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Aliases for OR10A3 Gene

Aliases for OR10A3 Gene

  • Olfactory Receptor Family 10 Subfamily A Member 3 2 3 5
  • Olfactory Receptor OR11-97 3 4
  • Olfactory Receptor 10A3 3 4
  • HTPCRX12 3 4
  • Olfactory Receptor, Family 10, Subfamily A, Member 3 2
  • HSHTPCRX12 3

External Ids for OR10A3 Gene

Previous GeneCards Identifiers for OR10A3 Gene

  • GC11M008760
  • GC11U900024
  • GC11M007919
  • GC11M007924
  • GC11M007916
  • GC11M007960
  • GC11M007942
  • GC11M007943
  • GC11M007954
  • GC11M007944
  • GC11M007946
  • GC11M007947
  • GC11M007948
  • GC11M007950
  • GC11M007951
  • GC11M007952
  • GC11M007953

Summaries for OR10A3 Gene

Entrez Gene Summary for OR10A3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10A3 Gene

OR10A3 (Olfactory Receptor Family 10 Subfamily A Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10A6.

UniProtKB/Swiss-Prot for OR10A3 Gene

Gene Wiki entry for OR10A3 Gene

Additional gene information for OR10A3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10A3 Gene

Genomics for OR10A3 Gene

GeneHancer (GH) Regulatory Elements for OR10A3 Gene

Promoters and enhancers for OR10A3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J007890 Enhancer 1.2 FANTOM5 Ensembl ENCODE 20.2 +48.7 48707 6.8 ELF3 CTCF SP1 RAD21 IKZF1 EZH2 REST POLR2A TRIM22 IKZF2 PIR41542 OR10A3 NLRP10 NLRP14 OR10A6 PIR32361 ENSG00000254951 LOC283299
GH11J007962 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 11 -25.1 -25103 8.4 CC2D1A FOS JUND POLR2A EGR2 CBFA2T3 NLRP10 GC11M007966 OR10A3 CASC23 TUB EIF3F
GH11J007904 Promoter/Enhancer 1.1 Ensembl ENCODE 11.1 +35.1 35124 4.4 CTCF ZBTB33 CEBPB SCRT2 KLF4 TCF7L2 GLIS1 NANOG POLR2A LOC283299 PIR62490 ENSG00000254951 NLRP10 OR10A6 OR10A3 OVCH2 CASC23 TUB EIF3F
GH11J007900 Enhancer 0.8 Ensembl ENCODE 11 +40.1 40127 2.4 SP1 CTBP1 CEBPB DPF2 HNF4A FOS RXRA SMARCE1 PIR32361 NLRP10 OR10A6 OR10A3 CASC23 TUB OVCH2 ENSG00000254951 LOC283299 PIR62490
GH11J007898 Enhancer 0.6 ENCODE 11 +42.2 42230 1.5 PKNOX1 CEBPB RCOR1 EP300 STAT3 JUNB TCF7L2 BATF PIR32361 OR10A3 NLRP10 PIR41542 LOC283299 ENSG00000254951
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10A3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR10A3 gene promoter:
  • c-Myc
  • FOXC1
  • LCR-F1
  • Max1
  • MIF-1
  • Nkx2-5
  • NRSF form 1
  • NRSF form 2
  • Pbx1a
  • STAT1

Genomic Locations for OR10A3 Gene

Genomic Locations for OR10A3 Gene
4,538 bases
Minus strand
1,061 bases
Minus strand

Genomic View for OR10A3 Gene

Genes around OR10A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10A3 Gene

Proteins for OR10A3 Gene

  • Protein details for OR10A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactory receptor 10A3
    Protein Accession:
    Secondary Accessions:
    • B9EH39
    • Q6IF58
    • Q96R11

    Protein attributes for OR10A3 Gene

    314 amino acids
    Molecular mass:
    35535 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10A3 Gene

Post-translational modifications for OR10A3 Gene

  • Glycosylation at posLast=55
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10A3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10A3 Gene

Domains & Families for OR10A3 Gene

Gene Families for OR10A3 Gene

Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10A3 Gene

Suggested Antigen Peptide Sequences for OR10A3 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-97 (O10A3_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10A3: view

Function for OR10A3 Gene

Molecular function for OR10A3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR10A3 Gene

