Aliases for OLFM4 Gene
External Ids for OLFM4 Gene
Previous GeneCards Identifiers for OLFM4 Gene
This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. [provided by RefSeq, Mar 2011]
GeneCards Summary for OLFM4 Gene
OLFM4 (Olfactomedin 4) is a Protein Coding gene. Diseases associated with OLFM4 include Pancreatic Cancer and Ovary Serous Adenocarcinoma. Among its related pathways are Innate Immune System and Adhesion. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and cadherin binding. An important paralog of this gene is OLFM1.
UniProtKB/Swiss-Prot Summary for OLFM4 Gene
May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin.