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Aliases for OPN1MW2 Gene

Aliases for OPN1MW2 Gene

  • Opsin 1, Medium Wave Sensitive 2 2 3 5
  • Opsin 1 (Cone Pigments), Medium-Wave-Sensitive 2 2 3
  • Opsin 1 Cone Pigments Medium-Wave-Sensitive 2 3 4
  • Green Cone Photoreceptor Pigment 3 4
  • Green-Sensitive Opsin 3 4
  • GOP 3 4
  • Medium-Wave-Sensitive Opsin 1 3

External Ids for OPN1MW2 Gene

Previous GeneCards Identifiers for OPN1MW2 Gene

  • GC0XU900626
  • GC0XP153138
  • GC0XP153485

Summaries for OPN1MW2 Gene

Entrez Gene Summary for OPN1MW2 Gene

  • This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called green cone photopigment or medium-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. The long-wavelength opsin gene and multiple copies of the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of deutanopic colorblindness. [provided by RefSeq, Mar 2009]

GeneCards Summary for OPN1MW2 Gene

OPN1MW2 (Opsin 1, Medium Wave Sensitive 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and photoreceptor activity. An important paralog of this gene is OPN1MW.

UniProtKB/Swiss-Prot for OPN1MW2 Gene

  • Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.

Additional gene information for OPN1MW2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OPN1MW2 Gene

Genomics for OPN1MW2 Gene

GeneHancer (GH) Regulatory Elements for OPN1MW2 Gene

Promoters and enhancers for OPN1MW2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI154219 Promoter 0.5 EPDnew 550.8 +0.0 25 0.1 OPN1MW2 LOC102030688
GH0XI154246 Enhancer 0.5 Ensembl 0.3 +28.0 27967 2.6 CC2D1A ATF4 ZNF318 NCOR1 GABPB1 CBFA2T3 ZBTB5 LOC102030688 OPN1MW2
GH0XI154231 Enhancer 0.2 Ensembl 0.4 +11.8 11767 0.2 OPN1MW2 LOC102030688
GH0XI154243 Enhancer 0.2 Ensembl 0.3 +23.9 23867 0.4 LOC102030688 OPN1MW2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OPN1MW2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OPN1MW2 gene promoter:

Genomic Locations for OPN1MW2 Gene

Genomic Locations for OPN1MW2 Gene
13,553 bases
Plus strand

Genomic View for OPN1MW2 Gene

Genes around OPN1MW2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OPN1MW2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OPN1MW2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OPN1MW2 Gene

Proteins for OPN1MW2 Gene

  • Protein details for OPN1MW2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Medium-wave-sensitive opsin 2
    Protein Accession:

    Protein attributes for OPN1MW2 Gene

    364 amino acids
    Molecular mass:
    40584 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OPN1MW2 Gene

Post-translational modifications for OPN1MW2 Gene

  • Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.

Other Protein References for OPN1MW2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OPN1MW2 Gene

Domains & Families for OPN1MW2 Gene

Gene Families for OPN1MW2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for OPN1MW2 Gene

Suggested Antigen Peptide Sequences for OPN1MW2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
  • Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
genes like me logo Genes that share domains with OPN1MW2: view

Function for OPN1MW2 Gene

Molecular function for OPN1MW2 Gene

UniProtKB/Swiss-Prot Function:
Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.

Gene Ontology (GO) - Molecular Function for OPN1MW2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0008020 G-protein coupled photoreceptor activity IBA --
GO:0009881 photoreceptor activity IEA,IMP 8185948
GO:0042802 identical protein binding IDA 28402104
genes like me logo Genes that share ontologies with OPN1MW2: view
genes like me logo Genes that share phenotypes with OPN1MW2: view

Animal Model Products

miRNA for OPN1MW2 Gene

miRTarBase miRNAs that target OPN1MW2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OPN1MW2 Gene

Localization for OPN1MW2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OPN1MW2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OPN1MW2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OPN1MW2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001750 photoreceptor outer segment IBA --
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane TAS 2937147
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OPN1MW2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OPN1MW2 Gene

Pathways & Interactions for OPN1MW2 Gene

SuperPathways for OPN1MW2 Gene

No Data Available

Interacting Proteins for OPN1MW2 Gene

Gene Ontology (GO) - Biological Process for OPN1MW2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS,IEA --
GO:0007601 visual perception IEA --
GO:0007602 phototransduction IEA --
genes like me logo Genes that share ontologies with OPN1MW2: view

