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Aliases for OR10A4 Gene

Aliases for OR10A4 Gene

  • Olfactory Receptor Family 10 Subfamily A Member 4 2 3 5
  • Olfactory Receptor, Family 10, Subfamily A, Member 4 Pseudogene 2 3
  • Olfactory Receptor-Like Protein JCG5 3 4
  • OR10A4P 3 4
  • Olfactory Receptor, Family 10, Subfamily A, Member 4 2
  • Olfactory Receptor OR11-87 3
  • Olfactory Receptor 10A4 3
  • HP2 Olfactory Receptor 3
  • JCG5 3
  • HP2 4

External Ids for OR10A4 Gene

Previous HGNC Symbols for OR10A4 Gene

  • OR10A4P

Previous GeneCards Identifiers for OR10A4 Gene

  • GC11U990583
  • GC11P006863
  • GC11P006854

Summaries for OR10A4 Gene

Entrez Gene Summary for OR10A4 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10A4 Gene

OR10A4 (Olfactory Receptor Family 10 Subfamily A Member 4) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10A5.

UniProtKB/Swiss-Prot for OR10A4 Gene

  • Odorant receptor (Potential). May be involved in taste perception.

Gene Wiki entry for OR10A4 Gene

Additional gene information for OR10A4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10A4 Gene

Genomics for OR10A4 Gene

GeneHancer (GH) Regulatory Elements for OR10A4 Gene

Promoters and enhancers for OR10A4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J006742 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.7 -131.4 -131389 6.5 HDAC1 PKNOX1 SMAD1 RB1 NFRKB YBX1 BATF KLF5 TCF12 ZNF766 GVINP1 MRPL17 OR2AG2 ILK RRP8 ENSG00000254641 TAF10 OR10A4 APBB1 SMPD1
GH11J006468 Enhancer 1.2 FANTOM5 Ensembl ENCODE 10.1 -407.3 -407250 1.5 HDGF PKNOX1 ZNF335 POLR2B GLIS2 POLR2A ZBTB48 PATZ1 ZFP91 ATF7 OR56A1 OR10A4 OR2AG2 OR10A2 OR56A4 OR52W1 OR2AG1 OR56B4 OR10A5 OR6A2
GH11J006678 Enhancer 0.3 FANTOM5 4.8 -198.1 -198069 0.3 OR10A2 OR10A4 OR2AG2 OR52W1 OR2AG1 OR6A2 GC11P006674 MRPL17
GH11J006863 Enhancer 0.2 FANTOM5 5.7 -13.2 -13245 0 OR10A2 OR2AG1 OR10A4 OR2AG2 OR2D3 OR2D2 OR6A2 DCHS1 ENSG00000283415
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10A4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR10A4 gene promoter:
  • FAC1
  • GATA-3
  • GATA-2
  • GATA-1
  • c-Myc
  • Max1
  • TGIF
  • ATF6
  • Nkx3-1
  • Nkx3-1 v1

Genomic Locations for OR10A4 Gene

Genomic Locations for OR10A4 Gene
999 bases
Plus strand
999 bases
Plus strand

Genomic View for OR10A4 Gene

Genes around OR10A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10A4 Gene

Proteins for OR10A4 Gene

  • Protein details for OR10A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 10A4
    Protein Accession:
    Secondary Accessions:
    • B2RNP5
    • B9EH36
    • Q96R20

    Protein attributes for OR10A4 Gene

    315 amino acids
    Molecular mass:
    35117 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10A4 Gene

Post-translational modifications for OR10A4 Gene

Other Protein References for OR10A4 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10A4 Gene

Domains & Families for OR10A4 Gene

Gene Families for OR10A4 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10A4 Gene

Suggested Antigen Peptide Sequences for OR10A4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10A4: view

Function for OR10A4 Gene

Molecular function for OR10A4 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor (Potential). May be involved in taste perception.

