Aliases for OPTC Gene
External Ids for OPTC Gene
- HGNC: 8158
- Entrez Gene: 26254
- Ensembl: ENSG00000188770
- OMIM: 605127
- UniProtKB: Q9UBM4
Previous GeneCards Identifiers for OPTC Gene
- GC01M201246
- GC01M198990
- GC01P9D0052
- GC00P9S0052
- GC01P200194
- GC01P201729
- GC01P174628
Summaries for OPTC Gene
-
Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1). [provided by RefSeq, Jul 2008]
GeneCards Summary for OPTC Gene
OPTC (Opticin) is a Protein Coding gene. Diseases associated with OPTC include Posterior Column Ataxia and Vitreous Detachment. Among its related pathways are Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include extracellular matrix structural constituent. An important paralog of this gene is EPYC.
UniProtKB/Swiss-Prot for OPTC Gene
-
Binds collagen fibrils.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OPTC Gene
Genomics for OPTC Gene
GeneHancer (GH) Regulatory Elements for OPTC Gene
Promoters and enhancers for OPTC Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around OPTC on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for OPTC Gene
Genomic Locations for OPTC Gene
- chr1:203,494,143-203,508,949
- (GRCh38/hg38)
- Size:
- 14,807 bases
- Orientation:
- Plus strand
- chr1:203,463,271-203,478,077
- (GRCh37/hg19)
Genomic View for OPTC Gene
Genes around OPTC on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q32.1 by Ensembl
- 1q32.1 by Entrez Gene
- 1q32.1 by HGNC
OPTC Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for OPTC Gene
Proteins for OPTC Gene
-
Protein details for OPTC Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UBM4-OPT_HUMAN
- Recommended name:
- Opticin
- Protein Accession:
- Q9UBM4
- Q5T2G4
Protein attributes for OPTC Gene
- Size:
- 332 amino acids
- Molecular mass:
- 37261 Da
- Quaternary structure:
- No Data Available
Protein Expression for OPTC Gene
Post-translational modifications for OPTC Gene
- O-glycosylated.
- Glycosylation at Asn312
- Modification sites at PhosphoSitePlus
Other Protein References for OPTC Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for OPTC (Opticin)
-
Custom Antibody ServicesOriGene Antibodies for OPTC
- Novus Biologicals Antibodies for OPTC
-
Abcam antibodies for OPTC
-
Cloud-Clone Corp. Antibodies for OPTC
- Invitrogen Antibodies for OPTC
- GeneTex OPTC antibody for OPTC
-
Santa Cruz Biotechnology (SCBT) Antibodies for OPTC
Protein Products
-
OriGene Purified Proteins for OPTC
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- ProSpec Recombinant Proteins for OPTC
-
Cloud-Clone Corp. Proteins for OPTC
- antibodies-online: Search results for 6 available OPTC Proteins ranked by validation data
- Compare Top OPTC Proteins
-
Quality Products:
- Search GeneTex for Proteins for OPTC
-
Abcam proteins for OPTC
Assay Products
-
Cloud-Clone Corp. Assay Kits for OPTC
- antibodies-online: Search results for 11 available OPTC Elisa Kits ranked by validation data
- Compare Top OPTC Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for OPTC Gene
Domains & Families for OPTC Gene
Gene Families for OPTC Gene
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for OPTC Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for OPTC Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UBM4UniProtKB/Swiss-Prot:
OPT_HUMAN :- Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
- Family:
-
- Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.
Function for OPTC Gene
Molecular function for OPTC Gene
- UniProtKB/Swiss-Prot Function:
- Binds collagen fibrils.
