Free for academic non-profit institutions. Other users need a Commercial license
Aliases for OOSP2 Gene
Aliases for OOSP2 Gene
External Ids for OOSP2 Gene
- HGNC: 26699
- Entrez Gene: 219990
- Ensembl: ENSG00000149507
- UniProtKB: Q86WS3
Previous HGNC Symbols for OOSP2 Gene
- TMEM122
- PLAC1L
Previous GeneCards Identifiers for OOSP2 Gene
- GC11P059808
Summaries for OOSP2 Gene
GeneCards Summary for OOSP2 Gene
OOSP2 (Oocyte Secreted Protein 2) is a Protein Coding gene. An important paralog of this gene is PLAC1.
Additional gene information for OOSP2 Gene
- HGNC(26699)
- Entrez Gene(219990)
- Ensembl(ENSG00000149507)
- UniProtKB(Q86WS3)
- Open Targets Platform(ENSG00000149507)
- Search for OOSP2 at DataMed
- Search for OOSP2 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OOSP2 Gene
Genomics for OOSP2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for OOSP2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH11J060040 | Promoter | 0.3 | EPDnew | 600.7 | 0.0 | -19 | 0.1 | HSALNG0084438 OOSP2 NONHSAG008420.2 OOSP4B | ||
| GH11J060038 | Enhancer | 0.2 | Ensembl | 600.7 | -1.7 | -1708 | 0.2 | HSALNG0084438 OOSP2 NONHSAG008420.2 OOSP4B | ||
| GH11J060039 | Enhancer | 0.2 | Ensembl | 600.7 | -0.9 | -908 | 0.6 | HSALNG0084438 OOSP2 NONHSAG008420.2 OOSP4B | ||
| GH11J059968 | Enhancer | 0.9 | FANTOM5 | 11.2 | -72.1 | -72138 | 0.3 | LEF1 IKZF1 JUND DDX20 PKNOX1 ZNF24 REST ZNF740 BRD9 DPF2 | OOSP2 MS4A3 MS4A2 MRPL16 OOSP4A OOSP4B OOSP1 ENSG00000214788 | |
| GH11J060204 | Enhancer | 0.9 | Ensembl dbSUPER | 10.2 | +165.3 | 165292 | 2.6 | BACH1 JUND RELA TCF12 IKZF2 TRIM22 PKNOX1 EED ARID3A DPF2 | TCN1 OOSP2 MS4A6A MS4A4E MIR6503 piR-55655-088 MS4A4A |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around OOSP2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OOSP2
Genomic Locations for OOSP2 Gene
Genomic Locations for OOSP2 Gene
- chr11:60,040,409-60,048,044
- (GRCh38/hg38)
- Size:
- 7,636 bases
- Orientation:
- Plus strand
- chr11:59,807,748-59,815,517
- (GRCh37/hg19)
- Size:
- 7,770 bases
- Orientation:
- Plus strand
Genomic View for OOSP2 Gene
Genes around OOSP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q12.1 by HGNC
- 11q12.1 by Entrez Gene
- 11q12.1 by Ensembl
OOSP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for OOSP2 Gene
Proteins for OOSP2 Gene
-
Protein details for OOSP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86WS3-OOSP2_HUMAN
- Recommended name:
- Oocyte-secreted protein 2
- Protein Accession:
- Q86WS3
- E9PJA4
- Q8N9U6
Protein attributes for OOSP2 Gene
- Size:
- 158 amino acids
- Molecular mass:
- 17971 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AP000790; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Post-translational modifications for OOSP2 Gene
Other Protein References for OOSP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for OOSP2
- Novus Biologicals Antibodies for OOSP2
- Invitrogen Antibodies for OOSP2 (AFLGC-Oosp2)
- antibodies-online: Show 12 available PLAC1L Antibodies ranked by validation data
Protein Products
-
OriGene Purified Proteins for OOSP2
- Search Origene for MassSpec and Protein Over-expression Lysates for OOSP2
- Origene Custom Protein Services for OOSP2
-
Abcam proteins for OOSP2
No data available for DME Specific Peptides for OOSP2 Gene
Domains & Families for OOSP2 Gene
Gene Families for OOSP2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted secreted proteins
Suggested Antigen Peptide Sequences for OOSP2 Gene
- GenScript: Design optimal peptide antigens:
-
- Placenta-specific 1-like protein (PLACL_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q86WS3- Family:
-
- Belongs to the PLAC1 family.