Gene Ontology (GO) - Molecular Function for OR10A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR10A4: view
genes like me logo Genes that share phenotypes with OR10A4: view

Animal Models for OR10A4 Gene

MGI Knock Outs for OR10A4:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OR10A4 Gene

Localization for OR10A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10A4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10A4 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR10A4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10A4 Gene

Pathways & Interactions for OR10A4 Gene

genes like me logo Genes that share pathways with OR10A4: view

Pathways by source for OR10A4 Gene

1 BioSystems pathway for OR10A4 Gene
1 KEGG pathway for OR10A4 Gene

Interacting Proteins for OR10A4 Gene

Gene Ontology (GO) - Biological Process for OR10A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007411 axon guidance IEA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with OR10A4: view

No data available for SIGNOR curated interactions for OR10A4 Gene

Drugs & Compounds for OR10A4 Gene

No Compound Related Data Available

Transcripts for OR10A4 Gene

mRNA/cDNA for OR10A4 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OR10A4 Gene

Olfactory receptor, family 10, subfamily A, member 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR10A4 Gene

No ASD Table

Relevant External Links for OR10A4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR10A4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR10A4 Gene

mRNA differential expression in normal tissues according to GTEx for OR10A4 Gene

This gene is overexpressed in Testis (x14.5) and Brain - Putamen (basal ganglia) (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of OR10A4 Gene:


SOURCE GeneReport for Unigene cluster for OR10A4 Gene:


mRNA Expression by UniProt/SwissProt for OR10A4 Gene:

Tissue specificity: Expressed in the tongue.
genes like me logo Genes that share expression patterns with OR10A4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10A4 Gene

Orthologs for OR10A4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR10A4 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia OR28A08 34
  • 90 (a)
OR10A4 33
  • 88.78 (n)
-- 34
  • 68 (a)
(Bos Taurus)
Mammalia OR10A4 34 33
  • 88.47 (n)
(Mus musculus)
Mammalia Or10a4 51 Olfr17 16 34 33
  • 86.24 (n)
Or10al2 51 Olfr118
  • chr17:37,671,989-37,672,987
Or10al3 51 Olfr119
  • chr17:37,700,672-37,701,634
Or10al4 51 Olfr120
  • chr17:37,725,999-37,726,988
Or10al6 51 Olfr122
  • chr17:37,771,628-37,772,617
Or10al8 51 Olfr1558
  • chr17:37,725,999-37,726,988
(Rattus norvegicus)
Mammalia Olr231 33
  • 85.29 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 80 (a)
-- 34
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 70 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 50 (a)
Species where no ortholog for OR10A4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10A4 Gene

Gene Tree for OR10A4 (if available)
Gene Tree for OR10A4 (if available)
Evolutionary constrained regions (ECRs) for OR10A4: view image

Paralogs for OR10A4 Gene

Paralogs for OR10A4 Gene

(454) SIMAP similar genes for OR10A4 Gene using alignment to 1 proteins:

  • O10A4_HUMAN
genes like me logo Genes that share paralogs with OR10A4: view

Variants for OR10A4 Gene

Sequence variations from dbSNP and Humsavar for OR10A4 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000983356 -- 6,875,966(+) T/G upstream_transcript_variant
rs1001034278 -- 6,875,711(+) A/C upstream_transcript_variant
rs1001176962 -- 6,874,876(+) T/A/G upstream_transcript_variant
rs1002223397 -- 6,876,131(+) C/T upstream_transcript_variant
rs1002439547 -- 6,876,365(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR10A4 Gene

Variant ID Type Subtype PubMed ID
dgv1056n100 CNV loss 25217958
dgv1626n54 CNV loss 21841781
nsv1035138 CNV gain 25217958
nsv1046129 CNV loss 25217958
nsv825756 CNV loss 20364138
nsv832061 CNV loss 17160897

Variation tolerance for OR10A4 Gene

Residual Variation Intolerance Score: 88.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.13; 96.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10A4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10A4 Gene

Disorders for OR10A4 Gene

Additional Disease Information for OR10A4

No disorders were found for OR10A4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10A4 Gene

Publications for OR10A4 Gene

  1. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  2. Genomic analysis of orthologous mouse and human olfactory receptor loci. (PMID: 11416212) Lane RP … Trask BJ (Proceedings of the National Academy of Sciences of the United States of America 2001) 3 4 58
  3. New GPCRs from a human lingual cDNA library. (PMID: 11705801) Gaudin JC … Haertlé T (Chemical senses 2001) 3 4 58
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 58
  5. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 58

Products for OR10A4 Gene

Sources for OR10A4 Gene

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