Aliases for OPALIN Gene

Aliases for OPALIN Gene

  • Oligodendrocytic Myelin Paranodal And Inner Loop Protein 2 3 4 5
  • Transmembrane Protein 10 2 3 4
  • Opalin 3 4
  • TMEM10 3 4
  • HTMP10 3 4
  • Transmembrane Protein TMP10 3
  • TMP10 3

External Ids for OPALIN Gene

Previous HGNC Symbols for OPALIN Gene

  • TMEM10

Previous GeneCards Identifiers for OPALIN Gene

  • GC10M098093
  • GC10M091730

Summaries for OPALIN Gene

GeneCards Summary for OPALIN Gene

OPALIN (Oligodendrocytic Myelin Paranodal And Inner Loop Protein) is a Protein Coding gene. Diseases associated with OPALIN include Fucosidosis and Opportunistic Bacterial Infectious Disease.

Gene Wiki entry for OPALIN Gene

Additional gene information for OPALIN Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OPALIN Gene

Genomics for OPALIN Gene

GeneHancer (GH) Regulatory Elements for OPALIN Gene

Promoters and enhancers for OPALIN Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J096358 Promoter/Enhancer 0.5 EPDnew dbSUPER 500.7 +0.3 346 0.1 OPALIN piR-53338-019
GH10J095906 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 9.2 +451.9 451864 2.2 ZNF217 NRF1 MYC POLR2G PHF8 SIX5 ZFX CTCF ZIC2 POLR2A CC2D2B ENTPD1 OPALIN TCTN3 piR-39870 ENSG00000270099 ENTPD1-AS1
GH10J096286 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 9.7 +70.4 70429 5.2 RXRA ZBTB40 ZNF217 SP1 NCOR1 EP300 KDM6A RELA MEF2C CUX1 BLNK OPALIN RNU6-271P TLL2 lnc-DNTT-1 HSALNG0079877
GH10J096617 Enhancer 1.3 Ensembl ENCODE dbSUPER 9.3 -260.2 -260171 4.3 PHB2 ZIC2 ZBTB11 AFF1 TARDBP REST HES1 TOE1 MYC CTBP1 RF00001-048 RNA5SP324 lnc-TM9SF3-1 NPM1P26 PIK3AP1 MIR607 LCOR OPALIN RPS2P36 lnc-TM9SF3-2
GH10J096242 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.1 +115.9 115861 3.4 EP300 RELA MEF2C RCOR1 TRIM22 BCL11A TCF12 CREB1 CBFB POLR2A BLNK OPALIN CC2D2B piR-57845-001 lnc-BLNK-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OPALIN on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OPALIN

Top Transcription factor binding sites by QIAGEN in the OPALIN gene promoter:
  • AML1a
  • c-Myc
  • COMP1
  • CUTL1
  • GCNF
  • Max1
  • STAT1
  • STAT1alpha
  • STAT1beta
  • YY1

Genomic Locations for OPALIN Gene

Genomic Locations for OPALIN Gene
16,150 bases
Minus strand
16,120 bases
Minus strand

Genomic View for OPALIN Gene

Genes around OPALIN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OPALIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OPALIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OPALIN Gene

Proteins for OPALIN Gene

  • Protein details for OPALIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8MX69
    • A8MYG4
    • B4DK96
    • B4DKH0
    • Q5W102

    Protein attributes for OPALIN Gene

    141 amino acids
    Molecular mass:
    15683 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OPALIN Gene


neXtProt entry for OPALIN Gene

Post-translational modifications for OPALIN Gene

  • Glycosylation at Thr14, Asn6, and Asn12
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for OPALIN Gene

Domains & Families for OPALIN Gene

Gene Families for OPALIN Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for OPALIN Gene


Suggested Antigen Peptide Sequences for OPALIN Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53053, highly similar to Transmembrane protein 10 (A8MX69_HUMAN)
  • cDNA, FLJ78989, highly similar to Transmembrane protein 10 (B4DK96_HUMAN)
  • Transmembrane protein 10 (OPALI_HUMAN)
  • cDNA FLJ76376, highly similar to Homo sapiens transmembrane protein 10 (TMEM10), mRNA (Q5W102_HUMAN)
genes like me logo Genes that share domains with OPALIN: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for OPALIN Gene

Function for OPALIN Gene

Phenotypes From GWAS Catalog for OPALIN Gene

genes like me logo Genes that share phenotypes with OPALIN: view

Animal Models for OPALIN Gene

MGI Knock Outs for OPALIN:

