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OLAH (Oleoyl-ACP Hydrolase) is a Protein Coding gene. Diseases associated with OLAH include Rheumatoid Arthritis and Arthritis. Among its related pathways are Fatty acid biosynthesis (KEGG) and Metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on ester bonds and myristoyl-[acyl-carrier-protein] hydrolase activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004320 | oleoyl-[acyl-carrier-protein] hydrolase activity | IEA | -- |
GO:0016295 | myristoyl-[acyl-carrier-protein] hydrolase activity | IEA,IDA | 26663084 |
GO:0016296 | palmitoyl-[acyl-carrier-protein] hydrolase activity | IEA,IDA | 26663084 |
GO:0016297 | acyl-[acyl-carrier-protein] hydrolase activity | IEA | -- |
GO:0016787 | hydrolase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | ISS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Metabolism |
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2 | Fatty Acyl-CoA Biosynthesis | ||
3 | Fatty acid biosynthesis (KEGG) | ||
4 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006629 | lipid metabolic process | IEA | -- |
GO:0006631 | fatty acid metabolic process | IEA | -- |
GO:0006633 | fatty acid biosynthetic process | IEA | -- |
GO:0008610 | lipid biosynthetic process | IBA | 21873635 |
GO:0009058 | biosynthetic process | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
lauric acid | Approved, Experimental | Pharma | Agonist | 0 | ||
oleic acid | Approved, Investigational, Vet_approved | Pharma | Agonist, Full agonist, Activator, Activation | 0 | ||
Palmitic Acid | Approved | Pharma | Agonist, Full agonist | 27 | ||
Stearic acid | Approved, Experimental | Pharma | 0 | |||
Water | Approved | Pharma | 0 |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||
SP4: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | OLAH 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Olah 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Olah 30 |
|
||
Cow (Bos Taurus) |
Mammalia | OLAH 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | OLAH 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | OLAH 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | OLAH 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | olah 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | olah 30 31 |
|
OneToOne |
Disorder | Aliases | PubMed IDs |
---|---|---|
rheumatoid arthritis |
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arthritis |
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paronychia |
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wolff-parkinson-white syndrome |
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