Aliases for ONECUT2 Gene
External Ids for ONECUT2 Gene
Previous GeneCards Identifiers for ONECUT2 Gene
This gene encodes a member of the onecut family of transcription factors, which are characterized by a cut domain and an atypical homeodomain. The protein binds to specific DNA sequences and stimulates expression of target genes, including genes involved in melanocyte and hepatocyte differentiation. [provided by RefSeq, Jul 2008]
GeneCards Summary for ONECUT2 Gene
ONECUT2 (One Cut Homeobox 2) is a Protein Coding gene. Diseases associated with ONECUT2 include Hemophilia B and Suppurative Thyroiditis. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific. An important paralog of this gene is ONECUT1.
UniProtKB/Swiss-Prot Summary for ONECUT2 Gene
Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B.