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Aliases for OLIG1 Gene

Aliases for OLIG1 Gene

  • Oligodendrocyte Transcription Factor 1 2 3 3 5
  • Oligodendrocyte-Specific BHLH Transcription Factor 1 2 3
  • Basic Domain, Helix-Loop-Helix Protein, Class B, 6 2 3
  • Oligodendrocyte Lineage Transcription Factor 1 2 3
  • Class E Basic Helix-Loop-Helix Protein 21 3 4
  • Class B Basic Helix-Loop-Helix Protein 6 3 4
  • BHLHE21 3 4
  • Oligo1 3 4
  • BHLHB6 3 4
  • BHLHe21 4
  • BHLHb6 4

External Ids for OLIG1 Gene

Previous GeneCards Identifiers for OLIG1 Gene

  • GC21P031019
  • GC21P033362
  • GC21P033364
  • GC21P034442
  • GC21P019853

Summaries for OLIG1 Gene

GeneCards Summary for OLIG1 Gene

OLIG1 (Oligodendrocyte Transcription Factor 1) is a Protein Coding gene. Diseases associated with OLIG1 include Oligodendroglioma and Grade Iii Astrocytoma. Among its related pathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers and Neural Crest Differentiation. Gene Ontology (GO) annotations related to this gene include protein dimerization activity. An important paralog of this gene is OLIG2.

UniProtKB/Swiss-Prot for OLIG1 Gene

  • Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity).

Gene Wiki entry for OLIG1 Gene

Additional gene information for OLIG1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLIG1 Gene

Genomics for OLIG1 Gene

GeneHancer (GH) Regulatory Elements for OLIG1 Gene

Promoters and enhancers for OLIG1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J033070 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 650.7 +0.4 357 0.2 KLF1 SUZ12 MAX KLF17 KLF14 ZFHX2 POLR2A PRDM10 EZH2 ZBTB20 ENSG00000227757 OLIG1
GH21J033071 Enhancer 0.6 ENCODE dbSUPER 650.7 +1.0 959 0.1 CTBP2 EZH2 OLIG1 ENSG00000227757
GH21J033127 Enhancer 1.2 Ensembl ENCODE dbSUPER 16 +57.2 57209 0.7 RB1 MZF1 BMI1 ZNF2 RAD21 ARID2 ZNF366 ZSCAN5C ZNF143 RUNX3 OLIG1 MIS18A-AS1 LINC01548 ENSG00000227757 TMEM50B EXOSC3P1 LOC101928107 ENSG00000226433
GH21J033011 Enhancer 1.4 FANTOM5 Ensembl ENCODE 13.7 -58.6 -58608 0.9 PKNOX1 FOXA2 INSM2 KLF14 ZNF366 ZNF548 FOS EGR2 SP3 ZNF362 PAXBP1 TMEM50B SON IFNGR2 OLIG1 EVA1C ENSG00000227757 PAXBP1-AS1 GART LINC01548
GH21J033042 Enhancer 0.8 ENCODE dbSUPER 17.9 -27.1 -27116 0.2 ZBTB21 ZEB2 ZIC2 ZNF518A JUND ZNF692 ZNF629 PRDM10 FOS ZNF600 OLIG1 ENSG00000227757 LOC105372785 LINC00945
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OLIG1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OLIG1 gene promoter:
  • NRSF form 2
  • NRSF form 1
  • Ik-2
  • AP-1
  • MyoD
  • Arnt
  • NF-Y
  • CBF(2)

Genomic Locations for OLIG1 Gene

Genomic Locations for OLIG1 Gene
chr21:33,070,144-33,072,422
(GRCh38/hg38)
Size:
2,279 bases
Orientation:
Plus strand
chr21:34,442,450-34,444,728
(GRCh37/hg19)
Size:
2,279 bases
Orientation:
Plus strand

Genomic View for OLIG1 Gene

Genes around OLIG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OLIG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OLIG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLIG1 Gene

Proteins for OLIG1 Gene

  • Protein details for OLIG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAK6-OLIG1_HUMAN
    Recommended name:
    Oligodendrocyte transcription factor 1
    Protein Accession:
    Q8TAK6
    Secondary Accessions:
    • Q7RTS0

    Protein attributes for OLIG1 Gene

    Size:
    271 amino acids
    Molecular mass:
    27905 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH26989.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=DAA01058.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for OLIG1 Gene

Post-translational modifications for OLIG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OLIG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for OLIG1
  • Boster Bio Antibodies for OLIG1

No data available for DME Specific Peptides for OLIG1 Gene

Domains & Families for OLIG1 Gene

Gene Families for OLIG1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for OLIG1 Gene

Suggested Antigen Peptide Sequences for OLIG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with OLIG1: view

No data available for UniProtKB/Swiss-Prot for OLIG1 Gene

Function for OLIG1 Gene

Molecular function for OLIG1 Gene

UniProtKB/Swiss-Prot Function:
Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity).

