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Aliases for OLFM2 Gene

Aliases for OLFM2 Gene

  • Olfactomedin 2 2 3 5
  • NOE2 3 4
  • Neuronal Olfactomedin Related ER Localized Protein 2 3
  • Olfactomedin-2 4
  • NOELIN2_V1 3
  • Noelin-2 3
  • Noelin 2 2
  • NOELIN2 3
  • OlfC 3

External Ids for OLFM2 Gene

Previous GeneCards Identifiers for OLFM2 Gene

  • GC19M010085
  • GC19M010187
  • GC19M009809
  • GC19M009825
  • GC19M009964
  • GC19M009545

Summaries for OLFM2 Gene

GeneCards Summary for OLFM2 Gene

OLFM2 (Olfactomedin 2) is a Protein Coding gene. An important paralog of this gene is OLFM3.

UniProtKB/Swiss-Prot for OLFM2 Gene

  • Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes (PubMed:25298399). Plays a role in AMPAR complex organization (By similarity). Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling (By similarity).

Gene Wiki entry for OLFM2 Gene

Additional gene information for OLFM2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OLFM2 Gene

Genomics for OLFM2 Gene

GeneHancer (GH) Regulatory Elements for OLFM2 Gene

Promoters and enhancers for OLFM2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J009936 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 659.5 -0.3 -285 1.7 ZSCAN5A BCOR PKNOX1 KLF1 USF1 SIN3A ZEB1 HIC1 ZFHX2 GLIS2 OLFM2 ZNF177 ENSG00000267273 ENSG00000200237 OR7D2 ENSG00000267650
GH19J009935 Enhancer 0.7 ENCODE 650.7 +0.7 670 0.1 PKNOX1 MXI1 KLF1 ZSCAN18 ZSCAN4 KLF17 SIN3A ZNF2 HIC1 ZNF335 OLFM2 LOC100418883 OR7H1P OR7E19P OR7E24 OR7E25P OR7E18P ELOCP29 OR7G3 OR7E16P
GH19J009913 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE 14.2 +22.1 22125 1.7 HDGF ATF1 ARNT SIN3A ZNF48 GLIS2 ZNF213 ZNF143 FOS ATF7 OLFM2 COL5A3 RDH8 ENSG00000267273 ZNF266 GC19P009927 PIR54152
GH19J009944 Enhancer 1.4 FANTOM5 Ensembl ENCODE 16.7 -9.0 -8979 1.9 HDAC1 PKNOX1 INSM2 KLF17 NFXL1 ZEB1 ZNF335 GLIS2 EGR1 ZNF366 ZNF266 ZNF317 OLFM2 ILF3 ZNF559 RAVER1 ZNF699 FBXL12 KRI1 DNMT1
GH19J009933 Enhancer 0.9 ENCODE 14.9 +2.2 2224 0.9 ATF1 ARID4B GLIS2 ARID2 ZNF143 KLF7 ATF7 RUNX3 KLF13 SP3 ZNF177 OLFM2 ENSG00000267273 ENSG00000200237 GC19P009927
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OLFM2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the OLFM2 gene promoter:
  • ER-alpha
  • Bach1
  • Bach2
  • c-Myc
  • Max
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for OLFM2 Gene

Genomic Locations for OLFM2 Gene
chr19:9,853,718-9,936,552
(GRCh38/hg38)
Size:
82,835 bases
Orientation:
Minus strand
chr19:9,964,394-10,047,228
(GRCh37/hg19)
Size:
82,835 bases
Orientation:
Minus strand

Genomic View for OLFM2 Gene

Genes around OLFM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OLFM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OLFM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLFM2 Gene

Proteins for OLFM2 Gene

  • Protein details for OLFM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95897-NOE2_HUMAN
    Recommended name:
    Noelin-2
    Protein Accession:
    O95897
    Secondary Accessions:
    • Q6IMJ3
    • Q96FC2

    Protein attributes for OLFM2 Gene

    Size:
    454 amino acids
    Molecular mass:
    51386 Da
    Quaternary structure:
    • Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including OLFM2. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing. Interacts with GRIA2 (By similarity). Interacts with OLFM1 and OLFM3 (PubMed:21228389). Interacts with SRF; the interaction promotes dissociation of SRF from the transcriptional repressor HEY2 (PubMed:25298399). Interacts with RUNX2 (By similarity).

