Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This opsin gene is expressed in the eye, brain, testes, and spinal cord. This gene belongs to the seven-exon subfamily of mammalian opsin genes that includes peropsin (RRH) and retinal G protein coupled receptor (RGR). Like these other seven-exon opsin genes, this family membe... See more...

Aliases for OPN5 Gene

Aliases for OPN5 Gene

  • Opsin 5 2 3 5
  • Transmembrane Protein 13 2 3 4
  • Neuropsin 2 3 4
  • G-Protein Coupled Receptor 136 3 4
  • Opsin-5 3 4
  • TMEM13 3 4
  • GPR136 3 4
  • PGR12 3 4
  • G-Protein Coupled Receptor PGR12 4
  • GRP136 3

External Ids for OPN5 Gene

Previous HGNC Symbols for OPN5 Gene

  • TMEM13

Previous GeneCards Identifiers for OPN5 Gene

  • GC06P047796
  • GC06P047857
  • GC06P047477

Summaries for OPN5 Gene

Entrez Gene Summary for OPN5 Gene

  • Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This opsin gene is expressed in the eye, brain, testes, and spinal cord. This gene belongs to the seven-exon subfamily of mammalian opsin genes that includes peropsin (RRH) and retinal G protein coupled receptor (RGR). Like these other seven-exon opsin genes, this family member may encode a protein with photoisomerase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

GeneCards Summary for OPN5 Gene

OPN5 (Opsin 5) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and 11-cis retinal binding. An important paralog of this gene is OPN4.

Gene Wiki entry for OPN5 Gene

Additional gene information for OPN5 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OPN5 Gene

Genomics for OPN5 Gene

GeneHancer (GH) Regulatory Elements for OPN5 Gene

Promoters and enhancers for OPN5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J047780 Enhancer 0.8 Ensembl ENCODE 500.7 +0.6 598 1 CTCF REST RFX1 RAD21 TRIM22 SMC3 ZBTB17 ZNF335 ZNF654 MITF OPN5 NONHSAG043899.2
GH06J047788 Promoter 0.3 EPDnew 500.4 +6.8 6757 0.1 OPN5 RNU1-105P NONHSAG043899.2
GH06J047475 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 11 -302.0 -301962 5.7 HNRNPK ZBTB40 CTCF SIN3A USF1 POLR2G NCOR1 PHF8 ZFX ZIC2 ENSG00000270761 CD2AP ADGRF2 SLC25A27 OPN5 ENSG00000199762
GH06J047493 Enhancer 1 Ensembl ENCODE 10.1 -282.6 -282601 11.4 BCLAF1 DNMT1 PRPF4 MIER1 HDAC3 NCOR1 ZNF316 NFIC MAFF TRIM24 ADGRF2 ENSG00000270761 CD2AP OPN5 ENSG00000199762 piR-61028-501
GH06J047518 Enhancer 0.9 Ensembl ENCODE 10.1 -261.0 -261035 8.5 TCF7 ZSCAN9 FOXA2 SAP130 POLR2A CREM FOXP1 SMAD4 ZGPAT BCL6 ADGRF2 CD2AP ENSG00000270761 OPN5 ADGRF4 lnc-TNFRSF21-1 piR-52438-098
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OPN5 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OPN5

Top Transcription factor binding sites by QIAGEN in the OPN5 gene promoter:
  • AhR
  • Arnt
  • ISGF-3
  • POU2F1
  • STAT5A
  • STAT5B

Genomic Locations for OPN5 Gene

Genomic Locations for OPN5 Gene
chr6:47,780,302-47,857,840
(GRCh38/hg38)
Size:
77,539 bases
Orientation:
Plus strand
chr6:47,749,718-47,800,516
(GRCh37/hg19)
Size:
50,799 bases
Orientation:
Plus strand

Genomic View for OPN5 Gene

Genes around OPN5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OPN5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OPN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OPN5 Gene

Proteins for OPN5 Gene

  • Protein details for OPN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6U736-OPN5_HUMAN
    Recommended name:
    Opsin-5
    Protein Accession:
    Q6U736
    Secondary Accessions:
    • A0AV33
    • Q5T5B9
    • Q5T886
    • Q7Z603
    • Q86SL5

    Protein attributes for OPN5 Gene

    Size:
    354 amino acids
    Molecular mass:
    39727 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI20454.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for OPN5 Gene

Post-translational modifications for OPN5 Gene

  • It is uncertain whether Cys-315 or Cys-316 is palmitoylated.
  • Glycosylation at Asn4
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for OPN5 Gene

Domains & Families for OPN5 Gene

Gene Families for OPN5 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OPN5 Gene

Blocks:
  • Opsin
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OPN5 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein 13 (OPN5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6U736

UniProtKB/Swiss-Prot:

OPN5_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
genes like me logo Genes that share domains with OPN5: view

