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Aliases for OMG Gene

Aliases for OMG Gene

  • Oligodendrocyte Myelin Glycoprotein 2 3 5
  • OMGP 3 4
  • Oligodendrocyte-Myelin Glycoprotein 3

External Ids for OMG Gene

Previous GeneCards Identifiers for OMG Gene

  • GC17P029688
  • GC17M031528
  • GC17M029471
  • GC17M029767
  • GC17M026645
  • GC17M029621
  • GC17M025832

Summaries for OMG Gene

GeneCards Summary for OMG Gene

OMG (Oligodendrocyte Myelin Glycoprotein) is a Protein Coding gene. Diseases associated with OMG include Internuclear Ophthalmoplegia and Ectopic Thymus. Among its related pathways are p75 NTR receptor-mediated signalling and Spinal Cord Injury. Gene Ontology (GO) annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot for OMG Gene

  • Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system.

Gene Wiki entry for OMG Gene

Additional gene information for OMG Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OMG Gene

Genomics for OMG Gene

GeneHancer (GH) Regulatory Elements for OMG Gene

Promoters and enhancers for OMG Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I031297 Promoter 0.6 EPDnew 550.8 +0.3 280 0.1 REST OMG LOC101927057 NF1
GH17I031306 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.8 -13.3 -13282 9.5 HDGF PKNOX1 ARNT TCF12 ZNF766 ARID2 FOS RUNX3 JUNB NCOA1 EVI2B EVI2A OMG RAB11FIP4 CRLF3 ADAP2 ENSG00000265118 NF1
GH17I031267 Enhancer 1 Ensembl ENCODE 25 +28.5 28466 3.3 FEZF1 RFX5 ZEB1 SCRT2 RCOR1 FOS USF2 CEBPB SP1 MAFF OMG EVI2A NF1 RAB11FIP4 LOC101927057 GC17P031252 GC17P031255 GC17P031253
GH17I031093 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.2 +202.2 202225 2.8 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF213 FOS MIR4733 LOC105371722 NF1 ENSG00000264456 RNF135 SUZ12 UTP6 SH3GL1P2 SH3GL1P1 ATAD5
GH17I031248 Enhancer 0.6 ENCODE 23.9 +47.0 46955 4.4 FOXA2 EBF1 CEBPG FEZF1 ZNF644 JUND POLR2A IKZF1 CEBPA FOSL2 OMG EVI2A NF1 RAB11FIP4 GC17P031255 GC17P031253 GC17P031252 GC17P031148
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around OMG on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OMG gene promoter:

Genomic Locations for OMG Gene

Genomic Locations for OMG Gene
25,527 bases
Minus strand

Genomic View for OMG Gene

Genes around OMG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OMG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OMG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OMG Gene

Proteins for OMG Gene

  • Protein details for OMG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Oligodendrocyte-myelin glycoprotein
    Protein Accession:
    Secondary Accessions:
    • E1P659

    Protein attributes for OMG Gene

    440 amino acids
    Molecular mass:
    49608 Da
    Quaternary structure:
    • Binds to RTN4R.

neXtProt entry for OMG Gene

Post-translational modifications for OMG Gene

  • O-glycosylated in its Ser/Thr-rich repeat domain.
  • Glycosylation at Asn45, isoforms=61, isoforms=103, isoforms=152, isoforms=176, isoforms=189, Asn192, Asn234, isoforms=364, Asn389, and isoforms=425

Other Protein References for OMG Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OMG Gene

Domains & Families for OMG Gene

Gene Families for OMG Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for OMG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with OMG: view

No data available for UniProtKB/Swiss-Prot for OMG Gene

Function for OMG Gene

Molecular function for OMG Gene

GENATLAS Biochemistry:
oligodendrocyte-myelin glycoprotein (embedded in NF1 first intron in opposite orientation)
UniProtKB/Swiss-Prot Function:
Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system.

Phenotypes From GWAS Catalog for OMG Gene

genes like me logo Genes that share phenotypes with OMG: view

Animal Models for OMG Gene

MGI Knock Outs for OMG:

Animal Model Products

miRNA for OMG Gene

miRTarBase miRNAs that target OMG

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OMG Gene

Localization for OMG Gene

Subcellular locations from UniProtKB/Swiss-Prot for OMG Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OMG gene
Compartment Confidence
plasma membrane 5
extracellular 4
nucleus 2
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for OMG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IBA --
GO:0005615 extracellular space IBA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with OMG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OMG Gene

Pathways & Interactions for OMG Gene

genes like me logo Genes that share pathways with OMG: view

SIGNOR curated interactions for OMG Gene


Gene Ontology (GO) - Biological Process for OMG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007409 axonogenesis IBA --
GO:0050771 negative regulation of axonogenesis TAS --
genes like me logo Genes that share ontologies with OMG: view

