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Aliases for OPALIN Gene

Aliases for OPALIN Gene

  • Oligodendrocytic Myelin Paranodal And Inner Loop Protein 2 3 4 5
  • Transmembrane Protein 10 2 3 4
  • TMEM10 3 4
  • HTMP10 3 4
  • Transmembrane Protein TMP10 3
  • Opalin 3
  • TMP10 3

External Ids for OPALIN Gene

Previous HGNC Symbols for OPALIN Gene

  • TMEM10

Previous GeneCards Identifiers for OPALIN Gene

  • GC10M098093
  • GC10M091730

Summaries for OPALIN Gene

GeneCards Summary for OPALIN Gene

OPALIN (Oligodendrocytic Myelin Paranodal And Inner Loop Protein) is a Protein Coding gene.

Gene Wiki entry for OPALIN Gene

Additional gene information for OPALIN Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OPALIN Gene

Genomics for OPALIN Gene

GeneHancer (GH) Regulatory Elements for OPALIN Gene

Promoters and enhancers for OPALIN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J096358 Promoter/Enhancer 0.7 EPDnew dbSUPER 650.7 +0.3 346 0.1 OPALIN GC10P096338 GC10M096095
GH10J096286 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9.7 +70.4 70429 5.2 PKNOX1 FOXA2 SMAD1 ZNF133 IRF4 YY1 ZFP91 ATF7 RUNX3 RXRA BLNK OPALIN RNU6-271P TLL2 DNTT GC10M096095
GH10J095906 Promoter/Enhancer 1.5 Ensembl ENCODE 9.2 +451.8 451764 2 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF213 ZNF207 ZNF143 SP3 CC2D2B ENTPD1 OPALIN TCTN3 PIR62915 ENSG00000270099 ENTPD1-AS1
GH10J096242 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.1 +115.9 115861 3.4 EBF1 BATF YY1 RELA POLR2A NFATC1 EED HNF4G ATF7 ETV6 BLNK OPALIN CC2D2B GC10M096216 GC10M096200 GC10M096095
GH10J096292 Enhancer 1 Ensembl ENCODE dbSUPER 9.7 +65.8 65835 1.1 CTCF ZNF654 FOXA2 RXRA TRIM22 REST IRF4 RAD21 RFX5 SKI BLNK OPALIN RNU6-271P ENSG00000229418 DNTT GC10M096095
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OPALIN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OPALIN gene promoter:
  • YY1
  • Max1
  • c-Myc
  • STAT1
  • STAT1alpha
  • STAT1beta
  • CUTL1
  • COMP1
  • AML1a
  • GCNF

Genomic Locations for OPALIN Gene

Genomic Locations for OPALIN Gene
chr10:96,343,216-96,359,365
(GRCh38/hg38)
Size:
16,150 bases
Orientation:
Minus strand
chr10:98,102,973-98,119,092
(GRCh37/hg19)
Size:
16,120 bases
Orientation:
Minus strand

Genomic View for OPALIN Gene

Genes around OPALIN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OPALIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OPALIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OPALIN Gene

Proteins for OPALIN Gene

  • Protein details for OPALIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PE5-OPALI_HUMAN
    Recommended name:
    Opalin
    Protein Accession:
    Q96PE5
    Secondary Accessions:
    • A8MX69
    • A8MYG4
    • B4DK96
    • B4DKH0
    • Q5W102

    Protein attributes for OPALIN Gene

    Size:
    141 amino acids
    Molecular mass:
    15683 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OPALIN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OPALIN Gene

Post-translational modifications for OPALIN Gene

  • Glycosylation at isoforms=214, Asn12, and Asn6
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for OPALIN Gene

Domains & Families for OPALIN Gene

Gene Families for OPALIN Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for OPALIN Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with OPALIN: view

No data available for UniProtKB/Swiss-Prot for OPALIN Gene

Function for OPALIN Gene

genes like me logo Genes that share phenotypes with OPALIN: view

Animal Model Products

miRNA for OPALIN Gene

miRTarBase miRNAs that target OPALIN

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OPALIN Gene

Localization for OPALIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for OPALIN Gene

Cell membrane; Single-pass type I membrane protein. Note=In the CNS, enriched in the myelin paranodal and inner loop membranes, but not that of the PNS. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OPALIN gene
Compartment Confidence
plasma membrane 5
golgi apparatus 5
extracellular 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for OPALIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0044291 cell-cell contact zone IEA --
genes like me logo Genes that share ontologies with OPALIN: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OPALIN Gene

