This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. [provided by RefSeq, Mar 2011] See more...

Aliases for OLFM4 Gene

Aliases for OLFM4 Gene

  • Olfactomedin 4 2 3 5
  • GW112 2 3 4
  • G-CSF-Stimulated Clone 1 Protein 3 4
  • Antiapoptotic Protein GW112 3 4
  • Olfactomedin-4 3 4
  • HGC-1 3 4
  • HOLfD 3 4
  • OLM4 3 4
  • OlfD 2 3
  • GC1 2 3
  • BA209J19.1 3
  • UNQ362 3
  • OLFM4 5

External Ids for OLFM4 Gene

Previous GeneCards Identifiers for OLFM4 Gene

  • GC13P051401
  • GC13P052500
  • GC13P053602
  • GC13P034317

Summaries for OLFM4 Gene

Entrez Gene Summary for OLFM4 Gene

  • This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. [provided by RefSeq, Mar 2011]

GeneCards Summary for OLFM4 Gene

OLFM4 (Olfactomedin 4) is a Protein Coding gene. Diseases associated with OLFM4 include Pancreatic Cancer and Ovary Serous Adenocarcinoma. Among its related pathways are Adhesion and Innate Immune System. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and cadherin binding. An important paralog of this gene is OLFM1.

UniProtKB/Swiss-Prot Summary for OLFM4 Gene

  • May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OLFM4 Gene

Genomics for OLFM4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for OLFM4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J053026 Promoter/Enhancer 0.8 EPDnew Ensembl dbSUPER 284.1 0.0 -12 4 SP1 OLFM4 lnc-PCDH8-6 piR-32214-154 PCDH8
GH13J053010 Enhancer 1 Ensembl ENCODE dbSUPER 12 -12.0 -12012 17.6 MAFF ZNF623 ZNF433 ZNF316 MAFK SPI1 POLR2A MAFG REST ZNF518A HNRNPA1L2 OLFM4 UTP14C piR-32214-154 lnc-PCDH8-6 PCDH8
GH13J052999 Enhancer 0.6 Ensembl ENCODE dbSUPER 11.5 -27.9 -27912 3.8 PKNOX1 OLFM4 HSALNG0097291 piR-32214-154 PCDH8
GH13J053033 Enhancer 0.4 Ensembl dbSUPER 14.1 +4.6 4588 1.2 SCRT2 OLFM4 lnc-PCDH8-6 lnc-OLFM4-1
GH13J052832 Enhancer 0.5 Ensembl 13.4 -194.7 -194712 3.4 NFIC FEZF1 NFIB GATA2 ZFHX2 PPIAP26 OLFM4 MIR759 piR-50129-056 PCDH8 CNMD
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OLFM4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OLFM4

Top Transcription factor binding sites by QIAGEN in the OLFM4 gene promoter:
  • C/EBPalpha
  • CUTL1
  • HSF2
  • Lhx3a
  • LHX3b
  • NF-AT
  • NF-AT1
  • RORalpha2

Genomic Locations for OLFM4 Gene

Latest Assembly
chr13:53,028,813-53,052,057
(GRCh38/hg38)
Size:
23,245 bases
Orientation:
Plus strand

Previous Assembly
chr13:53,602,948-53,626,192
(GRCh37/hg19 by Entrez Gene)
Size:
23,245 bases
Orientation:
Plus strand

chr13:53,602,894-53,626,192
(GRCh37/hg19 by Ensembl)
Size:
23,299 bases
Orientation:
Plus strand

Genomic View for OLFM4 Gene

Genes around OLFM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OLFM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OLFM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLFM4 Gene

Proteins for OLFM4 Gene

  • Protein details for OLFM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UX06-OLFM4_HUMAN
    Recommended name:
    Olfactomedin-4
    Protein Accession:
    Q6UX06
    Secondary Accessions:
    • O95362
    • Q5VWG0
    • Q86T22

    Protein attributes for OLFM4 Gene

    Size:
    510 amino acids
    Molecular mass:
    57280 Da
    Quaternary structure:
    • Homomultimer; disulfide-linked. Interacts with NDUFA13. Interacts with cell surface lectins (locutions ricinus communis agglutinin I, concanavalin-A and wheat germ agglutinin) and cadherin.
    SequenceCaution:
    • Sequence=AAC72970.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAC72970.1; Type=Frameshift; Evidence={ECO:0000305};

neXtProt entry for OLFM4 Gene

Post-translational modifications for OLFM4 Gene

  • N-glycosylated.
  • Glycosylation at Asn72, Asn136, Asn193, Asn253, Asn352, and Asn411
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • OLFM4_HUMAN (1585)

Other Protein References for OLFM4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OLFM4 Gene

Domains & Families for OLFM4 Gene

Gene Families for OLFM4 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for OLFM4 Gene

InterPro:
Blocks:
  • Olfactomedin-like

Suggested Antigen Peptide Sequences for OLFM4 Gene

GenScript: Design optimal peptide antigens:
  • hOLfD (OLFM4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6UX06

UniProtKB/Swiss-Prot:

OLFM4_HUMAN :
  • The olfactomedin-like domain is involved in the interaction with cadherin.
Domain:
  • The olfactomedin-like domain is involved in the interaction with cadherin.
genes like me logo Genes that share domains with OLFM4: view

Function for OLFM4 Gene

Molecular function for OLFM4 Gene

UniProtKB/Swiss-Prot Function:
May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin.
UniProtKB/Swiss-Prot Induction:
By retinoic acid. This induction requires functional NFKB pathway.

Phenotypes From GWAS Catalog for OLFM4 Gene

Gene Ontology (GO) - Molecular Function for OLFM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0005198 structural molecule activity IDA 16566923
GO:0005515 protein binding IPI 20534456
GO:0045296 cadherin binding IMP 16566923
genes like me logo Genes that share ontologies with OLFM4: view
genes like me logo Genes that share phenotypes with OLFM4: view

Animal Models for OLFM4 Gene

MGI Knock Outs for OLFM4:

Animal Models for research

  • Taconic Biosciences Mouse Models for OLFM4

miRNA for OLFM4 Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OLFM4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OLFM4 Gene

Localization for OLFM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLFM4 Gene

Secreted, extracellular space. Mitochondrion. Note=Subcellular location is not clearly defined: has been shown to be secreted (PubMed:16566923), but also in the mitochondrion (PubMed:15059901 and PubMed:20724538), cytoplasm and plasma membrane (PubMed:20724538) and in the nucleus (PubMed:15059901). {ECO:0000269 PubMed:15059901, ECO:0000269 PubMed:16566923, ECO:0000269 PubMed:20724538}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OLFM4 gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 5
nucleus 4
cytosol 4
cytoskeleton 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Plasma membrane (3)
  • Cytokinetic bridge (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OLFM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IMP 16566923
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with OLFM4: view

Pathways & Interactions for OLFM4 Gene

PathCards logo

SuperPathways for OLFM4 Gene

genes like me logo Genes that share pathways with OLFM4: view

Pathways by source for OLFM4 Gene

3 Reactome pathways for OLFM4 Gene
1 Cell Signaling Technology pathway for OLFM4 Gene

Gene Ontology (GO) - Biological Process for OLFM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0010939 NOT regulation of necrotic cell death IMP 23922742
GO:0042981 NOT regulation of apoptotic process IMP 23922742
GO:0043312 neutrophil degranulation TAS --
GO:0050764 NOT regulation of phagocytosis IMP 23922742
genes like me logo Genes that share ontologies with OLFM4: view

No data available for SIGNOR curated interactions for OLFM4 Gene

Drugs & Compounds for OLFM4 Gene

No Compound Related Data Available

Transcripts for OLFM4 Gene

mRNA/cDNA for OLFM4 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OLFM4

Alternative Splicing Database (ASD) splice patterns (SP) for OLFM4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - -
SP2: - - - - - -
SP3: -
SP4:

Relevant External Links for OLFM4 Gene

GeneLoc Exon Structure for
OLFM4

Expression for OLFM4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OLFM4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OLFM4 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x17.7), Pancreas (x11.4), Vagina (x7.7), and Colon - Transverse (x7.1).

Protein differential expression in normal tissues from HIPED for OLFM4 Gene

This gene is overexpressed in Islet of Langerhans (29.4), Neutrophil (18.8), Pancreatic juice (8.8), and Urine (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OLFM4 Gene



Protein tissue co-expression partners for OLFM4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OLFM4

SOURCE GeneReport for Unigene cluster for OLFM4 Gene:

Hs.508113

mRNA Expression by UniProt/SwissProt for OLFM4 Gene:

Q6UX06-OLFM4_HUMAN
Tissue specificity: Expressed during myeloid lineage development. Much higher expression in bone marrow neutrophils than in peripheral blood neutrophils (at protein level). Strongly expressed in the prostate, small intestine and colon and moderately expressed in the bone marrow and stomach. Overexpressed in some pancreatic cancer tissues.

