This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of p... See more...

Aliases for OPRK1 Gene

Aliases for OPRK1 Gene

  • Opioid Receptor Kappa 1 2 3 5
  • OPRK 2 3 4
  • Kappa-Type Opioid Receptor 3 4
  • K-OR-1 3 4
  • KOR-1 3 4
  • KOR 2 3
  • Opioid Receptor, Kappa 1 2
  • Opiate Receptor, Kappa-1 3
  • Kappa Opioid Receptor 3
  • OPRK1 5
  • KOR1 3
  • KOP 3

External Ids for OPRK1 Gene

Previous GeneCards Identifiers for OPRK1 Gene

  • GC08M053424
  • GC08M054146
  • GC08M053864
  • GC08M054191
  • GC08M054304
  • GC08M049605
  • GC08M054138

Summaries for OPRK1 Gene

Entrez Gene Summary for OPRK1 Gene

  • This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]

GeneCards Summary for OPRK1 Gene

OPRK1 (Opioid Receptor Kappa 1) is a Protein Coding gene. Diseases associated with OPRK1 include Morphine Dependence and Alcohol Dependence. Among its related pathways are DREAM Repression and Dynorphin Expression and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and opioid receptor activity. An important paralog of this gene is OPRM1.

UniProtKB/Swiss-Prot Summary for OPRK1 Gene

  • G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

Tocris Summary for OPRK1 Gene

  • The kappa opioid receptor, (also known as OP2, KOP, KOR), is a member of the opioid family of G-protein-coupled receptors that also includes mu, delta and NOP receptors. Three variants of the receptor (designated kappa1, kappa2, and kappa3) have been characterized.

Gene Wiki entry for OPRK1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OPRK1 Gene

Genomics for OPRK1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OPRK1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J053251 Promoter 0.7 EPDnew Ensembl 250.7 +0.2 236 1.2 OPRK1 lnc-OPRK1-4 HSALNG0065297 ENSG00000254687 NPBWR1
GH08J053253 Enhancer 0.3 Ensembl 0.7 -2.2 -2164 1.2 CTCF HSALNG0065299 OPRK1 lnc-OPRK1-4 ENSG00000254687 ATP6V1H
GH08J053343 Enhancer 0.8 FANTOM5 Ensembl ENCODE 0.2 -92.8 -92754 1.2 CEBPB ZNF217 EP300 ELF1 SMARCE1 MN298495 LOC100507516 lnc-OPRK1-1 HSALNG0065304 OPRK1 ATP6V1H
GH08J053287 Enhancer 0.5 Ensembl 0.3 -35.7 -35663 0.6 CTCF SMC3 ZNF384 ZNF143 ZNF444 piR-57460-642 HSALNG0065299 OPRK1 lnc-OPRK1-1 ATP6V1H
GH08J053218 Enhancer 0.3 Ensembl 0.3 +32.7 32736 1 CTCF CEBPB ENSG00000254687 HSALNG0065297 OPRK1 HSALNG0065296 LOC105375836 NPBWR1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OPRK1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OPRK1

Top Transcription factor binding sites by QIAGEN in the OPRK1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • c-Myc
  • FOXD3
  • Max1
  • MZF-1
  • Nkx2-5
  • Sp1

Genomic Locations for OPRK1 Gene

Latest Assembly
chr8:53,225,724-53,251,637
(GRCh38/hg38)
Size:
25,914 bases
Orientation:
Minus strand

Previous Assembly
chr8:54,138,284-54,164,197
(GRCh37/hg19 by Entrez Gene)
Size:
25,914 bases
Orientation:
Minus strand

chr8:54,138,284-54,164,257
(GRCh37/hg19 by Ensembl)
Size:
25,974 bases
Orientation:
Minus strand

Genomic View for OPRK1 Gene

Genes around OPRK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OPRK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OPRK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OPRK1 Gene

Proteins for OPRK1 Gene

  • Protein details for OPRK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41145-OPRK_HUMAN
    Recommended name:
    Kappa-type opioid receptor
    Protein Accession:
    P41145
    Secondary Accessions:
    • E5RHC9
    • Q499G4

    Protein attributes for OPRK1 Gene

    Size:
    380 amino acids
    Molecular mass:
    42645 Da
    Quaternary structure:
    • Interacts with SLC9A3R1. Interacts with GABARAPL1.

