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Aliases for OPRD1 Gene

Aliases for OPRD1 Gene

  • Opioid Receptor Delta 1 2 3 5
  • D-OR-1 3 4
  • DOR-1 3 4
  • OPRD 3 4
  • Delta-Type Opioid Receptor 3
  • Opioid Receptor, Delta 1 2
  • Delta Opioid Receptor 1 3

External Ids for OPRD1 Gene

Previous GeneCards Identifiers for OPRD1 Gene

  • GC01P029144
  • GC01P028304
  • GC01P028643
  • GC01P028959
  • GC01P029011
  • GC01P027391

Summaries for OPRD1 Gene

GeneCards Summary for OPRD1 Gene

OPRD1 (Opioid Receptor Delta 1) is a Protein Coding gene. Diseases associated with OPRD1 include Neonatal Abstinence Syndrome and Heroin Dependence. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and opioid receptor activity. An important paralog of this gene is OPRM1.

UniProtKB/Swiss-Prot for OPRD1 Gene

  • G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.

Tocris Summary for OPRD1 Gene

  • The delta opioid receptor (also known as OP1, DOP, DOR) is a member of the opioid family of G-protein-coupled receptors that also includes mu, kappa and NOP receptors. In the CNS, delta opioid receptors are primarily distributed in the olfactory bulb, nucleus accumbens and neocortex.

Gene Wiki entry for OPRD1 Gene

Additional gene information for OPRD1 Gene

No data available for Entrez Gene Summary , CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OPRD1 Gene

Genomics for OPRD1 Gene

GeneHancer (GH) Regulatory Elements for OPRD1 Gene

Promoters and enhancers for OPRD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J028812 Promoter 0.8 EPDnew 650.7 +0.0 9 0.1 ZFHX2 USF1 POLR2A SUZ12 USF2 EGR2 OPRD1 ENSG00000233427
GH01J028859 Enhancer 1.1 Ensembl ENCODE 11.3 +48.5 48498 1.7 PKNOX1 SMAD1 FEZF1 ZNF121 GLIS2 ZNF662 TSHZ1 ZNF488 SMARCA4 ZNF585B OPRD1 TMEM200B DNAJC8 TRNAU1AP EPB41 ENSG00000233427
GH01J028718 Enhancer 1 Ensembl ENCODE 10.7 -93.2 -93176 0.5 HDAC1 HDGF E2F8 ATF7 REST ZNF592 SMARCA4 ZNF184 GMEB1 IKZF1 ENSG00000252777 GMEB1 OPRD1 GC01P028719 YTHDF2
GH01J028748 Enhancer 0.8 Ensembl 11.1 -63.0 -63041 1.4 HDGF ARNT NFRKB MZF1 FEZF1 E2F8 SCRT2 ATF7 ZNF362 CEBPB ENSG00000252777 GMEB1 OPRD1 ENSG00000233427 TRNAU1AP PHACTR4 GC01P028737 YTHDF2 GC01M028770
GH01J028751 Enhancer 0.7 Ensembl 11.1 -60.7 -60673 0.5 HDAC1 MEIS2 TAL1 JUN FOSL1 TCF12 CTBP1 FOXK2 NCOR1 ADNP GMEB1 SRSF4 TRNAU1AP ENSG00000252777 OPRD1 ENSG00000233427 SNHG12 YTHDF2 PPP1R8 GC01P028737
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OPRD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OPRD1 gene promoter:
  • Pax-5
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • FOXO1a
  • FOXO1
  • AP-1

Genomic Locations for OPRD1 Gene

Genomic Locations for OPRD1 Gene
chr1:28,812,142-28,871,267
(GRCh38/hg38)
Size:
59,126 bases
Orientation:
Plus strand
chr1:29,138,654-29,190,208
(GRCh37/hg19)
Size:
51,555 bases
Orientation:
Plus strand

Genomic View for OPRD1 Gene

Genes around OPRD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OPRD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OPRD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OPRD1 Gene

Proteins for OPRD1 Gene

  • Protein details for OPRD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41143-OPRD_HUMAN
    Recommended name:
    Delta-type opioid receptor
    Protein Accession:
    P41143
    Secondary Accessions:
    • B5B0B8

    Protein attributes for OPRD1 Gene

    Size:
    372 amino acids
    Molecular mass:
    40369 Da
    Quaternary structure:
    • May form homooligomers. Forms a heterodimer with OPRM1 (By similarity). Interacts with GPRASP1 (PubMed:12142540, PubMed:15086532). Interacts with RTP4; the interaction promotes cell surface localization of the OPRD1-OPRM1 heterodimer (By similarity).

