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Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
OR10A3 (Olfactory Receptor Family 10 Subfamily A Member 3) is a Protein Coding gene. Among its related pathways are Olfactory transduction and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10A6.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004984 | olfactory receptor activity | NAS | 1370859 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Signaling by GPCR | ||
2 | Olfactory transduction |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IEA | -- |
GO:0007608 | sensory perception of smell | NAS | 1370859 |
GO:0050896 | response to stimulus | IEA | -- |
GO:0050911 | detection of chemical stimulus involved in sensory perception of smell | IEA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | LOC466434 32 |
|
||
cow (Bos Taurus) |
Mammalia | -- 33 |
|
OneToMany | |
-- 33 |
|
OneToMany | |||
OR10A6 32 |
|
||||
-- 33 |
|
OneToMany | |||
dog (Canis familiaris) |
Mammalia | -- 33 |
|
OneToMany | |
-- 33 |
|
OneToMany | |||
rat (Rattus norvegicus) |
Mammalia | Olr282 32 |
|
||
mouse (Mus musculus) |
Mammalia | Or10a3 49 Olfr518 17 33 32 |
|
|
|
Or10a3b 49 Olfr516 33 |
|
ManyToMany |
|
||
Olfr517 33 |
|
ManyToMany | |||
Or10a47 49 Olfr512 33 |
|
ManyToMany |
|
||
Or10a50 49 Olfr519 33 |
|
ManyToMany |
|
||
Or10a48 49 Olfr514 33 |
|
ManyToMany |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 33 |
|
OneToMany | |
oppossum (Monodelphis domestica) |
Mammalia | -- 33 |
|
ManyToMany | |
lizard (Anolis carolinensis) |
Reptilia | -- 33 |
|
OneToMany |
SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000050091 | -- | 7,938,725(-) | A/G | coding_sequence_variant, missense_variant | |
rs1000153609 | -- | 7,941,496(-) | A/T | upstream_transcript_variant | |
rs1001567605 | -- | 7,938,754(-) | T/C | coding_sequence_variant, missense_variant | |
rs1002014211 | -- | 7,939,838(-) | C/A/G | upstream_transcript_variant | |
rs1003255613 | -- | 7,939,984(-) | C/T | upstream_transcript_variant |
No disorders were found for OR10A3 Gene.