    Three dimensional structures from OCA and Proteopedia for OPRK1 Gene

    Alternative splice isoforms for OPRK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OPRK1 Gene

Post-translational modifications for OPRK1 Gene

  • Glycosylation at Asn25 and Asn39
  • Modification sites at PhosphoSitePlus

Other Protein References for OPRK1 Gene

No data available for DME Specific Peptides for OPRK1 Gene

Domains & Families for OPRK1 Gene

Gene Families for OPRK1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OPRK1 Gene

InterPro:
Blocks:
  • Kappa opioid receptor signature
  • Opioid receptor signature

Suggested Antigen Peptide Sequences for OPRK1 Gene

GenScript: Design optimal peptide antigens:
  • Kappa-type opioid receptor (OPRK_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P41145

UniProtKB/Swiss-Prot:

OPRK_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OPRK1: view

Function for OPRK1 Gene

Molecular function for OPRK1 Gene

UniProtKB/Swiss-Prot Function:
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
GENATLAS Biochemistry:
opioid receptor kappa,primarily postsynaptic,G protein coupled receptor superfamily,inhibiting a G protein-modulated K+ channel

Phenotypes From GWAS Catalog for OPRK1 Gene

Gene Ontology (GO) - Molecular Function for OPRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0004985 opioid receptor activity IDA 22437504
GO:0005515 protein binding IPI 16431922
GO:0033612 receptor serine/threonine kinase binding IEA --
GO:0038048 dynorphin receptor activity IMP 7624359
genes like me logo Genes that share ontologies with OPRK1: view
genes like me logo Genes that share phenotypes with OPRK1: view

Animal Models for OPRK1 Gene

MGI Knock Outs for OPRK1:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OPRK1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OPRK1 Gene

Localization for OPRK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OPRK1 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OPRK1 gene
Compartment Confidence
plasma membrane 5
nucleus 4
cytosol 4
extracellular 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Cytosol (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OPRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS,IMP 7624359
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with OPRK1: view

Pathways & Interactions for OPRK1 Gene

genes like me logo Genes that share pathways with OPRK1: view

Pathways by source for OPRK1 Gene

1 KEGG pathway for OPRK1 Gene
1 Qiagen pathway for OPRK1 Gene
  • DREAM Repression and Dynorphin Expression

SIGNOR curated interactions for OPRK1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for OPRK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response IDA 8755601
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway TAS 7624359
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway ISS --
genes like me logo Genes that share ontologies with OPRK1: view

Drugs & Compounds for OPRK1 Gene

(178) Drugs for OPRK1 Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Morphine Approved, Investigational Pharma Agonist, Partial agonist, Target 1511
Nalbuphine Approved Pharma Agonist, Full agonist, Target, antagonist 68
Naloxone Approved, Vet_approved Pharma Antagonist, Target 381
Naltrexone Approved, Investigational, Vet_approved Pharma Antagonist, Target 444
Alvimopan Approved, Investigational Pharma Target, antagonist Mu-opioid receptors antagonist 25

(55) Additional Compounds for OPRK1 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(-)-EKC
Agonist, Full agonist
(-)-quadazocine
Antagonist
[<sup>3</sup>H]CI977
EKC
Agonist, Full agonist
TRK820
Agonist, Full agonist

(5) Tocris Compounds for OPRK1 Gene

Compound Action Cas Number
(-)-U-50488 hydrochloride Standard selective kappa agonist. More active enantiomer of (+-)-U-50488 (Cat. No. 0495) 114528-79-9
(+)-U-50488 hydrochloride Standard selective kappa agonist. Less active enantiomer of (+-)-U-50488 (Cat. No. 0495) 114528-81-3
(+-)-U-50488 hydrochloride Standard selective kappa agonist 67197-96-0
6'-GNTI dihydrochloride Selective kappa/delta opioid heterodimer receptor agonist
U-54494A hydrochloride kappa agonist 112465-94-8