    Three dimensional structures from OCA and Proteopedia for OPRD1 Gene

neXtProt entry for OPRD1 Gene

Post-translational modifications for OPRD1 Gene

  • N-glycosylated.
  • Ubiquitinated. A basal ubiquitination seems not to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4.
  • Glycosylation at isoforms=33 and Asn18
  • Modification sites at PhosphoSitePlus

Other Protein References for OPRD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for OPRD1 Gene

Domains & Families for OPRD1 Gene

Gene Families for OPRD1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for OPRD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P41143

UniProtKB/Swiss-Prot:

OPRD_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OPRD1: view

Function for OPRD1 Gene

Molecular function for OPRD1 Gene

UniProtKB/Swiss-Prot Function:
G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.
GENATLAS Biochemistry:
opioid receptor delta 1,G protein coupled receptor superfamily,depressing cAMP levels,opening a G protein-modulated K+ channel,regulating G protein expression in pineal gland

Phenotypes From GWAS Catalog for OPRD1 Gene

Gene Ontology (GO) - Molecular Function for OPRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 obsolete signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IBA,IEA --
GO:0004985 opioid receptor activity IDA,IEA 22184124
GO:0005515 protein binding IPI 15086532
GO:0038046 enkephalin receptor activity IEA,IMP 9548483
genes like me logo Genes that share ontologies with OPRD1: view
genes like me logo Genes that share phenotypes with OPRD1: view

Animal Models for OPRD1 Gene

MGI Knock Outs for OPRD1:

Animal Model Products

  • Taconic Biosciences Mouse Models for OPRD1

Clone Products

  • Addgene plasmids for OPRD1
  • R&D Systems cDNA Clones for OPRD1 (delta Opioid R/OPRD1)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OPRD1 Gene

Localization for OPRD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OPRD1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OPRD1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OPRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7808419
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OPRD1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OPRD1 Gene

Pathways & Interactions for OPRD1 Gene

genes like me logo Genes that share pathways with OPRD1: view

Gene Ontology (GO) - Biological Process for OPRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IDA 16325578
GO:0006955 immune response TAS 9548483
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS,IEA --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 7808419
genes like me logo Genes that share ontologies with OPRD1: view

No data available for SIGNOR curated interactions for OPRD1 Gene

Drugs & Compounds for OPRD1 Gene

(197) Drugs for OPRD1 Gene - From: DrugBank, PharmGKB, DGIdb, FDA Approved Drugs, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Naltrexone Approved, Investigational, Vet_approved Pharma Antagonist, antagonist, Target Opioid receptor antagonist 406
Oxymorphone Approved, Investigational, Vet_approved Pharma agonist, Target, antagonist 27
Morphine Approved, Investigational Pharma Full agonist, Agonist, Partial agonist, agonist, Target 1100
Naloxone Approved, Vet_approved Pharma Antagonist, antagonist, Target 276
Alvimopan Approved, Investigational Pharma antagonist, Target Mu-opioid receptors antagonist 23

(55) Additional Compounds for OPRD1 Gene - From: Novoseek and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(-)-EKC
Full agonist, Agonist
(-)-quadazocine
Antagonist
[<sup>3</sup>H]naltrindole
Antagonist
beta-FNA
Antagonist
TIPPpsi
Inverse agonist, Antagonist

(5) Tocris Compounds for OPRD1 Gene

Compound Action Cas Number
[D-Ala2]-Deltorphin II Selective delta agonist peptide 122752-16-3
DPDPE Selective delta agonist 88373-73-3
FIT Irreversible delta agonist 85951-63-9
SB 205607 dihydrobromide Selective, high affinity non-peptide delta1 agonist 1217628-73-3
SNC 80 Highly selective non-peptide delta agonist 156727-74-1
genes like me logo Genes that share compounds with OPRD1: view

Transcripts for OPRD1 Gene

mRNA/cDNA for OPRD1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OPRD1 Gene

Opioid receptor, delta 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for OPRD1
  • R&D Systems cDNA Clones for OPRD1 (delta Opioid R/OPRD1)

Alternative Splicing Database (ASD) splice patterns (SP) for OPRD1 Gene

No ASD Table

Relevant External Links for OPRD1 Gene

GeneLoc Exon Structure for
OPRD1
ECgene alternative splicing isoforms for
OPRD1

Expression for OPRD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OPRD1 Gene

mRNA differential expression in normal tissues according to GTEx for OPRD1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x10.8), Brain - Cortex (x8.6), and Brain - Anterior cingulate cortex (BA24) (x7.8).