Phenotypes From GWAS Catalog for OPTC Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005201 | extracellular matrix structural constituent | TAS | 10636917 |
Phenotypes for OPTC Gene
- MGI mutant phenotypes for OPTC:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for OPTC:
Animal Models for OPTC Gene
- MGI Knock Outs for OPTC:
-
- Optc tm1.1Pnb
Animal Model Products
-
Taconic Biosciences Mouse Models for OPTC
- Cyagen custom Knockout/knockin (KOKI) mouse models for OPTC
-
-
ViGene Biosciences lentiviral particle packaged cDNA for OPTC gene
-
ViGene Biosciences ready-to-package AAV shRNAs for OPTC gene
- Search ViGene Biosciences for OPTC
CRISPR Products
-
OriGene CRISPR knockouts for OPTC
- genomics-online: gRNA clones - Search results for 114 available OPTC gene related products
- Overview of 114 available OPTC gene related products
- Applied Biological Materials CRISPR for OPTC
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for OPTC
- GenScript: Design CRISPR guide RNA sequences for OPTC
miRNA Products
- Search ViGene Biosciences for OPTC
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for OPTC
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- genomics-online: shRNA clones - Search results for 114 available OPTC gene related products
- Overview of 114 available OPTC gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for OPTC gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for OPTC
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for OPTC
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for OPTC
-
ViGene Biosciences adenoviral particle packaged cDNA for OPTC gene
-
ViGene Biosciences lentiviral particle packaged cDNA for OPTC gene
-
ViGene Biosciences ready-to-package AAV shRNAs for OPTC gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OPTC Gene
Localization for OPTC Gene
Subcellular locations from UniProtKB/Swiss-Prot for OPTC Gene
- Secreted, extracellular space, extracellular matrix.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005578 | proteinaceous extracellular matrix | TAS,IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for OPTC Gene
Pathways & Interactions for OPTC Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Degradation of the extracellular matrix | ||
Pathways by source for OPTC Gene
2 Reactome pathways for OPTC Gene
Interacting Proteins for OPTC Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0022617 | extracellular matrix disassembly | TAS | -- |
No data available for SIGNOR curated interactions for OPTC Gene
Transcripts for OPTC Gene
mRNA/cDNA for OPTC Gene
- (2) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (66) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for OPTC
- genomics-online: gRNA clones - Search results for 114 available OPTC gene related products
- Overview of 114 available OPTC gene related products
- Applied Biological Materials CRISPR for OPTC
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for OPTC
- GenScript: Design CRISPR guide RNA sequences for OPTC
miRNA Products
- Search ViGene Biosciences for OPTC
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for OPTC
- Browse OriGene Inhibitory RNA Products For OPTC
- genomics-online: shRNA clones - Search results for 114 available OPTC gene related products
- Overview of 114 available OPTC gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for OPTC gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for OPTC
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for OPTC
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for OPTC
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||
| SP2: | - |
Expression for OPTC Gene
mRNA differential expression in normal tissues according to GTEx for OPTC Gene
This gene is overexpressed in Testis (x7.1).
This gene is overexpressed in Vitreous humor (67.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OPTC Gene
NURSA nuclear receptor signaling pathways regulating expression of OPTC Gene:
OPTCSOURCE GeneReport for Unigene cluster for OPTC Gene:
Hs.632468mRNA Expression by UniProt/SwissProt for OPTC Gene:
Q9UBM4-OPT_HUMAN
Tissue specificity:
Retina, iris, ligament, skin and fetal liver.
