Aliases for OLFML2A Gene

Aliases for OLFML2A Gene

  • Olfactomedin Like 2A 2 3 5
  • Olfactomedin-Like Protein 2A 3 4
  • Photomedin-1 3 4
  • Olfactomedin-Like 2A 2
  • PRO34319 3
  • FLJ00237 2
  • OLFML2A 5

External Ids for OLFML2A Gene

Previous GeneCards Identifiers for OLFML2A Gene

  • GC09P122916
  • GC09P124618
  • GC09P126579
  • GC09P127539
  • GC09P097152

Summaries for OLFML2A Gene

GeneCards Summary for OLFML2A Gene

OLFML2A (Olfactomedin Like 2A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and extracellular matrix binding. An important paralog of this gene is OLFML2B.

Additional gene information for OLFML2A Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OLFML2A Gene

Genomics for OLFML2A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OLFML2A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OLFML2A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OLFML2A

Top Transcription factor binding sites by QIAGEN in the OLFML2A gene promoter:
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for OLFML2A Gene

Genomic Locations for OLFML2A Gene
chr9:124,777,133-124,814,891
(GRCh38/hg38)
Size:
37,759 bases
Orientation:
Plus strand
chr9:127,539,437-127,577,164
(GRCh37/hg19)
Size:
37,728 bases
Orientation:
Plus strand

Genomic View for OLFML2A Gene

Genes around OLFML2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OLFML2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OLFML2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLFML2A Gene

Proteins for OLFML2A Gene

  • Protein details for OLFML2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68BL7-OLM2A_HUMAN
    Recommended name:
    Olfactomedin-like protein 2A
    Protein Accession:
    Q68BL7
    Secondary Accessions:
    • Q5JTM5
    • Q5JTM6
    • Q6UXW1
    • Q7Z5V3

    Protein attributes for OLFML2A Gene

    Size:
    652 amino acids
    Molecular mass:
    73054 Da
    Quaternary structure:
    • Homodimer. Binds to heparin and chondroitin sulfate E.

    Alternative splice isoforms for OLFML2A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OLFML2A Gene

Post-translational modifications for OLFML2A Gene

Other Protein References for OLFML2A Gene

No data available for DME Specific Peptides for OLFML2A Gene

Domains & Families for OLFML2A Gene

Gene Families for OLFML2A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for OLFML2A Gene

InterPro:
Blocks:
  • Olfactomedin-like
ProtoNet:

Suggested Antigen Peptide Sequences for OLFML2A Gene

GenScript: Design optimal peptide antigens:
  • Photomedin-1 (OLM2A_HUMAN)
  • FLJ00237 protein (Q8TEG0_HUMAN)
genes like me logo Genes that share domains with OLFML2A: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for OLFML2A Gene

Function for OLFML2A Gene

Phenotypes From GWAS Catalog for OLFML2A Gene

Gene Ontology (GO) - Molecular Function for OLFML2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IEA --
GO:0050840 extracellular matrix binding IEA --
genes like me logo Genes that share ontologies with OLFML2A: view
genes like me logo Genes that share phenotypes with OLFML2A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OLFML2A

CRISPR Products

miRNA for OLFML2A Gene

miRTarBase miRNAs that target OLFML2A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OLFML2A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OLFML2A Gene

Localization for OLFML2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLFML2A Gene

Secreted. Note=Localizes to the podocyte major processes. Colocalized with the major process protein VIM throughout podocyte development. {ECO:0000269 PubMed:22913984}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OLFML2A gene
Compartment Confidence
extracellular 3
nucleus 2
cytosol 2
plasma membrane 1
cytoskeleton 1
lysosome 1
peroxisome 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OLFML2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0031012 extracellular matrix IEA --
genes like me logo Genes that share ontologies with OLFML2A: view

Pathways & Interactions for OLFML2A Gene

PathCards logo

SuperPathways for OLFML2A Gene

No Data Available

Interacting Proteins for OLFML2A Gene

Gene Ontology (GO) - Biological Process for OLFML2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030198 extracellular matrix organization IEA --
genes like me logo Genes that share ontologies with OLFML2A: view

