ONECUT2 Gene (Protein Coding)

One Cut Homeobox 2

GC18P057436
GIFtS:
36
This gene encodes a member of the onecut family of transcription factors, which are characterized by a cut domain and an atypical homeodomain. The protein binds to specific DNA sequences and stimulates expression of target genes, including genes involved in melanocyte and hepatocyte differentiation. [provided by RefSeq, Jul 2008] See more...

Aliases for ONECUT2 Gene

Aliases for ONECUT2 Gene

  • One Cut Homeobox 2 2 3 4 5
  • Hepatocyte Nuclear Factor 6-Beta 3 4
  • One Cut Domain Family Member 2 3 4
  • Transcription Factor ONECUT-2 3 4
  • HNF-6-Beta 3 4
  • OC-2 3 4
  • ONECUT-2 Homeodomain Transcription Factor 3
  • One Cut Domain, Family Member 2 2
  • Onecut 2 3
  • HNF6B 4
  • OC2 3

External Ids for ONECUT2 Gene

Previous GeneCards Identifiers for ONECUT2 Gene

  • GC18P055133
  • GC18P054887
  • GC18P053251
  • GC18P053253
  • GC18P055102
  • GC18P051813

Summaries for ONECUT2 Gene

Entrez Gene Summary for ONECUT2 Gene

  • This gene encodes a member of the onecut family of transcription factors, which are characterized by a cut domain and an atypical homeodomain. The protein binds to specific DNA sequences and stimulates expression of target genes, including genes involved in melanocyte and hepatocyte differentiation. [provided by RefSeq, Jul 2008]

GeneCards Summary for ONECUT2 Gene

ONECUT2 (One Cut Homeobox 2) is a Protein Coding gene. Diseases associated with ONECUT2 include Suppurative Thyroiditis. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific. An important paralog of this gene is ONECUT1.

UniProtKB/Swiss-Prot Summary for ONECUT2 Gene

  • Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B.

Additional gene information for ONECUT2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ONECUT2 Gene

Genomics for ONECUT2 Gene

GeneHancer (GH) Regulatory Elements for ONECUT2 Gene

Promoters and enhancers for ONECUT2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH18J057426 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 769 +1.4 1381 20.2 CTCF ZBTB6 MLX RBPJ POLR2A NR2F1 NR2F6 CREB1 MIXL1 ZNF133 ONECUT2 ST8SIA3 LINC02565 ENSG00000277837 lnc-ONECUT2-2
GH18J056745 Enhancer 0.2 Ensembl 11.3 -688.6 -688573 2 ONECUT2 TXNL1 KY994054-031 piR-50443-186 WDR7
GH18J056746 Enhancer 0.2 Ensembl 11.3 -689.9 -689873 0.2 ONECUT2 KY994054-031 piR-50443-186 WDR7
GH18J056799 Enhancer 0.2 Ensembl 5.7 -635.7 -635673 1.4 ONECUT2 lnc-BOD1L2-2 ENSG00000206865 WDR7
GH18J057447 Enhancer 1 Ensembl ENCODE dbSUPER 0.4 +12.1 12127 1 SP1 ZIC2 REST ZNF143 CTCF ZNF316 MAFK ZNF766 EHMT2 HDAC2 ST8SIA3 ONECUT2 lnc-ONECUT2-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ONECUT2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ONECUT2 gene promoter:
  • aMEF-2
  • AREB6
  • Cdc5
  • CUTL1
  • Elk-1
  • FOXL1
  • GATA-1
  • GR
  • GR-alpha
  • MEF-2A

Genomic Locations for ONECUT2 Gene

Genomic Locations for ONECUT2 Gene
chr18:57,435,374-57,491,298
(GRCh38/hg38)
Size:
55,925 bases
Orientation:
Plus strand
chr18:55,102,917-55,158,530
(GRCh37/hg19)
Size:
55,614 bases
Orientation:
Plus strand

Genomic View for ONECUT2 Gene

Genes around ONECUT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ONECUT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ONECUT2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ONECUT2 Gene

Proteins for ONECUT2 Gene

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  • Protein details for ONECUT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95948-ONEC2_HUMAN
    Recommended name:
    One cut domain family member 2
    Protein Accession:
    O95948

    Protein attributes for ONECUT2 Gene

    Size:
    504 amino acids
    Molecular mass:
    54303 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAB38253.1; Type=Frameshift; Positions=18; Evidence={ECO:0000305};

neXtProt entry for ONECUT2 Gene

Post-translational modifications for ONECUT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ONECUT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ONECUT2 Gene

Domains & Families for ONECUT2 Gene

Gene Families for ONECUT2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ONECUT2 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ONECUT2 Gene

GenScript: Design optimal peptide antigens:
  • Transcription factor ONECUT-2 (ONEC2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95948

UniProtKB/Swiss-Prot:

ONEC2_HUMAN :
  • Belongs to the CUT homeobox family.
Family:
  • Belongs to the CUT homeobox family.
genes like me logo Genes that share domains with ONECUT2: view

Function for ONECUT2 Gene

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  2. CRISPR
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Molecular function for ONECUT2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B.
GENATLAS Biochemistry:
one cut domain, family member 2

Phenotypes From GWAS Catalog for ONECUT2 Gene

Gene Ontology (GO) - Molecular Function for ONECUT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 11478782
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 11478782
GO:0003677 DNA binding IBA 21873635
GO:0003700 DNA-binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with ONECUT2: view
genes like me logo Genes that share phenotypes with ONECUT2: view

Animal Models for ONECUT2 Gene

MGI Knock Outs for ONECUT2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ONECUT2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ONECUT2 Gene

