This gene encodes an olfactomedin domain-containing protein. Most olfactomedin domain-containing proteins are secreted glycoproteins. [provided by RefSeq, Dec 2016] See more...

Aliases for OLFML2B Gene

Aliases for OLFML2B Gene

  • Olfactomedin Like 2B 2 3 5
  • Olfactomedin-Like Protein 2B 3 4
  • Photomedin-2 3 4
  • Olfactomedin-Like 2B 2
  • DKFZP586L151 2
  • OLFML2B 5

External Ids for OLFML2B Gene

Previous GeneCards Identifiers for OLFML2B Gene

  • GC01M159141
  • GC01M158684
  • GC01M160219
  • GC01M133197

Summaries for OLFML2B Gene

Entrez Gene Summary for OLFML2B Gene

  • This gene encodes an olfactomedin domain-containing protein. Most olfactomedin domain-containing proteins are secreted glycoproteins. [provided by RefSeq, Dec 2016]

GeneCards Summary for OLFML2B Gene

OLFML2B (Olfactomedin Like 2B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include extracellular matrix binding. An important paralog of this gene is OLFML2A.

Additional gene information for OLFML2B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OLFML2B Gene

Genomics for OLFML2B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OLFML2B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J162021 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 604.8 +1.5 1525 3.9 PRDM10 ZNF629 ZNF692 PRDM1 ZIC2 PATZ1 CTCF ZNF501 POLR2A EZH2 OLFML2B DUSP12 USP21 PPOX PCP4L1 UHMK1 piR-30182 ATF6
GH01J162025 Promoter 0.3 Ensembl 600.7 -0.6 -636 0.2 OLFML2B ENSG00000227818 NOS1AP
GH01J161113 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 9.7 +906.2 906200 8.6 HNRNPL CREB1 GATAD2A CTCF TEAD4 PRDM10 ZNF629 TFE3 IKZF1 ZNF692 NIT1 PFDN2 lnc-PFDN2-1 piR-45071 RPSAP18 DUSP12 B4GALT3 OLFML2B F11R HSPA6
GH01J162560 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 9.7 -538.1 -538070 4.9 SP1 CREB1 GATAD2A HNRNPL PRDM10 ZNF629 REST TFE3 IKZF1 NFKBIZ ENSG00000259788 LOC102724358 UAP1 DUSP12 DDR2 UHMK1 OLFML2B MN309007
GH01J162131 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.5 -107.6 -107609 2 GATAD2A PRDM10 REST TFE3 RCOR2 RXRB IRF2 SP1 GABPA CEBPA C1orf226 OLFML2B SPATA46 MIR4654 piR-32810-008 LOC105371475 NOS1AP ENSG00000254706
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OLFML2B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OLFML2B

Top Transcription factor binding sites by QIAGEN in the OLFML2B gene promoter:
  • aMEF-2
  • AML1a
  • AREB6
  • GATA-1
  • MEF-2A
  • Nkx2-5
  • RFX1
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for OLFML2B Gene

Genomic Locations for OLFML2B Gene
chr1:161,983,192-162,024,465
(GRCh38/hg38)
Size:
41,274 bases
Orientation:
Minus strand
chr1:161,952,982-161,993,644
(GRCh37/hg19)
Size:
40,663 bases
Orientation:
Minus strand

Genomic View for OLFML2B Gene

Genes around OLFML2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OLFML2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OLFML2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLFML2B Gene

Proteins for OLFML2B Gene

  • Protein details for OLFML2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68BL8-OLM2B_HUMAN
    Recommended name:
    Olfactomedin-like protein 2B
    Protein Accession:
    Q68BL8
    Secondary Accessions:
    • B7ZA39
    • Q5VU96
    • Q6NX46
    • Q86X11
    • Q9Y3X6

    Protein attributes for OLFML2B Gene

    Size:
    750 amino acids
    Molecular mass:
    83999 Da
    Quaternary structure:
    • Homodimer. Binds to heparin and chondroitin sulfate E (By similarity).

    Alternative splice isoforms for OLFML2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OLFML2B Gene

Post-translational modifications for OLFML2B Gene

  • O-glycosylated and N-glycosylated.
  • Glycosylation at Asn695, Asn187, Asn213, Thr343, Thr346, Ser357, Thr358, and Thr361
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for OLFML2B Gene

Domains & Families for OLFML2B Gene

Gene Families for OLFML2B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for OLFML2B Gene

InterPro:
Blocks:
  • Olfactomedin-like
ProtoNet:

Suggested Antigen Peptide Sequences for OLFML2B Gene

GenScript: Design optimal peptide antigens:
  • Photomedin-2 (OLM2B_HUMAN)
genes like me logo Genes that share domains with OLFML2B: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for OLFML2B Gene

Function for OLFML2B Gene

Phenotypes From GWAS Catalog for OLFML2B Gene

Gene Ontology (GO) - Molecular Function for OLFML2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050840 extracellular matrix binding IEA --
genes like me logo Genes that share ontologies with OLFML2B: view
genes like me logo Genes that share phenotypes with OLFML2B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OLFML2B

CRISPR Products

miRNA for OLFML2B Gene

miRTarBase miRNAs that target OLFML2B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OLFML2B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OLFML2B Gene

