This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region ... See more...

Aliases for OLIG2 Gene

Aliases for OLIG2 Gene

  • Oligodendrocyte Transcription Factor 2 2 3 4 5
  • Oligodendrocyte-Specific BHLH Transcription Factor 2 2 3
  • Basic Domain, Helix-Loop-Helix Protein, Class B, 1 2 3
  • Oligodendrocyte Lineage Transcription Factor 2 2 3
  • Human Protein Kinase C-Binding Protein RACK17 2 3
  • Class E Basic Helix-Loop-Helix Protein 19 3 4
  • Class B Basic Helix-Loop-Helix Protein 1 3 4
  • Protein Kinase C-Binding Protein 2 3 4
  • PRKCBP2 3 4
  • BHLHe19 3 4
  • BHLHB1 3 4
  • RACK17 3 4
  • Protein Kinase C-Binding Protein RACK17 4
  • Protein Kinase C Binding Protein 2 2
  • BHLHE19 4
  • OLIGO2 3
  • Oligo2 4
  • BHLHb1 4

External Ids for OLIG2 Gene

Previous HGNC Symbols for OLIG2 Gene

  • PRKCBP2
  • BHLHB1

Previous GeneCards Identifiers for OLIG2 Gene

  • GC21P030975
  • GC21P033318
  • GC21P033320
  • GC21P034398
  • GC21P019809

Summaries for OLIG2 Gene

Entrez Gene Summary for OLIG2 Gene

  • This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008]

GeneCards Summary for OLIG2 Gene

OLIG2 (Oligodendrocyte Transcription Factor 2) is a Protein Coding gene. Diseases associated with OLIG2 include Oligodendroglioma and Dysembryoplastic Neuroepithelial Tumor. Among its related pathways are Neural Crest Differentiation and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding. An important paralog of this gene is OLIG3.

UniProtKB/Swiss-Prot Summary for OLIG2 Gene

  • Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Functions together with ZNF488 to promote oligodendrocyte differentiation. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.

Gene Wiki entry for OLIG2 Gene

Additional gene information for OLIG2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OLIG2 Gene

Genomics for OLIG2 Gene

GeneHancer (GH) Regulatory Elements for OLIG2 Gene

Promoters and enhancers for OLIG2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J033026 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 500.7 0.0 -7 1 USF1 ZNF639 ZNF10 ZIC2 ZBTB10 ZNF423 ZBTB26 CTCF ATF2 ZEB1 OLIG2 MIS18A TMEM50B DONSON CRYZL1 PAXBP1 C21orf62-AS1 piR-56341-135 ENSG00000227757
GH21J033029 Promoter/Enhancer 0.8 Ensembl dbSUPER 500.7 +1.5 1493 0.8 USF1 EZH2 POLR2A CBX8 SUZ12 RNF2 EGR1 OLIG2 OLIG1 ENSG00000227757 lnc-C21orf62-4
GH21J033028 Promoter/Enhancer 0.8 Ensembl dbSUPER 500.7 +0.8 793 0.2 EZH2 CBX8 RNF2 ZNF596 SUZ12 SCRT2 OLIG2 lnc-C21orf62-4 ENSG00000227757
GH21J033913 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.3 +889.5 889535 3.1 ZNF217 EP300 SIN3A NRF1 POLR2G SP1 GTF2E2 JUND SIX5 ZNF639 ATP5PO LINC00649 lnc-CRYZL1-82 OLIG2 piR-38499 ENSG00000249209
GH21J033196 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +176.8 176830 12.5 CTCF TCF12 POLR2G NCOR1 JUND FOS ZNF639 ZNF10 KDM6A REST TMEM50B PAXBP1 SON EVA1C DONSON GART IFNAR2 IFNGR2 URB1 LINC01548
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OLIG2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OLIG2

Top Transcription factor binding sites by QIAGEN in the OLIG2 gene promoter:
  • Cart-1
  • Elk-1
  • FOXF2
  • FOXO4
  • GATA-2
  • LCR-F1
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for OLIG2 Gene

Genomic Locations for OLIG2 Gene
chr21:33,025,908-33,029,196
(GRCh38/hg38)
Size:
3,289 bases
Orientation:
Plus strand
chr21:34,398,153-34,401,504
(GRCh37/hg19)
Size:
3,352 bases
Orientation:
Plus strand