Gene Ontology (GO) - Molecular Function for OR10A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 1370859
genes like me logo Genes that share ontologies with OR10A3: view
genes like me logo Genes that share phenotypes with OR10A3: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for OR10A3 - Now 50% OFF >
  • * OR10A3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * OR10A3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10A3 Gene

Localization for OR10A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10A3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10A3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR10A3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10A3 Gene

Pathways & Interactions for OR10A3 Gene

genes like me logo Genes that share pathways with OR10A3: view

Pathways by source for OR10A3 Gene

Interacting Proteins for OR10A3 Gene

Gene Ontology (GO) - Biological Process for OR10A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell NAS 1370859
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10A3: view

No data available for SIGNOR curated interactions for OR10A3 Gene

Drugs & Compounds for OR10A3 Gene

No Compound Related Data Available

Transcripts for OR10A3 Gene

mRNA/cDNA for OR10A3 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for OR10A3 Gene

Olfactory receptor, family 10, subfamily A, member 3:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for OR10A3 - Now 50% OFF >
  • * OR10A3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * OR10A3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for OR10A3 Gene

No ASD Table

Relevant External Links for OR10A3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OR10A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR10A3 Gene

mRNA differential expression in normal tissues according to GTEx for OR10A3 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x13.5), Skin - Not Sun Exposed (Suprapubic) (x11.5), and Bladder (x6.7).

NURSA nuclear receptor signaling pathways regulating expression of OR10A3 Gene:


SOURCE GeneReport for Unigene cluster for OR10A3 Gene:

genes like me logo Genes that share expression patterns with OR10A3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10A3 Gene

Orthologs for OR10A3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR10A3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC466434 34
  • 99.03 (n)
(Bos Taurus)
Mammalia -- 35
  • 89 (a)
-- 35
  • 89 (a)
OR10A6 34
  • 86.2 (n)
-- 35
  • 85 (a)
(Canis familiaris)
Mammalia -- 35
  • 86 (a)
-- 35
  • 83 (a)
(Rattus norvegicus)
Mammalia Olr282 34
  • 82.8 (n)
(Mus musculus)
Mammalia Or10a3 51 Olfr518 17 35 34
  • 82.42 (n)
Or10a3b 51 Olfr516 35
  • 80 (a)
Olfr517 35
  • 77 (a)
Or10a47 51 Olfr512 35
  • 76 (a)
Or10a50 51 Olfr519 35
  • 76 (a)
Or10a48 51 Olfr514 35
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 60 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 46 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 47 (a)
Species where no ortholog for OR10A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10A3 Gene

Gene Tree for OR10A3 (if available)
Gene Tree for OR10A3 (if available)
Evolutionary constrained regions (ECRs) for OR10A3: view image

Paralogs for OR10A3 Gene

(449) SIMAP similar genes for OR10A3 Gene using alignment to 1 proteins:

  • O10A3_HUMAN Pseudogenes for OR10A3 Gene

genes like me logo Genes that share paralogs with OR10A3: view

Variants for OR10A3 Gene

Sequence variations from dbSNP and Humsavar for OR10A3 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000050091 -- 7,938,725(-) A/G coding_sequence_variant, missense_variant
rs1000153609 -- 7,941,496(-) A/T upstream_transcript_variant
rs1001567605 -- 7,938,754(-) T/C coding_sequence_variant, missense_variant
rs1002014211 -- 7,939,838(-) C/A/G upstream_transcript_variant
rs1003255613 -- 7,939,984(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR10A3 Gene

Variant ID Type Subtype PubMed ID
esv3625306 CNV gain 21293372
nsv499766 OTHER inversion 21111241
nsv7215 OTHER inversion 18451855

Variation tolerance for OR10A3 Gene

Residual Variation Intolerance Score: 92.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10A3 Gene

Disorders for OR10A3 Gene

Additional Disease Information for OR10A3

No disorders were found for OR10A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10A3 Gene

Publications for OR10A3 Gene

  1. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PMID: 1370859) Parmentier M … Perret J (Nature 1992) 2 3 4 58
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4 58
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  4. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  5. Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population. (PMID: 23042114) Hirota T … Tamari M (Nature genetics 2012) 3 58

Products for OR10A3 Gene

Sources for OR10A3 Gene

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