Localization for ONECUT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ONECUT2 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ONECUT2 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Actin filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ONECUT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with ONECUT2: view

Pathways & Interactions for ONECUT2 Gene

genes like me logo Genes that share pathways with ONECUT2: view

Pathways by source for ONECUT2 Gene

Gene Ontology (GO) - Biological Process for ONECUT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development IEA --
GO:0001952 regulation of cell-matrix adhesion IEA --
GO:0002064 epithelial cell development IEA --
GO:0009653 anatomical structure morphogenesis IEA --
GO:0009887 animal organ morphogenesis TAS 9915796
genes like me logo Genes that share ontologies with ONECUT2: view

No data available for SIGNOR curated interactions for ONECUT2 Gene

Drugs & Compounds for ONECUT2 Gene

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  1. Drug
No Compound Related Data Available

Transcripts for ONECUT2 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for ONECUT2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ONECUT2

Alternative Splicing Database (ASD) splice patterns (SP) for ONECUT2 Gene

No ASD Table

Relevant External Links for ONECUT2 Gene

GeneLoc Exon Structure for
ONECUT2
ECgene alternative splicing isoforms for
ONECUT2

Expression for ONECUT2 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ONECUT2 Gene

mRNA expression in normal human tissues for ONECUT2 Gene
mRNA expression by BioGPS for ONECUT2 GenemRNA expression by GTEx for ONECUT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ONECUT2 Gene

This gene is overexpressed in Liver (x11.0), Brain - Putamen (basal ganglia) (x9.4), Brain - Caudate (basal ganglia) (x8.2), Brain - Nucleus accumbens (basal ganglia) (x7.0), and Pancreas (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of ONECUT2 Gene:

ONECUT2

SOURCE GeneReport for Unigene cluster for ONECUT2 Gene:

Hs.194725
genes like me logo Genes that share expression patterns with ONECUT2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ONECUT2 Gene

Orthologs for ONECUT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ONECUT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ONECUT2 33 32
  • 99.12 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia ONECUT2 33
  • 98 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia ONECUT2 33
  • 94 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia ONECUT2 33
  • 93 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia ONECUT2 33
  • 92 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Onecut2 17 33 32
  • 91.65 (n)
rat
(Rattus norvegicus)
 Mammalia Onecut2 32
  • 90.87 (n)
chicken
(Gallus gallus)
 Aves ONECUT2 33 32
  • 79.02 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia ONECUT2 33
  • 75 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia onecut2 32
  • 80.54 (n)
zebrafish
(Danio rerio)
 Actinopterygii ONECUT2 33
  • 80 (a)
 OneToOne
si:ch1073-41k10.1 32
  • 78.34 (n)
fruit fly
(Drosophila melanogaster)
 Insecta onecut 33 34
  • 20 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea C17H12.9 34
  • 80 (a)
ceh-38 34
  • 50 (a)
ceh-48 33
  • 38 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 33
  • 30 (a)
 OneToMany
Species where no ortholog for ONECUT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ONECUT2 Gene

ENSEMBL:
Gene Tree for ONECUT2 (if available)
TreeFam:
Gene Tree for ONECUT2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ONECUT2: view image

Paralogs for ONECUT2 Gene

Paralogs for ONECUT2 Gene

(2) SIMAP similar genes for ONECUT2 Gene using alignment to 2 proteins:

  • ONEC2_HUMAN
  • H7C5F3_HUMAN
genes like me logo Genes that share paralogs with ONECUT2: view

Variants for ONECUT2 Gene

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Sequence variations from dbSNP and Humsavar for ONECUT2 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000004692 -- 57,434,927(+) G/C upstream_transcript_variant
rs1000141172 -- 57,468,289(+) C/T intron_variant
rs1000216654 -- 57,459,836(+) G/A intron_variant
rs1000238353 -- 57,484,371(+) C/T 3_prime_UTR_variant
rs1000273246 -- 57,444,158(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ONECUT2 Gene

Variant ID Type Subtype PubMed ID
dgv1614n106 CNV deletion 24896259
esv1478795 CNV insertion 17803354
esv3347167 CNV insertion 20981092
esv995991 CNV insertion 20482838
nsv1072806 CNV deletion 25765185
nsv476415 CNV novel sequence insertion 20440878
nsv476913 CNV novel sequence insertion 20440878
nsv828250 CNV gain 20364138
nsv953552 CNV deletion 24416366

Variation tolerance for ONECUT2 Gene

Residual Variation Intolerance Score: 11.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ONECUT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ONECUT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ONECUT2 Gene

Disorders for ONECUT2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ONECUT2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
suppurative thyroiditis
  • acute suppurative thyroiditis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ONECUT2

Genetic Association Database
(GAD)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ONECUT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ONECUT2 Gene

Publications for ONECUT2 Gene

  1. OC-2, a novel mammalian member of the ONECUT class of homeodomain transcription factors whose function in liver partially overlaps with that of hepatocyte nuclear factor-6. (PMID: 9915796) Jacquemin P … Lemaigre FP (The Journal of biological chemistry 1999) 2 3 4 23 56
  2. The transcription factor onecut-2 controls the microphthalmia-associated transcription factor gene. (PMID: 11478782) Jacquemin P … Rousseau GG (Biochemical and biophysical research communications 2001) 3 23 56
  3. ONECUT2 is a driver of neuroendocrine prostate cancer. (PMID: 30655535) Guo H … He HH (Nature communications 2019) 3 56
  4. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 56
  5. ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the androgen axis. (PMID: 30478421) Rotinen M … Freeman MR (Nature medicine 2018) 3 56

ExternalLinks

View latest publications for ONECUT2 gene in Mastermind

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