Aliases for OPRL1 Gene
External Ids for OPRL1 Gene
Previous GeneCards Identifiers for OPRL1 Gene
The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A promoter region between this gene and the 5'-adjacent RGS19 (regulator of G-protein signaling 19) gene on the opposite strand functions bi-directionally as a core-promoter for both genes, suggesting co-operative transcriptional regulation of these two functionally related genes. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
GeneCards Summary for OPRL1 Gene
OPRL1 (Opioid Related Nociceptin Receptor 1) is a Protein Coding gene. Diseases associated with OPRL1 include Drug Dependence and Pain Agnosia. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and nociceptin receptor activity. An important paralog of this gene is OPRK1.
UniProtKB/Swiss-Prot Summary for OPRL1 Gene
G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
The NOP receptor, (also known as ORL1, N/OFQ receptor), is a member of the opioid family of G-protein-coupled receptors that also includes kappa, delta and mu receptors. The human gene encoding the NOP receptor has been localized to chromosome 20 (20q13.33).