Aliases for ONECUT3 Gene

Aliases for ONECUT3 Gene

  • One Cut Homeobox 3 2 3 4 5
  • One Cut Domain Family Member 3 3 4
  • Transcription Factor ONECUT-3 3 4
  • OC-3 3 4
  • One Cut Domain, Family Member 3 2
  • OC3 3

External Ids for ONECUT3 Gene

Previous GeneCards Identifiers for ONECUT3 Gene

  • GC19U990205
  • GC19P001727
  • GC19P001506

Summaries for ONECUT3 Gene

GeneCards Summary for ONECUT3 Gene

ONECUT3 (One Cut Homeobox 3) is a Protein Coding gene. Diseases associated with ONECUT3 include Dracunculiasis. Among its related pathways are Regulation of beta-cell development and Developmental Biology. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is ONECUT1.

UniProtKB/Swiss-Prot Summary for ONECUT3 Gene

  • Transcriptional activator. Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR (By similarity).

Additional gene information for ONECUT3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ONECUT3 Gene

Genomics for ONECUT3 Gene

GeneHancer (GH) Regulatory Elements for ONECUT3 Gene

Promoters and enhancers for ONECUT3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J001753 Enhancer 0.7 ENCODE dbSUPER 500.7 0.0 -19 0.1 ZIC2 EZH2 POLR2A SUZ12 GLIS1 RNF2 MAZ PATZ1 ZBTB20 ZFX ONECUT3 ENSG00000267073
GH19J001725 Promoter/Enhancer 1.4 FANTOM5 ENCODE CraniofacialAtlas 12.1 -27.8 -27783 0.7 NRF1 ZBTB5 ZBTB26 RFX1 ZBTB25 MYC HINFP ZNF341 RBM25 OSR2 ENSG00000275642 ONECUT3 ATP8B3 REXO1 RNU6-1223P TCF3 APC2 CBARP HSALNG0123072
GH19J001788 Promoter 0.7 Ensembl 13.4 +36.5 36495 1.2 GABPB1 VEZF1 ZBTB33 EZH2 HNRNPL SUZ12 CTCF KDM1A ONECUT3 RF00017-2728 piR-54452 ATP8B3
GH19J001696 Enhancer 0.6 Ensembl 12.5 -51.9 -51906 1.2 TRIM25 EZH2 BCOR HDAC2 NCOA4 POLR2A ZNF48 ZNF366 ZNF202 MCM2 ONECUT3 TCF3 RNU6-1223P ENSG00000275642 lnc-ONECUT3-4
GH19J001745 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 1.8 -5.6 -5554 5.5 ZSCAN5C GTF2E2 ZNF639 ZIC2 POLR2A ZBTB10 ZNF263 ZBTB11 AFF1 ZBTB26 ENSG00000267073 HSALNG0123072 PWWP3A SLC39A3 FAM174C ATP8B3 REXO1 CIRBP DOT1L AP3D1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ONECUT3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ONECUT3

Top Transcription factor binding sites by QIAGEN in the ONECUT3 gene promoter:
  • HSF1 (long)
  • HSF1short
  • MZF-1
  • NF-1
  • NF-1/L
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for ONECUT3 Gene

Genomic Locations for ONECUT3 Gene
chr19:1,753,506-1,780,988
(GRCh38/hg38)
Size:
27,483 bases
Orientation:
Plus strand
chr19:1,752,372-1,780,987
(GRCh37/hg19)
Size:
28,616 bases
Orientation:
Plus strand

Genomic View for ONECUT3 Gene

Genes around ONECUT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ONECUT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ONECUT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ONECUT3 Gene

Proteins for ONECUT3 Gene

  • Protein details for ONECUT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60422-ONEC3_HUMAN
    Recommended name:
    One cut domain family member 3
    Protein Accession:
    O60422
    Secondary Accessions:
    • A8MZM7

    Protein attributes for ONECUT3 Gene

    Size:
    494 amino acids
    Molecular mass:
    50037 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ONECUT3 Gene

Post-translational modifications for ONECUT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ONECUT3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ONECUT3 Gene

Domains & Families for ONECUT3 Gene

Gene Families for ONECUT3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ONECUT3 Gene

Suggested Antigen Peptide Sequences for ONECUT3 Gene

GenScript: Design optimal peptide antigens:
  • Transcription factor ONECUT-3 (ONEC3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60422

UniProtKB/Swiss-Prot:

ONEC3_HUMAN :
  • Belongs to the CUT homeobox family.
Family:
  • Belongs to the CUT homeobox family.
genes like me logo Genes that share domains with ONECUT3: view

Function for ONECUT3 Gene

Molecular function for ONECUT3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator. Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR (By similarity).

