592680
nsv527100 CNV loss 19592680
nsv7215 OTHER inversion 18451855

Variation tolerance for OR10A6 Gene

Residual Variation Intolerance Score: 82.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.87; 96.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10A6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10A6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10A6 Gene

Disorders for OR10A6 Gene

Additional Disease Information for OR10A6

No disorders were found for OR10A6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10A6 Gene

Publications for OR10A6 Gene

  1. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  2. Personal receptor repertoires: olfaction as a model. (PMID: 22908908) Olender T … Lancet D (BMC genomics 2012) 3 58
  3. A probabilistic classifier for olfactory receptor pseudogenes. (PMID: 16939646) Menashe I … Lancet D (BMC bioinformatics 2006) 3 58
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for OR10A6 Gene

Sources for OR10A6 Gene

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