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OLFM2 (Olfactomedin 2) is a Protein Coding gene. Diseases associated with OLFM2 include Arteriosclerosis Obliterans and Open-Angle Glaucoma. An important paralog of this gene is OLFM3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 25298399 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IDA | 21228389 |
GO:0005634 | nucleus | IEA,IDA | 25298399 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IEA,IDA | 25298399 |
GO:0016020 | membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007601 | visual perception | IEA | -- |
GO:0007626 | locomotory behavior | IEA | -- |
GO:0009306 | protein secretion | IDA | 21228389 |
GO:0051152 | positive regulation of smooth muscle cell differentiation | IMP | 25298399 |
GO:1905174 | regulation of vascular smooth muscle cell dedifferentiation | IEA,ISS | -- |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||
SP2: | - | ||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||
SP4: | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | OLFM2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | OLFM2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | OLFM2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Olfm2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Olfm2 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | OLFM2 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | OLFM2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | olfm2 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | olfm2a 30 |
|
||
olfm2b 31 |
|
OneToOne | |||
Dr.10562 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.278 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
780531 | Benign: not provided | 9,854,869(-) | G/A | INTRON_VARIANT | |
rs1298178636 | A colorectal cancer sample | p.Thr86Met | |||
rs11556087 | - | p.Thr127Met | |||
rs2303100 | - | p.Arg106Gln |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1710n106 | CNV | deletion | 24896259 |
dgv1711n106 | CNV | deletion | 24896259 |
esv2656960 | CNV | deletion | 23128226 |
esv3643644 | CNV | loss | 21293372 |
nsv1059984 | CNV | gain | 25217958 |
nsv1072320 | CNV | deletion | 25765185 |
nsv520683 | CNV | loss | 19592680 |
nsv833742 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
arteriosclerosis obliterans |
|
|
open-angle glaucoma |
|
|
glaucoma, primary open angle |
|
|