Aliases for OPLAH Gene
External Ids for OPLAH Gene
Previous GeneCards Identifiers for OPLAH Gene
The protein encoded by this gene acts as a homodimer, using ATP hydrolysis to catalyze the conversion of 5-oxo-L-proline to L-glutamate. Defects in this gene are a cause of 5-oxoprolinase deficiency (OPLAHD). [provided by RefSeq, Jun 2012]
GeneCards Summary for OPLAH Gene
OPLAH (5-Oxoprolinase, ATP-Hydrolysing) is a Protein Coding gene. Diseases associated with OPLAH include 5-Oxoprolinase Deficiency and Glutathione Synthetase Deficiency. Among its related pathways are Glutathione metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity and 5-oxoprolinase (ATP-hydrolyzing) activity.
UniProtKB/Swiss-Prot for OPLAH Gene
Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.