Localization for OLFML2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLFML2B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OLFML2B gene
Compartment Confidence
extracellular 4
nucleus 2
cytosol 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1
lysosome 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for OLFML2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0031012 extracellular matrix IEA --
genes like me logo Genes that share ontologies with OLFML2B: view

Pathways & Interactions for OLFML2B Gene

PathCards logo

SuperPathways for OLFML2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for OLFML2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030198 extracellular matrix organization IEA --
genes like me logo Genes that share ontologies with OLFML2B: view

No data available for Pathways by source and SIGNOR curated interactions for OLFML2B Gene

Drugs & Compounds for OLFML2B Gene

No Compound Related Data Available

Transcripts for OLFML2B Gene

mRNA/cDNA for OLFML2B Gene

3 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OLFML2B

Alternative Splicing Database (ASD) splice patterns (SP) for OLFML2B Gene

No ASD Table

Relevant External Links for OLFML2B Gene

GeneLoc Exon Structure for
OLFML2B

Expression for OLFML2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OLFML2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OLFML2B Gene

This gene is overexpressed in Artery - Tibial (x5.0).

Protein differential expression in normal tissues from HIPED for OLFML2B Gene

This gene is overexpressed in Rectum (67.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for OLFML2B Gene



Protein tissue co-expression partners for OLFML2B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OLFML2B

SOURCE GeneReport for Unigene cluster for OLFML2B Gene:

Hs.507515

Evidence on tissue expression from TISSUES for OLFML2B Gene

  • Nervous system(4.4)
  • Eye(4.3)
genes like me logo Genes that share expression patterns with OLFML2B: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OLFML2B Gene

Orthologs for OLFML2B Gene

This gene was present in the common ancestor of animals.

Orthologs for OLFML2B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia OLFML2B 30 31
  • 98.71 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia OLFML2B 30 31
  • 86.01 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olfml2b 30
  • 84.5 (n)
Mouse
(Mus musculus)
Mammalia Olfml2b 30 17 31
  • 84.32 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia OLFML2B 30 31
  • 83.15 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia OLFML2B 31
  • 68 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia OLFML2B 31
  • 51 (a)
OneToOne
Chicken
(Gallus gallus)
Aves OLFML2B 30 31
  • 71.03 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia OLFML2B 31
  • 61 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia olfml2b 30
  • 64.36 (n)
Zebrafish
(Danio rerio)
Actinopterygii olfml2ba 30 31
  • 63.77 (n)
OneToMany
olfml2bb 31
  • 51 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG6867 31
  • 11 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea cof-2 31
  • 21 (a)
ManyToMany
unc-122 31
  • 18 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 51 (a)
OneToMany
Species where no ortholog for OLFML2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for OLFML2B Gene

ENSEMBL:
Gene Tree for OLFML2B (if available)
TreeFam:
Gene Tree for OLFML2B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OLFML2B: view image

Paralogs for OLFML2B Gene

Paralogs for OLFML2B Gene

(7) SIMAP similar genes for OLFML2B Gene using alignment to 4 proteins:

  • OLM2B_HUMAN
  • F2Z3N3_HUMAN
  • H0YE85_HUMAN
  • H0YEW8_HUMAN
genes like me logo Genes that share paralogs with OLFML2B: view

Variants for OLFML2B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OLFML2B Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
775620 Benign: not provided 161,998,252(-) A/G SYNONYMOUS_VARIANT
780275 Benign: not provided 161,984,140(-) A/G SYNONYMOUS_VARIANT
791819 Benign: not provided 161,998,282(-) G/A SYNONYMOUS_VARIANT
rs142806829 Likely Pathogenic: not provided 161,998,241(-) C/T MISSENSE_VARIANT
rs185436876 Likely Pathogenic: not provided 161,984,849(-) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for OLFML2B Gene

Structural Variations from Database of Genomic Variants (DGV) for OLFML2B Gene

Variant ID Type Subtype PubMed ID
esv33393 CNV gain+loss 17666407
nsv1007108 CNV gain 25217958
nsv3287 CNV insertion 18451855
nsv464206 CNV gain 19166990
nsv470744 CNV gain 18288195
nsv548077 CNV gain 21841781
nsv548078 CNV gain 21841781
nsv831747 CNV loss 17160897

Variation tolerance for OLFML2B Gene

Residual Variation Intolerance Score: 76.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.62; 72.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OLFML2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OLFML2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OLFML2B Gene

Disorders for OLFML2B Gene

Additional Disease Information for OLFML2B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for OLFML2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OLFML2B Gene

Publications for OLFML2B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  2. Integrative predictive model of coronary artery calcification in atherosclerosis. (PMID: 19948975) McGeachie M … Ramoni MF (Circulation 2009) 3 41
  3. Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies. (PMID: 19587794) Nolte IM … Jamshidi Y (PloS one 2009) 3 41
  4. Bioinformatic exploration of OLFML2B overexpression in gastric cancer base on multiple analyzing tools. (PMID: 30866865) Liu J … Yao D (BMC cancer 2019) 3
  5. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3

Products for OLFML2B Gene

Sources for OLFML2B Gene