Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone rec... See more...

Aliases for OR10A3 Gene

Aliases for OR10A3 Gene

  • Olfactory Receptor Family 10 Subfamily A Member 3 2 3 5
  • HTPCRX12 2 3 4
  • Olfactory Receptor OR11-97 3 4
  • Olfactory Receptor 10A3 3 4
  • HSHTPCRX12 2 3
  • Olfactory Receptor, Family 10, Subfamily A, Member 3 2
  • OR10A3 5

External Ids for OR10A3 Gene

Previous GeneCards Identifiers for OR10A3 Gene

  • GC11M008760
  • GC11U900024
  • GC11M007919
  • GC11M007924
  • GC11M007916
  • GC11M007960
  • GC11M007942
  • GC11M007943
  • GC11M007954
  • GC11M007955
  • GC11M007953
  • GC11M007952
  • GC11M007944
  • GC11M007946
  • GC11M007947
  • GC11M007948
  • GC11M007950

Summaries for OR10A3 Gene

Entrez Gene Summary for OR10A3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10A3 Gene

OR10A3 (Olfactory Receptor Family 10 Subfamily A Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory transduction. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10A6.

UniProtKB/Swiss-Prot Summary for OR10A3 Gene

Gene Wiki entry for OR10A3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OR10A3 Gene

Genomics for OR10A3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OR10A3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J007962 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE dbSUPER 11 -25.1 -25103 8.4 JUND TBP BHLHE40 ARID1B EGR2 RAD51 POLR2A FOS CC2D1A CEBPB NLRP10 OR10A3 CASC23 TUB EIF3F lnc-NLRP10-2
GH11J007890 Enhancer 1.2 FANTOM5 Ensembl ENCODE CraniofacialAtlas 9.5 +48.8 48812 6.2 ZNF654 YY1 REST CEBPB TRIM22 CTCF EP300 RAD21 IRF4 SMC3 piR-48543 OR10A3 NLRP14 OR10A6 HSALNG0082519-001 LOC283299 OR5P3
GH11J007974 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.8 -35.3 -35293 4.4 MYC JUND BRCA1 CEBPB MAX EP300 TAL1 STAT3 TBP TCF7L2 COX6CP5 lnc-TUB-5 EIF3F OR10A3 CASC23 TUB OVCH2 lnc-NLRP10-2
GH11J007903 Promoter/Enhancer 0.9 Ensembl ENCODE 11.1 +35.4 35424 5 POLR2A CEBPB TCF7L2 RAD21 CTCF GLIS1 NANOG ZBTB33 SCRT2 HSALNG0082519-002 LOC283299 LOC107984307 piR-30876-021 piR-39445-001 NLRP10 OR10A6 OR10A3 OVCH2 CASC23
GH11J007900 Enhancer 0.7 Ensembl ENCODE 11 +40.1 40127 2.4 CEBPB CTBP1 RXRA SMARCE1 DPF2 HNF4A FOS SP1 piR-31362 NLRP10 OR10A6 OR10A3 TUB CASC23 OVCH2 HSALNG0082520 LOC283299 piR-39445-001
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OR10A3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OR10A3

Top Transcription factor binding sites by QIAGEN in the OR10A3 gene promoter:
  • c-Myc
  • FOXC1
  • LCR-F1
  • Max1
  • MIF-1
  • Nkx2-5
  • NRSF form 1
  • NRSF form 2
  • Pbx1a
  • STAT1

Genomic Locations for OR10A3 Gene

Latest Assembly
chr11:7,937,171-7,941,708
(GRCh38/hg38)
Size:
4,538 bases
Orientation:
Minus strand

Previous Assembly
chr11:7,958,718-7,963,255
(GRCh37/hg19 by Entrez Gene)
Size:
4,538 bases
Orientation:
Minus strand

chr11:7,960,081-7,961,141
(GRCh37/hg19 by Ensembl)
Size:
1,061 bases
Orientation:
Minus strand

Alternative Locations (GRCh38/hg38)

  • chr11(ALT_REF_LOCI_1):168,672-173,209 (-)
  • chr11(PATCHES):168,165-172,702 (-)

Genomic View for OR10A3 Gene

Genes around OR10A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10A3 Gene

Proteins for OR10A3 Gene

  • Protein details for OR10A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58181-O10A3_HUMAN
    Recommended name:
    Olfactory receptor 10A3
    Protein Accession:
    P58181
    Secondary Accessions:
    • B9EH39
    • Q6IF58
    • Q96R11

    Protein attributes for OR10A3 Gene

    Size:
    314 amino acids
    Molecular mass:
    35535 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR10A3 Gene

