Aliases for OMG Gene

Aliases for OMG Gene

  • Oligodendrocyte Myelin Glycoprotein 2 3 5
  • Oligodendrocyte-Myelin Glycoprotein 3 4
  • OMGP 3 4

External Ids for OMG Gene

Previous GeneCards Identifiers for OMG Gene

  • GC17P029688
  • GC17M031528
  • GC17M029471
  • GC17M029767
  • GC17M026645
  • GC17M029621
  • GC17M025832

Summaries for OMG Gene

GeneCards Summary for OMG Gene

OMG (Oligodendrocyte Myelin Glycoprotein) is a Protein Coding gene. Diseases associated with OMG include Internuclear Ophthalmoplegia and Primary Progressive Multiple Sclerosis. Among its related pathways are RET signaling and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is LINGO3.

UniProtKB/Swiss-Prot Summary for OMG Gene

  • Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system.

Gene Wiki entry for OMG Gene

Additional gene information for OMG Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OMG Gene

Genomics for OMG Gene

GeneHancer (GH) Regulatory Elements for OMG Gene

Promoters and enhancers for OMG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J031294 Promoter/Enhancer 0.8 EPDnew Ensembl 750.6 +1.2 1239 2.6 USF2 PRDM1 SCRT2 USF1 REST OMG lnc-OMG-1 RAB11FIP4 piR-48209-288 NF1
GH17J031093 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.2 +202.1 202138 3.2 ZBTB6 RBPJ POLR2A CREB1 ZNF362 ZNF701 ELF1 ZNF148 GTF2F1 ELF3 NF1 ENSG00000264107 LOC105371722 MIR4733 RNF135 ENSG00000264456 SH3GL1P2 SUZ12 UTP6 DPRXP4
GH17J031267 Enhancer 0.9 Ensembl ENCODE 25 +28.4 28438 3.4 USF2 SP1 BCL6B MAFK CEBPG PRDM1 POLR2A CEBPA PRDM10 GATAD2A OMG EVI2A NF1 RAB11FIP4 LOC101927057 lnc-OMG-2
GH17J031306 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.8 -13.3 -13302 9.5 SMARCE1 CC2D1A ELF1 TEAD4 CBFA2T2 MLLT1 SP7 ZNF687 SMARCA4 TRIM24 EVI2B EVI2A OMG RAB11FIP4 CRLF3 ADAP2 ENSG00000265118 NF1
GH17J031548 Promoter/Enhancer 1.6 ENCODE CraniofacialAtlas dbSUPER 12.8 -252.4 -252350 2.2 GTF3C2 ZNF785 SIN3A ZNF24 SP1 ZBTB40 ZBTB6 MLX RBPJ POLR2A lnc-EVI2A-3 TRT-CGT4-1 UTP6 ENSG00000266490 SUZ12 SUZ12P1 NF1 ZNF207 LRRC37BP1 SH3GL1P2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OMG on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OMG gene promoter:
  • AhR
  • Arnt
  • C/EBPalpha
  • CHOP-10
  • Evi-1
  • FOXD3
  • HTF
  • MyoD
  • Sox5

Genomic Locations for OMG Gene

Genomic Locations for OMG Gene
chr17:31,272,013-31,297,539
(GRCh38/hg38)
Size:
25,527 bases
Orientation:
Minus strand
chr17:29,599,031-29,624,557
(GRCh37/hg19)
Size:
25,527 bases
Orientation:
Minus strand

Genomic View for OMG Gene

Genes around OMG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OMG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OMG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OMG Gene

Proteins for OMG Gene

  • Protein details for OMG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23515-OMGP_HUMAN
    Recommended name:
    Oligodendrocyte-myelin glycoprotein
    Protein Accession:
    P23515
    Secondary Accessions:
    • E1P659

    Protein attributes for OMG Gene

    Size:
    440 amino acids
    Molecular mass:
    49608 Da
    Quaternary structure:
    • Binds to RTN4R.

neXtProt entry for OMG Gene

Post-translational modifications for OMG Gene

  • O-glycosylated in its Ser/Thr-rich repeat domain.
  • Glycosylation at Asn45, Asn61, Asn103, Asn152, Asn176, Asn189, Asn192, Asn234, Asn364, Asn389, and Asn425
  • Modification sites at PhosphoSitePlus

Other Protein References for OMG Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OMG Gene

Domains & Families for OMG Gene

Gene Families for OMG Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for OMG Gene

GenScript: Design optimal peptide antigens:
  • Oligodendrocyte-myelin glycoprotein (OMGP_HUMAN)
genes like me logo Genes that share domains with OMG: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for OMG Gene

Function for OMG Gene

Molecular function for OMG Gene

UniProtKB/Swiss-Prot Function:
Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system.
GENATLAS Biochemistry:
oligodendrocyte-myelin glycoprotein (embedded in NF1 first intron in opposite orientation)

Phenotypes From GWAS Catalog for OMG Gene

genes like me logo Genes that share phenotypes with OMG: view

Animal Models for OMG Gene

MGI Knock Outs for OMG:
  • Omg Omg<tm1Shmi>
  • Omg Omg<tm1Bzh>
  • Omg Omg<tm1.1Bzh>
  • Omg Omg<tm1.3Bzh>

Animal Model Products

CRISPR Products

miRNA for OMG Gene

miRTarBase miRNAs that target OMG

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OMG Gene

Localization for OMG Gene

Subcellular locations from UniProtKB/Swiss-Prot for OMG Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OMG gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 2
cytoskeleton 1
cytosol 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for OMG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with OMG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OMG Gene