Drugs & Compounds for OMG Gene

No Compound Related Data Available

Transcripts for OMG Gene

Unigene Clusters for OMG Gene

Oligodendrocyte myelin glycoprotein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OMG Gene

No ASD Table

Relevant External Links for OMG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OMG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OMG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OMG Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.9), Brain - Hippocampus (x4.8), Brain - Amygdala (x4.7), Brain - Putamen (basal ganglia) (x4.6), Brain - Caudate (basal ganglia) (x4.5), Brain - Spinal cord (cervical c-1) (x4.4), Brain - Cortex (x4.3), Brain - Substantia nigra (x4.2), and Brain - Anterior cingulate cortex (BA24) (x4.1).

Protein differential expression in normal tissues from HIPED for OMG Gene

This gene is overexpressed in Frontal cortex (26.7), Brain (17.3), Spinal cord (7.9), and Cerebrospinal fluid (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OMG Gene

Protein tissue co-expression partners for OMG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OMG Gene:


SOURCE GeneReport for Unigene cluster for OMG Gene:


mRNA Expression by UniProt/SwissProt for OMG Gene:

Tissue specificity: Oligodendrocytes and myelin of the central nervous system.

Evidence on tissue expression from TISSUES for OMG Gene

  • Nervous system(5)
genes like me logo Genes that share expression patterns with OMG: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for OMG Gene

Orthologs for OMG Gene

This gene was present in the common ancestor of chordates.

Orthologs for OMG Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OMG 33 34
  • 99.7 (n)
(Canis familiaris)
Mammalia OMG 33 34
  • 95.91 (n)
(Bos Taurus)
Mammalia OMG 33 34
  • 94.92 (n)
(Rattus norvegicus)
Mammalia Omg 33
  • 90.34 (n)
(Mus musculus)
Mammalia Omg 33 16 34
  • 90.19 (n)
(Ornithorhynchus anatinus)
Mammalia OMG 34
  • 65 (a)
(Gallus gallus)
Aves OMG 33 34
  • 65.61 (n)
(Anolis carolinensis)
Reptilia OMG 34
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia omg 33
  • 53.71 (n)
(Danio rerio)
Actinopterygii omga 34
  • 49 (a)
ogmb 34
  • 41 (a)
OMG (3 of 3) 34
  • 31 (a)
Species where no ortholog for OMG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OMG Gene

Gene Tree for OMG (if available)
Gene Tree for OMG (if available)

Paralogs for OMG Gene

No data available for Paralogs for OMG Gene

Variants for OMG Gene

Sequence variations from dbSNP and Humsavar for OMG Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs143996004 likely-benign, not provided 31,295,110(-) T/C coding_sequence_variant, missense_variant
rs16972169 likely-benign, not provided 31,295,028(-) A/G coding_sequence_variant, missense_variant
rs1000286742 -- 31,296,575(-) C/G intron_variant
rs1000343494 -- 31,296,209(-) A/G coding_sequence_variant, synonymous_variant
rs1000746571 -- 31,297,371(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OMG Gene

Variant ID Type Subtype PubMed ID
nsv833413 CNV gain+loss 17160897
nsv1061870 CNV loss 25217958

Variation tolerance for OMG Gene

Residual Variation Intolerance Score: 33.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.83; 58.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OMG Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OMG Gene

Disorders for OMG Gene

MalaCards: The human disease database

(7) MalaCards diseases for OMG Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search OMG in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OMG

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with OMG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OMG Gene

Publications for OMG Gene

  1. The gene encoding the oligodendrocyte-myelin glycoprotein is embedded within the neurofibromatosis type 1 gene. (PMID: 1899288) Viskochil D … White R (Molecular and cellular biology 1991) 2 3 4 22 58
  2. Structure and chromosomal localization of the gene for the oligodendrocyte-myelin glycoprotein. (PMID: 2277079) Mikol DD … Stefansson K (The Journal of cell biology 1990) 2 3 4 22 58
  3. Mutations and novel polymorphisms in coding regions and UTRs of CDK5R1 and OMG genes in patients with non-syndromic mental retardation. (PMID: 16425041) Venturin M … Riva P (Neurogenetics 2006) 3 22 44 58
  4. The oligodendrocyte-myelin glycoprotein belongs to a distinct family of proteins and contains the HNK-1 carbohydrate. (PMID: 1688857) Mikol DD … Stefansson K (The Journal of cell biology 1990) 3 4 22 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for OMG Gene

Sources for OMG Gene

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