neXtProt entry for OLFM2 Gene

Post-translational modifications for OLFM2 Gene

  • N-glycosylated.
  • Glycosylation at isoforms=441, isoforms=399, isoforms=310, Asn275, Asn155, and Asn74
  • Modification sites at PhosphoSitePlus

Other Protein References for OLFM2 Gene

No data available for DME Specific Peptides for OLFM2 Gene

Domains & Families for OLFM2 Gene

Gene Families for OLFM2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for OLFM2 Gene

Suggested Antigen Peptide Sequences for OLFM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with OLFM2: view

No data available for UniProtKB/Swiss-Prot for OLFM2 Gene

Function for OLFM2 Gene

Molecular function for OLFM2 Gene

UniProtKB/Swiss-Prot Function:
Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes (PubMed:25298399). Plays a role in AMPAR complex organization (By similarity). Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling (By similarity).
UniProtKB/Swiss-Prot Induction:
By TGF-beta.

Phenotypes From GWAS Catalog for OLFM2 Gene

Gene Ontology (GO) - Molecular Function for OLFM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25298399
genes like me logo Genes that share ontologies with OLFM2: view
genes like me logo Genes that share phenotypes with OLFM2: view

Animal Models for OLFM2 Gene

MGI Knock Outs for OLFM2:

Animal Model Products

  • Taconic Biosciences Mouse Models for OLFM2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OLFM2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for OLFM2 Gene

Localization for OLFM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLFM2 Gene

Secreted. Cell junction, synapse. Membrane. Nucleus. Cytoplasm. Note=Nuclear localization is induced by TGF-beta. {ECO:0000269 PubMed:25298399}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OLFM2 gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 4
lysosome 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for OLFM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 21228389
GO:0005634 nucleus IEA,IDA 25298399
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA,IEA 25298399
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with OLFM2: view

Pathways & Interactions for OLFM2 Gene

SuperPathways for OLFM2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OLFM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007601 visual perception IEA --
GO:0007626 locomotory behavior IEA --
GO:0009306 protein secretion IDA 21228389
GO:0051152 positive regulation of smooth muscle cell differentiation IMP 25298399
GO:1905174 regulation of vascular smooth muscle cell dedifferentiation IEA,ISS --
genes like me logo Genes that share ontologies with OLFM2: view

No data available for Pathways by source and SIGNOR curated interactions for OLFM2 Gene

Drugs & Compounds for OLFM2 Gene

No Compound Related Data Available

Transcripts for OLFM2 Gene

mRNA/cDNA for OLFM2 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(114) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OLFM2 Gene

Olfactomedin 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for OLFM2

Alternative Splicing Database (ASD) splice patterns (SP) for OLFM2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
SP1: - -
SP2: -
SP3: - -
SP4: -

Relevant External Links for OLFM2 Gene

GeneLoc Exon Structure for
OLFM2
ECgene alternative splicing isoforms for
OLFM2

Expression for OLFM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OLFM2 Gene

mRNA differential expression in normal tissues according to GTEx for OLFM2 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x4.5), Brain - Amygdala (x4.1), and Brain - Nucleus accumbens (basal ganglia) (x4.0).

Protein differential expression in normal tissues from HIPED for OLFM2 Gene

This gene is overexpressed in Vitreous humor (47.3) and Serum (16.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for OLFM2 Gene



NURSA nuclear receptor signaling pathways regulating expression of OLFM2 Gene:

OLFM2

SOURCE GeneReport for Unigene cluster for OLFM2 Gene:

Hs.169743

mRNA Expression by UniProt/SwissProt for OLFM2 Gene:

O95897-NOE2_HUMAN
Tissue specificity: Expressed in aortic smooth muscle (at protein level) (PubMed:25298399). In the fetus, expressed in the brain and ocular tissues including lens vesicle and optic cup (PubMed:27844144).

Evidence on tissue expression from TISSUES for OLFM2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with OLFM2: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for OLFM2 Gene

Orthologs for OLFM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OLFM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OLFM2 34 33
  • 99.41 (n)
OneToOne
dog
(Canis familiaris)
Mammalia OLFM2 34 33
  • 93.09 (n)
OneToOne
cow
(Bos Taurus)
Mammalia OLFM2 34 33
  • 92.35 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olfm2 33
  • 88.38 (n)
mouse
(Mus musculus)
Mammalia Olfm2 16 34 33
  • 88.23 (n)
oppossum
(Monodelphis domestica)
Mammalia OLFM2 34
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OLFM2 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia olfm2 33
  • 73.98 (n)
zebrafish
(Danio rerio)
Actinopterygii olfm2a 33
  • 73.36 (n)
olfm2b 34
  • 49 (a)
OneToOne
Dr.10562 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.278 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 23 (a)
OneToMany
Species where no ortholog for OLFM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OLFM2 Gene

ENSEMBL:
Gene Tree for OLFM2 (if available)
TreeFam:
Gene Tree for OLFM2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OLFM2: view image

Paralogs for OLFM2 Gene

Paralogs for OLFM2 Gene

(9) SIMAP similar genes for OLFM2 Gene using alignment to 5 proteins:

  • NOE2_HUMAN
  • K7EIS8_HUMAN
  • K7EKW2_HUMAN
  • K7ELC6_HUMAN
  • L8E9J3_HUMAN
genes like me logo Genes that share paralogs with OLFM2: view

Variants for OLFM2 Gene

Sequence variations from dbSNP and Humsavar for OLFM2 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
VAR_036532 A colorectal cancer sample p.Thr86Met
rs1000022610 -- 9,859,871(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000048748 -- 9,913,836(-) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000068125 -- 9,853,804(-) TGGGGGTGGGGGTGGGGGTGGG/TGGGGGTGGGGGTGGG/TGGGGGTGGGGGTGGGGGTGGGGGTGGG 3_prime_UTR_variant
rs1000069185 -- 9,933,427(-) GGGG/GGG genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for OLFM2 Gene

Variant ID Type Subtype PubMed ID
dgv1710n106 CNV deletion 24896259
dgv1711n106 CNV deletion 24896259
esv2656960 CNV deletion 23128226
esv3643644 CNV loss 21293372
nsv1059984 CNV gain 25217958
nsv1072320 CNV deletion 25765185
nsv520683 CNV loss 19592680
nsv833742 CNV loss 17160897

Variation tolerance for OLFM2 Gene

Residual Variation Intolerance Score: 13.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.91; 93.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OLFM2 Gene

Human Gene Mutation Database (HGMD)
OLFM2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OLFM2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OLFM2 Gene

Disorders for OLFM2 Gene

Additional Disease Information for OLFM2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for OLFM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OLFM2 Gene

Publications for OLFM2 Gene

  1. SNPs and interaction analyses of noelin 2, myocilin, and optineurin genes in Japanese patients with open-angle glaucoma. (PMID: 17122126) Funayama T … Glaucoma Gene Research Group (Investigative ophthalmology & visual science 2006) 3 22 44 58
  2. Bioinformatic approaches for identification and characterization of olfactomedin related genes with a potential role in pathogenesis of ocular disorders. (PMID: 15123989) Mukhopadhyay A … Ray K (Molecular vision 2004) 3 4 22 58
  3. Identification and functional characterisation of genetic variants in OLFM2 in children with developmental eye disorders. (PMID: 27844144) Holt R … Ragge N (Human genetics 2017) 3 4 58
  4. Olfactomedin 2, a novel regulator for transforming growth factor-β-induced smooth muscle differentiation of human embryonic stem cell-derived mesenchymal cells. (PMID: 25298399) Shi N … Chen SY (Molecular biology of the cell 2014) 3 4 58
  5. Olfactomedin 2: expression in the eye and interaction with other olfactomedin domain-containing proteins. (PMID: 21228389) Sultana A … Tomarev SI (Investigative ophthalmology & visual science 2011) 3 4 58

Products for OLFM2 Gene

Sources for OLFM2 Gene

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