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Aliases for OLFML2A Gene

Aliases for OLFML2A Gene

  • Olfactomedin Like 2A 2 3 5
  • Olfactomedin-Like Protein 2A 3 4
  • Photomedin-1 3 4
  • Olfactomedin-Like 2A 2
  • PRO34319 3

External Ids for OLFML2A Gene

Previous GeneCards Identifiers for OLFML2A Gene

  • GC09P122916
  • GC09P124618
  • GC09P126579
  • GC09P127539
  • GC09P097152

Summaries for OLFML2A Gene

GeneCards Summary for OLFML2A Gene

OLFML2A (Olfactomedin Like 2A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and extracellular matrix binding. An important paralog of this gene is OLFML2B.

Additional gene information for OLFML2A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLFML2A Gene

Genomics for OLFML2A Gene

GeneHancer (GH) Regulatory Elements for OLFML2A Gene

Promoters and enhancers for OLFML2A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J124776 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 600.7 +1.7 1703 4.5 ZNF652 NKRF SP7 CREB1 ZBTB8A SOX13 BACH1 LARP7 ZEB2 ZNF629 OLFML2A SCAI GOLGA1 PIR55692
GH09J124777 Promoter 0.5 Ensembl 600.7 -0.9 -932 0.4 OLFML2A NR6A1
GH09J124510 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.4 -264.6 -264575 4.1 ELF3 MNT CBFA2T2 CEBPG GTF2F1 TFE3 TRIM24 SP1 SP5 ZNF644 GOLGA1 OLFML2A GAPVD1 ENSG00000231149 NR5A1
GH09J124799 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 11.5 +24.2 24180 3.3 CREM MLLT1 IKZF1 IKZF2 ZIC2 RFX5 ZNF335 EBF1 GLIS1 WDR38 ARPC5L RPL35 OLFML2A GAPVD1 RNU6-1020P MIR181A2HG PIR55692
GH09J125407 Enhancer 1.3 FANTOM5 ENCODE 11.4 +632.4 632420 3.6 MTA3 SP1 ZFX CC2D1A CTCF CBFA2T2 ZNF148 MLLT1 ZNF121 GTF2F1 LOC101929014 GAPVD1 PRPS1P2 GOLGA1 LOC101929116 OLFML2A RPL35 PPP6C PBX3 GC09P125379
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OLFML2A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OLFML2A gene promoter:
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for OLFML2A Gene

Genomic Locations for OLFML2A Gene
chr9:124,777,133-124,814,891
(GRCh38/hg38)
Size:
37,759 bases
Orientation:
Plus strand
chr9:127,539,437-127,577,164
(GRCh37/hg19)
Size:
37,728 bases
Orientation:
Plus strand

Genomic View for OLFML2A Gene

Genes around OLFML2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OLFML2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OLFML2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLFML2A Gene

Proteins for OLFML2A Gene

  • Protein details for OLFML2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68BL7-OLM2A_HUMAN
    Recommended name:
    Olfactomedin-like protein 2A
    Protein Accession:
    Q68BL7
    Secondary Accessions:
    • Q5JTM5
    • Q5JTM6
    • Q6UXW1
    • Q7Z5V3

    Protein attributes for OLFML2A Gene

    Size:
    652 amino acids
    Molecular mass:
    73054 Da
    Quaternary structure:
    • Homodimer. Binds to heparin and chondroitin sulfate E.

    Alternative splice isoforms for OLFML2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OLFML2A Gene

Post-translational modifications for OLFML2A Gene

Other Protein References for OLFML2A Gene

No data available for DME Specific Peptides for OLFML2A Gene

Domains & Families for OLFML2A Gene

Gene Families for OLFML2A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for OLFML2A Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OLFML2A Gene

GenScript: Design optimal peptide antigens:
  • Photomedin-1 (OLM2A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with OLFML2A: view

No data available for UniProtKB/Swiss-Prot for OLFML2A Gene

Function for OLFML2A Gene

Phenotypes From GWAS Catalog for OLFML2A Gene

Gene Ontology (GO) - Molecular Function for OLFML2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IEA --
GO:0050840 extracellular matrix binding IEA --
genes like me logo Genes that share ontologies with OLFML2A: view
genes like me logo Genes that share phenotypes with OLFML2A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OLFML2A

CRISPR Products

miRNA for OLFML2A Gene

miRTarBase miRNAs that target OLFML2A

Clone Products

  • Applied Biological Materials (abm): Clones for OLFML2A - Now 50% OFF >
  • * OLFML2A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * OLFML2A tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OLFML2A Gene

Localization for OLFML2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLFML2A Gene

Secreted. Note=Localizes to the podocyte major processes. Colocalized with the major process protein VIM throughout podocyte development. {ECO:0000269 PubMed:22913984}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OLFML2A gene
Compartment Confidence
extracellular 3
nucleus 2
cytosol 2
lysosome 1
peroxisome 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OLFML2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031012 extracellular matrix IEA --
genes like me logo Genes that share ontologies with OLFML2A: view

