Aliases for OLIG3 Gene

Aliases for OLIG3 Gene

  • Oligodendrocyte Transcription Factor 3 2 3 4 5
  • Class E Basic Helix-Loop-Helix Protein 20 3 4
  • Class B Basic Helix-Loop-Helix Protein 7 3 4
  • BHLHe20 3 4
  • Oligo3 3 4
  • BHLHE20 4
  • Bhlhb7 3
  • BHLHB7 4
  • BHLHb7 4

External Ids for OLIG3 Gene

Previous GeneCards Identifiers for OLIG3 Gene

  • GC06M137660
  • GC06M137793
  • GC06M137855
  • GC06M135375

Summaries for OLIG3 Gene

GeneCards Summary for OLIG3 Gene

OLIG3 (Oligodendrocyte Transcription Factor 3) is a Protein Coding gene. Diseases associated with OLIG3 include Central Hypoventilation Syndrome, Congenital. Among its related pathways are Neural Crest Differentiation. Gene Ontology (GO) annotations related to this gene include protein dimerization activity. An important paralog of this gene is OLIG2.

UniProtKB/Swiss-Prot Summary for OLIG3 Gene

  • May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons.

Additional gene information for OLIG3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OLIG3 Gene

Genomics for OLIG3 Gene

GeneHancer (GH) Regulatory Elements for OLIG3 Gene

Promoters and enhancers for OLIG3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J137495 Enhancer 0.5 ENCODE 500.7 -1.4 -1365 0.2 HDAC2 EZH2 JUND RNF2 SUZ12 SP1 EGR1 CTBP2 OLIG3 piR-36366-016 piR-31179-001
GH06J137494 Enhancer 0.5 ENCODE 500.7 -0.1 -145 0.2 EZH2 POLR2A SIN3A RNF2 SUZ12 CBX8 CTCF OLIG3 piR-36366-016 piR-31179-001
GH06J137826 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 11.1 -335.7 -335736 6.4 GTF2E2 FOS EP300 TRIM28 RELA RUNX1 JUN RBM25 LEF1 ZNF384 TNFAIP3 WAKMAR2 OLIG3 lnc-TNFAIP3-1
GH06J137093 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 9.5 +393.8 393756 14.6 ZBTB40 CTCF USF1 SP1 EP300 JUND REST RELA MEF2C RCOR1 IL22RA2 IFNGR1 OLIG3 IL20RA RF00017-5799 piR-35674-458
GH06J137387 Enhancer 1.2 FANTOM5 Ensembl ENCODE 10.9 +105.0 104993 6.8 EP300 RELA TRIM22 ZNF274 BCL11A RXRA ZNF316 CBFB MAFF FOS TNFAIP3 OLIG3 IFNGR1 piR-57387-046 LOC102723633
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OLIG3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OLIG3

Top Transcription factor binding sites by QIAGEN in the OLIG3 gene promoter:
  • CUTL1
  • HNF-1
  • HNF-1A
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • SRF
  • SRF (504 AA)

Genomic Locations for OLIG3 Gene

Genomic Locations for OLIG3 Gene
chr6:137,492,199-137,494,394
(GRCh38/hg38)
Size:
2,196 bases
Orientation:
Minus strand
chr6:137,813,336-137,815,531
(GRCh37/hg19)
Size:
2,196 bases
Orientation:
Minus strand

Genomic View for OLIG3 Gene

Genes around OLIG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OLIG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OLIG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLIG3 Gene

Proteins for OLIG3 Gene

  • Protein details for OLIG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTU3-OLIG3_HUMAN
    Recommended name:
    Oligodendrocyte transcription factor 3
    Protein Accession:
    Q7RTU3
    Secondary Accessions:
    • Q8N8Q0

    Protein attributes for OLIG3 Gene

    Size:
    272 amino acids
    Molecular mass:
    29358 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=DAA00303.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OLIG3 Gene

Post-translational modifications for OLIG3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OLIG3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OLIG3 Gene

Domains & Families for OLIG3 Gene

Gene Families for OLIG3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for OLIG3 Gene

Blocks:
  • Basic helix-loop-helix dimerization domain bHLH
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OLIG3 Gene

GenScript: Design optimal peptide antigens:
  • Class E basic helix-loop-helix protein 20 (OLIG3_HUMAN)
genes like me logo Genes that share domains with OLIG3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for OLIG3 Gene

Function for OLIG3 Gene

Molecular function for OLIG3 Gene

UniProtKB/Swiss-Prot Function:
May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons.

Phenotypes From GWAS Catalog for OLIG3 Gene

Gene Ontology (GO) - Molecular Function for OLIG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003677 DNA binding IEA --
GO:0003714 transcription corepressor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with OLIG3: view
genes like me logo Genes that share phenotypes with OLIG3: view

Animal Models for OLIG3 Gene

MGI Knock Outs for OLIG3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OLIG3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OLIG3 Gene

Localization for OLIG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLIG3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OLIG3 gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2
extracellular 1
cytoskeleton 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for OLIG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with OLIG3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OLIG3 Gene

Pathways & Interactions for OLIG3 Gene

PathCards logo

SuperPathways for OLIG3 Gene

SuperPathway Contained pathways
1 Neural Crest Differentiation
genes like me logo Genes that share pathways with OLIG3: view

Pathways by source for OLIG3 Gene

1 BioSystems pathway for OLIG3 Gene

Gene Ontology (GO) - Biological Process for OLIG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0010468 regulation of gene expression IEA --
GO:0021520 spinal cord motor neuron cell fate specification IEA --
GO:0021522 spinal cord motor neuron differentiation IEA --
genes like me logo Genes that share ontologies with OLIG3: view

No data available for SIGNOR curated interactions for OLIG3 Gene

Drugs & Compounds for OLIG3 Gene

No Compound Related Data Available

Transcripts for OLIG3 Gene

mRNA/cDNA for OLIG3 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OLIG3

Alternative Splicing Database (ASD) splice patterns (SP) for OLIG3 Gene

No ASD Table

Relevant External Links for OLIG3 Gene

GeneLoc Exon Structure for
OLIG3

Expression for OLIG3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OLIG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for OLIG3 Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OLIG3 Gene



Protein tissue co-expression partners for OLIG3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OLIG3

SOURCE GeneReport for Unigene cluster for OLIG3 Gene:

Hs.195398
genes like me logo Genes that share expression patterns with OLIG3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OLIG3 Gene

Orthologs for OLIG3 Gene

This gene was present in the common ancestor of animals.

Orthologs for OLIG3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OLIG3 31 30
  • 99.26 (n)
OneToOne
cow
(Bos Taurus)
Mammalia OLIG3 31 30
  • 94.24 (n)
OneToOne
dog
(Canis familiaris)
Mammalia OLIG3 31 30
  • 93.38 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OLIG3 31
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olig3 30
  • 91.79 (n)
mouse
(Mus musculus)
Mammalia Olig3 17 31 30
  • 91.18 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia OLIG3 31
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves OLIG3 31
  • 86 (a)
OneToOne
LOC100857919 30
  • 83.64 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia olig3 30
  • 71.1 (n)
Str.11145 30
zebrafish
(Danio rerio)
Actinopterygii olig3 30
  • 72.84 (n)
olig4 31
  • 44 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea hlh-16 31
  • 29 (a)
OneToMany
Species where no ortholog for OLIG3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OLIG3 Gene

ENSEMBL:
Gene Tree for OLIG3 (if available)
TreeFam:
Gene Tree for OLIG3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OLIG3: view image

Paralogs for OLIG3 Gene

(2) SIMAP similar genes for OLIG3 Gene using alignment to 1 proteins:

  • OLIG3_HUMAN
genes like me logo Genes that share paralogs with OLIG3: view

Variants for OLIG3 Gene

Additional dbSNP identifiers (rs#s) for OLIG3 Gene

Structural Variations from Database of Genomic Variants (DGV) for OLIG3 Gene

Variant ID Type Subtype PubMed ID
nsv470863 CNV loss 18288195
nsv5491 CNV insertion 18451855

Variation tolerance for OLIG3 Gene

Residual Variation Intolerance Score: 39.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.48; 55.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OLIG3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OLIG3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OLIG3 Gene

Disorders for OLIG3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OLIG3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
central hypoventilation syndrome, congenital
  • cchs
- elite association - COSMIC cancer census association via MalaCards
Search OLIG3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OLIG3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with OLIG3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OLIG3 Gene

Publications for OLIG3 Gene

  1. Genome-wide searching of rare genetic variants in WTCCC data. (PMID: 20549515) Feng T … Zhu X (Human genetics 2010) 3 41 54
  2. Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort. (PMID: 20353580) Morgan AW … YEAR Consortium (Arthritis research & therapy 2010) 3 41 54
  3. Genetic variants in the prediction of rheumatoid arthritis. (PMID: 20439292) van der Helm-van Mil AH … Huizinga TW (Annals of the rheumatic diseases 2010) 3 41 54
  4. Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score. (PMID: 19879194) De Jager PL … Karlson EW (The Lancet. Neurology 2009) 3 41 54
  5. Common variants at CD40 and other loci confer risk of rheumatoid arthritis. (PMID: 18794853) Raychaudhuri S … Plenge RM (Nature genetics 2008) 3 41 54

Products for OLIG3 Gene

Sources for OLIG3 Gene