Genomic View for OLIG2 Gene

Genes around OLIG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OLIG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OLIG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLIG2 Gene

Proteins for OLIG2 Gene

  • Protein details for OLIG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13516-OLIG2_HUMAN
    Recommended name:
    Oligodendrocyte transcription factor 2
    Protein Accession:
    Q13516
    Secondary Accessions:
    • B3KRF3
    • Q05BP9
    • Q49AL3
    • Q86X04
    • Q9NZ14

    Protein attributes for OLIG2 Gene

    Size:
    323 amino acids
    Molecular mass:
    32385 Da
    Quaternary structure:
    • Interacts with NKX2-2. Interacts with ZNF488.
    SequenceCaution:
    • Sequence=AAC72247.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAF61215.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OLIG2 Gene

Post-translational modifications for OLIG2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OLIG2 Gene

No data available for DME Specific Peptides for OLIG2 Gene

Domains & Families for OLIG2 Gene

Gene Families for OLIG2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for OLIG2 Gene

Blocks:
  • Basic helix-loop-helix dimerization domain bHLH
  • Regulator of chromosome condensation, RCC1
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OLIG2 Gene

GenScript: Design optimal peptide antigens:
  • Protein kinase C-binding protein RACK17 (OLIG2_HUMAN)
  • OLIG2 protein (Q05BP9_HUMAN)
  • OLIG2 protein (Q49AL3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13516

UniProtKB/Swiss-Prot:

OLIG2_HUMAN :
  • The bHLH is essential for interaction with NKX2-2.
Domain:
  • The bHLH is essential for interaction with NKX2-2.
genes like me logo Genes that share domains with OLIG2: view

Function for OLIG2 Gene

Molecular function for OLIG2 Gene

UniProtKB/Swiss-Prot Function:
Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Functions together with ZNF488 to promote oligodendrocyte differentiation. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development.
UniProtKB/Swiss-Prot Induction:
By SHH. Also induced by NKX6-1 in the developing spinal cord, but not in the rostral hindbrain (By similarity).

Phenotypes From GWAS Catalog for OLIG2 Gene

Gene Ontology (GO) - Molecular Function for OLIG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS,IEA 19274049
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0042803 protein homodimerization activity IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with OLIG2: view
genes like me logo Genes that share phenotypes with OLIG2: view

Animal Models for OLIG2 Gene

MGI Knock Outs for OLIG2:

Animal Model Products

CRISPR Products

miRNA for OLIG2 Gene

miRTarBase miRNAs that target OLIG2
Targeted motifs for OLIG2 Gene
HOMER Transcription Factor Regulatory Elements motif OLIG2
  • Consensus sequence: RCCATMTGTT Submotif: canonical Cell Type: Neuron GEO ID: GSE30882

Clone Products

  • Addgene plasmids for OLIG2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for OLIG2 Gene

Localization for OLIG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLIG2 Gene

Nucleus. Cytoplasm. Note=The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OLIG2 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytoskeleton 3
extracellular 2
mitochondrion 2
cytosol 2
golgi apparatus 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OLIG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with OLIG2: view

Pathways & Interactions for OLIG2 Gene

genes like me logo Genes that share pathways with OLIG2: view

Pathways by source for OLIG2 Gene

1 BioSystems pathway for OLIG2 Gene

SIGNOR curated interactions for OLIG2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for OLIG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0021522 spinal cord motor neuron differentiation IEA --
genes like me logo Genes that share ontologies with OLIG2: view

Drugs & Compounds for OLIG2 Gene

(1) Additional Compounds for OLIG2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with OLIG2: view

Transcripts for OLIG2 Gene

mRNA/cDNA for OLIG2 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for OLIG2

Alternative Splicing Database (ASD) splice patterns (SP) for OLIG2 Gene

No ASD Table

Relevant External Links for OLIG2 Gene

GeneLoc Exon Structure for
OLIG2

Expression for OLIG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OLIG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OLIG2 Gene

This gene is overexpressed in Brain - Substantia nigra (x6.5), Brain - Amygdala (x6.4), Brain - Hippocampus (x5.8), Brain - Putamen (basal ganglia) (x5.4), Brain - Spinal cord (cervical c-1) (x5.2), Brain - Hypothalamus (x4.6), and Brain - Caudate (basal ganglia) (x4.3).

Protein differential expression in normal tissues from HIPED for OLIG2 Gene

This gene is overexpressed in Pancreas (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OLIG2 Gene



Protein tissue co-expression partners for OLIG2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OLIG2

SOURCE GeneReport for Unigene cluster for OLIG2 Gene:

Hs.176977

mRNA Expression by UniProt/SwissProt for OLIG2 Gene:

Q13516-OLIG2_HUMAN
Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.

Evidence on tissue expression from TISSUES for OLIG2 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with OLIG2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for OLIG2 Gene

Orthologs for OLIG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for OLIG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OLIG2 31 30
  • 99.28 (n)
OneToOne
dog
(Canis familiaris)
Mammalia OLIG2 31 30
  • 90.82 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olig2 30
  • 88.44 (n)
mouse
(Mus musculus)
Mammalia Olig2 17 31 30
  • 88.13 (n)
oppossum
(Monodelphis domestica)
Mammalia OLIG2 31
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves OLIG2 31
  • 81 (a)
OneToOne
OLIG3 30
  • 79.54 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia olig2 30
  • 74.76 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15193 30
zebrafish
(Danio rerio)
Actinopterygii olig2 31 30
  • 67.92 (n)
OneToOne
-- 30
worm
(Caenorhabditis elegans)
Secernentea hlh-16 31
  • 30 (a)
OneToMany
Species where no ortholog for OLIG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OLIG2 Gene

ENSEMBL:
Gene Tree for OLIG2 (if available)
TreeFam:
Gene Tree for OLIG2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OLIG2: view image

Paralogs for OLIG2 Gene

(2) SIMAP similar genes for OLIG2 Gene using alignment to 4 proteins:

  • OLIG2_HUMAN
  • C9J444_HUMAN
  • Q05BP9_HUMAN
  • Q49AL3_HUMAN
genes like me logo Genes that share paralogs with OLIG2: view

Variants for OLIG2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OLIG2 Gene

SNP ID Clinical significance and condition Chr 21 pos Variation AA Info Type
rs1270614322 Uncertain Significance: Inborn genetic diseases 33,027,211(+) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for OLIG2 Gene

Structural Variations from Database of Genomic Variants (DGV) for OLIG2 Gene

Variant ID Type Subtype PubMed ID
nsv520925 CNV loss 19592680

Variation tolerance for OLIG2 Gene

Gene Damage Index Score: 1.16; 23.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OLIG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OLIG2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OLIG2 Gene

Disorders for OLIG2 Gene

MalaCards: The human disease database

(44) MalaCards diseases for OLIG2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
oligodendroglioma
  • oligodendroglial neoplasm
dysembryoplastic neuroepithelial tumor
  • dysembryoplastic neuroepithelial neoplasm
papillary glioneuronal tumors
  • papillary glioneuronal tumor
central neurocytoma
  • neurolipocytoma
third ventricle chordoid glioma
  • chordoid glioma of 3rd ventricle
- elite association - COSMIC cancer census association via MalaCards
Search OLIG2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

OLIG2_HUMAN
  • Note=A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA. {ECO:0000269 PubMed:10737801}.

Additional Disease Information for OLIG2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with OLIG2: view

No data available for Genatlas for OLIG2 Gene

Publications for OLIG2 Gene

  1. A genetic family-based association study of OLIG2 in obsessive-compulsive disorder. (PMID: 17283288) Stewart SE … Pauls DL (Archives of general psychiatry 2007) 3 23 41 54
  2. Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors. (PMID: 11526205) Lu QR … Black PM (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 4 54
  3. The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene. (PMID: 10737801) Wang J … Aplan PD (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4 23 54
  4. Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2. (PMID: 23165259) Meijer DH … Rowitch DH (Nature reviews. Neuroscience 2012) 2 3 54
  5. 1p19q LOH patterns and expression of p53 and Olig2 in gliomas: relation with histological types and prognosis. (PMID: 20081802) Durand KS … Labrousse FJ (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2010) 3 23 54

Products for OLIG2 Gene

Sources for OLIG2 Gene