OOSP2 Gene (Protein Coding)

Oocyte Secreted Protein 2

GC11P060040
GIFtS:
28
See more...

Aliases for OOSP2 Gene

Aliases for OOSP2 Gene

  • Oocyte Secreted Protein 2 2 3 5
  • Placenta-Specific 1-Like Protein 3 4
  • Transmembrane Protein 122 2 3
  • Oocyte-Secreted Protein 2 3 4
  • TMEM122 3 4
  • OOSP2A 2 3
  • PLAC1L 3 4
  • Testicular Tissue Protein Li 142 3
  • Placenta-Specific 1-Like 2
  • Protein TMEM122 4
  • FLJ36198 2
  • OOSP2 5

External Ids for OOSP2 Gene

Previous HGNC Symbols for OOSP2 Gene

  • TMEM122
  • PLAC1L

Previous GeneCards Identifiers for OOSP2 Gene

  • GC11P059808

Summaries for OOSP2 Gene

GeneCards Summary for OOSP2 Gene

OOSP2 (Oocyte Secreted Protein 2) is a Protein Coding gene. Diseases associated with OOSP2 include Postinfectious Encephalitis. An important paralog of this gene is PLAC1.

Additional gene information for OOSP2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OOSP2 Gene

Genomics for OOSP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for OOSP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH11J060040 Promoter 0.3 EPDnew 250.7 0.0 -19 0.1 HSALNG0084438 OOSP2 NONHSAG008420.2 OOSP4B
GH11J060039 Enhancer 0.2 Ensembl 250.7 -0.9 -908 0.6 HSALNG0084438 OOSP2 NONHSAG008420.2 OOSP4B
GH11J060038 Enhancer 0.2 Ensembl 250.7 -1.7 -1708 0.2 HSALNG0084438 OOSP2 NONHSAG008420.2 OOSP4B
GH11J059968 Enhancer 0.9 FANTOM5 11.2 -72.1 -72138 0.3 IKZF1 MBD2 ARNT REST ZNF395 ZEB2 TAL1 NCOR1 MYNN ZNF316 OOSP2 MS4A3 MS4A2 MRPL16 OOSP4A OOSP4B ENSG00000214788 OOSP1
GH11J060204 Enhancer 0.9 Ensembl dbSUPER 10.2 +165.3 165292 2.6 BCL11A TRIM22 IRF4 EBF1 FOSL1 CBFB NFE2 BHLHE40 BATF STAT5A TCN1 OOSP2 MS4A6A MS4A4E MIR6503 piR-55655-088 HSALNG0084449 MS4A4A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OOSP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OOSP2

Genomic Locations for OOSP2 Gene

Latest Assembly
chr11:60,040,409-60,048,044
(GRCh38/hg38)
Size:
7,636 bases
Orientation:
Plus strand

Previous Assembly
chr11:59,807,882-59,815,517
(GRCh37/hg19 by Entrez Gene)
Size:
7,636 bases
Orientation:
Plus strand

chr11:59,807,748-59,815,517
(GRCh37/hg19 by Ensembl)
Size:
7,770 bases
Orientation:
Plus strand

Genomic View for OOSP2 Gene

Genes around OOSP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OOSP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OOSP2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for OOSP2 Gene

Proteins for OOSP2 Gene

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  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for OOSP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WS3-OOSP2_HUMAN
    Recommended name:
    Oocyte-secreted protein 2
    Protein Accession:
    Q86WS3
    Secondary Accessions:
    • E9PJA4
    • Q8N9U6

    Protein attributes for OOSP2 Gene

    Size:
    158 amino acids
    Molecular mass:
    17971 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AP000790; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for OOSP2 Gene

Post-translational modifications for OOSP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OOSP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OOSP2 Gene

Domains & Families for OOSP2 Gene

Gene Families for OOSP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for OOSP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OOSP2 Gene

