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Aliases for OLFML1 Gene

Aliases for OLFML1 Gene

  • Olfactomedin Like 1 2 3 5
  • Olfactomedin-Like Protein 1 3 4
  • Olfactomedin-Like 1 2
  • MVAL564 3
  • UNQ564 3

External Ids for OLFML1 Gene

Previous GeneCards Identifiers for OLFML1 Gene

  • GC11P007472
  • GC11P007165

Summaries for OLFML1 Gene

GeneCards Summary for OLFML1 Gene

OLFML1 (Olfactomedin Like 1) is a Protein Coding gene. An important paralog of this gene is OLFML3.

Additional gene information for OLFML1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLFML1 Gene

Genomics for OLFML1 Gene

GeneHancer (GH) Regulatory Elements for OLFML1 Gene

Promoters and enhancers for OLFML1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J007484 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 600.7 +0.6 631 3.2 NFIB SP1 NFIC HNF4A RXRA HNF4G KDM1A OLFML1 ENSG00000251364 GC11M007483
GH11J007985 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 32.7 +502.3 502260 3.5 ZFX SP1 CC2D1A CTCF ELF3 SIX5 CBFA2T2 NKRF CEBPG GTF2F1 EIF3F OLFML1 SNORA3B TMEM9B-AS1 RPL27A ST5 CASC23 TUB ENSG00000254921 ZNF214
GH11J006616 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 13.3 -867.0 -866952 3.6 SP1 ELF3 CBFA2T2 NKRF POLR2A MLLT1 GTF2F1 FOS AHR BACH1 TPP1 ENSG00000285338 ENSG00000255680 RRP8 OLFML1 MRPL17 ENSG00000241678 ENSG00000254595 TIMM10B DCHS1
GH11J006925 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 13.6 -558.5 -558494 2.7 ZFX MLLT1 GTF2F1 BACH1 TRIM24 PRDM1 EGR1 SMARCA4 GLIS2 POLR2A ZNF215 OR2AG2 ENSG00000283415 OLFML1 RRP8 ENSG00000254595 ENSG00000251364
GH11J007571 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.6 +90.5 90542 9.3 CTCF ELF3 POLR2A CEBPG RERE TFE3 SP7 RELA SP1 HNF1A PPFIBP2 OLFML1 OVCH2 NLRP10 ENSG00000254864 LOC105376535
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OLFML1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OLFML1 gene promoter:
  • FOXO1
  • FOXO1a
  • Gfi-1
  • HSF2
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • SRY

Genomic Locations for OLFML1 Gene

Genomic Locations for OLFML1 Gene
26,529 bases
Plus strand
26,009 bases
Plus strand

Genomic View for OLFML1 Gene

Genes around OLFML1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OLFML1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OLFML1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLFML1 Gene

Proteins for OLFML1 Gene

  • Protein details for OLFML1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Olfactomedin-like protein 1
    Protein Accession:
    Secondary Accessions:
    • B4DP03
    • Q569G4

    Protein attributes for OLFML1 Gene

    402 amino acids
    Molecular mass:
    45951 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OLFML1 Gene

Post-translational modifications for OLFML1 Gene

  • Highly N-glycosylated.
  • Glycosylation at isoforms=66, isoforms=138, and posLast=183183
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • OLFL1_HUMAN (1586)

No data available for DME Specific Peptides for OLFML1 Gene

Domains & Families for OLFML1 Gene

Gene Families for OLFML1 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for OLFML1 Gene


Suggested Antigen Peptide Sequences for OLFML1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactomedin-like protein 1 (OLFL1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with OLFML1: view

No data available for UniProtKB/Swiss-Prot for OLFML1 Gene

Function for OLFML1 Gene

Phenotypes From GWAS Catalog for OLFML1 Gene

genes like me logo Genes that share phenotypes with OLFML1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OLFML1

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for OLFML1 - Now 50% OFF >
  • * OLFML1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * OLFML1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OLFML1 Gene

Localization for OLFML1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLFML1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OLFML1 gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 2
lysosome 0
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for OLFML1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with OLFML1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OLFML1 Gene