NURSA nuclear receptor signaling pathways regulating expression of OPRD1 Gene:

OPRD1

SOURCE GeneReport for Unigene cluster for OPRD1 Gene:

Hs.372

mRNA Expression by UniProt/SwissProt for OPRD1 Gene:

P41143-OPRD_HUMAN
Tissue specificity: Detected in oocytes (at protein level). Detected in brain cortex, hypothalamus, hippocampus and olfactory bulb. Detected in oocytes.

Evidence on tissue expression from TISSUES for OPRD1 Gene

  • Nervous system(4.3)
  • Kidney(4)
genes like me logo Genes that share expression patterns with OPRD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for OPRD1 Gene

Orthologs for OPRD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OPRD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OPRD1 34 33
  • 99.19 (n)
OneToOne
dog
(Canis familiaris)
Mammalia OPRD1 34 33
  • 93.98 (n)
OneToOne
cow
(Bos Taurus)
Mammalia OPRD1 34 33
  • 92.65 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Oprd1 33
  • 90.5 (n)
mouse
(Mus musculus)
Mammalia Oprd1 16 34 33
  • 89.16 (n)
oppossum
(Monodelphis domestica)
Mammalia OPRD1 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves OPRD1 34 33
  • 79.08 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OPRD1 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia oprd1 33
  • 67.99 (n)
zebrafish
(Danio rerio)
Actinopterygii oprd1b 34
  • 67 (a)
OneToMany
oprd1a 34 33
  • 66.85 (n)
OneToMany
oprd1 33
Species where no ortholog for OPRD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OPRD1 Gene

ENSEMBL:
Gene Tree for OPRD1 (if available)
TreeFam:
Gene Tree for OPRD1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OPRD1: view image

Paralogs for OPRD1 Gene

(24) SIMAP similar genes for OPRD1 Gene using alignment to 1 proteins:

  • OPRD_HUMAN
genes like me logo Genes that share paralogs with OPRD1: view

Variants for OPRD1 Gene

Sequence variations from dbSNP and Humsavar for OPRD1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000160351 -- 28,813,304(+) C/T intron_variant
rs1000295585 -- 28,821,307(+) T/C intron_variant
rs1000343641 -- 28,861,575(+) G/T intron_variant
rs1000355615 -- 28,850,888(+) A/G intron_variant
rs1000392698 -- 28,814,453(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OPRD1 Gene

Variant ID Type Subtype PubMed ID
dgv3n21 CNV loss 19592680
esv2745841 CNV deletion 23290073
esv3585594 CNV loss 21293372
nsv1076315 CNV deletion 25765185
nsv1119673 CNV deletion 24896259
nsv460928 CNV loss 19166990
nsv519203 CNV gain 19592680
nsv525310 CNV loss 19592680
nsv545921 CNV loss 21841781

Variation tolerance for OPRD1 Gene

Residual Variation Intolerance Score: 25.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.67; 57.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OPRD1 Gene

Human Gene Mutation Database (HGMD)
OPRD1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OPRD1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OPRD1 Gene

Disorders for OPRD1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for OPRD1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
neonatal abstinence syndrome
  • drug withdrawal syndrome in newborn
heroin dependence
morphine dependence
drug dependence
opiate dependence
  • opioid type dependence
- elite association - COSMIC cancer census association via MalaCards
Search OPRD1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OPRD1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with OPRD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OPRD1 Gene

Publications for OPRD1 Gene

  1. Association analysis of delta-opioid receptor gene polymorphisms in methamphetamine dependence/psychosis. (PMID: 16741914) Kobayashi H … Sora I (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2006) 3 22 44 58
  2. Identification of a human delta opioid receptor: cloning and expression. (PMID: 8201839) Knapp RJ … Roeske WR (Life sciences 1994) 3 4 22 58
  3. Cys-27 variant of human δ-opioid receptor modulates maturation and cell surface delivery of Phe-27 variant via heteromerization. (PMID: 22184124) Leskelä TT … Petäjä-Repo UE (The Journal of biological chemistry 2012) 3 4 58
  4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 44 58
  5. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro AP … Woodside DB (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 44 58

Products for OPRD1 Gene

  • Addgene plasmids for OPRD1

Sources for OPRD1 Gene

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