Aliases for OPCML Gene
External Ids for OPCML Gene
Previous GeneCards Identifiers for OPCML Gene
This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
GeneCards Summary for OPCML Gene
OPCML (Opioid Binding Protein/Cell Adhesion Molecule Like) is a Protein Coding gene. Diseases associated with OPCML include Ovarian Cancer and Hypogonadotropic Hypogonadism 14 With Or Without Anosmia. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. Gene Ontology (GO) annotations related to this gene include opioid receptor activity. An important paralog of this gene is NTM.
UniProtKB/Swiss-Prot Summary for OPCML Gene
Binds opioids in the presence of acidic lipids; probably involved in cell contact.