(46) ApexBio Compounds for OPRK1 Gene

Compound Action Cas Number
(-)-U-50488 hydrochloride κ-opioid receptor agonist, selective 114528-79-9
(+)-U-50488 hydrochloride Selective κ-opioid agonist 114528-81-3
(±)-U-50488 hydrochloride κ-opioid receptor agonist, selective 67197-96-0
[Leu5]-Enkephalin 58822-25-6
Adrenorphin Endogenous μ/κ opioid agonist,potent and selective 88377-68-8
Alvimopan Mu-opioid receptors antagonist 156053-89-3
Beta-Lipotropin (1-10), porcine Morphine-like substance 77875-68-4
BNTX maleate 864461-31-4
BRL 52537 hydrochloride κ/μ opioid receptor agonist,potent and selective 112282-24-3
CTAP 103429-32-9
CTOP 103429-31-8
DADLE 63631-40-3
DAMGO 78123-71-4
Deltorphin I 122752-15-2
DIPPA hydrochloride 155512-52-0
Diprenorphine 14357-78-9
DPDPE 88373-73-3
DSLET 75644-90-5
Dynorphin A 80448-90-4
Dynorphin B 83335-41-5
Endomorphin-1 Agonist of μopioid receptors,highly potent and selective 189388-22-5
Endomorphin-2 141801-26-5
FIT 85951-63-9
GNTI dihydrochloride 351183-88-5
GR 89696 fumarate 126766-32-3
ICI 154,129 83420-94-4
ICI 174,864 89352-67-0
ICI 199,441 hydrochloride 115199-84-3
ICI 204,448 hydrochloride 121264-04-8
JDTic Opioid antagonist 361444-66-8
JDTic 2HCl κ-opioid receptor antagonist 785835-79-2
Meptazinol HCl 59263-76-2
ML 190 1355244-02-8
Naloxonazine dihydrochloride 880759-65-9
Naltriben mesylate 122517-78-6
Naltrindole hydrochloride 111469-81-9
N-Benzylnaltrindole hydrochloride 1206487-81-1
N-MPPP Hydrochloride 207452-97-9
nor-Binaltorphimine dihydrochloride 113158-34-2
PL 017 83397-56-2
Salvinorin A 83729-01-5
SB 205607 dihydrobromide 1217628-73-3
SDM25N hydrochloride 342884-71-3
SNC 162 178803-51-5
SNC 80 156727-74-1
Trimebutine Antimuscarinic 39133-31-8
genes like me logo Genes that share compounds with OPRK1: view

Drug products for research

Transcripts for OPRK1 Gene

mRNA/cDNA for OPRK1 Gene

3 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OPRK1

Alternative Splicing Database (ASD) splice patterns (SP) for OPRK1 Gene

No ASD Table

Relevant External Links for OPRK1 Gene

GeneLoc Exon Structure for
OPRK1

Expression for OPRK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OPRK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OPRK1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x9.3), Brain - Hypothalamus (x7.1), Brain - Amygdala (x5.3), Brain - Anterior cingulate cortex (BA24) (x4.9), and Brain - Caudate (basal ganglia) (x4.7).

Protein differential expression in normal tissues from HIPED for OPRK1 Gene

This gene is overexpressed in Fetal testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OPRK1 Gene



Protein tissue co-expression partners for OPRK1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OPRK1

SOURCE GeneReport for Unigene cluster for OPRK1 Gene:

Hs.106795

mRNA Expression by UniProt/SwissProt for OPRK1 Gene:

P41145-OPRK_HUMAN
Tissue specificity: Detected in brain and placenta.