Phenotypes From GWAS Catalog for ONECUT3 Gene

Gene Ontology (GO) - Molecular Function for ONECUT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IEA --
GO:0003677 DNA binding IBA 21873635
GO:0003700 DNA-binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with ONECUT3: view

Phenotypes for ONECUT3 Gene

genes like me logo Genes that share phenotypes with ONECUT3: view

Animal Model Products

CRISPR Products

miRNA for ONECUT3 Gene

miRTarBase miRNAs that target ONECUT3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ONECUT3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ONECUT3 Gene

Localization for ONECUT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ONECUT3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ONECUT3 gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ONECUT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA 21873635
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with ONECUT3: view

Pathways & Interactions for ONECUT3 Gene

genes like me logo Genes that share pathways with ONECUT3: view

Gene Ontology (GO) - Biological Process for ONECUT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0030154 cell differentiation IBA 21873635
GO:0045944 positive regulation of transcription by RNA polymerase II IEA,IBA 21873635
genes like me logo Genes that share ontologies with ONECUT3: view

No data available for SIGNOR curated interactions for ONECUT3 Gene

Drugs & Compounds for ONECUT3 Gene

No Compound Related Data Available

Transcripts for ONECUT3 Gene

mRNA/cDNA for ONECUT3 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ONECUT3

Alternative Splicing Database (ASD) splice patterns (SP) for ONECUT3 Gene

No ASD Table

Relevant External Links for ONECUT3 Gene

GeneLoc Exon Structure for
ONECUT3

Expression for ONECUT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ONECUT3 Gene

mRNA differential expression in normal tissues according to GTEx for ONECUT3 Gene

This gene is overexpressed in Testis (x26.6), Stomach (x10.2), and Brain - Hypothalamus (x8.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ONECUT3

SOURCE GeneReport for Unigene cluster for ONECUT3 Gene:

Hs.654347
genes like me logo Genes that share expression patterns with ONECUT3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ONECUT3 Gene

Orthologs for ONECUT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ONECUT3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ONECUT3 31 30
  • 94.14 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Onecut3 31
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ONECUT3 31 30
  • 90.67 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 88 (a)
OneToMany
-- 31
  • 67 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ONECUT3 31
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves ONECUT3 31
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 53 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ONECUT3 (2 of 2) 31
  • 65 (a)
OneToMany
onecut3a 31
  • 64 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta onecut 31
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ceh-48 31
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 25 (a)
OneToMany
Species where no ortholog for ONECUT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ONECUT3 Gene

ENSEMBL:
Gene Tree for ONECUT3 (if available)
TreeFam:
Gene Tree for ONECUT3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ONECUT3: view image

Paralogs for ONECUT3 Gene

Paralogs for ONECUT3 Gene

(2) SIMAP similar genes for ONECUT3 Gene using alignment to 1 proteins:

  • ONEC3_HUMAN
genes like me logo Genes that share paralogs with ONECUT3: view

Variants for ONECUT3 Gene

Additional dbSNP identifiers (rs#s) for ONECUT3 Gene

Structural Variations from Database of Genomic Variants (DGV) for ONECUT3 Gene

Variant ID Type Subtype PubMed ID
esv2671081 CNV deletion 23128226
esv32942 CNV gain+loss 17666407
esv3893156 CNV loss 25118596
esv7507 CNV gain 19470904
nsv1072301 CNV deletion 25765185
nsv1129613 CNV tandem duplication 24896259
nsv1136265 CNV deletion 24896259
nsv1146134 CNV insertion 26484159
nsv953942 CNV deletion 24416366

Variation tolerance for ONECUT3 Gene

Gene Damage Index Score: 0.34; 7.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ONECUT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ONECUT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ONECUT3 Gene

Disorders for ONECUT3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ONECUT3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
dracunculiasis
  • dracontiasis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ONECUT3

genes like me logo Genes that share disorders with ONECUT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ONECUT3 Gene

Publications for ONECUT3 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 54
  2. OC-3, a novel mammalian member of the ONECUT class of transcription factors. (PMID: 11944891) Vanhorenbeeck V … Rousseau GG (Biochemical and biophysical research communications 2002) 3 4 54
  3. OC-2, a novel mammalian member of the ONECUT class of homeodomain transcription factors whose function in liver partially overlaps with that of hepatocyte nuclear factor-6. (PMID: 9915796) Jacquemin P … Lemaigre FP (The Journal of biological chemistry 1999) 2 3 54
  4. ONECUT transcription factors induce neuronal characteristics and remodel chromatin accessibility. (PMID: 31049588) van der Raadt J … Albers CA (Nucleic acids research 2019) 3 54
  5. Discrimination of CD44 and Oct3/4 Expression in Pancreatic Adenocarcinoma from Benign Pancreatic Ducts in Small Biopsy Specimens. (PMID: 28464601) Lee CC … Tsai WC (The Chinese journal of physiology 2017) 3 54

Products for ONECUT3 Gene

Sources for ONECUT3 Gene