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Aliases for OR10A2 Gene

Aliases for OR10A2 Gene

  • Olfactory Receptor Family 10 Subfamily A Member 2 2 3 5
  • Olfactory Receptor OR11-86 3 4
  • OR10A2P 3 4
  • Olfactory Receptor, Family 10, Subfamily A, Member 2 Pseudogene 3
  • Olfactory Receptor, Family 10, Subfamily A, Member 2 2
  • Olfactory Receptor OR11-82 Pseudogene 3
  • Olfactory Receptor 10A2 3
  • HP4 Olfactory Receptor 3
  • OR11-82 3
  • OR11-86 3
  • OST363 3
  • HP4 4

External Ids for OR10A2 Gene

Previous HGNC Symbols for OR10A2 Gene

  • OR10A2P

Previous GeneCards Identifiers for OR10A2 Gene

  • GC11P006850
  • GC11P006841

Summaries for OR10A2 Gene

Entrez Gene Summary for OR10A2 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR10A2 Gene

OR10A2 (Olfactory Receptor Family 10 Subfamily A Member 2) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR10A5.

UniProtKB/Swiss-Prot for OR10A2 Gene

  • Odorant receptor.

Additional gene information for OR10A2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR10A2 Gene

Genomics for OR10A2 Gene

GeneHancer (GH) Regulatory Elements for OR10A2 Gene

Promoters and enhancers for OR10A2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I006863 Enhancer 0.2 FANTOM5 552.3 +0.3 319 0 OR10A2 OR2AG1 OR10A4 OR2AG2 OR2D3 OR2D2 OR6A2 DCHS1 ENSG00000283415
GH11I006468 Enhancer 1.2 FANTOM5 Ensembl ENCODE 9.1 -393.7 -393686 1.5 HDGF PKNOX1 ZNF335 POLR2B GLIS2 POLR2A ZBTB48 PATZ1 ATF7 CREM OR56A1 OR10A4 OR2AG2 OR10A2 OR56A4 OR52W1 OR2AG1 OR56B4 OR10A5 OR6A2
GH11I006742 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 3.8 -117.8 -117825 6.5 PKNOX1 SMAD1 YBX1 TCF12 ZNF766 ZNF207 RUNX3 JUNB ZNF592 SMARCA4 GVINP1 OR2AG2 ILK RRP8 ENSG00000254641 TAF10 OR10A4 APBB1 SMPD1 OR2AG1
GH11I006678 Enhancer 0.3 FANTOM5 6.4 -184.5 -184505 0.3 OR10A2 OR10A4 OR2AG2 OR52W1 OR2AG1 OR6A2 GC11P006674 MRPL17
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OR10A2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OR10A2 gene promoter:

Genomic Locations for OR10A2 Gene

Genomic Locations for OR10A2 Gene
chr11:6,863,057-6,874,717
(GRCh38/hg38)
Size:
11,661 bases
Orientation:
Plus strand
chr11:6,890,924-6,891,976
(GRCh37/hg19)

Genomic View for OR10A2 Gene

Genes around OR10A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR10A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR10A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OR10A2 Gene

Proteins for OR10A2 Gene

  • Protein details for OR10A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H208-O10A2_HUMAN
    Recommended name:
    Olfactory receptor 10A2
    Protein Accession:
    Q9H208
    Secondary Accessions:
    • B2RNL9
    • Q6IFG9

    Protein attributes for OR10A2 Gene

    Size:
    303 amino acids
    Molecular mass:
    33817 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG45207.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OR10A2 Gene

Post-translational modifications for OR10A2 Gene

No Post-translational modifications

Other Protein References for OR10A2 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR10A2 Gene

Domains & Families for OR10A2 Gene

Gene Families for OR10A2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR10A2 Gene

Suggested Antigen Peptide Sequences for OR10A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H208

UniProtKB/Swiss-Prot:

O10A2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR10A2: view

Function for OR10A2 Gene

Molecular function for OR10A2 Gene

UniProtKB/Swiss-Prot Function:
Odorant receptor.

Phenotypes From GWAS Catalog for OR10A2 Gene

Gene Ontology (GO) - Molecular Function for OR10A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR10A2: view
genes like me logo Genes that share phenotypes with OR10A2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR10A2 Gene

Localization for OR10A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR10A2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR10A2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR10A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR10A2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR10A2 Gene

Pathways & Interactions for OR10A2 Gene

genes like me logo Genes that share pathways with OR10A2: view

Pathways by source for OR10A2 Gene

1 BioSystems pathway for OR10A2 Gene
1 KEGG pathway for OR10A2 Gene

Interacting Proteins for OR10A2 Gene

Gene Ontology (GO) - Biological Process for OR10A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR10A2: view

No data available for SIGNOR curated interactions for OR10A2 Gene

Drugs & Compounds for OR10A2 Gene

No Compound Related Data Available

Transcripts for OR10A2 Gene

mRNA/cDNA for OR10A2 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for OR10A2 Gene

No ASD Table

Relevant External Links for OR10A2 Gene

GeneLoc Exon Structure for
OR10A2
ECgene alternative splicing isoforms for
OR10A2

Expression for OR10A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR10A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR10A2 Gene:

OR10A2

SOURCE GeneReport for Unigene cluster for OR10A2 Gene:

Hs.371762
genes like me logo Genes that share expression patterns with OR10A2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR10A2 Gene

Orthologs for OR10A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OR10A2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 34
  • 90 (a)
ManyToMany
-- 34
  • 89 (a)
ManyToMany
-- 34
  • 89 (a)
ManyToMany
OR10B10 34
  • 89 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Or10a2 51 Olfr714 33 16 34
  • 88.08 (n)
Olfr713 34
  • 86 (a)
ManyToMany
Or10al7 51 Olfr129
  • chr17:38,054,602-38,055,744
Or5o1 51 Olfr1321
  • chrX:49,726,976-49,728,208
cow
(Bos Taurus)
Mammalia -- 34
  • 88 (a)
ManyToMany
-- 34
  • 87 (a)
ManyToMany
-- 34
  • 84 (a)
ManyToMany
-- 34
  • 84 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Olr230 33
  • 87.31 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 73 (a)
ManyToMany
-- 34
  • 72 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 71 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 47 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 46 (a)
OneToMany
Species where no ortholog for OR10A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR10A2 Gene

ENSEMBL:
Gene Tree for OR10A2 (if available)
TreeFam:
Gene Tree for OR10A2 (if available)

Paralogs for OR10A2 Gene

Paralogs for OR10A2 Gene

(457) SIMAP similar genes for OR10A2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR10A2: view

Variants for OR10A2 Gene

Sequence variations from dbSNP and Humsavar for OR10A2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1002002334 -- 6,870,726(+) T/C downstream_transcript_variant
rs1003877839 -- 6,870,951(+) T/C downstream_transcript_variant
rs1004563404 -- 6,870,686(+) C/T downstream_transcript_variant
rs1005825653 -- 6,869,556(+) T/A upstream_transcript_variant
rs1009640257 -- 6,870,862(+) T/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OR10A2 Gene

Variant ID Type Subtype PubMed ID
nsv975148 CNV duplication 23825009
nsv832061 CNV loss 17160897
nsv467701 CNV loss 19166990
nsv1046129 CNV loss 25217958
nsv1035138 CNV gain 25217958
esv3625275 CNV loss 21293372
esv3579329 CNV loss 25503493
esv2664185 CNV deletion 23128226
dgv1626n54 CNV loss 21841781
dgv1056n100 CNV loss 25217958

Variation tolerance for OR10A2 Gene

Residual Variation Intolerance Score: 67.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.90; 98.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OR10A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR10A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR10A2 Gene

Disorders for OR10A2 Gene

Additional Disease Information for OR10A2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for OR10A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR10A2 Gene

Publications for OR10A2 Gene

  1. Olfactory receptor gene polymorphisms and nonallergic vasomotor rhinitis. (PMID: 18446592) Bernstein JA … Nebert DW (The Journal of asthma : official journal of the Association for the Care of Asthma 2008) 3 44 58
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4 58
  3. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  4. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 58
  5. Genomic analysis of orthologous mouse and human olfactory receptor loci. (PMID: 11416212) Lane RP … Trask BJ (Proceedings of the National Academy of Sciences of the United States of America 2001) 3 4 58

Products for OR10A2 Gene

Sources for OR10A2 Gene

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