Function for OPN5 Gene

Phenotypes From GWAS Catalog for OPN5 Gene

Gene Ontology (GO) - Molecular Function for OPN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G protein-coupled receptor activity IEA --
GO:0005502 11-cis retinal binding IEA --
GO:0008020 G protein-coupled photoreceptor activity IBA 21873635
GO:0009881 photoreceptor activity IEA --
genes like me logo Genes that share ontologies with OPN5: view
genes like me logo Genes that share phenotypes with OPN5: view

Animal Models for OPN5 Gene

MGI Knock Outs for OPN5:
  • Opn5 Opn5<tm1.1Yau>
  • Opn5 Opn5<tm1.1Lan>

Animal Model Products

  • Taconic Biosciences Mouse Models for OPN5

CRISPR Products

Clone Products

  • Addgene plasmids for OPN5

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OPN5 Gene

Localization for OPN5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OPN5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OPN5 gene
Compartment Confidence
plasma membrane 4
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for OPN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001750 photoreceptor outer segment IBA 21873635
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OPN5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OPN5 Gene

Pathways & Interactions for OPN5 Gene

genes like me logo Genes that share pathways with OPN5: view

Gene Ontology (GO) - Biological Process for OPN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G protein-coupled receptor signaling pathway IBA 21873635
GO:0007601 visual perception IEA --
GO:0007602 phototransduction IBA 21873635
GO:0009584 detection of visible light IEA --
genes like me logo Genes that share ontologies with OPN5: view

No data available for SIGNOR curated interactions for OPN5 Gene

Drugs & Compounds for OPN5 Gene

No Compound Related Data Available

Transcripts for OPN5 Gene

mRNA/cDNA for OPN5 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for OPN5

Alternative Splicing Database (ASD) splice patterns (SP) for OPN5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - -
SP2:
SP3: - - - -
SP4:
SP5: -

Relevant External Links for OPN5 Gene

GeneLoc Exon Structure for
OPN5

Expression for OPN5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OPN5 Gene

mRNA differential expression in normal tissues according to GTEx for OPN5 Gene

This gene is overexpressed in Testis (x39.8) and Heart - Left Ventricle (x4.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OPN5

SOURCE GeneReport for Unigene cluster for OPN5 Gene:

Hs.213717

mRNA Expression by UniProt/SwissProt for OPN5 Gene:

Q6U736-OPN5_HUMAN
Tissue specificity: Detected in brain and retina and cell lines derived from neural retina.
genes like me logo Genes that share expression patterns with OPN5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OPN5 Gene

Orthologs for OPN5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OPN5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OPN5 31 30
  • 99.81 (n)
OneToOne
dog
(Canis familiaris)
Mammalia OPN5 31 30
  • 94.03 (n)
OneToOne
cow
(Bos Taurus)
Mammalia OPN5 31 30
  • 92.9 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Opn5 17 31 30
  • 89.96 (n)
rat
(Rattus norvegicus)
Mammalia Opn5 30
  • 88.28 (n)
oppossum
(Monodelphis domestica)
Mammalia OPN5 31
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OPN5 31
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves OPN5 31 30
  • 74.95 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OPN5 31
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia opn5 30
  • 72.9 (n)
zebrafish
(Danio rerio)
Actinopterygii opn5 31 30
  • 67.15 (n)
OneToOne
Species where no ortholog for OPN5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OPN5 Gene

ENSEMBL:
Gene Tree for OPN5 (if available)
TreeFam:
Gene Tree for OPN5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OPN5: view image

Paralogs for OPN5 Gene

Paralogs for OPN5 Gene

(3) SIMAP similar genes for OPN5 Gene using alignment to 3 proteins:

  • OPN5_HUMAN
  • D6RDV4_HUMAN
  • J3KPQ2_HUMAN
genes like me logo Genes that share paralogs with OPN5: view

Variants for OPN5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OPN5 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
787666 Benign: not provided 47,795,524(+) G/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for OPN5 Gene

Structural Variations from Database of Genomic Variants (DGV) for OPN5 Gene

Variant ID Type Subtype PubMed ID
esv3305039 CNV mobile element insertion 20981092
esv3324219 CNV insertion 20981092
nsv1017113 CNV gain 25217958

Variation tolerance for OPN5 Gene

Residual Variation Intolerance Score: 26.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OPN5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OPN5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OPN5 Gene

Disorders for OPN5 Gene

Additional Disease Information for OPN5

No disorders were found for OPN5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OPN5 Gene

Publications for OPN5 Gene

  1. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. (PMID: 14623098) Fredriksson R … Schiöth HB (FEBS letters 2003) 2 3 4 54
  2. Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue. (PMID: 14623103) Tarttelin EE … Lucas RJ (FEBS letters 2003) 2 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 54
  5. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 54

Products for OPN5 Gene

Sources for OPN5 Gene