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This gene encodes a member of the onecut family of transcription factors, which are characterized by a cut domain and an atypical homeodomain. The protein binds to specific DNA sequences and stimulates expression of target genes, including genes involved in melanocyte and hepatocyte differentiation. [provided by RefSeq, Jul 2008]
ONECUT2 (One Cut Homeobox 2) is a Protein Coding gene. Diseases associated with ONECUT2 include Suppurative Thyroiditis. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific. An important paralog of this gene is ONECUT1.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH18J057426 | Promoter/Enhancer | 2.5 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER | 769 | +1.4 | 1381 | 20.2 | CTCF ZBTB6 MLX RBPJ POLR2A NR2F1 NR2F6 CREB1 MIXL1 ZNF133 | ONECUT2 ST8SIA3 LINC02565 ENSG00000277837 lnc-ONECUT2-2 | |
GH18J056745 | Enhancer | 0.2 | Ensembl | 11.3 | -688.6 | -688573 | 2 | ONECUT2 TXNL1 KY994054-031 piR-50443-186 WDR7 | ||
GH18J056746 | Enhancer | 0.2 | Ensembl | 11.3 | -689.9 | -689873 | 0.2 | ONECUT2 KY994054-031 piR-50443-186 WDR7 | ||
GH18J056799 | Enhancer | 0.2 | Ensembl | 5.7 | -635.7 | -635673 | 1.4 | ONECUT2 lnc-BOD1L2-2 ENSG00000206865 WDR7 | ||
GH18J057447 | Enhancer | 1 | Ensembl ENCODE dbSUPER | 0.4 | +12.1 | 12127 | 1 | SP1 ZIC2 REST ZNF143 CTCF ZNF316 MAFK ZNF766 EHMT2 HDAC2 | ST8SIA3 ONECUT2 lnc-ONECUT2-2 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 11478782 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | NAS | 19274049 |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 11478782 |
GO:0003677 | DNA binding | IBA | 21873635 |
GO:0003700 | DNA-binding transcription factor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0015629 | actin cytoskeleton | IDA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001889 | liver development | IEA | -- |
GO:0001952 | regulation of cell-matrix adhesion | IEA | -- |
GO:0002064 | epithelial cell development | IEA | -- |
GO:0009653 | anatomical structure morphogenesis | IEA | -- |
GO:0009887 | animal organ morphogenesis | TAS | 9915796 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | ONECUT2 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | ONECUT2 33 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | ONECUT2 33 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | ONECUT2 33 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | ONECUT2 33 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Onecut2 17 33 32 |
|
||
rat (Rattus norvegicus) |
Mammalia | Onecut2 32 |
|
||
chicken (Gallus gallus) |
Aves | ONECUT2 33 32 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | ONECUT2 33 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | onecut2 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | ONECUT2 33 |
|
OneToOne | |
si:ch1073-41k10.1 32 |
|
||||
fruit fly (Drosophila melanogaster) |
Insecta | onecut 33 34 |
|
OneToMany | |
worm (Caenorhabditis elegans) |
Secernentea | C17H12.9 34 |
|
|
|
ceh-38 34 |
|
|
|||
ceh-48 33 |
|
OneToMany | |||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToMany |
SNP ID | Clin | Chr 18 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000004692 | -- | 57,434,927(+) | G/C | upstream_transcript_variant | |
rs1000141172 | -- | 57,468,289(+) | C/T | intron_variant | |
rs1000216654 | -- | 57,459,836(+) | G/A | intron_variant | |
rs1000238353 | -- | 57,484,371(+) | C/T | 3_prime_UTR_variant | |
rs1000273246 | -- | 57,444,158(+) | A/C | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1614n106 | CNV | deletion | 24896259 |
esv1478795 | CNV | insertion | 17803354 |
esv3347167 | CNV | insertion | 20981092 |
esv995991 | CNV | insertion | 20482838 |
nsv1072806 | CNV | deletion | 25765185 |
nsv476415 | CNV | novel sequence insertion | 20440878 |
nsv476913 | CNV | novel sequence insertion | 20440878 |
nsv828250 | CNV | gain | 20364138 |
nsv953552 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
suppurative thyroiditis |
|
|