No data available for Pathways by source and SIGNOR curated interactions for OLFML2A Gene

Drugs & Compounds for OLFML2A Gene

No Compound Related Data Available

Transcripts for OLFML2A Gene

mRNA/cDNA for OLFML2A Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OLFML2A

Alternative Splicing Database (ASD) splice patterns (SP) for OLFML2A Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: - - -
SP2: -
SP3:
SP4:

Relevant External Links for OLFML2A Gene

GeneLoc Exon Structure for
OLFML2A

Expression for OLFML2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OLFML2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for OLFML2A Gene

This gene is overexpressed in Platelet (51.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OLFML2A Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OLFML2A

SOURCE GeneReport for Unigene cluster for OLFML2A Gene:

Hs.357004

mRNA Expression by UniProt/SwissProt for OLFML2A Gene:

Q68BL7-OLM2A_HUMAN
Tissue specificity: In the kidney expressed only by podocytes, wherein they localize to major processes.

Evidence on tissue expression from TISSUES for OLFML2A Gene

  • Eye(4.3)
genes like me logo Genes that share expression patterns with OLFML2A: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for OLFML2A Gene

Orthologs for OLFML2A Gene

This gene was present in the common ancestor of animals.

Orthologs for OLFML2A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia OLFML2A 30 31
  • 98.88 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia OLFML2A 30 31
  • 88.51 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia OLFML2A 30 31
  • 86.75 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Olfml2a 30 17 31
  • 83.31 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olfml2a 30
  • 82.27 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia OLFML2A 31
  • 72 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia OLFML2A 31
  • 64 (a)
OneToOne
Chicken
(Gallus gallus)
Aves OLFML2A 30 31
  • 74.14 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia OLFML2A 31
  • 67 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia olfml2a 30
  • 64.92 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC100330530 30
  • 66.78 (n)
olfml2a 31
  • 61 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG6867 31
  • 12 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea cof-2 31
  • 18 (a)
ManyToMany
unc-122 31
  • 17 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 49 (a)
OneToMany
Species where no ortholog for OLFML2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for OLFML2A Gene

ENSEMBL:
Gene Tree for OLFML2A (if available)
TreeFam:
Gene Tree for OLFML2A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OLFML2A: view image

Paralogs for OLFML2A Gene

Paralogs for OLFML2A Gene

(4) SIMAP similar genes for OLFML2A Gene using alignment to 2 proteins:

  • OLM2A_HUMAN
  • Q5JTM7_HUMAN
genes like me logo Genes that share paralogs with OLFML2A: view

Variants for OLFML2A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OLFML2A Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs16927649 - p.Arg425Gln
rs7874348 - p.Thr309Ala

Additional dbSNP identifiers (rs#s) for OLFML2A Gene

Structural Variations from Database of Genomic Variants (DGV) for OLFML2A Gene

Variant ID Type Subtype PubMed ID
esv2761558 CNV gain 21179565
esv3621725 CNV loss 21293372
nsv524034 CNV loss 19592680
nsv831721 CNV gain 17160897

Variation tolerance for OLFML2A Gene

Residual Variation Intolerance Score: 91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.30; 62.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OLFML2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OLFML2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OLFML2A Gene

Disorders for OLFML2A Gene

No disorders were found for OLFML2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OLFML2A Gene

Publications for OLFML2A Gene

  1. Olfactomedin-like 2 A and B (OLFML2A and OLFML2B) expression profile in primates (human and baboon). (PMID: 27821182) Pérez-Ibave DC … Rodríguez-Sánchez IP (Biological research 2016) 2 3
  2. Neuronal proteins are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent formation. (PMID: 22913984) Sistani L … Patrakka J (Kidney international 2013) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  4. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  5. Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease. (PMID: 27503909) Teixeira FR … Laman H (The Biochemical journal 2016) 3

Products for OLFML2A Gene

Sources for OLFML2A Gene