Function for OOSP2 Gene
Phenotypes From GWAS Catalog for OOSP2 Gene
Phenotypes for OOSP2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for OOSP2 - Select products 50% OFF >
- * OOSP2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for OOSP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for OOSP2
miRNA for OOSP2 Gene
- miRTarBase miRNAs that target OOSP2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for OOSP2
- Browse OriGene Inhibitory RNA Products For OOSP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OOSP2
Clone Products
- Applied Biological Materials (abm): Clones for OOSP2 - Select products 50% OFF >
- * OOSP2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for OOSP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for OOSP2
Cell Line Products
-
Horizon Cell Lines for OOSP2
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OOSP2 Gene
Localization for OOSP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for OOSP2 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 4 |
| plasma membrane | 1 |
| endoplasmic reticulum | 0 |
| lysosome | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for OOSP2 Gene
Pathways & Interactions for OOSP2 Gene
Interacting Proteins for OOSP2 Gene
GPS-Prot Interaction Network for OOSP2
No data available for Pathways by source and SIGNOR curated interactions for OOSP2 Gene
Transcripts for OOSP2 Gene
mRNA/cDNA for OOSP2 Gene
- 1 REFSEQ mRNAs :
- 4 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000278855 1499 nts (view in UCSC)
- ENST00000527395 329 nts (view in UCSC)
- ENST00000532905 496 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for OOSP2 - Select products 50% OFF >
- * OOSP2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for OOSP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for OOSP2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for OOSP2
- Browse OriGene Inhibitory RNA Products For OOSP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OOSP2
Clone Products
- Applied Biological Materials (abm): Clones for OOSP2 - Select products 50% OFF >
- * OOSP2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for OOSP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for OOSP2
Relevant External Links for OOSP2 Gene
- GeneLoc Exon Structure for
- OOSP2
Expression for OOSP2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Ovary (Reproductive System)
- Secondary Oocyte Antral Follicle
- Secondary follicles
-
Gonad
- Secondary Oocyte Antral Follicle
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for OOSP2 Gene
This gene is overexpressed in Testis (x52.4).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OOSP2
Primer Products
-
OriGene qPCR primer pairs for OOSP2
-
OriGene qPCR primer pairs and template standards for OOSP2
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OOSP2 Gene
Orthologs for OOSP2 Gene
This gene was present in the common ancestor of human and mouse.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PLAC1L 30 |
|
||
| OOSP2 31 |
|
OneToOne | |||
| Mouse (Mus musculus) |
Mammalia | Oosp2 30 17 |
|
||
| Plac1l 31 |
|
OneToOne | |||
| Rat (Rattus norvegicus) |
Mammalia | Oosp2 30 |
|
- Species where no ortholog for OOSP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Cow (Bos Taurus)
- Dog (Canis familiaris)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for OOSP2 Gene
- ENSEMBL:
- Gene Tree for OOSP2 (if available)
- TreeFam:
- Gene Tree for OOSP2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for OOSP2: view image
Paralogs for OOSP2 Gene
Variants for OOSP2 Gene
Residual Variation Intolerance Score:
50% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.17;
23.64% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for OOSP2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- OOSP2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OOSP2 Gene
Disorders for OOSP2 Gene
Additional Disease Information for OOSP2
No disorders were found for OOSP2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OOSP2 Gene
Publications for OOSP2 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods NT … Monteiro AN (Science signaling 2012) 3
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4
ExternalLinks
Products for OOSP2 Gene
- Custom Antibody ServicesOriGene Antibodies for OOSP2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for OOSP2
- Search Origene for MassSpec and Protein Over-expression Lysates for OOSP2
- Origene Custom Protein Services for OOSP2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for OOSP2
- Browse OriGene Inhibitory RNA Products For OOSP2
- OriGene qPCR primer pairs for OOSP2
- OriGene qPCR primer pairs and template standards for OOSP2
- OriGene CRISPR knockouts for OOSP2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For OOSP2
- Sino Biological Human cDNA Clone for OOSP2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for OOSP2
- Novus Biologicals proteins and lysates for OOSP2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam proteins for OOSP2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for OOSP2 (AFLGC-Oosp2)
- VectorBuilder Custom and pre-made DNA vectors for OOSP2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for OOSP2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for OOSP2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for OOSP2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for OOSP2
- antibodies-online: Show 12 available PLAC1L Antibodies ranked by validation data
- antibodies-online: Search results for available PLAC1L related products ranked by validation data
- antibodies-online: Search results for available PLAC1L related products ranked by validation data
- Horizon Cell Lines for OOSP2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for OOSP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for OOSP2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for OOSP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OOSP2
Sources for OOSP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB