Aliases for OPRD1 Gene
External Ids for OPRD1 Gene
Previous GeneCards Identifiers for OPRD1 Gene
GeneCards Summary for OPRD1 Gene
OPRD1 (Opioid Receptor Delta 1) is a Protein Coding gene. Diseases associated with OPRD1 include Morphine Dependence and Heroin Dependence. Among its related pathways are Signaling by GPCR and Sphingolipid signaling pathway. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and opioid receptor activity. An important paralog of this gene is OPRM1.
UniProtKB/Swiss-Prot Summary for OPRD1 Gene
G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.
The delta opioid receptor (also known as OP1, DOP, DOR) is a member of the opioid family of G-protein-coupled receptors that also includes mu, kappa and NOP receptors. In the CNS, delta opioid receptors are primarily distributed in the olfactory bulb, nucleus accumbens and neocortex.