Evidence on tissue expression from TISSUES for OPTC Gene
- Eye(4.8)
- Bone marrow(4.1)
Primer Products
-
OriGene qPCR primer pairs for OPTC
- genomics-online: primer clones - Search results for 114 available OPTC gene related products
- Overview of 114 available OPTC gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for OPTC Gene
Orthologs for OPTC Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | OPTC 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | OPTC 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | OPTC 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Optc 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Optc 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | OPTC 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | OPTC 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | OPTC 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | optc 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | optc 33 34 |
|
- Species where no ortholog for OPTC was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for OPTC Gene
(2) SIMAP similar genes for OPTC Gene using alignment to 3 proteins:
Variants for OPTC Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000191026 | -- | 203,508,414(+) | G/A | intron_variant | |
| rs1000428075 | -- | 203,505,949(+) | AGAG/AG | intron_variant | |
| rs1000600219 | -- | 203,506,402(+) | C/T | intron_variant | |
| rs1000646284 | -- | 203,499,957(+) | T/C | intron_variant | |
| rs1000793272 | -- | 203,507,078(+) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1567874 | CNV | insertion | 17803354 |
| esv2762217 | CNV | gain | 21179565 |
| nsv1069209 | CNV | deletion | 25765185 |
| nsv952640 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
77.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.09;
75.38% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for OPTC Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OPTC Gene
Disorders for OPTC Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| posterior column ataxia |
|
|
| vitreous detachment |
|
|
| open-angle glaucoma |
|
|
| macular degeneration, age-related, 1 |
|
|
| retinitis pigmentosa 12 |
|
|
Search OPTC in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for OPTC
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for OPTC Gene
Publications for OPTC Gene
- Identification in vitreous and molecular cloning of opticin, a novel member of the family of leucine-rich repeat proteins of the extracellular matrix. (PMID: 10636917) Reardon AJ … Bishop PN (The Journal of biological chemistry 2000) 2 3 4 22 58
- An evaluation of OPTC and EPYC as candidate genes for high myopia. (PMID: 19844586) Wang P … Zhang Q (Molecular vision 2009) 3 22 44 58
- Evaluation of the OPTC gene in primary open angle glaucoma: functional significance of a silent change. (PMID: 17359525) Acharya M … Ray K (BMC molecular biology 2007) 3 22 44 58
- Protein localization in the human eye and genetic screen of opticin. (PMID: 12019215) Friedman JS … Walter MA (Human molecular genetics 2002) 3 4 22 58
- Cloning, modeling, and chromosomal localization for a small leucine-rich repeat proteoglycan (SLRP) family member expressed in human eye. (PMID: 10837509) Hobby P … Wistow G (Molecular vision 2000) 3 4 22 58
Products for OPTC Gene
- R&D Systems Antibodies for OPTC (Opticin)
- Browse R&D Systems for Human Recombinant Proteins
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- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Custom Antibody ServicesOriGene Antibodies for OPTC
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for OPTC
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- Novus Biologicals
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- Browse Antibodies
- Browse Peptides and Proteins
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- Abcam antibodies for OPTC
- Abcam proteins for OPTC
- Find your target
- Browse Primary Antibodies
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- ProSpec Recombinant Proteins for OPTC
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- Cloud-Clone Corp. disease models service
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- Cloud-Clone Corp. primary cells service
- Taconic Biosciences Mouse Models for OPTC
- Find your next knockout model in the Taconic Knockout Repository
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- Humanized Mice
- Invitrogen Antibodies for OPTC
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- VectorBuilder custom plasmid, inducible vectors for OPTC
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for OPTC
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 26 available OPTC Antibodies ranked by validation data
- Compare Top OPTC Antibodies
- antibodies-online: Search results for 11 available OPTC Elisa Kits ranked by validation data
- Compare Top OPTC Elisa Kits
- Quality Products:
- antibodies-online: Search results for 6 available OPTC Proteins ranked by validation data
- Compare Top OPTC Proteins
- Quality Products:
- GeneTex OPTC antibody for OPTC
- Search GeneTex for Proteins for OPTC
- ViGene Biosciences adenoviral particle packaged cDNA for OPTC gene
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- ViGene Biosciences ready-to-package AAV shRNAs for OPTC gene
- Search ViGene Biosciences for OPTC
- Santa Cruz Biotechnology (SCBT) Antibodies for OPTC
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- Santa Cruz Biotechnology (SCBT) CRISPR for OPTC
- Horizon Cell Lines for OPTC
- genomics-online: cdna clones - Search results for 114 available OPTC gene related products
- Overview of 114 available OPTC gene related products
- orf clones - Search results for 114 available OPTC gene related products
- Overview of 114 available OPTC gene related products
- genomics-online: gRNA clones - Search results for 114 available OPTC gene related products
- Overview of 114 available OPTC gene related products
- genomics-online: primer clones - Search results for 114 available OPTC gene related products
- Overview of 114 available OPTC gene related products
- genomics-online: shRNA clones - Search results for 114 available OPTC gene related products
- Overview of 114 available OPTC gene related products
Sources for OPTC Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