Animal Model Products

CRISPR Products

miRNA for OPALIN Gene

miRTarBase miRNAs that target OPALIN

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OPALIN Gene

Localization for OPALIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for OPALIN Gene

Cell membrane; Single-pass type I membrane protein. Note=In the CNS, enriched in the myelin paranodal and inner loop membranes, but not that of the PNS. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OPALIN gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4
extracellular 2
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1
endoplasmic reticulum 0

Gene Ontology (GO) - Cellular Components for OPALIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0044291 cell-cell contact zone IBA 21873635
genes like me logo Genes that share ontologies with OPALIN: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OPALIN Gene

Pathways & Interactions for OPALIN Gene

PathCards logo

SuperPathways for OPALIN Gene

No Data Available

Interacting Proteins for OPALIN Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000360214 Q96PE5-OPALI_HUMAN for OPALIN Gene via STRING IID


Gene Ontology (GO) - Biological Process for OPALIN Gene


No data available for Pathways by source and SIGNOR curated interactions for OPALIN Gene

Drugs & Compounds for OPALIN Gene

No Compound Related Data Available

Transcripts for OPALIN Gene


20 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OPALIN Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - - - -
SP2: - -
SP3: - - - - - -
SP4: - - - - -
SP5: -

Relevant External Links for OPALIN Gene

GeneLoc Exon Structure for

Expression for OPALIN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OPALIN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OPALIN Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x8.3), Brain - Amygdala (x7.6), Brain - Hippocampus (x7.3), Brain - Caudate (basal ganglia) (x5.6), and Brain - Substantia nigra (x4.3).

Protein differential expression in normal tissues from HIPED for OPALIN Gene

This gene is overexpressed in Frontal cortex (65.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OPALIN Gene

Protein tissue co-expression partners for OPALIN Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OPALIN

SOURCE GeneReport for Unigene cluster for OPALIN Gene:


mRNA Expression by UniProt/SwissProt for OPALIN Gene:

Tissue specificity: Brain specific.

Evidence on tissue expression from TISSUES for OPALIN Gene

  • Nervous system(5)
  • Lung(4)
genes like me logo Genes that share expression patterns with OPALIN: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for OPALIN Gene

Orthologs for OPALIN Gene

This gene was present in the common ancestor of mammals.

Orthologs for OPALIN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OPALIN 31 30
  • 99.29 (n)
(Canis familiaris)
Mammalia OPALIN 31 30
  • 87.23 (n)
(Bos Taurus)
Mammalia OPALIN 31 30
  • 83.45 (n)
(Mus musculus)
Mammalia Opalin 17 31 30
  • 78.96 (n)
(Rattus norvegicus)
Mammalia Opalin 30
  • 78.01 (n)
(Monodelphis domestica)
Mammalia OPALIN 31
  • 41 (a)
Species where no ortholog for OPALIN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OPALIN Gene

Gene Tree for OPALIN (if available)
Gene Tree for OPALIN (if available)
Evolutionary constrained regions (ECRs) for OPALIN: view image

Paralogs for OPALIN Gene

No data available for Paralogs for OPALIN Gene

Variants for OPALIN Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OPALIN Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
734836 Benign: not provided 96,346,034(-) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for OPALIN Gene

Structural Variations from Database of Genomic Variants (DGV) for OPALIN Gene

Variant ID Type Subtype PubMed ID
nsv1110852 OTHER inversion 24896259
nsv1137947 CNV deletion 24896259
nsv831949 CNV gain 17160897
nsv831950 CNV gain 17160897

Variation tolerance for OPALIN Gene

Residual Variation Intolerance Score: 82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 33.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OPALIN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OPALIN Gene

Disorders for OPALIN Gene

MalaCards: The human disease database

(3) MalaCards diseases for OPALIN Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • alpha-l-fucosidase deficiency
opportunistic bacterial infectious disease
  • nocardia infectious disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for OPALIN

genes like me logo Genes that share disorders with OPALIN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OPALIN Gene

Publications for OPALIN Gene

  1. Identification and characterization of a novel human brain-specific gene, homologous to S. scrofa tmp83.5, in the chromosome 10q24 critical region for temporal lobe epilepsy and spastic paraplegia. (PMID: 11814680) Nobile C … Michelucci R (Gene 2002) 2 3 4 54
  2. An oligodendrocyte enhancer in a phylogenetically conserved intron region of the mammalian myelin gene Opalin. (PMID: 17442045) Aruga J … Furuichi T (Journal of neurochemistry 2007) 2 3 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3 54
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54

Products for OPALIN Gene

Sources for OPALIN Gene