Aliases for OPRK1 Gene
External Ids for OPRK1 Gene
Previous GeneCards Identifiers for OPRK1 Gene
This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
GeneCards Summary for OPRK1 Gene
OPRK1 (Opioid Receptor Kappa 1) is a Protein Coding gene. Diseases associated with OPRK1 include Morphine Dependence and Alcohol Dependence. Among its related pathways are DREAM Repression and Dynorphin Expression and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and opioid receptor activity. An important paralog of this gene is OPRM1.
UniProtKB/Swiss-Prot Summary for OPRK1 Gene
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
The kappa opioid receptor, (also known as OP2, KOP, KOR), is a member of the opioid family of G-protein-coupled receptors that also includes mu, delta and NOP receptors. Three variants of the receptor (designated kappa1, kappa2, and kappa3) have been characterized.