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This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
OPCML (Opioid Binding Protein/Cell Adhesion Molecule Like) is a Protein Coding gene. Diseases associated with OPCML include Ovarian Cancer and Hypogonadotropic Hypogonadism 14 With Or Without Anosmia. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. Gene Ontology (GO) annotations related to this gene include opioid receptor activity. An important paralog of this gene is NTM.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J133532 | Promoter/Enhancer | 1.1 | EPDnew Ensembl ENCODE | 600.7 | +0.4 | 434 | 1.4 | KDM1A POLR2A RAD21 TBP EGR1 | ENSG00000287068 OPCML SNODB780 | |
GH11J132943 | Promoter | 1 | EPDnew Ensembl | 600 | +588.8 | 588834 | 1.8 | CTCF EZH2 RAD21 BHLHE40 BACH1 | lnc-SPATA19-8 OPCML piR-50444-072 | |
GH11J133505 | Enhancer | 0.6 | Ensembl | 11.7 | +26.2 | 26234 | 2.6 | IKZF2 TRIM22 DPF2 RELB RUNX3 GATAD2B IKZF1 BMI1 NR2F1 IRF4 | OPCML ENSG00000287068 SNODB780 | |
GH11J133580 | Enhancer | 0.6 | Ensembl ENCODE CraniofacialAtlas | 11.5 | -47.2 | -47219 | 1.3 | TBP | OPCML HSALNG0088331 piR-41245-057 SPATA19 | |
GH11J133441 | Enhancer | 0.6 | Ensembl ENCODE | 11.3 | +89.4 | 89433 | 2.6 | HNF4A NANOG POU5F1 RXRA | OPCML SNODB780 ENSG00000287068 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0031225 | anchored component of membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007155 | cell adhesion | TAS,IEA | -- |
GO:0008038 | neuron recognition | TAS | 7891157 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Methylphenidate | Approved, Investigational | Pharma | 431 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | OPCML 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | OPCML 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Opcml 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | OPCML 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | OPCML 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Opcml 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | OPCML 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | OPCML 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | OPCML 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | opcml 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | opcml 30 31 |
|
OneToMany | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010222 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG31646 30 31 |
|
ManyToMany | |
CG11320 31 |
|
ManyToMany | |||
Lac 31 |
|
ManyToMany | |||
Ama 31 |
|
ManyToMany | |||
CG40378 31 |
|
ManyToMany | |||
CG14521 31 |
|
ManyToMany | |||
CG14010 31 |
|
ManyToMany | |||
CG42368 31 |
|
ManyToMany | |||
CG34391 31 |
|
ManyToMany | |||
CG31708 31 |
|
ManyToMany | |||
CG42343 31 |
|
ManyToMany | |||
CG7166 31 |
|
ManyToMany | |||
CG32791 31 |
|
ManyToMany | |||
CG34353 31 |
|
ManyToMany | |||
CG31814 31 |
|
ManyToMany | |||
wrapper 31 |
|
ManyToMany | |||
klg 31 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | rig-5 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs137852691 | Pathogenic: Neoplasm of ovary. Ovarian cancer (OC) [MIM:167000] | 132,657,203(-) | G/Cp.Pro95Arg | MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
ovarian cancer |
|
|
hypogonadotropic hypogonadism 14 with or without anosmia |
|
|
jacobsen syndrome |
|
|