Post-translational modifications for OR10A3 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

Other Protein References for OR10A3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10A3 Gene

Domains & Families for OR10A3 Gene

Gene Families for OR10A3 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10A3 Gene

InterPro:
Blocks:
  • Olfactory receptor signature

Suggested Antigen Peptide Sequences for OR10A3 Gene

GenScript: Design optimal peptide antigens:
  • Olfactory receptor OR11-97 (O10A3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P58181

UniProtKB/Swiss-Prot:

O10A3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10A3: view

Function for OR10A3 Gene

Molecular function for OR10A3 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR10A3 Gene

Gene Ontology (GO) - Molecular Function for OR10A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0004984 olfactory receptor activity NAS 1370859
genes like me logo Genes that share ontologies with OR10A3: view
genes like me logo Genes that share phenotypes with OR10A3: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR10A3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10A3 Gene

Localization for OR10A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10A3 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10A3 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for OR10A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OR10A3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10A3 Gene

Pathways & Interactions for OR10A3 Gene

genes like me logo Genes that share pathways with OR10A3: view

Pathways by source for OR10A3 Gene

Interacting Proteins for OR10A3 Gene

Gene Ontology (GO) - Biological Process for OR10A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IEA --
GO:0007608 sensory perception of smell NAS 1370859
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10A3: view

No data available for SIGNOR curated interactions for OR10A3 Gene

Drugs & Compounds for OR10A3 Gene

No Compound Related Data Available

Transcripts for OR10A3 Gene

mRNA/cDNA for OR10A3 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OR10A3

Alternative Splicing Database (ASD) splice patterns (SP) for OR10A3 Gene

No ASD Table

Relevant External Links for OR10A3 Gene

GeneLoc Exon Structure for
OR10A3

Expression for OR10A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OR10A3 Gene

mRNA differential expression in normal tissues according to GTEx for OR10A3 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x13.5), Skin - Not Sun Exposed (Suprapubic) (x11.5), and Bladder (x6.7).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OR10A3

SOURCE GeneReport for Unigene cluster for OR10A3 Gene:

Hs.381322
genes like me logo Genes that share expression patterns with OR10A3: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10A3 Gene

Orthologs for OR10A3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR10A3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC466434 29
  • 99.03 (n)
Cow
(Bos Taurus)
Mammalia -- 30
  • 89 (a)
OneToMany
-- 30
  • 89 (a)
OneToMany
OR10A6 29
  • 86.2 (n)
-- 30
  • 85 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 30
  • 86 (a)
OneToMany
-- 30
  • 83 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Olr282 29
  • 82.8 (n)
Mouse
(Mus musculus)
Mammalia Or10a3 45 Olfr518 29 16 30
  • 82.42 (n)
ManyToMany
Or10a3b 45 Olfr516 30
  • 80 (a)
ManyToMany
Olfr517 30
  • 77 (a)
ManyToMany
Or10a47 45 Olfr512 30
  • 76 (a)
ManyToMany
Or10a50 45 Olfr519 30
  • 76 (a)
ManyToMany
Or10a48 45 Olfr514 30
  • 75 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 60 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 46 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 47 (a)
OneToMany
Species where no ortholog for OR10A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OR10A3 Gene

ENSEMBL:
Gene Tree for OR10A3 (if available)
TreeFam:
Gene Tree for OR10A3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OR10A3: view image
Alliance of Genome Resources:
Additional Orthologs for OR10A3

Paralogs for OR10A3 Gene

(449) SIMAP similar genes for OR10A3 Gene using alignment to 1 proteins:

  • O10A3_HUMAN

Pseudogenes.org Pseudogenes for OR10A3 Gene

genes like me logo Genes that share paralogs with OR10A3: view

Variants for OR10A3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OR10A3 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs16934214 -- p.Phe20Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OR10A3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OR10A3 Gene

Variant ID Type Subtype PubMed ID
esv3625306 CNV gain 21293372
nsv499766 OTHER inversion 21111241
nsv7215 OTHER inversion 18451855

Variation tolerance for OR10A3 Gene

Residual Variation Intolerance Score: 92.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.54; 44.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10A3
Leiden Open Variation Database (LOVD)
OR10A3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10A3 Gene

Disorders for OR10A3 Gene

Additional Disease Information for OR10A3

No disorders were found for OR10A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10A3 Gene

Publications for OR10A3 Gene

  1. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. (PMID: 1370859) Parmentier M … Perret J (Nature 1992) 2 3 4
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4
  4. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4
  5. Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population. (PMID: 23042114) Hirota T … Tamari M (Nature genetics 2012) 3

Products for OR10A3 Gene

Sources for OR10A3 Gene