Evidence on tissue expression from TISSUES for OPRK1 Gene

  • Nervous system(4.5)
  • Kidney(2.4)
  • Intestine(2.2)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with OPRK1: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for OPRK1 Gene

Orthologs for OPRK1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OPRK1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia OPRK1 29 30
  • 96.64 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia OPRK1 30
  • 92 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia OPRK1 29 30
  • 90.26 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia OPRK1 29 30
  • 89.04 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia OPRK1 30
  • 89 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Oprk1 29
  • 86.93 (n)
Mouse
(Mus musculus)
Mammalia Oprk1 29 16 30
  • 86.67 (n)
OneToOne
Chicken
(Gallus gallus)
Aves OPRK1 29 30
  • 77.02 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia OPRK1 30
  • 79 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia oprk1 29
  • 68.82 (n)
Zebrafish
(Danio rerio)
Actinopterygii oprk1 29 30
  • 68.64 (n)
OneToOne
Species where no ortholog for OPRK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for OPRK1 Gene

ENSEMBL:
Gene Tree for OPRK1 (if available)
TreeFam:
Gene Tree for OPRK1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OPRK1: view image
Alliance of Genome Resources:
Additional Orthologs for OPRK1

Paralogs for OPRK1 Gene

(39) SIMAP similar genes for OPRK1 Gene using alignment to 2 proteins:

  • OPRK_HUMAN
  • E5RJI5_HUMAN
genes like me logo Genes that share paralogs with OPRK1: view

Variants for OPRK1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OPRK1 Gene

SNP ID Clinical significance and condition Chr 08 pos Variation AA Info Type
rs139043596 Likely Benign: not provided 53,229,675(-) G/A
NM_000912.5(OPRK1):c.765C>T (p.Ser255=)
SYNONYMOUS
rs200733685 Likely Benign: not provided 53,250,921(-) G/A
NM_000912.5(OPRK1):c.117C>T (p.Asn39=)
SYNONYMOUS_VARIANT,FIVE_PRIME_UTR
rs60353047 Benign: not provided 53,229,588(-) G/A
NM_000912.5(OPRK1):c.852C>T (p.Val284=)
SYNONYMOUS
rs77476023 Benign: not provided 53,234,771(-) T/C
NM_000912.5(OPRK1):c.598A>G (p.Lys200Glu)
MISSENSE
rs78517449 Benign: not provided 53,229,492(-) G/A
NM_000912.5(OPRK1):c.948C>T (p.Ile316=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OPRK1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OPRK1 Gene

Variant ID Type Subtype PubMed ID
esv3303089 CNV tandem duplication 20981092
nsv1016224 CNV gain 25217958
nsv397858 CNV insertion 16902084
nsv438054 CNV loss 16468122
nsv6193 CNV insertion 18451855
nsv6194 CNV insertion 18451855

Variation tolerance for OPRK1 Gene

Residual Variation Intolerance Score: 17.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OPRK1 Gene

Human Gene Mutation Database (HGMD)
OPRK1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OPRK1
Leiden Open Variation Database (LOVD)
OPRK1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OPRK1 Gene

Disorders for OPRK1 Gene

MalaCards: The human disease database

(19) MalaCards diseases for OPRK1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
morphine dependence
alcohol dependence
  • alcoholism
cocaine dependence
opiate dependence
  • opioid type dependence
drug dependence
- elite association - COSMIC cancer census association via MalaCards
Search OPRK1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OPRK1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with OPRK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OPRK1 Gene

Publications for OPRK1 Gene

  1. Effects of opioid receptor gene variation on targeted nalmefene treatment in heavy drinkers. (PMID: 18537939) Arias AJ … Kranzler HR (Alcoholism, clinical and experimental research 2008) 3 22 40
  2. Human kappa opioid receptor gene (OPRK1) polymorphism is associated with opiate addiction. (PMID: 17373729) Gerra G … Donnini C (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007) 3 22 40
  3. Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study. (PMID: 17374034) Gelernter J … VA Cooperative Study #425 Study Group (Alcoholism, clinical and experimental research 2007) 3 22 40
  4. Association of the kappa-opioid system with alcohol dependence. (PMID: 16924269) Xuei X … Edenberg HJ (Molecular psychiatry 2006) 3 22 40
  5. Redefinition of the human kappa opioid receptor gene (OPRK1) structure and association of haplotypes with opiate addiction. (PMID: 15608558) Yuferov V … Kreek MJ (Pharmacogenetics 2004) 3 22 40

Products for OPRK1 Gene

Sources for OPRK1 Gene