Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OOEP Gene

Aliases for OOEP Gene

  • Oocyte Expressed Protein 2 3 5
  • KH Homology Domain-Containing Protein 2 3 4
  • Oocyte Expressed Protein Homolog (Dog) 2 3
  • Oocyte- And Embryo-Specific Protein 19 3 4
  • KH Homology Domain Containing 2 2 3
  • C6orf156 3 4
  • HOEP19 3 4
  • KHDC2 3 4
  • Chromosome 6 Open Reading Frame 156 2
  • Oocyte-Expressed Protein Homolog 3
  • Oocyte And Embryo Protein 19 3
  • FLOPED 3
  • OEP19 4

External Ids for OOEP Gene

Previous HGNC Symbols for OOEP Gene

  • C6orf156

Previous GeneCards Identifiers for OOEP Gene

  • GC06M074137
  • GC06M074079
  • GC06M071276

Summaries for OOEP Gene

GeneCards Summary for OOEP Gene

OOEP (Oocyte Expressed Protein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include RNA binding. An important paralog of this gene is KHDC3L.

UniProtKB/Swiss-Prot for OOEP Gene

  • As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions.

Additional gene information for OOEP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OOEP Gene

Genomics for OOEP Gene

GeneHancer (GH) Regulatory Elements for OOEP Gene

Promoters and enhancers for OOEP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I073394 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 561.1 +0.3 328 1.3 PKNOX1 ZNF687 CLOCK DDX20 CHD1 MAX SIN3A MNT ZBTB7B ZNF217 OOEP DDX43 MTO1
GH06I073369 Promoter 0.6 EPDnew 550.3 +25.3 25262 0.1 ZBTB33 OOEP-AS1 OOEP RPL39P3
GH06I073421 Enhancer 1 Ensembl ENCODE 11.8 -27.3 -27304 2 HDAC1 PKNOX1 ATF1 NFRKB TCF12 ZNF766 ATF7 RUNX3 CREM ZBTB11 OOEP DDX43 RPS6P8 RPL39P3 OOEP-AS1 CGAS
GH06I073348 Enhancer 0.5 ENCODE 11.2 +45.8 45795 2.2 SP1 POU5F1 ETS1 EZH2 OOEP-AS1 RPL39P3 OOEP KHDC1 RPS6P8 DDX43 MTO1 SLC17A5 DPPA5 PAICSP3
GH06I073247 Promoter 0.5 EPDnew 10.5 +147.6 147641 0.1 KHDC1 OOEP DDX43 RPS6P8 GC06P073237 ENSG00000243501
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OOEP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OOEP gene promoter:

Genomic Locations for OOEP Gene

Genomic Locations for OOEP Gene
chr6:73,368,555-73,395,133
(GRCh38/hg38)
Size:
26,579 bases
Orientation:
Minus strand
chr6:74,078,278-74,104,856
(GRCh37/hg19)

Genomic View for OOEP Gene

Genes around OOEP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OOEP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OOEP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OOEP Gene

Proteins for OOEP Gene

  • Protein details for OOEP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NGQ2-OOEP_HUMAN
    Recommended name:
    Oocyte-expressed protein homolog
    Protein Accession:
    A6NGQ2
    Secondary Accessions:
    • A6NIN5
    • A9UIB7

    Protein attributes for OOEP Gene

    Size:
    149 amino acids
    Molecular mass:
    17170 Da
    Quaternary structure:
    • Component of the SCMC which also includes at least KHDC3L, NLRP5 and TLE6.

neXtProt entry for OOEP Gene

Post-translational modifications for OOEP Gene

No Post-translational modifications

Other Protein References for OOEP Gene

No data available for DME Specific Peptides for OOEP Gene

Domains & Families for OOEP Gene

Gene Families for OOEP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for OOEP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OOEP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NGQ2

UniProtKB/Swiss-Prot:

OOEP_HUMAN :
  • Contains an atypical KH domain with amino acid changes at critical sites, suggesting that it may not bind RNA.
  • Belongs to the KHDC1 family.
Domain:
  • Contains an atypical KH domain with amino acid changes at critical sites, suggesting that it may not bind RNA.
Family:
  • Belongs to the KHDC1 family.
genes like me logo Genes that share domains with OOEP: view

Function for OOEP Gene

Molecular function for OOEP Gene

UniProtKB/Swiss-Prot Function:
As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions.