Pathways & Interactions for OMG Gene

genes like me logo Genes that share pathways with OMG: view

SIGNOR curated interactions for OMG Gene

Activates:

Gene Ontology (GO) - Biological Process for OMG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0031102 neuron projection regeneration IBA 21873635
GO:0050771 negative regulation of axonogenesis TAS --
genes like me logo Genes that share ontologies with OMG: view

Drugs & Compounds for OMG Gene

No Compound Related Data Available

Transcripts for OMG Gene

mRNA/cDNA for OMG Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OMG Gene

No ASD Table

Relevant External Links for OMG Gene

GeneLoc Exon Structure for
OMG
ECgene alternative splicing isoforms for
OMG

Expression for OMG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OMG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OMG Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.9), Brain - Hippocampus (x4.8), Brain - Amygdala (x4.7), Brain - Putamen (basal ganglia) (x4.6), Brain - Caudate (basal ganglia) (x4.5), Brain - Spinal cord (cervical c-1) (x4.4), Brain - Cortex (x4.3), Brain - Substantia nigra (x4.2), and Brain - Anterior cingulate cortex (BA24) (x4.1).

Protein differential expression in normal tissues from HIPED for OMG Gene

This gene is overexpressed in Frontal cortex (26.7), Brain (17.3), Spinal cord (7.9), and Cerebrospinal fluid (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OMG Gene



Protein tissue co-expression partners for OMG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OMG Gene:

OMG

SOURCE GeneReport for Unigene cluster for OMG Gene:

Hs.113874

mRNA Expression by UniProt/SwissProt for OMG Gene:

P23515-OMGP_HUMAN
Tissue specificity: Oligodendrocytes and myelin of the central nervous system.

Evidence on tissue expression from TISSUES for OMG Gene

  • Nervous system(5)
genes like me logo Genes that share expression patterns with OMG: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for OMG Gene

Orthologs for OMG Gene

This gene was present in the common ancestor of chordates.

Orthologs for OMG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OMG 33 32
  • 99.7 (n)
OneToOne
dog
(Canis familiaris)
Mammalia OMG 33 32
  • 95.91 (n)
OneToOne
cow
(Bos Taurus)
Mammalia OMG 33 32
  • 94.92 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Omg 32
  • 90.34 (n)
mouse
(Mus musculus)
Mammalia Omg 17 33 32
  • 90.19 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia OMG 33
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves OMG 33 32
  • 65.61 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OMG 33
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia omg 32
  • 53.71 (n)
zebrafish
(Danio rerio)
Actinopterygii omga 33
  • 49 (a)
OneToMany
ogmb 33
  • 41 (a)
OneToMany
OMG (3 of 3) 33
  • 31 (a)
OneToMany
Species where no ortholog for OMG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OMG Gene

ENSEMBL:
Gene Tree for OMG (if available)
TreeFam:
Gene Tree for OMG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OMG: view image

Paralogs for OMG Gene

Paralogs for OMG Gene

genes like me logo Genes that share paralogs with OMG: view

Variants for OMG Gene

Sequence variations from dbSNP and Humsavar for OMG Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs16972169 likely-benign, not provided, - 31,295,028(-) A/G coding_sequence_variant, missense_variant
rs143996004 likely-benign, not provided 31,295,110(-) T/C coding_sequence_variant, missense_variant
rs1000286742 -- 31,296,575(-) C/G intron_variant
rs1000343494 -- 31,296,209(-) A/G coding_sequence_variant, synonymous_variant
rs1000746571 -- 31,297,371(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for OMG Gene

Variant ID Type Subtype PubMed ID
nsv1061870 CNV loss 25217958
nsv833413 CNV gain+loss 17160897

Variation tolerance for OMG Gene

Residual Variation Intolerance Score: 33.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.83; 58.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OMG Gene

Human Gene Mutation Database (HGMD)
OMG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OMG

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OMG Gene

Disorders for OMG Gene

MalaCards: The human disease database

(6) MalaCards diseases for OMG Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
internuclear ophthalmoplegia
primary progressive multiple sclerosis
  • ppms
ectopic thymus
neuromuscular junction disease
  • neuromuscular junction diseases
dissociative disorder
  • dissociative disease
- elite association - COSMIC cancer census association via MalaCards
Search OMG in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OMG

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with OMG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OMG Gene

Publications for OMG Gene

  1. The gene encoding the oligodendrocyte-myelin glycoprotein is embedded within the neurofibromatosis type 1 gene. (PMID: 1899288) Viskochil D … White R (Molecular and cellular biology 1991) 2 3 4 23 56
  2. Structure and chromosomal localization of the gene for the oligodendrocyte-myelin glycoprotein. (PMID: 2277079) Mikol DD … Stefansson K (The Journal of cell biology 1990) 2 3 4 23 56
  3. Mutations and novel polymorphisms in coding regions and UTRs of CDK5R1 and OMG genes in patients with non-syndromic mental retardation. (PMID: 16425041) Venturin M … Riva P (Neurogenetics 2006) 3 23 43 56
  4. The oligodendrocyte-myelin glycoprotein belongs to a distinct family of proteins and contains the HNK-1 carbohydrate. (PMID: 1688857) Mikol DD … Stefansson K (The Journal of cell biology 1990) 3 4 23 56
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56

Products for OMG Gene

Sources for OMG Gene