Aliases for OLFML1 Gene

Aliases for OLFML1 Gene

  • Olfactomedin Like 1 2 3 5
  • Olfactomedin-Like Protein 1 3 4
  • Olfactomedin-Like 1 2
  • MVAL564 3
  • UNQ564 3

External Ids for OLFML1 Gene

Previous GeneCards Identifiers for OLFML1 Gene

  • GC11P007472
  • GC11P007463
  • GC11P007165

Summaries for OLFML1 Gene

GeneCards Summary for OLFML1 Gene

OLFML1 (Olfactomedin Like 1) is a Protein Coding gene. An important paralog of this gene is OLFML3.

Additional gene information for OLFML1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OLFML1 Gene

Genomics for OLFML1 Gene

GeneHancer (GH) Regulatory Elements for OLFML1 Gene

Promoters and enhancers for OLFML1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J007484 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.5 527 3 TEAD4 NFIC RXRA KDM1A HNF4A HNF4G EZH2 FOXA1 SP1 OLFML1 ENSG00000251364 PPFIBP2
GH11J007483 Enhancer 0.2 Ensembl 500.7 -1.5 -1468 0.2 OLFML1 ENSG00000251364 OR2AG1 RF00017-851
GH11J006601 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 26.5 -877.9 -877873 12.4 HNRNPK ZBTB40 EP300 CTCF SIN3A NRF1 TCF12 MYC POLR2G SP1 RRP8 ILK NONHSAG007540.2 TAF10 OLFML1 FAM160A2 ENSG00000251364 CAVIN3 DCHS1 ENSG00000254400
GH11J007571 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.6 +90.5 90542 9.3 FOXK2 CTCF TCF12 POLR2G USF1 NCOR1 JUND TEAD4 ZIC2 KDM6A PPFIBP2 lnc-OLFML1-2 OLFML1 OVCH2 NLRP10 ENSG00000254864 LOC105376535
GH11J007511 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.1 +28.0 27966 4.5 CTCF SIN3A POLR2G USF1 SP1 PHF8 EP300 ZIC2 POLR2A ZBTB26 ENSG00000251364 PPFIBP2 OLFML1 lnc-CYB5R2-6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OLFML1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OLFML1

Top Transcription factor binding sites by QIAGEN in the OLFML1 gene promoter:
  • FOXO1
  • FOXO1a
  • Gfi-1
  • HSF2
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • SRY

Genomic Locations for OLFML1 Gene

Genomic Locations for OLFML1 Gene
chr11:7,485,369-7,511,897
(GRCh38/hg38)
Size:
26,529 bases
Orientation:
Plus strand
chr11:7,506,600-7,532,608
(GRCh37/hg19)
Size:
26,009 bases
Orientation:
Plus strand

Genomic View for OLFML1 Gene

Genes around OLFML1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OLFML1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OLFML1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLFML1 Gene

Proteins for OLFML1 Gene

  • Protein details for OLFML1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWY5-OLFL1_HUMAN
    Recommended name:
    Olfactomedin-like protein 1
    Protein Accession:
    Q6UWY5
    Secondary Accessions:
    • B4DP03
    • Q569G4

    Protein attributes for OLFML1 Gene

    Size:
    402 amino acids
    Molecular mass:
    45951 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OLFML1 Gene

Post-translational modifications for OLFML1 Gene

  • Highly N-glycosylated.
  • Glycosylation at Asn66, Asn138, and Asn183
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • OLFL1_HUMAN (1586)

Other Protein References for OLFML1 Gene

No data available for DME Specific Peptides for OLFML1 Gene

Domains & Families for OLFML1 Gene

Gene Families for OLFML1 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for OLFML1 Gene

Blocks:
  • Olfactomedin-like
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OLFML1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactomedin-like protein 1 (OLFL1_HUMAN)
genes like me logo Genes that share domains with OLFML1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for OLFML1 Gene

Function for OLFML1 Gene

Phenotypes From GWAS Catalog for OLFML1 Gene

genes like me logo Genes that share phenotypes with OLFML1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OLFML1