Phenotypes From GWAS Catalog for OOEP Gene

Gene Ontology (GO) - Molecular Function for OOEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26537248
genes like me logo Genes that share ontologies with OOEP: view

Phenotypes for OOEP Gene

MGI mutant phenotypes for OOEP:
inferred from 2 alleles
GenomeRNAi human phenotypes for OOEP:
genes like me logo Genes that share phenotypes with OOEP: view

Animal Models for OOEP Gene

MGI Knock Outs for OOEP:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OOEP Gene

Localization for OOEP Gene

Subcellular locations from UniProtKB/Swiss-Prot for OOEP Gene

Cytoplasm. Note=In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages. From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OOEP gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for OOEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0043234 protein complex IDA 26537248
genes like me logo Genes that share ontologies with OOEP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OOEP Gene

Pathways & Interactions for OOEP Gene

No Data Available

Gene Ontology (GO) - Biological Process for OOEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with OOEP: view

No data available for Pathways by source and SIGNOR curated interactions for OOEP Gene

Drugs & Compounds for OOEP Gene

No Compound Related Data Available

Transcripts for OOEP Gene

mRNA/cDNA for OOEP Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OOEP Gene

Oocyte expressed protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OOEP Gene

No ASD Table

Relevant External Links for OOEP Gene

GeneLoc Exon Structure for
OOEP
ECgene alternative splicing isoforms for
OOEP

Expression for OOEP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OOEP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OOEP Gene

This gene is overexpressed in Testis (x31.3).

NURSA nuclear receptor signaling pathways regulating expression of OOEP Gene:

OOEP

SOURCE GeneReport for Unigene cluster for OOEP Gene:

Hs.671212
genes like me logo Genes that share expression patterns with OOEP: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OOEP Gene

Orthologs for OOEP Gene

This gene was present in the common ancestor of mammals.

Orthologs for OOEP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OOEP 33 34
  • 99.33 (n)
dog
(Canis familiaris)
Mammalia OOEP 33 34
  • 78.75 (n)
cow
(Bos Taurus)
Mammalia OOEP 33 34
  • 77.38 (n)
mouse
(Mus musculus)
Mammalia Ooep 33 16 34
  • 68.21 (n)
Species where no ortholog for OOEP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OOEP Gene

ENSEMBL:
Gene Tree for OOEP (if available)
TreeFam:
Gene Tree for OOEP (if available)

Paralogs for OOEP Gene

Paralogs for OOEP Gene

(2) SIMAP similar genes for OOEP Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for OOEP Gene

genes like me logo Genes that share paralogs with OOEP: view

Variants for OOEP Gene

Sequence variations from dbSNP and Humsavar for OOEP Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000338324 -- 73,369,521(-) AAA/A intron_variant
rs1000853553 -- 73,370,582(-) C/G upstream_transcript_variant
rs1000941999 -- 73,370,608(-) G/A upstream_transcript_variant
rs1001305732 -- 73,370,271(-) C/T upstream_transcript_variant
rs1001310409 -- 73,370,906(-) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OOEP Gene

Variant ID Type Subtype PubMed ID
nsv830693 CNV loss 17160897

Variation tolerance for OOEP Gene

Residual Variation Intolerance Score: 48.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.78; 47.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OOEP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OOEP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OOEP Gene

Disorders for OOEP Gene

Additional Disease Information for OOEP

No disorders were found for OOEP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OOEP Gene

Publications for OOEP Gene

  1. Atypical structure and phylogenomic evolution of the new eutherian oocyte- and embryo-expressed KHDC1/DPPA5/ECAT1/OOEP gene family. (PMID: 17913455) Pierre A … Monget P (Genomics 2007) 2 3 4 58
  2. TLE6 mutation causes the earliest known human embryonic lethality. (PMID: 26537248) Alazami AM … Alkuraya FS (Genome biology 2015) 3 4 58
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. The sequence of the human genome. (PMID: 11181995) Venter JC … Zhu X (Science (New York, N.Y.) 2001) 3 58

Products for OOEP Gene

Sources for OOEP Gene

Content
Loading form....