Aliases for ONECUT1 Gene
External Ids for ONECUT1 Gene
Previous HGNC Symbols for ONECUT1 Gene
Previous GeneCards Identifiers for ONECUT1 Gene
This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
GeneCards Summary for ONECUT1 Gene
ONECUT1 (One Cut Homeobox 1) is a Protein Coding gene. Diseases associated with ONECUT1 include Maturity-Onset Diabetes Of The Young. Among its related pathways are Regulation of beta-cell development and Signaling pathways regulating pluripotency of stem cells. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is ONECUT2.
UniProtKB/Swiss-Prot for ONECUT1 Gene
Transcriptional activator. Binds the consensus sequence 5-DHWATTGAYTWWD-3 on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription.