This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. While the exact function of the encoded protein is not known, its abundant expression in brain suggests that it may have an essential role in nerve tissue. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [pr... See more...

Aliases for OLFM1 Gene

Aliases for OLFM1 Gene

  • Olfactomedin 1 2 3 5
  • Noelin 2 3 4
  • Neuronal Olfactomedin-Related ER Localized Protein 3 4
  • NOE1 3 4
  • Olfactomedin Related ER Localized Protein 3
  • Neuroblastoma Protein 3
  • Olfactomedin-1 4
  • Pancortin 1 3
  • Pancortin 2
  • NOELIN1 3
  • NOEL1 4
  • OlfA 3
  • AMY 3

External Ids for OLFM1 Gene

Previous GeneCards Identifiers for OLFM1 Gene

  • GC09P129117
  • GC09P129736
  • GC09P131490
  • GC09P133406
  • GC09P135193
  • GC09P137106
  • GC09P137967
  • GC09P107430

Summaries for OLFM1 Gene

Entrez Gene Summary for OLFM1 Gene

  • This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. While the exact function of the encoded protein is not known, its abundant expression in brain suggests that it may have an essential role in nerve tissue. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for OLFM1 Gene

OLFM1 (Olfactomedin 1) is a Protein Coding gene. Diseases associated with OLFM1 include Ectopic Pregnancy and Neuroblastoma. Gene Ontology (GO) annotations related to this gene include amyloid-beta binding. An important paralog of this gene is OLFM3.

UniProtKB/Swiss-Prot Summary for OLFM1 Gene

  • Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1. Inhibits RTN4R-mediated axon growth cone collapse (By similarity). May play an important role in regulating the production of neural crest cells by the neural tube (By similarity). May be required for normal responses to olfactory stimuli (By similarity).

Gene Wiki entry for OLFM1 Gene

Additional gene information for OLFM1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for OLFM1 Gene

Genomics for OLFM1 Gene

GeneHancer (GH) Regulatory Elements for OLFM1 Gene

Promoters and enhancers for OLFM1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J135074 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 500.7 +0.5 458 1.8 ZNF217 GABPA CTBP1 MXI1 SIN3A MYC ELK1 SMC3 CTCF POLR2A OLFM1 lnc-OLFM1-1
GH09J135106 Promoter 0.4 EPDnew 500.3 +30.4 30448 0.1 KLF1 OLFM1 lnc-OLFM1-1
GH09J135499 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 13.2 +425.7 425748 4 HNRNPK ZNF217 CTCF SIN3A NRF1 TCF12 POLR2G USF1 SP1 GTF2E2 C9orf116 MRPS2 lnc-GLT6D1-3 INPP5E ENTR1 SEC16A OLFM1 QSOX2 SNAPC4 COL5A1-AS1
GH09J134363 Promoter/Enhancer 2 VISTA FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 13.2 -709.0 -709004 5.4 EP300 ZNF217 TCF12 NCOR1 ZFX ZNF10 ZIC2 KDM6A ZBTB10 CLOCK WDR5 BRD3OS OLFM1 BRD3 RXRA lnc-BRD3-7
GH09J135440 Enhancer 1.1 Ensembl ENCODE 13.2 +366.2 366204 2.3 CTCF AFF1 REST TOE1 CTBP1 SREBF2 MIER1 HDAC3 NCOR1 NFRKB OLFM1 PPP1R26-AS1 piR-34232 RF00017-8049 lnc-GLT6D1-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around OLFM1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for OLFM1

Top Transcription factor binding sites by QIAGEN in the OLFM1 gene promoter:
  • NRSF form 1
  • NRSF form 2

Genomic Locations for OLFM1 Gene

Genomic Locations for OLFM1 Gene
chr9:135,075,243-135,121,184
(GRCh38/hg38)
Size:
45,942 bases
Orientation:
Plus strand
chr9:137,967,089-138,013,030
(GRCh37/hg19)
Size:
45,942 bases
Orientation:
Plus strand

Genomic View for OLFM1 Gene

Genes around OLFM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OLFM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OLFM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OLFM1 Gene

Proteins for OLFM1 Gene

  • Protein details for OLFM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99784-NOE1_HUMAN
    Recommended name:
    Noelin
    Protein Accession:
    Q99784
    Secondary Accessions:
    • Q53XZ8
    • Q6IMJ4
    • Q6IMJ5
    • Q8N8R0
    • Q969S7
    • Q99452

    Protein attributes for OLFM1 Gene

    Size:
    485 amino acids
    Molecular mass:
    55343 Da
    Quaternary structure:
    • Homotetramer; disulfide-linked. Dimer of dimers, giving rise to a V-shaped homotretramer. Isoform 1 and isoform 3 interact with RTN4R. Identified in a complex with RTN4R and LINGO1. Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including OLFM1. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing (By similarity). Interacts with OLFM2 (PubMed:21228389).