Pathways & Interactions for OPALIN Gene

SuperPathways for OPALIN Gene

No Data Available

Interacting Proteins for OPALIN Gene

Selected Interacting proteins: Q96PE5-OPALI_HUMAN for OPALIN Gene via IID

Symbol External ID(s) Details
--

Gene Ontology (GO) - Biological Process for OPALIN Gene

None

No data available for Pathways by source and SIGNOR curated interactions for OPALIN Gene

Drugs & Compounds for OPALIN Gene

No Compound Related Data Available

Transcripts for OPALIN Gene

Unigene Clusters for OPALIN Gene

Oligodendrocytic myelin paranodal and inner loop protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OPALIN Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - - - -
SP2: - -
SP3: - - - - - -
SP4: - - - - -
SP5: -
SP6:

Relevant External Links for OPALIN Gene

GeneLoc Exon Structure for
OPALIN
ECgene alternative splicing isoforms for
OPALIN

Expression for OPALIN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OPALIN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OPALIN Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x8.3), Brain - Amygdala (x7.6), Brain - Hippocampus (x7.3), Brain - Caudate (basal ganglia) (x5.6), and Brain - Substantia nigra (x4.3).

Protein differential expression in normal tissues from HIPED for OPALIN Gene

This gene is overexpressed in Frontal cortex (65.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OPALIN Gene



Protein tissue co-expression partners for OPALIN Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OPALIN Gene:

OPALIN

SOURCE GeneReport for Unigene cluster for OPALIN Gene:

Hs.12449

mRNA Expression by UniProt/SwissProt for OPALIN Gene:

Q96PE5-OPALI_HUMAN
Tissue specificity: Brain specific.

Evidence on tissue expression from TISSUES for OPALIN Gene

  • Nervous system(5)
  • Lung(4)
genes like me logo Genes that share expression patterns with OPALIN: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for OPALIN Gene

Orthologs for OPALIN Gene

This gene was present in the common ancestor of mammals.

Orthologs for OPALIN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OPALIN 34 33
  • 99.29 (n)
OneToOne
dog
(Canis familiaris)
Mammalia OPALIN 34 33
  • 87.23 (n)
OneToOne
cow
(Bos Taurus)
Mammalia OPALIN 34 33
  • 83.45 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Opalin 16 34 33
  • 78.96 (n)
rat
(Rattus norvegicus)
Mammalia Opalin 33
  • 78.01 (n)
oppossum
(Monodelphis domestica)
Mammalia OPALIN 34
  • 41 (a)
OneToOne
Species where no ortholog for OPALIN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OPALIN Gene

ENSEMBL:
Gene Tree for OPALIN (if available)
TreeFam:
Gene Tree for OPALIN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OPALIN: view image

Paralogs for OPALIN Gene

No data available for Paralogs for OPALIN Gene

Variants for OPALIN Gene

Sequence variations from dbSNP and Humsavar for OPALIN Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000121271 -- 96,353,164(-) C/A intron_variant
rs1000175447 -- 96,353,546(-) G/A intron_variant
rs1000300067 -- 96,359,472(-) C/A upstream_transcript_variant
rs1000401931 -- 96,359,791(-) G/A upstream_transcript_variant
rs1000447957 -- 96,347,584(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OPALIN Gene

Variant ID Type Subtype PubMed ID
nsv1110852 OTHER inversion 24896259
nsv1137947 CNV deletion 24896259
nsv831949 CNV gain 17160897
nsv831950 CNV gain 17160897

Variation tolerance for OPALIN Gene

Residual Variation Intolerance Score: 82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 33.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OPALIN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OPALIN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OPALIN Gene

Disorders for OPALIN Gene

Additional Disease Information for OPALIN

No disorders were found for OPALIN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OPALIN Gene

Publications for OPALIN Gene

  1. Identification and characterization of a novel human brain-specific gene, homologous to S. scrofa tmp83.5, in the chromosome 10q24 critical region for temporal lobe epilepsy and spastic paraplegia. (PMID: 11814680) Nobile C … Michelucci R (Gene 2002) 2 3 4 58
  2. An oligodendrocyte enhancer in a phylogenetically conserved intron region of the mammalian myelin gene Opalin. (PMID: 17442045) Aruga J … Furuichi T (Journal of neurochemistry 2007) 2 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Opalin, a transmembrane sialylglycoprotein located in the central nervous system myelin paranodal loop membrane. (PMID: 18490449) Yoshikawa F … Furuichi T (The Journal of biological chemistry 2008) 3 58
  5. Identification of Tmem10/Opalin as a novel marker for oligodendrocytes using gene expression profiling. (PMID: 18439243) Kippert A … Simons M (BMC neuroscience 2008) 22 58

Products for OPALIN Gene

Sources for OPALIN Gene

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