Pathways & Interactions for OLFML1 Gene

PathCards logo

SuperPathways for OLFML1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OLFML1 Gene


No data available for Pathways by source and SIGNOR curated interactions for OLFML1 Gene

Drugs & Compounds for OLFML1 Gene

No Compound Related Data Available

Transcripts for OLFML1 Gene

Unigene Clusters for OLFML1 Gene

Olfactomedin-like 1:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for OLFML1 - Now 50% OFF >
  • * OLFML1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * OLFML1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for OLFML1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3

Relevant External Links for OLFML1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OLFML1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OLFML1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for OLFML1 Gene

This gene is overexpressed in Ovary (18.8), Gallbladder (9.8), and Prostate (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OLFML1 Gene

Protein tissue co-expression partners for OLFML1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OLFML1 Gene:


SOURCE GeneReport for Unigene cluster for OLFML1 Gene:


mRNA Expression by UniProt/SwissProt for OLFML1 Gene:

Tissue specificity: Mainly expressed in the small intestine, liver, lung and heart.

Evidence on tissue expression from TISSUES for OLFML1 Gene

  • Pancreas(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with OLFML1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for OLFML1 Gene

Orthologs for OLFML1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OLFML1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OLFML1 35 34
  • 99.25 (n)
(Canis familiaris)
Mammalia OLFML1 35 34
  • 88.53 (n)
(Mus musculus)
Mammalia Olfml1 17 35 34
  • 84.43 (n)
(Bos Taurus)
Mammalia OLFML1 35 34
  • 84.33 (n)
(Rattus norvegicus)
Mammalia Olfml1 34
  • 84.16 (n)
(Monodelphis domestica)
Mammalia OLFML1 35
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 50 (a)
-- 35
  • 42 (a)
(Gallus gallus)
Aves OLFML1 35 34
  • 60.47 (n)
(Anolis carolinensis)
Reptilia OLFML1 35
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia olfml1 34
  • 53.77 (n)
(Danio rerio)
Actinopterygii LOC100003048 34
  • 52.03 (n)
BX294190.1 35
  • 41 (a)
Species where no ortholog for OLFML1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OLFML1 Gene

Gene Tree for OLFML1 (if available)
Gene Tree for OLFML1 (if available)
Evolutionary constrained regions (ECRs) for OLFML1: view image

Paralogs for OLFML1 Gene

Paralogs for OLFML1 Gene

(4) SIMAP similar genes for OLFML1 Gene using alignment to 3 proteins:

  • E9PN44_HUMAN
genes like me logo Genes that share paralogs with OLFML1: view

Variants for OLFML1 Gene

Sequence variations from dbSNP and Humsavar for OLFML1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000244523 -- 7,500,911(+) A/C intron_variant
rs1000412057 -- 7,491,936(+) A/C intron_variant
rs1000526057 -- 7,511,015(+) C/T 3_prime_UTR_variant
rs1000535892 -- 7,511,257(+) C/T 3_prime_UTR_variant
rs1000598683 -- 7,500,595(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OLFML1 Gene

Variant ID Type Subtype PubMed ID
dgv576e59 CNV tandem duplication 20981092
esv3360494 CNV duplication 20981092
nsv1129510 CNV tandem duplication 24896259
nsv499766 OTHER inversion 21111241
nsv7215 OTHER inversion 18451855

Variation tolerance for OLFML1 Gene

Residual Variation Intolerance Score: 93.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.49; 82.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OLFML1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OLFML1 Gene

Disorders for OLFML1 Gene

Additional Disease Information for OLFML1

No disorders were found for OLFML1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OLFML1 Gene

Publications for OLFML1 Gene

  1. hOLFML1, a novel secreted glycoprotein, enhances the proliferation of human cancer cell lines in vitro. (PMID: 18708057) Wan B … Han ZG (FEBS letters 2008) 3 4 23 58
  2. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 58

Products for OLFML1 Gene

Sources for OLFML1 Gene

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