    Three dimensional structures from OCA and Proteopedia for OLFM1 Gene

    Alternative splice isoforms for OLFM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OLFM1 Gene

Post-translational modifications for OLFM1 Gene

  • Glycosylation at Asn33, Asn103, Asn187, Asn288, Asn307, Asn394, Asn431, and Asn473
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

No data available for DME Specific Peptides for OLFM1 Gene

Domains & Families for OLFM1 Gene

Gene Families for OLFM1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for OLFM1 Gene

Blocks:
  • Olfactomedin-like
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OLFM1 Gene

GenScript: Design optimal peptide antigens:
  • Olfactomedin-1 (NOE1_HUMAN)
  • Olfactomedin 1, isoform CRA_d (Q6IMJ7_HUMAN)
  • Olfactomedin 1, isoform CRA_c (Q6IMJ8_HUMAN)
  • OLFM1 protein (Q96BL8_HUMAN)
  • Olfactomedin 1, isoform CRA_b (Q9BWJ9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99784

UniProtKB/Swiss-Prot:

NOE1_HUMAN :
  • The protein contains a globular N-terminal tetramerization domain, a long stalk formed by the coiled coil region and a C-terminal olfactomedin-like domain. Interactions between dimers are mediated by the coiled coil region. The dimers interact mostly via the N-terminal tetramerization domain, giving rise to a V-shaped overall architecture of the tetramer.
Domain:
  • The protein contains a globular N-terminal tetramerization domain, a long stalk formed by the coiled coil region and a C-terminal olfactomedin-like domain. Interactions between dimers are mediated by the coiled coil region. The dimers interact mostly via the N-terminal tetramerization domain, giving rise to a V-shaped overall architecture of the tetramer.
genes like me logo Genes that share domains with OLFM1: view

Function for OLFM1 Gene

Molecular function for OLFM1 Gene

UniProtKB/Swiss-Prot Function:
Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1. Inhibits RTN4R-mediated axon growth cone collapse (By similarity). May play an important role in regulating the production of neural crest cells by the neural tube (By similarity). May be required for normal responses to olfactory stimuli (By similarity).

Phenotypes From GWAS Catalog for OLFM1 Gene

Gene Ontology (GO) - Molecular Function for OLFM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17043677
genes like me logo Genes that share ontologies with OLFM1: view
genes like me logo Genes that share phenotypes with OLFM1: view

Animal Models for OLFM1 Gene

MGI Knock Outs for OLFM1:

Animal Model Products

  • Taconic Biosciences Mouse Models for OLFM1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OLFM1 Gene

Localization for OLFM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OLFM1 Gene

Secreted. Cell junction, synapse. Endoplasmic reticulum. Cell projection, axon. Perikaryon.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OLFM1 gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 4
mitochondrion 2
nucleus 2
cytosol 2
plasma membrane 1
cytoskeleton 1
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for OLFM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space ISS --
GO:0005623 cell ISS --
GO:0005783 endoplasmic reticulum ISS --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with OLFM1: view

Pathways & Interactions for OLFM1 Gene

PathCards logo

SuperPathways for OLFM1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OLFM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003190 atrioventricular valve formation ISS --
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development TAS,IEA 9039501
GO:0010628 positive regulation of gene expression ISS --
GO:0010629 negative regulation of gene expression ISS --
genes like me logo Genes that share ontologies with OLFM1: view

No data available for Pathways by source and SIGNOR curated interactions for OLFM1 Gene

Drugs & Compounds for OLFM1 Gene

No Compound Related Data Available

Transcripts for OLFM1 Gene

mRNA/cDNA for OLFM1 Gene

5 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OLFM1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b ^ 13
SP1: - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - -
SP4: - - -
SP5:
SP6: - -
SP7: - - - - - - -
SP8: - - - - - - - - -
SP9: -
SP10:
SP11:

Relevant External Links for OLFM1 Gene

GeneLoc Exon Structure for
OLFM1

Expression for OLFM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for OLFM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OLFM1 Gene

This gene is overexpressed in Brain - Cortex (x8.1), Brain - Frontal Cortex (BA9) (x8.0), Brain - Anterior cingulate cortex (BA24) (x6.8), Brain - Hippocampus (x4.8), and Brain - Amygdala (x4.6).

Protein differential expression in normal tissues from HIPED for OLFM1 Gene

This gene is overexpressed in Serum (36.8), Plasma (9.2), and Synovial fluid (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for OLFM1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for OLFM1

SOURCE GeneReport for Unigene cluster for OLFM1 Gene:

Hs.522484

Evidence on tissue expression from TISSUES for OLFM1 Gene

  • Nervous system(5)
  • Eye(4.4)
  • Bone marrow(4)
genes like me logo Genes that share expression patterns with OLFM1: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OLFM1 Gene

Orthologs for OLFM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OLFM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OLFM1 31 30
  • 99.07 (n)
OneToOne
cow
(Bos Taurus)
Mammalia OLFM1 31
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Olfm1 30
  • 92.23 (n)
dog
(Canis familiaris)
Mammalia OLFM1 31 30
  • 92.18 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Olfm1 17 31 30
  • 91.34 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia OLFM1 31
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OLFM1 31
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves OLFM1 31 30
  • 86.46 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OLFM1 31
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia olfm1 30
  • 83.78 (n)
Str.12087 30
African clawed frog
(Xenopus laevis)
Amphibia LOC398287 30
zebrafish
(Danio rerio)
Actinopterygii olfm1a 31
  • 76 (a)
OneToMany
olfm1b 31
  • 75 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 24 (a)
OneToMany
Species where no ortholog for OLFM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OLFM1 Gene

ENSEMBL:
Gene Tree for OLFM1 (if available)
TreeFam:
Gene Tree for OLFM1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for OLFM1: view image

Paralogs for OLFM1 Gene

Paralogs for OLFM1 Gene

(12) SIMAP similar genes for OLFM1 Gene using alignment to 12 proteins:

  • NOE1_HUMAN
  • F5GZQ2_HUMAN
  • F5H810_HUMAN
  • F8W870_HUMAN
  • H0YFB9_HUMAN
  • Q5VZL8_HUMAN
  • Q6IMJ5_HUMAN
  • Q6IMJ6_HUMAN
  • Q6IMJ7_HUMAN
  • Q6IMJ8_HUMAN
  • Q96BL8_HUMAN
  • Q9BWJ9_HUMAN
genes like me logo Genes that share paralogs with OLFM1: view

Variants for OLFM1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for OLFM1 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
768338 Benign: not provided 135,106,789(+) C/T SYNONYMOUS_VARIANT
784078 Benign: not provided 135,106,834(+) C/T SYNONYMOUS_VARIANT
787891 Benign: not provided 135,119,662(+) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for OLFM1 Gene

Structural Variations from Database of Genomic Variants (DGV) for OLFM1 Gene

Variant ID Type Subtype PubMed ID
esv1343927 CNV insertion 17803354
esv2025540 CNV deletion 18987734
esv2739138 CNV deletion 23290073
esv29590 CNV loss 19812545
esv3346368 CNV duplication 20981092
esv3384326 CNV duplication 20981092
esv3621975 CNV loss 21293372
nsv1039646 CNV gain 25217958
nsv1043726 CNV gain 25217958
nsv1125319 OTHER inversion 24896259
nsv1142712 CNV deletion 24896259
nsv1143237 CNV tandem duplication 24896259
nsv509330 CNV insertion 20534489
nsv513001 CNV insertion 21212237
nsv615842 CNV gain 21841781
nsv6756 CNV insertion 18451855
nsv825156 CNV gain 20364138
nsv825157 CNV gain 20364138
nsv831754 CNV loss 17160897
nsv951817 CNV deletion 24416366

Variation tolerance for OLFM1 Gene

Residual Variation Intolerance Score: 8.78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.54; 11.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for OLFM1 Gene

Human Gene Mutation Database (HGMD)
OLFM1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
OLFM1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OLFM1 Gene

Disorders for OLFM1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for OLFM1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ectopic pregnancy
  • eccyesis
neuroblastoma
  • nb
- elite association - COSMIC cancer census association via MalaCards
Search OLFM1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for OLFM1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with OLFM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OLFM1 Gene

Publications for OLFM1 Gene

  1. Identification and cloning of neuroblastoma-specific and nerve tissue-specific genes through compiled expression profiles. (PMID: 9039501) Yokoyama M … Matsubara K (DNA research : an international journal for rapid publication of reports on genes and genomes 1996) 2 3 4 54
  2. Serum ferritin levels are associated with a distinct phenotype of chronic hepatitis C poorly responding to pegylated interferon-alpha and ribavirin therapy. (PMID: 22095909) Lange CM … Swiss Hepatitis C Cohort Study Group (Hepatology (Baltimore, Md.) 2012) 3 41 54
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  4. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PMID: 16335952) Liu T … Smith RD (Journal of proteome research 2005) 3 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for OLFM1 Gene

Sources for OLFM1 Gene