No data available for Pathways by source and SIGNOR curated interactions for OPN1MW2 Gene

Drugs & Compounds for OPN1MW2 Gene

No Compound Related Data Available

Transcripts for OPN1MW2 Gene

mRNA/cDNA for OPN1MW2 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OPN1MW2 Gene

Opsin 1 (cone pigments), medium-wave-sensitive 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OPN1MW2 Gene

No ASD Table

Relevant External Links for OPN1MW2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OPN1MW2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OPN1MW2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OPN1MW2 Gene:


SOURCE GeneReport for Unigene cluster for OPN1MW2 Gene:


Evidence on tissue expression from TISSUES for OPN1MW2 Gene

  • Eye(4.2)
genes like me logo Genes that share expression patterns with OPN1MW2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OPN1MW2 Gene

Orthologs for OPN1MW2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OPN1MW2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OPN1LW 34
  • 89 (a)
(Mus musculus)
Mammalia Opn1mw 34
  • 88 (a)
(Canis familiaris)
Mammalia OPN1LW 34
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia OPN1LW 34
  • 85 (a)
(Monodelphis domestica)
Mammalia OPN1LW 34
  • 83 (a)
(Gallus gallus)
Aves OPNP 34
  • 47 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 80 (a)
(Danio rerio)
Actinopterygii opn1lw1 34
  • 77 (a)
opn1lw2 34
  • 77 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11297 34
  • 39 (a)
-- 34
  • 37 (a)
Species where no ortholog for OPN1MW2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OPN1MW2 Gene

Gene Tree for OPN1MW2 (if available)
Gene Tree for OPN1MW2 (if available)

Paralogs for OPN1MW2 Gene

Paralogs for OPN1MW2 Gene

(7) SIMAP similar genes for OPN1MW2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OPN1MW2: view

Variants for OPN1MW2 Gene

Sequence variations from dbSNP and Humsavar for OPN1MW2 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1065427 -- 154,230,623(+) G/A coding_sequence_variant, missense_variant
rs1065430 -- 154,230,626(+) C/T coding_sequence_variant, synonymous_variant
rs1065432 -- 154,230,628(+) G/T coding_sequence_variant, synonymous_variant
rs1065433 -- 154,230,631(+) A/G coding_sequence_variant, synonymous_variant
rs1065434 -- 154,230,633(+) T/A coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for OPN1MW2 Gene

Variant ID Type Subtype PubMed ID
esv27518 CNV gain+loss 19812545
esv33199 CNV gain+loss 17666407
esv33784 CNV gain+loss 17666407
esv3384147 CNV duplication 20981092
esv3392584 CNV duplication 20981092
nsv1075344 CNV deletion 25765185
nsv1132791 CNV duplication 24896259
nsv515186 CNV gain 21397061
nsv519042 CNV gain 19592680
nsv7161 CNV deletion 18451855

Variation tolerance for OPN1MW2 Gene

Gene Damage Index Score: 0.18; 3.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OPN1MW2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OPN1MW2 Gene

Disorders for OPN1MW2 Gene

Additional Disease Information for OPN1MW2

No disorders were found for OPN1MW2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OPN1MW2 Gene

Publications for OPN1MW2 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  2. Hydrogen/Deuterium Exchange Mass Spectrometry of Human Green Opsin Reveals a Conserved Pro-Pro Motif in Extracellular Loop 2 of Monostable Visual G Protein-Coupled Receptors. (PMID: 28402104) Hofmann L … Palczewski K (Biochemistry 2017) 3 58
  3. G protein-coupled receptors participate in cytokinesis. (PMID: 22888021) Zhang X … Eggert US (Cytoskeleton (Hoboken, N.J.) 2012) 3 58
  4. X-linked cone dystrophy caused by mutation of the red and green cone opsins. (PMID: 20579627) Gardner JC … Hardcastle AJ (American journal of human genetics 2010) 3 58
  5. Expressions of rod and cone photoreceptor-like proteins in human epidermis. (PMID: 19493002) Tsutsumi M … Denda M (Experimental dermatology 2009) 3 58

Products for OPN1MW2 Gene

Sources for OPN1MW2 Gene

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