GenScript: Design optimal peptide antigens:
  • Placenta-specific 1-like protein (PLACL_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86WS3

UniProtKB/Swiss-Prot:

OOSP2_HUMAN :
  • Belongs to the PLAC1 family.
Family:
  • Belongs to the PLAC1 family.
genes like me logo Genes that share domains with OOSP2: view

Function for OOSP2 Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Phenotypes From GWAS Catalog for OOSP2 Gene

Gene Ontology (GO) - Molecular Function for OOSP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32814053
genes like me logo Genes that share ontologies with OOSP2: view
genes like me logo Genes that share phenotypes with OOSP2: view

miRNA for OOSP2 Gene

miRTarBase miRNAs that target OOSP2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OOSP2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OOSP2 Gene

Localization for OOSP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OOSP2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OOSP2 gene
Compartment Confidence
extracellular 4
plasma membrane 1
endoplasmic reticulum 0
lysosome 0

Gene Ontology (GO) - Cellular Components for OOSP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OOSP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OOSP2 Gene

Pathways & Interactions for OOSP2 Gene

PathCards logo

SuperPathways for OOSP2 Gene

No Data Available

Interacting Proteins for OOSP2 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: Q86WS3-OOSP2_HUMAN ENSP00000278855 for OOSP2 Gene via UniProtKB STRING IID

GPS-Prot Interaction Network for OOSP2

Gene Ontology (GO) - Biological Process for OOSP2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for OOSP2 Gene

Drugs & Compounds for OOSP2 Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for OOSP2 Gene

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  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for OOSP2 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OOSP2

Alternative Splicing Database (ASD) splice patterns (SP) for OOSP2 Gene

No ASD Table

Relevant External Links for OOSP2 Gene

GeneLoc Exon Structure for
OOSP2

Expression for OOSP2 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OOSP2 Gene

mRNA expression in normal human tissues for OOSP2 Gene
mRNA expression by BioGPS for OOSP2 GenemRNA expression by GTEx for OOSP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OOSP2 Gene

This gene is overexpressed in Testis (x52.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OOSP2

genes like me logo Genes that share expression patterns with OOSP2: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OOSP2 Gene

Orthologs for OOSP2 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for OOSP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia PLAC1L 30
  • 99.37 (n)
OOSP2 31
  • 99 (a)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Oosp2 30 17
  • 71.24 (n)
Plac1l 31
  • 50 (a)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Oosp2 30
  • 68.64 (n)
Species where no ortholog for OOSP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for OOSP2 Gene

ENSEMBL:
Gene Tree for OOSP2 (if available)
TreeFam:
Gene Tree for OOSP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OOSP2: view image

Paralogs for OOSP2 Gene

Paralogs for OOSP2 Gene

genes like me logo Genes that share paralogs with OOSP2: view

Variants for OOSP2 Gene

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dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OOSP2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OOSP2 Gene

Variant ID Type Subtype PubMed ID
nsv336 CNV insertion 18451855
nsv468579 CNV gain 19166990
nsv509411 CNV insertion 20534489
nsv555150 CNV gain 21841781
nsv832173 CNV gain 17160897

Variation tolerance for OOSP2 Gene

Residual Variation Intolerance Score: 50% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.17; 23.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OOSP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OOSP2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OOSP2 Gene

Disorders for OOSP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OOSP2 Gene - From: COP

Disorder Aliases PubMed IDs
postinfectious encephalitis
  • postinfective encephalitis
- elite association - COSMIC cancer census association via MalaCards
Search OOSP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OOSP2

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with OOSP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OOSP2 Gene

Publications for OOSP2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  4. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains. (PMID: 32814053) Haenig C … Wanker EE (Cell reports 2020) 3
  5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods NT … Monteiro AN (Science signaling 2012) 3

ExternalLinks

View latest publications for OOSP2 gene in Mastermind

Products for OOSP2 Gene

Sources for OOSP2 Gene