Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR10A5 Gene

Aliases for OR10A5 Gene

  • Olfactory Receptor Family 10 Subfamily A Member 5 2 3 5
  • Olfactory Receptor-Like Protein JCG6 3 4
  • Olfactory Receptor 11-403 3 4
  • Olfactory Receptor 10A1 3 4
  • Olfactory Receptor 10A5 3 4
  • OR11-403 3 4
  • OR10A1 3 4
  • HP3 3 4
  • Olfactory Receptor, Family 10, Subfamily A, Member 1 3
  • Olfactory Receptor, Family 10, Subfamily A, Member 5 2
  • Olfactory Receptor OR11-85 3
  • JCG6 3

External Ids for OR10A5 Gene

Previous HGNC Symbols for OR10A5 Gene

  • OR10A1

Previous GeneCards Identifiers for OR10A5 Gene

  • GC11U990582
  • GC11P006833
  • GC11P006823
  • GC11P006866

Summaries for OR10A5 Gene

Entrez Gene Summary for OR10A5 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10A5 Gene

OR10A5 (Olfactory Receptor Family 10 Subfamily A Member 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10A2.

UniProtKB/Swiss-Prot Summary for OR10A5 Gene

Gene Wiki entry for OR10A5 Gene

Additional gene information for OR10A5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR10A5 Gene

Genomics for OR10A5 Gene

GeneHancer (GH) Regulatory Elements for OR10A5 Gene

Promoters and enhancers for OR10A5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J006843 Enhancer 0.3 Ensembl 500.7 -1.7 -1651 0.4 FOXA2 YY1 ENSG00000254712 LOC100131597 OR10A5 lnc-OR6A2-1 OR6A2 ENSG00000283415 OR2AG2
GH11J006468 Enhancer 1.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas 2.3 -376.3 -376281 1.5 ZNF10 TRIM28 POLR2A KDM5B MBD2 KLF9 NFIC SP2 ZBTB17 ZNF263 OR56A1 OR10A4 OR2AG2 OR10A2 OR56A4 OR52W1 OR2AG1 OR56B4 OR10A5 OR6A2
GH11J006847 Enhancer 0.2 Ensembl 0.7 +2.5 2549 0.8 OR2D2 OR10A5 piR-48209-088 OR2AG2 ENSG00000283415
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10A5 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR10A5

Top Transcription factor binding sites by QIAGEN in the OR10A5 gene promoter:
  • AML1a
  • HOXA9
  • HOXA9B
  • LCR-F1
  • Meis-1
  • Pax-6
  • POU2F1
  • POU2F1a
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for OR10A5 Gene

Genomic Locations for OR10A5 Gene
chr11:6,845,652-6,846,705
(GRCh38/hg38)
Size:
1,054 bases
Orientation:
Plus strand
chr11:6,866,883-6,867,936
(GRCh37/hg19)
Size:
1,054 bases
Orientation:
Plus strand

Genomic View for OR10A5 Gene

Genes around OR10A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10A5 Gene

Proteins for OR10A5 Gene

  • Protein details for OR10A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H207-O10A5_HUMAN
    Recommended name:
    Olfactory receptor 10A5
    Protein Accession:
    Q9H207
    Secondary Accessions:
    • O95223
    • Q52M66
    • Q96R21
    • Q96R22

    Protein attributes for OR10A5 Gene

    Size:
    317 amino acids
    Molecular mass:
    35519 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10A5 Gene

Post-translational modifications for OR10A5 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10A5 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10A5 Gene

Domains & Families for OR10A5 Gene

Gene Families for OR10A5 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10A5 Gene

Blocks:
  • Olfactory receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OR10A5 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor-like protein JCG6 (O10A5_HUMAN)
  • Olfactory receptor, family 10, subfamily A, member 5 (Q6IFG6_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H207

UniProtKB/Swiss-Prot:

O10A5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10A5: view

Function for OR10A5 Gene

Molecular function for OR10A5 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor (Potential). May be involved in taste perception.

Phenotypes From GWAS Catalog for OR10A5 Gene

Gene Ontology (GO) - Molecular Function for OR10A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 9787077
genes like me logo Genes that share ontologies with OR10A5: view
genes like me logo Genes that share phenotypes with OR10A5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR10A5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10A5 Gene

Localization for OR10A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10A5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10A5 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 9787077
genes like me logo Genes that share ontologies with OR10A5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10A5 Gene

Pathways & Interactions for OR10A5 Gene

genes like me logo Genes that share pathways with OR10A5: view

Pathways by source for OR10A5 Gene

1 KEGG pathway for OR10A5 Gene

Interacting Proteins for OR10A5 Gene

;

Gene Ontology (GO) - Biological Process for OR10A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell NAS 9787077
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10A5: view

No data available for SIGNOR curated interactions for OR10A5 Gene

Drugs & Compounds for OR10A5 Gene

No Compound Related Data Available

Transcripts for OR10A5 Gene

mRNA/cDNA for OR10A5 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR10A5

Alternative Splicing Database (ASD) splice patterns (SP) for OR10A5 Gene

No ASD Table

Relevant External Links for OR10A5 Gene

GeneLoc Exon Structure for
OR10A5

Expression for OR10A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR10A5 Gene

Protein differential expression in normal tissues from HIPED for OR10A5 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OR10A5 Gene



Protein tissue co-expression partners for OR10A5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR10A5

SOURCE GeneReport for Unigene cluster for OR10A5 Gene:

Hs.447478

mRNA Expression by UniProt/SwissProt for OR10A5 Gene:

Q9H207-O10A5_HUMAN
Tissue specificity: Expressed in the tongue.

Evidence on tissue expression from TISSUES for OR10A5 Gene

  • Nervous system(4.9)
  • Liver(3.8)
genes like me logo Genes that share expression patterns with OR10A5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10A5 Gene

Orthologs for OR10A5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR10A5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC466419 30
  • 99.16 (n)
OR10A5 31
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 31
  • 93 (a)
ManyToMany
-- 31
  • 92 (a)
ManyToMany
-- 31
  • 92 (a)
ManyToMany
OR10B10 31
  • 91 (a)
ManyToMany
cOR10A9 30
  • 89.17 (n)
cow
(Bos Taurus)
Mammalia -- 31
  • 91 (a)
ManyToMany
-- 31
  • 90 (a)
ManyToMany
LOC790683 30
  • 88.96 (n)
-- 31
  • 88 (a)
ManyToMany
-- 31
  • 88 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Or10a5 47 Olfr713 17 31 30
  • 89.35 (n)
Olfr714 31
  • 89 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr227 30
  • 88.29 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 76 (a)
ManyToMany
-- 31
  • 75 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 72 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 48 (a)
OneToMany
Species where no ortholog for OR10A5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10A5 Gene

ENSEMBL:
Gene Tree for OR10A5 (if available)
TreeFam:
Gene Tree for OR10A5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR10A5: view image

Paralogs for OR10A5 Gene

(459) SIMAP similar genes for OR10A5 Gene using alignment to 2 proteins:

  • O10A5_HUMAN
  • Q6IFG6_HUMAN
genes like me logo Genes that share paralogs with OR10A5: view

Variants for OR10A5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR10A5 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs7949377 - p.Lys41Met

Additional dbSNP identifiers (rs#s) for OR10A5 Gene

Structural Variations from Database of Genomic Variants (DGV) for OR10A5 Gene

Variant ID Type Subtype PubMed ID
dgv1056n100 CNV loss 25217958
dgv1626n54 CNV loss 21841781
esv3579329 CNV loss 25503493
nsv1035138 CNV gain 25217958
nsv1046129 CNV loss 25217958
nsv467701 CNV loss 19166990
nsv832060 CNV gain 17160897
nsv982980 CNV duplication 23825009

Variation tolerance for OR10A5 Gene

Residual Variation Intolerance Score: 91.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.83; 67.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10A5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10A5 Gene

Disorders for OR10A5 Gene

Additional Disease Information for OR10A5

No disorders were found for OR10A5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10A5 Gene

Publications for OR10A5 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 54
  3. New GPCRs from a human lingual cDNA library. (PMID: 11705801) Gaudin JC … Haertlé T (Chemical senses 2001) 3 4 54
  4. Genomic analysis of orthologous mouse and human olfactory receptor loci. (PMID: 11416212) Lane RP … Trask BJ (Proceedings of the National Academy of Sciences of the United States of America 2001) 3 4 54
  5. Organization and evolution of olfactory receptor genes on human chromosome 11. (PMID: 9787077) Buettner JA … Evans GA (Genomics 1998) 3 4 54

Products for OR10A5 Gene

Sources for OR10A5 Gene