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OLFML1 Gene

Localization for OLFML1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLFML1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OLFML1 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 2
plasma membrane 1
nucleus 1
lysosome 0
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for OLFML1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with OLFML1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OLFML1 Gene

Pathways & Interactions for OLFML1 Gene

PathCards logo

SuperPathways for OLFML1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OLFML1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for OLFML1 Gene

Drugs & Compounds for OLFML1 Gene

No Compound Related Data Available

Transcripts for OLFML1 Gene

mRNA/cDNA for OLFML1 Gene

5 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OLFML1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3
SP1:
SP2:

Relevant External Links for OLFML1 Gene

GeneLoc Exon Structure for
OLFML1

Expression for OLFML1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OLFML1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for OLFML1 Gene

This gene is overexpressed in Ovary (18.8), Gallbladder (9.8), and Prostate (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OLFML1 Gene



Protein tissue co-expression partners for OLFML1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OLFML1

SOURCE GeneReport for Unigene cluster for OLFML1 Gene:

Hs.503500

mRNA Expression by UniProt/SwissProt for OLFML1 Gene:

Q6UWY5-OLFL1_HUMAN
Tissue specificity: Mainly expressed in the small intestine, liver, lung and heart.

Evidence on tissue expression from TISSUES for OLFML1 Gene

  • Pancreas(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with OLFML1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for OLFML1 Gene

Orthologs for OLFML1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OLFML1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OLFML1 31 30
  • 99.25 (n)
OneToOne
dog
(Canis familiaris)
Mammalia OLFML1 31 30
  • 88.53 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Olfml1 17 31 30
  • 84.43 (n)
cow
(Bos Taurus)
Mammalia OLFML1 31 30
  • 84.33 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olfml1 30
  • 84.16 (n)
oppossum
(Monodelphis domestica)
Mammalia OLFML1 31
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 50 (a)
OneToMany
-- 31
  • 42 (a)
OneToMany
chicken
(Gallus gallus)
Aves OLFML1 31 30
  • 60.47 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OLFML1 31
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia olfml1 30
  • 53.77 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100003048 30
  • 52.03 (n)
BX294190.1 31
  • 41 (a)
OneToOne
Species where no ortholog for OLFML1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OLFML1 Gene

ENSEMBL:
Gene Tree for OLFML1 (if available)
TreeFam:
Gene Tree for OLFML1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OLFML1: view image

Paralogs for OLFML1 Gene

Paralogs for OLFML1 Gene

(4) SIMAP similar genes for OLFML1 Gene using alignment to 3 proteins:

  • OLFL1_HUMAN
  • E9PKN7_HUMAN
  • E9PN44_HUMAN
genes like me logo Genes that share paralogs with OLFML1: view

Variants for OLFML1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OLFML1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs12803046 - p.Ala259Thr
rs12805648 - p.Glu113Val

Additional dbSNP identifiers (rs#s) for OLFML1 Gene

Structural Variations from Database of Genomic Variants (DGV) for OLFML1 Gene

Variant ID Type Subtype PubMed ID
dgv576e59 CNV tandem duplication 20981092
esv3360494 CNV duplication 20981092
nsv1129510 CNV tandem duplication 24896259
nsv499766 OTHER inversion 21111241
nsv7215 OTHER inversion 18451855

Variation tolerance for OLFML1 Gene

Residual Variation Intolerance Score: 93.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.49; 82.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OLFML1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OLFML1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OLFML1 Gene

Disorders for OLFML1 Gene

Additional Disease Information for OLFML1

No disorders were found for OLFML1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OLFML1 Gene

Publications for OLFML1 Gene

  1. hOLFML1, a novel secreted glycoprotein, enhances the proliferation of human cancer cell lines in vitro. (PMID: 18708057) Wan B … Han ZG (FEBS letters 2008) 3 4 23 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z … Henzel WJ (Protein science : a publication of the Protein Society 2004) 3 4 54
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 54
  5. Olfactomedin-like protein OLFML1 inhibits Hippo signaling and mineralization in osteoblasts. (PMID: 30266405) Murakami K … Nakamura Y (Biochemical and biophysical research communications 2018) 3 54

Products for OLFML1 Gene

Sources for OLFML1 Gene