Pathways & Interactions for OLFML2A Gene

PathCards logo

SuperPathways for OLFML2A Gene

No Data Available

Interacting Proteins for OLFML2A Gene

Gene Ontology (GO) - Biological Process for OLFML2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030198 extracellular matrix organization IEA --
genes like me logo Genes that share ontologies with OLFML2A: view

No data available for Pathways by source and SIGNOR curated interactions for OLFML2A Gene

Drugs & Compounds for OLFML2A Gene

No Compound Related Data Available

Transcripts for OLFML2A Gene

mRNA/cDNA for OLFML2A Gene

(2) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(130) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for OLFML2A Gene

Olfactomedin-like 2A:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for OLFML2A - Now 50% OFF >
  • * OLFML2A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * OLFML2A tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for OLFML2A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: - - -
SP2: -
SP3:
SP4:

Relevant External Links for OLFML2A Gene

GeneLoc Exon Structure for
OLFML2A
ECgene alternative splicing isoforms for
OLFML2A

Expression for OLFML2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OLFML2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for OLFML2A Gene

This gene is overexpressed in Platelet (51.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OLFML2A Gene



NURSA nuclear receptor signaling pathways regulating expression of OLFML2A Gene:

OLFML2A

SOURCE GeneReport for Unigene cluster for OLFML2A Gene:

Hs.357004

mRNA Expression by UniProt/SwissProt for OLFML2A Gene:

Q68BL7-OLM2A_HUMAN
Tissue specificity: In the kidney expressed only by podocytes, wherein they localize to major processes.

Evidence on tissue expression from TISSUES for OLFML2A Gene

  • Eye(4.2)
genes like me logo Genes that share expression patterns with OLFML2A: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for OLFML2A Gene

Orthologs for OLFML2A Gene

This gene was present in the common ancestor of animals.

Orthologs for OLFML2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OLFML2A 35 34
  • 98.88 (n)
OneToOne
cow
(Bos Taurus)
Mammalia OLFML2A 35 34
  • 88.51 (n)
OneToOne
dog
(Canis familiaris)
Mammalia OLFML2A 35 34
  • 86.75 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Olfml2a 17 35 34
  • 83.31 (n)
rat
(Rattus norvegicus)
Mammalia Olfml2a 34
  • 82.27 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia OLFML2A 35
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OLFML2A 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves OLFML2A 35 34
  • 74.14 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OLFML2A 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia olfml2a 34
  • 64.92 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100330530 34
  • 66.78 (n)
olfml2a 35
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6867 35
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cof-2 35
  • 18 (a)
ManyToMany
unc-122 35
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 49 (a)
OneToMany
Species where no ortholog for OLFML2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OLFML2A Gene

ENSEMBL:
Gene Tree for OLFML2A (if available)
TreeFam:
Gene Tree for OLFML2A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OLFML2A: view image

Paralogs for OLFML2A Gene

Paralogs for OLFML2A Gene

(4) SIMAP similar genes for OLFML2A Gene using alignment to 2 proteins:

  • OLM2A_HUMAN
  • Q5JTM7_HUMAN
genes like me logo Genes that share paralogs with OLFML2A: view

Variants for OLFML2A Gene

Sequence variations from dbSNP and Humsavar for OLFML2A Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000175242 -- 124,810,583(+) T/G 3_prime_UTR_variant
rs1000291329 -- 124,810,767(+) C/A 3_prime_UTR_variant
rs1000339169 -- 124,797,975(+) AGGAG/AG genic_upstream_transcript_variant, intron_variant
rs1000375878 -- 124,780,501(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000391465 -- 124,798,364(+) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OLFML2A Gene

Variant ID Type Subtype PubMed ID
esv2761558 CNV gain 21179565
esv3621725 CNV loss 21293372
nsv524034 CNV loss 19592680
nsv831721 CNV gain 17160897

Variation tolerance for OLFML2A Gene

Residual Variation Intolerance Score: 91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.30; 62.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OLFML2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OLFML2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OLFML2A Gene

Disorders for OLFML2A Gene

Additional Disease Information for OLFML2A

No disorders were found for OLFML2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OLFML2A Gene

Publications for OLFML2A Gene

  1. Olfactomedin-like 2 A and B (OLFML2A and OLFML2B) expression profile in primates (human and baboon). (PMID: 27821182) Pérez-Ibave DC … Rodríguez-Sánchez IP (Biological research 2016) 2 3 58
  2. Neuronal proteins are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent formation. (PMID: 22913984) Sistani L … Patrakka J (Kidney international 2013) 3 4 58
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  4. Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease. (PMID: 27503909) Teixeira FR … Laman H (The Biochemical journal 2016) 3 58
  5. A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis. (PMID: 23509962) Greliche N … Trégouët DA (BMC medical genetics 2013) 3 58

Products for OLFML2A Gene

Sources for OLFML2A Gene

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