Evidence on tissue expression from TISSUES for OLFM4 Gene

  • Intestine(5)
  • Nervous system(4.3)
  • Kidney(3.2)
  • Bone marrow(2.8)
  • Lung(2.7)
  • Pancreas(2.5)
  • Stomach(2.4)
  • Blood(2.2)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with OLFM4: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for OLFM4 Gene

Orthologs for OLFM4 Gene

This gene was present in the common ancestor of animals.

Orthologs for OLFM4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia OLFM4 29 30
  • 99.48 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia OLFM4 29 30
  • 85.61 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia OLFM4 29 30
  • 81.77 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Olfm4 29
  • 79.68 (n)
Mouse
(Mus musculus)
Mammalia Olfm4 29 16 30
  • 79.01 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia OLFM4 30
  • 65 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia OLFM4 30
  • 65 (a)
OneToOne
Chicken
(Gallus gallus)
Aves OLFM4 29 30
  • 65.98 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia OLFM4 30
  • 61 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia olfm4 29
  • 58.15 (n)
Str.6175 29
African clawed frog
(Xenopus laevis)
Amphibia Tiarin 29
Zebrafish
(Danio rerio)
Actinopterygii LOC569427 29
  • 50.32 (n)
OLFM4 (7 of 8) 30
  • 37 (a)
OneToMany
OLFM4 (2 of 8) 30
  • 35 (a)
OneToMany
OLFM4 (8 of 8) 30
  • 35 (a)
OneToMany
OLFM4 (1 of 8) 30
  • 34 (a)
OneToMany
OLFM4 (4 of 8) 30
  • 30 (a)
OneToMany
OLFM4 (5 of 8) 30
  • 28 (a)
OneToMany
OLFM4 (6 of 8) 30
  • 27 (a)
OneToMany
OLFM4 (3 of 8) 30
  • 26 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG6867 30
  • 9 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea cof-2 30
  • 15 (a)
ManyToMany
unc-122 30
  • 13 (a)
ManyToMany
Species where no ortholog for OLFM4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for OLFM4 Gene

ENSEMBL:
Gene Tree for OLFM4 (if available)
TreeFam:
Gene Tree for OLFM4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OLFM4: view image
Alliance of Genome Resources:
Additional Orthologs for OLFM4

Paralogs for OLFM4 Gene

Paralogs for OLFM4 Gene

Pseudogenes.org Pseudogenes for OLFM4 Gene

genes like me logo Genes that share paralogs with OLFM4: view

Variants for OLFM4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OLFM4 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
rs35790097 -- p.Ser36Pro

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for OLFM4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for OLFM4 Gene

Variant ID Type Subtype PubMed ID
esv3632112 CNV loss 21293372
nsv832613 CNV gain 17160897

Variation tolerance for OLFM4 Gene

Residual Variation Intolerance Score: 60.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.39; 42.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OLFM4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OLFM4
Leiden Open Variation Database (LOVD)
OLFM4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OLFM4 Gene

Disorders for OLFM4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for OLFM4 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
pancreatic cancer
  • pancreatic carcinoma
ovary serous adenocarcinoma
  • malignant ovarian serous tumor
- elite association - COSMIC cancer census association via MalaCards
Search OLFM4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OLFM4

genes like me logo Genes that share disorders with OLFM4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OLFM4 Gene

Publications for OLFM4 Gene

  1. A genome-wide association meta-analysis identifies new childhood obesity loci. (PMID: 22484627) Bradfield JP … Early Growth Genetics Consortium (Nature genetics 2012) 3 40
  2. Olfactomedin 4 is a novel target gene of retinoic acids and 5-aza-2'-deoxycytidine involved in human myeloid leukemia cell growth, differentiation, and apoptosis. (PMID: 20724538) Liu W … Rodgers GP (Blood 2010) 3 4
  3. Serum olfactomedin 4 (GW112, hGC-1) in combination with Reg IV is a highly sensitive biomarker for gastric cancer patients. (PMID: 19670418) Oue N … Yasui W (International journal of cancer 2009) 3 22
  4. Olfactomedin 4 promotes S-phase transition in proliferation of pancreatic cancer cells. (PMID: 17270022) Kobayashi D … Watanabe N (Cancer science 2007) 4 22
  5. The glycoprotein hGC-1 binds to cadherin and lectins. (PMID: 16566923) Liu W … Rodgers GP (Experimental cell research 2006) 3 4

Products for OLFM4 Gene

Sources for OLFM4 Gene