Phenotypes From GWAS Catalog for OLIG1 Gene

Gene Ontology (GO) - Molecular Function for OLIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 18923419
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with OLIG1: view
genes like me logo Genes that share phenotypes with OLIG1: view

Animal Models for OLIG1 Gene

MGI Knock Outs for OLIG1:

Animal Model Products

Clone Products

  • Addgene plasmids for OLIG1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OLIG1 Gene

Localization for OLIG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLIG1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OLIG1 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for OLIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with OLIG1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OLIG1 Gene

Pathways & Interactions for OLIG1 Gene

genes like me logo Genes that share pathways with OLIG1: view

Pathways by source for OLIG1 Gene

1 BioSystems pathway for OLIG1 Gene

SIGNOR curated interactions for OLIG1 Gene

Activates:

Gene Ontology (GO) - Biological Process for OLIG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0007275 multicellular organism development IEA --
GO:0048663 neuron fate commitment IEA --
genes like me logo Genes that share ontologies with OLIG1: view

Drugs & Compounds for OLIG1 Gene

No Compound Related Data Available

Transcripts for OLIG1 Gene

mRNA/cDNA for OLIG1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(73) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OLIG1 Gene

Oligodendrocyte transcription factor 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for OLIG1

Alternative Splicing Database (ASD) splice patterns (SP) for OLIG1 Gene

No ASD Table

Relevant External Links for OLIG1 Gene

GeneLoc Exon Structure for
OLIG1
ECgene alternative splicing isoforms for
OLIG1

Expression for OLIG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OLIG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OLIG1 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.0), Brain - Substantia nigra (x6.6), Brain - Amygdala (x6.1), Brain - Hippocampus (x5.6), Brain - Putamen (basal ganglia) (x5.1), and Brain - Hypothalamus (x4.7).

Protein differential expression in normal tissues from HIPED for OLIG1 Gene

This gene is overexpressed in Saliva (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OLIG1 Gene



Protein tissue co-expression partners for OLIG1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OLIG1 Gene:

OLIG1

SOURCE GeneReport for Unigene cluster for OLIG1 Gene:

Hs.56663

mRNA Expression by UniProt/SwissProt for OLIG1 Gene:

Q8TAK6-OLIG1_HUMAN
Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas is highly variable.

Evidence on tissue expression from TISSUES for OLIG1 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with OLIG1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for OLIG1 Gene

Orthologs for OLIG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for OLIG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OLIG1 34 33
  • 98.89 (n)
OneToOne
dog
(Canis familiaris)
Mammalia OLIG1 34 33
  • 92.37 (n)
OneToOne
cow
(Bos Taurus)
Mammalia OLIG1 34 33
  • 89.06 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olig1 33
  • 85.51 (n)
mouse
(Mus musculus)
Mammalia Olig1 16 34 33
  • 84.56 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia OLIG1 34
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OLIG1 34
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia olig1 33
  • 61.24 (n)
zebrafish
(Danio rerio)
Actinopterygii olig1 34 33
  • 59.65 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hlh-16 34
  • 28 (a)
OneToMany
Species where no ortholog for OLIG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OLIG1 Gene

ENSEMBL:
Gene Tree for OLIG1 (if available)
TreeFam:
Gene Tree for OLIG1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OLIG1: view image

Paralogs for OLIG1 Gene

Paralogs for OLIG1 Gene

genes like me logo Genes that share paralogs with OLIG1: view

Variants for OLIG1 Gene

Sequence variations from dbSNP and Humsavar for OLIG1 Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1000109904 -- 33,070,058(+) C/T upstream_transcript_variant
rs1000142336 -- 33,069,790(+) G/T upstream_transcript_variant
rs1000225219 -- 33,069,599(+) C/T upstream_transcript_variant
rs1004796618 -- 33,070,310(+) C/A coding_sequence_variant, synonymous_variant
rs1006121321 -- 33,072,729(+) A/T downstream_transcript_variant

Variation tolerance for OLIG1 Gene

Gene Damage Index Score: 2.04; 37.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OLIG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OLIG1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for OLIG1 Gene

Disorders for OLIG1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for OLIG1 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
oligodendroglioma
  • oligodendroglial neoplasm
grade iii astrocytoma
  • anaplastic astrocytoma
brain cancer
  • adult brain tumor
- elite association - COSMIC cancer census association via MalaCards
Search OLIG1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OLIG1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with OLIG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OLIG1 Gene

Publications for OLIG1 Gene

  1. A genetic family-based association study of OLIG2 in obsessive-compulsive disorder. (PMID: 17283288) Stewart SE … Pauls DL (Archives of general psychiatry 2007) 3 22 44 58
  2. Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors. (PMID: 11526205) Lu QR … Black PM (Proceedings of the National Academy of Sciences of the United States of America 2001) 2 3 4 58
  3. An Id-like molecule, HHM, is a synexpression group-restricted regulator of TGF-beta signalling. (PMID: 18923419) Ikushima H … Miyazono K (The EMBO journal 2008) 3 22 58
  4. Aberrant DNA methylation of OLIG1, a novel prognostic factor in non-small cell lung cancer. (PMID: 17388669) Brena RM … Plass C (PLoS medicine 2007) 3 22 58
  5. Oligodendroglial transcription factor (OLIG1 and OLIG2) mutations are not associated with Pelizaeus-Merzbacher-like leukodystrophy. (PMID: 17171653) Ruf N … Uhlenberg B (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007) 3 22 58

Products for OLIG1 Gene

  • Addgene plasmids for OLIG1

Sources for OLIG1 Gene

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